Network meta-analysis of comparative efficacy of animal-assisted therapy vs. pet-robot therapy in the management of dementia
Open accessAbstract
Objective: This network meta-analysis aimed to compare and rank the efficacy of animal-assisted therapy (AAT) and pet-robotic therapy (PRT) in the management of dementia. Methods: Relevant studies were identified by searching PubMed, EMBASE, the Cochrane Library, SCOPUS, and Web of Science (WoS) until October 13, 2022. Traditional meta-analysis was first conducted based on the random-effects model, then random network meta-analysis was conducted to determine the relative efficacy and rank probability of AAT and PRT. Results: Nineteen randomized controlled trials (RCTs) were included in this network meta-analysis. Network meta-analysis revealed that PRT marginally benefited agitation alleviation compared with control (standard mean difference [SMD]: −0.37, 95% confidence interval [95%CI]: −0.72 to −0.01) although both AAT and PRT did not improve cognitive function, reduce depression, and improve Quality of Life (QoL). The SUCRA probabilities indicated that PRT ranked better than AAT in agitation, cognitive function, and QoL, although there were no differences between the two therapies. Conclusion: The present network meta-analysis reveals that PRT may help alleviate agitated behaviors in people with dementia. However, future studies are warranted to establish evidence of the effectiveness of PRT and further evaluate the differences between different robot types in managing dementia.
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Cites
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552 · see citing works
Quantifying heterogeneity in a meta‐analysis
Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763 · see citing works
The Cochrane Collaboration's tool for assessing risk of bias in randomised trials
Higgins, J. P. T., Altman, D. G., Gotzsche, P. C., Juni, P., Moher, D., Oxman, A. D., Savovic, J., Schulz, K. F., Weeks, L., Sterne, J. A. C., et al. (2011) · BMJ · doi:10.1136/bmj.d5928 · Cited by 33,817 · see citing works
Dermyshi, E., Wang, Y., Yan, C., Hong, W., Qiu, G., Gong, X., & Zhang, T. (2017) · Neonatology · doi:10.1159/000454668 · Cited by 24,577 · see citing works
Wan, X., Wang, W., Liu, J., & Tong, T. (2014) · BMC Medical Research Methodology · doi:10.1186/1471-2288-14-135 · Cited by 11,735 · see citing works
Hutton, B., Salanti, G., Caldwell, D. M., Chaimani, A., Schmid, C. H., Cameron, C., Ioannidis, J. P. A., Straus, S., Thorlund, K., Jansen, J. P., et al. (2015) · Annals of Internal Medicine · doi:10.7326/m14-2385 · Cited by 8,269 · see citing works
The global prevalence of dementia: a systematic review and metaanalysis.
Prince, M., Bryce, R., Albanese, E., Wimo, A., Ribeiro, W., & Ferri, C. P. (2013) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2012.11.007 · Cited by 4,941 · see citing works
Salanti, G., Ades, A. E., & Ioannidis, J. P. A. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2010.03.016 · Cited by 3,766 · see citing works
Graphical tools for network meta-analysis in STATA
Chaimani, A., Higgins, J. P. T., Mavridis, D., Spyridonos, P., & Salanti, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076654 · Cited by 2,473 · see citing works
Investigating and dealing with publication and other biases in meta-analysis
Sterne, J. A. C., Egger, M., & Smith, G. D. (2001) · BMJ · doi:10.1136/bmj.323.7304.101 · Cited by 2,225 · see citing works
Combination of direct and indirect evidence in mixed treatment comparisons
Lu, G., & Ades, A. E. (2004) · Statistics in Medicine · doi:10.1002/sim.1875 · Cited by 2,149 · see citing works
Consistency and inconsistency in network meta-analysis: concepts and models for multi-arm studies
Higgins, J. P. T., Jackson, D., Barrett, J. K., Lu, G., Ades, A. E., & White, I. R. (2012) · Research Synthesis Methods · doi:10.1002/jrsm.1044 · Cited by 2,098 · see citing works
Salanti, G. (2012) · Research Synthesis Methods · doi:10.1002/jrsm.1037 · Cited by 1,729 · see citing works
Assessment and management of behavioral and psychological symptoms of dementia
Kales, H. C., Gitlin, L. N., & Lyketsos, C. G. (2015) · BMJ · doi:10.1136/bmj.h369 · Cited by 1,247 · cited 1× · see citing works
“, 2020), are pretty prevalent in patients diagnosed with dementia (Kales et al., 2015).”
