On the role of API in determining porosity, pore structure and bulk modulus of the skeletal material in pharmaceutical tablets formed with MCC as sole excipient
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The physical properties and mechanical integrity of pharmaceutical tablets are of major importance when loading with active pharmaceutical ingredient(s) (API) in order to ensure ease of processing, control of dosage and stability during transportation and handling prior to patient consumption. The interaction between API and excipient, acting as functional extender and binder, however, is little understood in this context. The API indomethacin is combined in this study with microcrystalline cellulose (MCC) at increasing loading levels. Tablets from the defined API/MCC ratios are made under conditions of controlled porosity and tablet thickness, resulting from different compression conditions, and thus compaction levels. Mercury intrusion porosimetry is used to establish the accessible pore volume, pore size distribution and, adopting the observed region of elastic intrusion-extrusion at high pressure, an elastic bulk modulus of the skeletal material is recorded. Porosity values are compared to previously published values derived from terahertz (THz) refractive index data obtained from exactly the same tablet sample sets. It is shown that the elastic bulk modulus is dependent on API wt% loading under constant tablet preparation conditions delivering equal dimensions and porosity. The findings are considered of novel value in respect to establishing consistency of tablet production and optimisation of physical properties.
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Mercury and helium porosimetry, the usual porosity techniques, take considerable time and damage the sample.
“This may be due partly to the relatively time-consuming and destructive nature of existing conventional porosity measurement methods like mercury or helium porosimetry 16,29,30 .”
From A Fast and Non-destructive Terahertz Dissolution Assay for Immediate Release Tablets (2021) · cites this paper as [30]
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Terahertz time-domain spectroscopy of water vapor
van Exter, M., Fattinger, C., & Grischkowsky, D. (1989) · Optics Letters · doi:10.1364/ol.14.001128 · Cited by 862 · see citing works
Microcrystalline cellulose, a direct compression binder in a quality by design environment—A review
Thoorens, G., Krier, F., Leclercq, B., Carlin, B. A. C., & Évrard, B. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.06.055 · Cited by 550 · see citing works
Optimisation of floating matrix tablets and evaluation of their gastric residence time
Baumgartner, S., Kristl, J., Vrečer, F., et al. (2000) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(99)00378-6 · Cited by 306 · see citing works
Nyström, C., Alderborn, G., Duberg, M., & Karehill, P.-G. (1993) · Drug Development and Industrial Pharmacy · doi:10.3109/03639049309047189 · Cited by 237 · see citing works
Parrott, E. P. J., Zeitler, J. A., Friščić, T., Pepper, M., Jones, W., Day, G. M., & Gladden, L. F. (2009) · Crystal Growth & Design · doi:10.1021/cg8008893 · Cited by 111 · see citing works
Self-citationGane, P. A. C., Kettle, J. P., Matthews, G. P., et al. (1996) · Industrial & Engineering Chemistry Research · doi:10.1021/ie950413m · Cited by 106 · see citing works
Self-citationTablet strength, porosity, elasticity and solid state structure of tablets compressed at high loads
Adolfsson, Å., & Nyström, C. (1996) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(95)04336-5 · Cited by 95 · see citing works
Li, R., Zeitler, J. A., Tomerini, D., Parrott, E. P. J., Gladden, L. F., & Day, G. M. (2010) · Physical Chemistry Chemical Physics · doi:10.1039/b926536h · Cited by 79 · see citing works
Self-citationEberle, V. A., Schoelkopf, J., Gane, P. A. C., et al. (2014) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2014.03.001 · Cited by 68 · see citing works
Self-citationPlasto-elasticity and tableting of paracetamol, Avicel and other powders
Malamataris, S., Baie, S., & Pilpel, N. (1984) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1984.tb04909.x · Cited by 60 · see citing works
Bangudu, A. B., & Pilpel, N. (1985) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1985.tb05068.x · Cited by 51 · see citing works
Modified calcium carbonate coatings with rapid absorption and extensive liquid uptake capacity
Ridgway, C. J., Gane, P. A. C., & Schoelkopf, J. (2004) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2003.12.030 · Cited by 50 · see citing works
Self-citationStirnimann, T., Maiuta, N. D., Gerard, D. E., Alles, R., Huwyler, J., & Puchkov, M. (2013) · Pharmaceutical Research · doi:10.1007/s11095-013-1034-3 · Cited by 46 · see citing works
