When it’s time for a change: failures to track context in schizophrenia
Open accessAbstract
Introduction Reduction of P300 event-related potential amplitude in schizophrenia is perhaps the most replicated biological reflection of the illness. P300 is typically elicited by infrequent deviant events that are imbedded in a series of identical frequent standard events. Deviants have features that explicitly distinguish them from standards, whereas standards can be distinguished from each other based on their local sequential probabilities within the stimulus series. The improbable occurrence of a standard should generate a P300, but only if the implicit local context generated by the recent stimulus history is processed.Method To assess the ability of schizophrenia patients to process this implicit contextual information, ERPs were elicited from 22 controls and 16 schizophrenia patients during an auditory oddball task containing infrequent target tones (15%) and novel distracter sounds (15%) imbedded pseudo-randomly in a series of standard tones (70%). Consecutively presented standards following deviant stimuli varied in sequential probability from p=1.0 for the 1st standard to p=0.16 for the 4th consecutive standard.Results Patients compared to controls demonstrated smaller P300 (P3a) to the fourth consecutive standard. However, in controls but not patients a contingent negative variation (CNV) was observed prior to the fourth standard, and an N2b/mismatch negativity (MMN) was observed following it.Conclusions These outcomes suggest that patients are deficient in using the implicit context established by recent stimulus history to anticipate that an otherwise standard stimulus was unlikely and its occurrence unexpected.
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Healthy control participants showed MMN to the 4th consecutive standard in the modified oddball paradigm.
“Healthy control participants showed MMN to the 4th consecutive standard.”
From A Predictive Coding Perspective on Mismatch Negativity Impairment in Schizophrenia (2020) · cites this paper as [33]
The MMN to the 4th consecutive standard was reduced in patients with schizophrenia.
“The MMN to the 4th consecutive standard was reduced in patients with schizophrenia.”
From A Predictive Coding Perspective on Mismatch Negativity Impairment in Schizophrenia (2020) · cites this paper as [33]
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Research works printed but not linked: 2
- Ford JM Gray M Whitfield SL Turken AU Glover G Faustman WO Mathalon DH Acquiring and inhibiting prepotent responses in schizophrenia: event-related brain potentials and functional magnetic resonance imaging Arch Gen Psychiatry 2004b 61 119 129 14757588
- Mathalon DH Hoffman RE Watson TD Miller RM Roach BJ Ford JM Neurophysiological distinction between schizophrenia and schizoaffective disorder Frontiers in Neuroscience 2010b PMC2816168 20140266
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Self-citationA Predictive Coding Perspective on Mismatch Negativity Impairment in Schizophrenia
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“Ford and colleagues used a modified oddball paradigm that had different conditional probabilities according to the length of repetitions (33) (Figure 2B).”
MethodRole of N-Methyl D-aspartate receptors in action-based predictive coding deficits in schizophrenia
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Self-citation
- Authors
- Ford, J. M., Roach, B. J., Miller, R. M., Duncan, C. C., Hoffman, R. E., & Mathalon, D. H.
- Affiliations
- San Francisco VA Medical Center (US)
- Uniformed Services University of the Health Sciences (US)
- Yale University (US)
- Corresponding author
- Ford, Judith M.
- Venue
- International Journal of Psychophysiology
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 78
- Issue
- 1
- Pages
- 3-13
- ISSN
- 0167-8760 (ISSN-L)
- PMC
- PMC4143242
- OpenAlex
- W2035630295
- Cited by
- 43
- References
- 71
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 3 · 2014: 1 · 2013: 4 · 2012: 8
- FWCI
- 3.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- International Journal of Psychophysiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- VA Schizophrenia Biological Research Center
- Research Career Scientist
- VA Merit Review
- NIMH
- NARSAD
- DHM
- VA Career Award
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- schizophrenia, P300, event-related potentials, auditory oddball paradigm, deviance detection, contingent negative variation, mismatch negativity, N2b
- MeSH terms
- Acoustic Stimulation, Adult, Evoked Potentials, Auditory, Female, Follow-Up Studies, Humans, Male, Middle Aged, Reaction Time, Schizophrenia, Event-Related Potentials, P300, Young Adult
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