BackgroundConceptual and technical challenges in network meta-analysis
Cipriani, A., Higgins, J. P. T., Geddes, J. R., & Salanti, G. (2013) · Annals of Internal Medicine · doi:10.7326/0003-4819-159-2-201307160-00008 · Cited by 1,072 · see citing works
The worldwide costs of dementia 2015 and comparisons with 2010
Wimo, A., Guerchet, M., Ali, G., Wu, Y., Prina, A. M., Winblad, B., Jönsson, L., Liu, Z., & Prince, M. (2017) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.07.150 · Cited by 1,066 · see citing works
Assessing Evidence Inconsistency in Mixed Treatment Comparisons
Lu, G., & Ades, A. E. (2006) · Journal of the American Statistical Association · doi:10.1198/016214505000001302 · Cited by 756 · see citing works
Gale, S. A., Acar, D., & Daffner, K. R. (2018) · The American Journal of Medicine · doi:10.1016/j.amjmed.2018.01.022 · Cited by 702 · see citing works
Approaches to interpreting and choosing the best treatments in network meta-analyses
Mbuagbaw, L., Rochwerg, B., Jaeschke, R., Heels-Andsell, D., Alhazzani, W., Thabane, L., & Guyatt, G. H. (2017) · Systematic Reviews · doi:10.1186/s13643-017-0473-z · Cited by 693 · see citing works
Effect of Citalopram on Agitation in Alzheimer Disease: The CitAD Randomized Clinical Trial
Porsteinsson, A. P., Drye, L. T., Pollock, B. G., Devanand, D. P., Frangakis, C., Ismail, Z., Marano, C., Meinert, C. L., Mintzer, J. E., Munro, C. A., et al. (2014) · JAMA · doi:10.1001/jama.2014.93 · Cited by 572 · see citing works
Bowden, J., Tierney, J. F., Copas, A. J., & Burdett, S. (2011) · BMC Medical Research Methodology · doi:10.1186/1471-2288-11-41 · Cited by 551 · see citing works
Tan, C.-C., Yu, J.-T., Wang, H.-F., Tan, M.-S., Meng, X.-F., Wang, C., Jiang, T., Zhu, X.-C., & Tan, L. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132690 · Cited by 484 · see citing works
Dyer, S. M., Harrison, S. L., Laver, K., Whitehead, C., & Crotty, M. (2017) · International Psychogeriatrics · doi:10.1017/s1041610217002344 · Cited by 388 · see citing works
Moyle, W., Cooke, M., Beattie, E., Jones, C., Klein, B., Cook, G., & Gray, C. (2013) · Journal of Gerontological Nursing · doi:10.3928/00989134-20130313-03 · Cited by 314 · see citing works
The Utilization of Robotic Pets in Dementia Care
Petersen, S. F., Houston, S. M., Qin, H., Tague, C., & Studley, J. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160703 · Cited by 304 · see citing works
Best practice in the management of behavioural and psychological symptoms of dementia
Tible, O., Riese, F., Savaskan, E., & von Gunten, A. (2017) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285617712979 · Cited by 302 · see citing works
Moyle, W., Jones, C. J., Murfield, J. E., Thalib, L., Beattie, E. R. A., Shum, D. K. H., O'Dwyer, S. T., Mervin, M. C., & Draper, B. M. (2017) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.03.018 · Cited by 284 · see citing works
Page, M. J., McKenzie, J. E., & Higgins, J. P. T. (2018) · BMJ Open · doi:10.1136/bmjopen-2017-019703 · Cited by 278 · see citing works
Jøranson, N., Pedersen, I., Rokstad, A. M. M., & Ihlebæk, C. (2015) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2015.05.002 · Cited by 268 · cited 4× · see citing works
“, 2016b) and six (Moyle et al., 2013, 2017, 2019; Jøranson et al., 2015; Liang et al., 2017; Pu et al., 2020) studies compared AAT and PRT with control, respectively.”