Bawuah, P., Tan, N., Tweneboah, S. N. A., Ervasti, T., Axel Zeitler, J., Ketolainen, J., & Peiponen, K.-E. (2016) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2016.06.007 · Cited by 42 · see citing works
Self-citationBawuah, P., Silfsten, P., Ervasti, T., Ketolainen, J., Zeitler, J. A., & Peiponen∥, K.-E. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.09.027 · Cited by 36 · see citing works
Self-citationErvasti, T., Silfsten, P., Ketolainen, J., & Peiponen∥, K.-E. (2012) · Applied Spectroscopy · doi:10.1366/11-06315 · Cited by 33 · see citing works
Self-citationBawuah, P., Chakraborty, M., Ervasti, T., Zeitler, J. A., Ketolainen, J., Gane, P. A. C., & Peiponen, K.-E. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.04.026 · Cited by 21 · see citing works
Self-citationEstimation of Young’s modulus of pharmaceutical tablet obtained by terahertz time-delay measurement
Peiponen∥, K.-E., Bawuah, P., Chakraborty, M., Juuti, M., Zeitler, J. A., & Ketolainen, J. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.04.068 · Cited by 20 · see citing works
Self-citationChakraborty, M., Bawuah, P., Tan, N. Y. J., Ervasti, T., Pääkkönen, P., Zeitler, J. A., Ketolainen, J., & Peiponen∥, K.-E. (2016) · Journal of Infrared Millimeter and Terahertz Waves · doi:10.1007/s10762-016-0262-0 · Cited by 19 · see citing works
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Research works printed but not linked: 1
- Kathpalia, H., Sule, Patil, A., Mahadik, A., Sharma, K., 2014. Controlled release orally disintegrating tablets: A review. International Journal of Pharmaceutical Sciences Review and Research 7, 35-42.
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Markl, D., Strobel, A., Schlossnikl, R., Bøtker, J., Bawuah, P., Ridgway, C., Rantanen, J., Rades, T., Gane, P., Peiponen, K.-E., et al. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.01.017 · Cited by 154 · see citing works
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Bawuah, P., Markl, D., Farrell, D., Evans, M., Portieri, A., Anderson, A., Goodwin, D., Lucas, R., & Zeitler, J. A. (2020) · Journal of Infrared Millimeter and Terahertz Waves · doi:10.1007/s10762-019-00659-0 · Cited by 92 · see citing works
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Bawuah, P., Markl, D., Turner, A., Evans, M., Portieri, A., Farrell, D., Lucas, R., Anderson, A., Goodwin, D. J., & Zeitler, J. A. (2021) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2020.11.041 · Cited by 45 · see citing works
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Markl, D., Bawuah, P., Ridgway, C., van den Ban, S., Goodwin, D. J., Ketolainen, J., Gane, P., Peiponen, K.-E., & Zeitler, J. A. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.12.029 · Cited by 42 · see citing works
Self-citationMeasuring Open Porosity of Porous Materials Using THz-TDS and an Index-Matching Medium
Naftaly, M., Tikhomirov, I., Hou, P., & Markl, D. (2020) · Sensors · doi:10.3390/s20113120 · Cited by 30 · see citing works
Self-citation
- Authors
- Ridgway, C., Bawuah, P., Markl, D., Zeitler, J. A., Ketolainen, J., Peiponen, K.-E., & Gane, P.
- Affiliations
- Omya (Switzerland) (CH)
- University of Eastern Finland (FI)
- University of Cambridge (GB)
- Corresponding author
- Ridgway, Cathy
- Venue
- International Journal of Pharmaceutics
- Publisher
- Elsevier BV
- Published
- 2017-06
- Volume
- 526
- Issue
- 1-2
- Pages
- 321-331
- ISSN
- 0378-5173 (ISSN-L)
- OpenAlex
- W2605953191
- Cited by
- 22
- References
- 19
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 6 · 2019: 1 · 2018: 3 · 2017: 1
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- green
- erepo.uef.fi
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- International Journal of Pharmaceutics (publishedVersion)
- PubMed (publishedVersion)
- Strathprints: The University of Strathclyde institutional repository (University of Strathclyde) (acceptedVersion)
- UEF eRepo (University of Eastern Finland) (submittedVersion, cc-by-nc-nd)
- UEF eRepo (University of Eastern Finland) (submittedVersion)
- Funders
- Itä-Suomen Yliopisto
- Topics
- Physical Sciences › Engineering › Computational Mechanics › Granular flow and fluidized beds
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Physical Sciences › Engineering › Mechanical Engineering › Mineral Processing and Grinding
- Keywords
- microcrystalline cellulose, tablet porosity, pore structure, indomethacin, compaction degree, terahertz refractive index, mercury intrusion porosimetry
- MeSH terms
- Cellulose, Chemistry, Pharmaceutical, Excipients, Pressure, Tablets, Porosity, Elastic Modulus
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