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Comparative efficacy of non-pharmacological interventions on agitation in people with dementia: A systematic review and Bayesian network meta-analysis
Abstract
Background Agitation in people with dementia is common and distressing and can lead to increased caregiver burden. However, medications often have adverse reactions and limited effectiveness. Thus, non-pharmacological interventions are being increasingly implemented. Objectives To compare and rank the efficacy of different non-pharmacological interventions in the management of agitation in people with dementia. Design Bayesian network meta-analysis. Methods A comprehensive electronic literature search was performed in five English databases and three Chinese databases to identify relevant randomized controlled trials (RCTs) that were published up to January 2019. A random-effects model was selected to conduct traditional meta-analysis to directly examine the efficacy of different non-pharmacological interventions. The consistency model was selected to conduct a network meta-analysis to evaluate the relative effects and rank probability of different non-pharmacological interventions. Results A total of 65 RCTs were included in this network meta-analysis involving 11 different non-pharmacological interventions. Network meta-analysis showed that massage therapy, animal-assisted intervention, and personally tailored intervention were associated with more substantial reductions in agitation compared with other interventions and controls. Conclusions Our study confirmed the effectiveness of non-pharmacological interventions for ameliorating agitation in people with dementia and rec…
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“Additionally, the difference between AAT and PRT in managing BPSD remains controversial, as only one study involving seven studies used a network meta-analysis to assess the comparative efficacy of these two therapies in reducing agitation (Leng et al., 2020).”
From Network meta-analysis of comparative efficacy of animal-assisted therapy vs. pet-robot therapy in the management of dementia (2023) · cites this paper as Leng et al., 2020
In the citing paper
“Additionally, the difference between AAT and PRT in managing BPSD remains controversial, as only one study involving seven studies used a network meta-analysis to assess the comparative efficacy of these two therapies in reducing agitation (Leng et al., 2020).”
From Network meta-analysis of comparative efficacy of animal-assisted therapy vs. pet-robot therapy in the management of dementia (2023) · cites this paper as Leng et al., 2020
In the citing paper
“The pooled result showed that AAT was not significantly different from PRT in reducing agitation (SMD: 0.41, 95%CI: −6.32 to 7.40)”
From Network meta-analysis of comparative efficacy of animal-assisted therapy vs. pet-robot therapy in the management of dementia (2023) · cites this paper as Leng et al., 2020
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van der Steen, J. T., van Soest-Poortvliet, M. C., van der Wouden, J. C., Bruinsma, M. S., Scholten, R. J., & Vink, A. C. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003477.pub3 · Cited by 408
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Cited by
Sorted by citations
Antipsychotics for agitation and psychosis in people with Alzheimer's disease and vascular dementia
Mühlbauer, V., Möhler, R., Dichter, M. N., Zuidema, S. U., Köpke, S., & Luijendijk, H. J. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013304.pub2 · Cited by 117
Du, H., Bo, L., Lai, X., Zhu, H., & Huo, X. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1095996 · Cited by 10
Metadata
- Authors
- Leng, M., Zhao, Y., & Wang, Z.
- Venue
- International Journal of Nursing Studies
- Publisher
- Elsevier BV
- Published
- 2020-02
- Volume
- 102
- Pages
- 103489
- ISSN
- 0020-7489
- Cited by
- 48
- References
- 12
- Language
- en
- Funders
- Beijing Municipal Science and Technology Commission (D171100008217007)
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