BackgroundInfluentialPrevention and management of dementia: a priority for public health
Frankish, H. M., & Horton, R. C. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31756-7 · Cited by 250 · see citing works
Social robots in advanced dementia
Valentí, M., Agüera-Ortíz, L., Rodríguez, J. O., Rebolledo, C. M., Muñoz, A. P., Pérez, I. R., Osa-Ruiz, E., Sánchez, A. B., Cano, V. H., Chillón, L. C., et al. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00133 · Cited by 247 · see citing works
A Pilot Randomized Trial of a Companion Robot for People With Dementia Living in the Community
Liang, A., Piroth, I., Robinson, H., MacDonald, B., Fisher, M., Nater, U. M., Skoluda, N., & Broadbent, E. (2017) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.05.019 · Cited by 223 · cited 10× · see citing works
“Overall, 18 studies (Moyle et al., 2013, 2017, 2019; Robinson et al., 2013; Travers et al., 2013; Bono et al., 2015; Friedmann et al., 2015; Jøranson et al., 2015, 2016; Pope et al., 2016; Olsen et al., 2016a,b; Liang et al., 2017; Petersen et al., 2017; Pu et al., 2020; Briones et al., 2021; Quintavalla et al., 2021;…”
BackgroundInfluentialKales, H. C., Lyketsos, C. G., Miller, E. M., & Ballard, C. (2019) · International Psychogeriatrics · doi:10.1017/s1041610218000534 · Cited by 220 · see citing works
Network meta-analysis explained
Dias, S., & Caldwell, D. M. (2018) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2018-315224 · Cited by 174 · see citing works
Gallaway, P. J., Miyake, H., Buchowski, M. S., Shimada, M., YOSHITAKE, Y., Kim, A., & Hongu, N. K. (2017) · Brain Sciences · doi:10.3390/brainsci7020022 · Cited by 169 · see citing works
Jøranson, N., Pedersen, I., Rokstad, A. M. M., & Ihlebæk, C. (2016) · Journal of Advanced Nursing · doi:10.1111/jan.13076 · Cited by 159 · see citing works
Olsen, C., Pedersen, I., Bergland, A., Enders‐Slegers, M., Patil, G., & Ihlebæk, C. (2016) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4436 · Cited by 156 · see citing works
The economic and societal burden of Alzheimer disease: managed care considerations
(2022) · The American Journal of Managed Care · doi:10.37765/ajmc.2022.89236 · Cited by 151 · see citing works
Suitability of Healthcare Robots for a Dementia Unit and Suggested Improvements
Robinson, H., MacDonald, B. A., Kerse, N. M., & Broadbent, E. (2012) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2012.09.006 · Cited by 133 · see citing works
Yu, C., Sommerlad, A., Sakure, L., & Livingston, G. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101633 · Cited by 131 · cited 1× · see citing works
“Among numerous non-pharmacological treatments available, animal-assisted therapy (AAT) and pet-robotic therapy (PRT) have been extensively used in the management of dementia due to their significant impact on the lives of people of all ages and socioeconomic backgrounds (Hughes et al., 2020; Yu et al., 2022).”
