Differential effects of prenatal stress on the morphological maturation of hippocampal neurons

Fujioka, A.; Fujioka, T.; Ishida, Y.; Maekawa, T.; Nakamura, S.

doi:10.1016/j.neuroscience.2006.04.046

Cited by 165Stress Responses and CortisolNeurogenesis and neuroplasticity mechanismsMemory and Neural Mechanisms

Differential effects of prenatal stress on the morphological maturation of hippocampal neurons

Fujioka, A., Fujioka, T., Ishida, Y., Maekawa, T., Nakamura, S.·2006·Neuroscience

DOI 10.1016/j.neuroscience.2006.04.046

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Abstract

The present study was designed to clarify an intensity-dependent effect of prenatal stress on the morphological development of hippocampal neurons in rats. In addition, the involvement of receptors for glucocorticoids, i.e. mineralocorticoid receptors and glucocorticoid receptors, in stress-induced changes in the morphology of hippocampal neurons was examined by an in vitro pharmacological approach. The effects of mild prenatal stress on neurogenesis and long-term potentiation in the hippocampus were also investigated in adult offspring. Prenatal stress affected the morphological development of the hippocampus in an intensity-dependent manner. Short-lasting, mild prenatal stress enhanced neonatal neurogenesis and differentiation of processes of hippocampal neurons, whereas long-lasting, severe stress impaired their morphology. Mineralocorticoid receptor was found to mediate enhancement of neurogenesis and differentiation of processes of cultured hippocampal neurons. In contrast, glucocorticoid receptor was involved in the suppression of their morphology. Short-lasting, mild prenatal stress, which has previously been shown to enhance learning performance in adult offspring, facilitated neurogenesis and long-term potentiation in the adult hippocampus. These findings suggest that prenatal stress has enhancing and suppressing effects on the development of hippocampal neurons depending on intensity, and that mineralocorticoid receptors and glucocorticoid receptors contribute to stress-induced morphological changes.

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Prenatally stressed animals repeatedly show impaired neurogenesis and related cognitive impairment.
“Impaired neurogenesis and associated cognitive impairment have been repeatedly reported in prenatally stressed animals (Lemaire et al., 2000; Fujioka et al., 2006; Lemaire et al., 2006).”
From High pregnancy anxiety during mid-gestation is associated with decreased gray matter density in 6-9-year-old children. (2010) · cites this paper as Fujioka et al., 2006
The findings are consistent with animal evidence that medial temporal and prefrontal cortical regions are shaped by early experience.
“Our findings are consistent with accumulating evidence from animal studies that medial temporal and prefrontal cortical regions are shaped by early experience (e.g. Coe et al., 2003; Salm et al., 2004; Fujioka et al., 2006; Murmu et al., 2006).”
From High pregnancy anxiety during mid-gestation is associated with decreased gray matter density in 6-9-year-old children. (2010) · cites this paper as Fujioka et al., 2006

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Authors: Fujioka, A., Fujioka, T., Ishida, Y., Maekawa, T., & Nakamura, S.
Affiliations: Yamaguchi University (JP)
Corresponding author: Fujioka, T.
Nakamura, S.
ORCID: Ishida, Y.
Nakamura, S.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2006
Volume: 141
Issue: 2
Pages: 907-915
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2006.04.046
OpenAlex: W2051951421
Cited by: 165
References: 33
Citations by year: 2026: 2 · 2025: 3 · 2024: 3 · 2023: 1 · 2022: 9 · 2021: 7 · 2020: 6 · 2019: 3 · 2018: 4 · 2017: 15 · 2016: 9 · 2015: 14 · 2014: 18 · 2013: 8 · 2012: 12
FWCI: 3.55
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: prenatal stress, hippocampal neurons, neuronal morphology, neurogenesis, mineralocorticoid receptor, glucocorticoid receptor, glucocorticoids, long-term potentiation, stress intensity, adult offspring, learning performance, hippocampal development
MeSH terms: Animals, Bromodeoxyuridine, Cell Differentiation, Cells, Cultured, Electric Stimulation, Embryo, Mammalian, Female, Glucocorticoids, Hippocampus, Immunohistochemistry, Microtubule-Associated Proteins, Neurons, Phosphopyruvate Hydratase, Pregnancy, Prenatal Exposure Delayed Effects, Stress, Physiological, Time Factors, Tubulin, Silver Staining, Rats, Sprague-Dawley, Long-Term Potentiation, Cell Size, Rats

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Differential effects of prenatal stress on the morphological maturation of hippocampal neurons

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