Time-course of changes in the social interaction test of anxiety following acute and chronic administration of nicotine

Irvine, E. E.; Cheeta, S.; File, S. E.

doi:10.1097/00008877-199911000-00016

Cited by 89Nicotinic Acetylcholine Receptors StudySmoking Behavior and CessationNeurotransmitter Receptor Influence on Behavior

Time-course of changes in the social interaction test of anxiety following acute and chronic administration of nicotine

Irvine, E. E., Cheeta, S., File, S. E.·1999·Behavioural Pharmacology

DOI 10.1097/00008877-199911000-00016

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Abstract

The purpose of these experiments was to explore the hypothesis that the effects of nicotine on anxiety depend on the time since administration and the duration of treatment. In the social interaction test of anxiety, acute nicotine administration (0.1 mg/kg, subcutaneously) decreased social interaction when rats were tested 5 min after injection, but increased it when they were tested 30 min after injection. Social interaction was also decreased 1 h post-injection, but levels returned to baseline between 3 and 30 h. As these changes were independent of any changes in locomotor activity, nicotine seemed to be having both anxiogenic and anxiolytic effects at different times after injection. An anxiolytic effect was also observed 30 min after the second nicotine injection, and the anxiogenic effect observed 5 min after injection remained after 4 days of nicotine administration. However, after 7 days of nicotine treatment, tolerance was observed to both these effects. When rats were tested 72 h after the last of 7 or 14 days of nicotine treatment, an anxiogenic withdrawal response was observed. Thus, an oppositional mechanism may underlie tolerance to the anxiolytic effects, whereas there is as yet no evidence for this type of mechanism mediating tolerance to the anxiogenic effects.

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Nicotine injections 5 minutes before a social interaction test decreased social interaction, an anxiogenic effect, while injections 30 minutes before increased social interaction, an anxiolytic effect.
“Irvine et al. (1999) found that nicotine injections 5 min before the behavioral test decreased social interaction, an anxiogenic effect, while injections 30 min before the task increased social interaction, an anxiolytic effect.”
From Nicotine addiction and psychiatric disorders (2015) · cites this paper as Irvine et al. (1999)