BackgroundLeng, M., Liu, P., Zhang, P., Hu, M., Zhou, H., Li, G., Yin, H., & Chen, L. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.12.032 · Cited by 122 · see citing works
Friedmann, E., Galik, E. M., Thomas, S. A., Hall, P. S., Chung, S.-Y., & McCune, S. (2014) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317514545477 · Cited by 116 · see citing works
Treatment of behavioral and psychological symptoms of dementias with psychopharmaceuticals: a review
Masopust, J., Protopopová, D., Vališ, M., Pavelek, Z., & Klímová, B. (2018) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s163842 · Cited by 113 · see citing works
Companion Animals and Health in Older Populations: A Systematic Review
Hughes, M. J., Verreynne, M., Harpur, P. D., & Pachana, N. A. (2019) · Clinical Gerontologist · doi:10.1080/07317115.2019.1650863 · Cited by 113 · see citing works
Ma, H., Huang, Y., Cong, Z., Wang, Y., Jiang, W., Gao, S., & Zhu, G. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140579 · Cited by 110 · see citing works
Tu, Y. (2016) · Value in Health · doi:10.1016/j.jval.2016.07.005 · Cited by 108 · see citing works
Effects of dog-assisted therapy in adults with dementia: a systematic review and meta-analysis
Zafra‐Tanaka, J. H., Pacheco‐Barrios, K., Tellez, W. A., & Taype-Rondán, Á. (2019) · BMC Psychiatry · doi:10.1186/s12888-018-2009-z · Cited by 108 · see citing works
Kishita, N., Backhouse, T., & Mioshi, E. (2020) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988719856690 · Cited by 103 · cited 1× · see citing works
“Dementia is a chronic degenerative encephalopathy condition characterized by cognitive and consciousness disorders, personality changes, abnormal behavior, and a decreased capacity for performing daily activities (Prince et al., 2013; Gallaway et al., 2017; Kishita et al., 2020).”
BackgroundReview of outcome measures in PARO robot intervention studies for dementia care
Kang, H. S., Makimoto, K., Konno, R., & Koh, I. S. (2019) · Geriatric Nursing · doi:10.1016/j.gerinurse.2019.09.003 · Cited by 100 · see citing works
Effectiveness of Companion Robot Care for Dementia: A Systematic Review and Meta-Analysis
Lu, L., Lan, S., Hsieh, Y., Lin, L., Lan, S., & Chen, J. (2021) · Innovation in Aging · doi:10.1093/geroni/igab013 · Cited by 100 · see citing works
Recommendations for the Management of Behavioral and Psychological Symptoms of Dementia
Herrmann, N. (2001) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100001268 · Cited by 91 · see citing works
The estimated cost of dementia in Japan, the most aged society in the world
Sado, M., Ninomiya, A., Shikimoto, R., Ikeda, B., Baba, T., Yoshimura, K., & Mimura, M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0206508 · Cited by 89 · see citing works
An Evaluation of Dog-Assisted Therapy for Residents of Aged Care Facilities with Dementia
Travers, C., Perkins, J., Rand, J. S., Bartlett, H., & Morton, J. M. (2013) · Anthrozoös · doi:10.2752/175303713x13636846944169 · Cited by 77 · see citing works
Pu, L., Moyle, W., Jones, C., & Todorovic, M. (2020) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2020.01.014 · Cited by 77 · see citing works
Lee, W. (1997) · Statistics in Medicine · doi:10.1002/(sici)1097-0258(19970415)16:7 · Cited by 74 · see citing works
Olsen, C., Pedersen, I., Bergland, A., Enders-Slegers, M.-J., & Ihlebæk, C. (2016) · Geriatric Nursing · doi:10.1016/j.gerinurse.2016.04.002 · Cited by 71 · see citing works
Moyle, W., Murfield, J., Jones, C., Beattie, E., Draper, B., & Ownsworth, T. (2018) · Aging & Mental Health · doi:10.1080/13607863.2018.1498447 · Cited by 62 · see citing works
Consideraciones prácticas acerca de la detección del sesgo de publicación
Pérez, S. P., & Rodríguez, M. (2006) · Gaceta Sanitaria · doi:10.1157/13101085 · Cited by 55 · see citing works
Leng, M., Zhao, Y., & Wang, Z. (2019) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2019.103489 · Cited by 51 · see citing works
Using Generalized Linear Mixed Models to Evaluate Inconsistency within a Network Meta-Analysis
Tu, Y. (2015) · Value in Health · doi:10.1016/j.jval.2015.10.002 · Cited by 48 · see citing works
Park, S., Bak, A.-R., Kim, S., Nam, Y., Kim, H. S., Yoo, D., & Moon, M. (2020) · Biomedicines · doi:10.3390/biomedicines8060150 · Cited by 48 · see citing works
Clinical practice guidelines and principles of care for people with dementia in Australia.
