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A structure parameter for porous pharmaceutical tablets obtained with the aid of Wiener bounds for effective permittivity and terahertz time-delay measurement
Open accessAbstract
A structure parameter that can be used to predict the pattern of arrangement of porous inclusions in pharmaceutical tablets is introduced. By utilizing the effective refractive index of a pharmaceutical tablet obtained from terahertz time-domain measurements, we have shown that there exists a promising correlation between the calculated structural parameter and the porosity of training sets of pharmaceutical tablets, having well-defined characterization. Knowing of the structural arrangement, i.e. combined constituent skeletal-pore elements in series, parallel or mixed within porous media, could serve as a basis for understanding the ingress and permeation of liquids in such media. In the realm of pharmaceutical applications, such knowledge of the structural arrangement of air voids within a medicinal tablet could enable correlation with mechanical strength and dissolution behaviour in aqueous systems.
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THz-TDS has been demonstrated to measure porosity of rocks and pharmaceutical tablets and to analyze anisotropy of pore structures.
“This method has been demonstrated to measure the porosity of rocks [20] and pharmaceutical tablets [21,22,23] as well as to analyze the anisotropy of pore structures [18,24].”
From Measuring Open Porosity of Porous Materials Using THz-TDS and an Index-Matching Medium (2020) · cites this paper as [24]
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Metadata
- Authors
- Bawuah, P., Chakraborty, M., Ervasti, T., Zeitler, J. A., Ketolainen, J., Gane, P. A. C., & Peiponen, K.-E.
- Affiliations
- University of Eastern Finland (FI)
- University of Cambridge (GB)
- Omya (Switzerland) (CH)
- Corresponding author
- Bawuah, Prince
- Venue
- International Journal of Pharmaceutics
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 506
- Issue
- 1-2
- Pages
- 87-92
- ISSN
- 0378-5173 (ISSN-L)
- OpenAlex
- W2336929163
- Cited by
- 21
- References
- 34
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2021: 2 · 2020: 3 · 2018: 3 · 2017: 6 · 2016: 1
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- International Journal of Pharmaceutics (publishedVersion)
- PubMed (publishedVersion)
- Apollo (University of Cambridge) (submittedVersion, cc-by-nc-nd)
- Aaltodoc (Aalto University) (submittedVersion, cc-by-nc-nd)
- Topics
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Terahertz technology and applications
- Physical Sciences › Engineering › Computational Mechanics › Heat and Mass Transfer in Porous Media
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Keywords
- structural parameters, effective permittivity, effective refractive index, porosity, pore structure, liquid permeation, dissolution behavior, mechanical strength
- MeSH terms
- Permeability, Solubility, Stress, Mechanical, Surface Properties, Tablets, Technology, Pharmaceutical, Porosity, Terahertz Spectroscopy
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