Is blunted cardiovascular reactivity in depression mood-state dependent? A comparison of major depressive disorder remitted depression and healthy controls
Open accessAbstract
Prior work has repeatedly demonstrated that people who have current major depression exhibit blunted cardiovascular reactivity to acute stressors (e.g., Salomon et al., 2009). A key question regards the psychobiological basis for these deficits, including whether such deficits are depressed mood-state dependent or whether these effects are trait-like and are observed outside of depression episodes in vulnerable individuals. To examine this issue, we assessed cardiovascular reactivity to a speech stressor task and a forehead cold pressor in 50 individuals with current major depressive disorder (MDD), 25 with remitted major depression (RMD), and 45 healthy controls. Heart rate (HR), blood pressure and impedance cardiography were assessed and analyses controlled for BMI and sex. Significant group effects were found for SBP, HR, and PEP for the speech preparation period and HR, CO, and PEP during the speech. For each of these parameters, only the MDD group exhibited attenuated reactivity as well as impaired SBP recovery. Reactivity and recovery in the RMD group more closely resembled the healthy controls. Speeches given by the MDD group were rated as less persuasive than the RMD or healthy controls' speeches. No significant differences were found for the cold pressor. Blunted cardiovascular reactivity and impaired recovery in current major depression may be mood-state dependent phenomena and may be more reflective of motivational deficits than deficits in the physiological integrity of the cardiovascular system.
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Salomon et al. found blunted sympathetic nervous system reactivity as indexed by lengthened pre-ejection period to a laboratory speech stressor task.
“For example, Salomon et al. (2009Salomon et al. ( , 2013) ) found blunted sympathetic nervous system reactivity as indexed by lengthened pre-ejection period (PEP) to a laboratory speech stressor task”
From Physiological feelings (2019) · cites this paper as Salomon et al., 2013
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Self-citationRespiratory sinus arrhythmia reactivity in current and remitted major depressive disorder
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Self-citation
- Authors
- Salomon, K., Bylsma, L. M., White, K. E., Panaite, V., & Rottenberg, J.
- Affiliations
- University of South Florida (US)
- Corresponding author
- Salomon, Kristen
- Venue
- International Journal of Psychophysiology
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 90
- Issue
- 1
- Pages
- 50-57
- ISSN
- 0167-8760 (ISSN-L)
- PMC
- PMC4386598
- OpenAlex
- W2120895059
- Cited by
- 95
- References
- 54
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 8 · 2023: 3 · 2022: 9 · 2021: 9 · 2020: 10 · 2019: 10 · 2018: 7 · 2017: 8 · 2016: 10 · 2015: 6 · 2014: 6 · 2013: 3
- FWCI
- 5.66
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- International Journal of Psychophysiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH/NIMH (R21MH077669-01A1)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- major depressive disorder, remitted depression, cold pressor task, heart rate, blood pressure, impedance cardiography, motivational deficits, stress reactivity
- MeSH terms
- Adolescent, Adult, Affect, Analysis of Variance, Blood Pressure, Cardiography, Impedance, Depression, Major Depressive Disorder, Female, Heart Rate, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Recurrence, Reproducibility of Results, Young Adult
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