Dyer, S. M., Laver, K., Pond, C. D., Cumming, R. G., Whitehead, C., & Crotty, M. (2016) · PubMed · Cited by 47 · see citing works
Chen, H., Wang, Y., Zhang, M., Wang, N., Li, Y., & Liu, Y. (2022) · Psychiatry Research · doi:10.1016/j.psychres.2022.114619 · Cited by 34 · see citing works
Ong, Y. C., Tang, A., & Tam, W. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.05.077 · Cited by 32 · see citing works
Briones-Peralta, M. Á., García, I. P., & Sotos, F. E. (2019) · Clinical Nursing Research · doi:10.1177/1054773819867250 · Cited by 29 · see citing works
Animal assisted therapy for elderly residents of a skilled nursing facility
Pope, W. S., Hunt, C. W., & Ellison, K. J. (2016) · Journal of Nursing Education and Practice · doi:10.5430/jnep.v6n9p56 · Cited by 24 · see citing works
Benefits of Dog-Assisted Therapy in Patients with Dementia Residing in Aged Care Centers in Spain
Vegue-Parra, E., Garre, J. M. H., & Pérez, P. E. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18041471 · Cited by 24 · see citing works
Bono, A. V., Benvenuti, C., Buzzi, M. G., Ciatti, R., V, C., Chiambretto, P., Morelli, C., Pinciroli, M., Pini, A., Prestigiacomo, T., et al. (2015) · Cited by 22 · see citing works
Batubara, S. O., Tonapa, S. I., Saragih, I. D., Mulyadi, M., & Lee, B.-O. (2021) · Geriatric Nursing · doi:10.1016/j.gerinurse.2021.10.016 · Cited by 17 · see citing works
Quintavalla, F., Cao, S., Spinelli, D., Caffarra, P., Rossi, F. M., Basini, G., & Sabbioni, A. (2021) · Animals · doi:10.3390/ani11051366 · Cited by 16 · see citing works
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Trajbarič, T., Muršec, D., Svenšek, A., Štiglic, G., & Gosak, L. (2026) · Applied Sciences · doi:10.3390/app16104683
- Authors
- Du, H., Bo, L., Lai, X., Zhu, H., & Huo, X.
- Affiliations
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Corresponding author
- Du, Hongdi
- Huo, Xiaopeng
- Venue
- Frontiers in Aging Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2023-05-31
- Volume
- 15
- Pages
- 1095996-1095996
- ISSN
- 1663-4365 (ISSN-L)
- PMC
- PMC10264590
- OpenAlex
- W4378901916
- Cited by
- 10
- References
- 70
- Citations by year
- 2026: 7 · 2025: 3
- FWCI
- 0.35
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Aging Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Peking Union Medical College Hospital (2022-PUMCH-B-031)
- Peking Union Medical College
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Human-Animal Interaction Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Social Psychology › Social Robot Interaction and HRI
- Keywords
- animal-assisted therapy, dementia, agitation, cognitive function, depression, quality of life, robot-assisted therapy
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