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Sanchez-Amate, M. D. C., Dávila, E., Cañadas, F., et al. (2002) · NeuroToxicology · doi:10.1016/s0161-813x(02)00032-3 · Cited by 17 · see citing works
Tolerance to midazolam's anxiolytic effects after short-term nicotine treatment
Irvine, E. E., Cheeta, S., Lovelock, C., & File, S. E. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(00)00211-2 · Cited by 17 · see citing works
Self-citation
Anxiety conditioned to nicotine in the elevated plus-maze is time dependent
Tucci, S. A., Cheeta, S., Genn, R. F., Seth, P., & File, S. E. (2002) · Behavioural Pharmacology · doi:10.1097/00008877-200212000-00002 · Cited by 15 · see citing works
“, 2001a) and in high doses is anxiogenic in animal tests of anxiety (File et al., 1998; Irvine et al., 1999; Ouagazzal et al., 1999a).”
BackgroundSelf-citation
Chronic nicotine attenuates phencyclidine-induced impulsivity in a mouse serial reaction time task
Scott, D., & Taylor, J. R. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.11.009 · Cited by 13 · see citing works
“While it is possible that chronic nicotine affected impulsive behavior in this task indirectly, perhaps through effects on social behaviors or anxiety, we find this explanation unlikely, as animals chronically exposed to nicotine display tolerance to such consequences of nicotine exposure [53].”
Background
Long-term effects of juvenile nicotine exposure on abstinence-related social anxiety-like behavior and amygdalar cannabinoid receptor 1 (CB1R) mRNA expression in the novelty-seeking phenotype
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DIMENSIONES PSICOPATOLÓGICAS ASOCIADAS AL CONSUMO DE TABACO EN POBLACIÓN UNIVERSITARIA
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Ventral hippocampal NMDA receptors mediate the effects of nicotine on stress-induced anxiety/exploratory behaviors in rats
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Differential sensitivity to the effects of nicotine and bupropion in adolescent and adult male OF1 mice during social interaction tests
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Social Influences on Nicotine-Related Behaviors
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Psychiatric Disorders as Vulnerability Factors for Nicotine Addiction: What Have We Learned from Animal Models?
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“Testing 5 min after a low dose produced anxiogenic effects, whereas testing 30 min after injection was anxiolytic and testing 60 min after injection was again anxiogenic (Irvine et al. 1999).”
BackgroundInfluential
Nicotine
Koob, G. F., & Moal, M. L. (2006) · Elsevier eBooks · doi:10.1016/b978-012419239-3/50043-6 · Cited by 10 · see citing works
Central histaminergic transmission modulates the expression of chronic nicotine withdrawal induced anxiety-like and somatic behavior in mice
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Ansiedad y Tabaco
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Nanonaringenin and Vitamin E Ameliorate Some Behavioral, Biochemical, and Brain Tissue Alterations Induced by Nicotine in Rats
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A specific anti‐aggressive effect of repeatedly administered lobeline
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“In rats, such effects depend on the dose(42) and time after injection.(43) In the social interaction test,”
Background
Nicotine treatment buffers negative behavioral consequences induced by exposure to physical and emotional stress in adolescent male mice
Parise, L. F., Sial, O. K., Warren, B. L., Sattler, C. R., Duperrouzel, J. C., Parise, E. M., & Bolaños‐Guzmán, C. A. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05598-6 · Cited by 7 · see citing works
Effects of chronic nicotine exposure on Δ9-tetrahydrocannabinol-induced locomotor activity and neural activation in male and female adolescent and adult rats
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Chronic oral nicotine administration and withdrawal regulate the expression of neuropeptide Y and its receptors in the mesocorticolimbic system
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Behavioral mirroring in Wistar rats investigated through temporal pattern analysis
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“Considering that all subjects were tested under environmental settings conducive to high anxiety (i.e., intense lightning and unfamiliar environment, see studies by File and Seth 20 and Irvine et al. 19 ), we argue that this outcome may be the result of stressful conditions.”
Influential
The potent and selective α4β2*/α6*‐nicotinic acetylcholine receptor partial agonist 2‐[5‐[5‐((S)Azetidin‐2‐ylmethoxy)‐3‐pyridinyl]‐3‐isoxazolyl]ethanol demonstrates antidepressive‐like behavior in animal models and a favorable ADME‐tox profile
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“Moreover, anxiolytic and anxiogenic effects of nicotine were observed at the same dose at different time points in the social interaction test (Irvine et al. 1999).”
Background
Nicotine, Corticotropin-Releasing Factor, and Anxiety-Like Behavior
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Effects of chronic nicotine administration on behavioral parameters and Na⁺/K⁺-ATPase mRNA expression in the brains of male Swiss Albino mice exposed to chronic stress during adolescence
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Electrolytic Evaluation of Nicotine Treated Rats
Obeten, K. E., Ekpefiong, R. P., & Mfem, C. C. (2014) · Journal of Biology Agriculture and Healthcare

The changing faces of nicotine's effects on anxiety after acute and chronic administration
Irvine, E., Cheeta, S., & File, S. E. (1999) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(99)80390-3
Self-citation
Oxytocin attenuates aversive response to nicotine and anxiety-like behavior in adolescent rats
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Behavioral Analysis of Nicotine Self‐Administration
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Chronic Nicotine Treatment During Adolescence Attenuates the Effects of Acute Nicotine in Adult Contextual Fear Learning
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Authors: Irvine, E. E., Cheeta, S., & File, S. E.
Affiliations: King's College London (GB)
Corresponding author: File, S. E.
ORCID: Irvine, E. E.
Cheeta, S.
Venue: Behavioural Pharmacology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1999-11
Volume: 10
Issue: 6
Pages: 691-697
ISSN: 0955-8810 (ISSN-L)
DOI: 10.1097/00008877-199911000-00016
OpenAlex: W1520255710
Cited by: 89
References: 0
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 6 · 2014: 4 · 2013: 3 · 2012: 3
FWCI: 2.64
Type: journal article
Language: en
Open access: closed
Locations: Behavioural Pharmacology (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: nicotine, anxiety, social interaction test, anxiogenic effects, anxiolytic effects, tolerance (pharmacology and immunology), withdrawal response, time course of drug effects, chronic nicotine administration, rats
MeSH terms: Animals, Dose-Response Relationship, Drug, Drug Tolerance, Interpersonal Relations, Male, Motor Activity, Nicotine, Social Behavior, Time Factors, Anti-Anxiety Agents, Nicotinic Agonists, Rats

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Time-course of changes in the social interaction test of anxiety following acute and chronic administration of nicotine

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