Cited by 24Inflammatory Bowel DiseaseSirtuins and Resveratrol in MedicineCircadian rhythm and melatonin

Evaluation of the therapeutic activity of melatonin and resveratrol in Inflammatory Bowel Disease: A longitudinal PET/CT study in an animal model

Seoane-Viaño, Iria, Gómez-Lado, Noemí, Lázare-Iglesias, Héctor, Rey-Bretal, David, Lamela-Gómez, Iván, Otero-Espinar, Francisco J., Blanco-Méndez, José, Antúnez-López, José Ramón +5 more·2019·International Journal of Pharmaceutics

Abstract

Inflammatory Bowel Disease (IBD) is a group of chronic disorders of the gastrointestinal tract, which two main types are Crohn's disease and ulcerative colitis. Although conventional therapeutic strategies have demonstrated to be effective in the IBD treatment, it is necessary to incorporate novel therapeutic agents that target other mechanisms involved in the pathogenesis of the disease, such as oxidative stress. For this reason, the efficacy in vivo of two antioxidant compounds, melatonin and resveratrol, has been investigated in an animal model of TNBS (2, 4, 6-trinitrobenzenesulfonic acid) induced colitis. PET/CT (Positron emission tomography/Computer Tomography) scans were performed to assess disease activity and evaluate treatment response. SUV max (Standardized Uptake Value) values, body weight changes and histological evaluation were used as inflammatory indices to measure the efficacy of both treatments. SUV max values increased rapidly after induction of colitis, but after the beginning of the treatment (day 3) a statistically significant decrease was observed on days 7 and 10 in treated animals compared to the non-treated group. This remission of the disease was also confirmed by histological analysis of the colon tissue using the Nancy histological index (p value < 0.05 for differences between non-treated and both groups of treated animals). Moreover, statistical analysis showed a correlation (R 2 = 65.52%) between SUV max values and weight changes throughout the treatment. Overall, this study demonstrates the potential of resveratrol, and melatonin in lower extent, as therapeutic agents in the IBD treatment.

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Crossref · 10.1016/j.ijpharm.2019.118713

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  • There are initial indications that the antioxidant and anti-inflammatory actions of melatonin may work together with select polyphenols (e.g., resveratrol, epigallocatechin 3-gallate) for therapeutic indications.

    “There are initial indications that the antioxidant and anti-inflammatory actions of melatonin may work together with select polyphenols (e.g., resveratrol, epigallocatechin 3-gallate) for therapeutic indications [48,49,50,51,52,53,54].”

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Authors
Seoane-Viaño, I., Gómez-Lado, N., Lázare-Iglesias, H., Rey-Bretal, D., Lamela-Gómez, I., Otero-Espinar, F. J., Blanco-Méndez, J., Antúnez-López, J. R., Pombo-Pasín, M., Aguiar, P., Ruibal, Á., Luzardo-Álvarez, A., & Fernández-Ferreiro, A.
Affiliations
  • Universidade de Santiago de Compostela (ES)
  • Complejo Hospitalario Universitario de Santiago (ES)
Venue
International Journal of Pharmaceutics
Publisher
Elsevier BV
Published
2019-12
Volume
572
Pages
118713
ISSN
0378-5173 (ISSN-L)
OpenAlex
W2979002554
Cited by
24
References
45
Citations by year
2026: 1 · 2025: 1 · 2024: 4 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 4
FWCI
1.96
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Pharmaceutics (publishedVersion)
  • PubMed (publishedVersion)
Funders
Instituto de Salud Carlos III (JR18/00014)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords
inflammatory bowel disease, melatonin, resveratrol, TNBS-induced colitis, Crohn's disease, ulcerative colitis, oxidative stress, antioxidant therapy, PET/CT, SUVmax, disease activity, animal models
MeSH terms
Positron Emission Tomography Computed Tomography, Resveratrol, Animals, Antioxidants, Colitis, Colon, Melatonin, Trinitrobenzenesulfonic Acid, Rats, Sprague-Dawley

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