The DOI matches its Crossref record; 162 of the 163 references it cites were found in a registry or an index.
Interferons: Signaling, antiviral and viral evasion
Open accessAbstract
Interferons (IFNs) were discovered as antiviral agents 50 years ago, and enormous progress has been made since then. Nowadays, IFNs (specifically type I IFNs), have been ascribed as the cytokines that bridge the innate and adaptive immunity soon after the recognition of pathogen-associated molecular patterns (PAMPs) by the infected host. Notably, a unifying mechanism for type I IFN production has been established upon innate immune detection. Thus, TLR 3, 4, 7 and 9 associate endosomal recognition of PAMPs to type I IFN responses, a mechanism that has been shown in plasmacytoid dendritic cells to be dependent on the PI3K/mTOR/S6K pathway. It is worth noting that pathogen recognition triggers a fine-tuned controlled program that not only includes the production of antiviral (IFN) and pro-inflammatory cytokines to initiate the antiviral response but also signals the cessation of the response through the induction of suppressors of cytokine signaling (SOCS). SOCS in turn is under tight regulation of the TAM receptors (protein tyrosine kinase receptors TYRO3, AXL and MER), and activation of which thereby protects the host from the threats of autoimmune diseases.
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“This is critical from the host perspective, as the virus-induced secretion of signaling factors mediates the onset of innate and adaptive immunity (116).”
From The Impact of Mass Spectrometry–Based Proteomics on Fundamental Discoveries in Virology (2014) · cites this paper as [116]
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“However, a recent report revealed that ISGF3 formation and translocation to the nucleus in response to IFN-␣ is dependent on the acetylation of all components of the heterotrimeric complex.”
BackgroundToll-like receptor control of the adaptive immune responses
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Metadata
- Authors
- Bonjardim, C. A., Ferreira, P. C. P., & Kroon, E. G.
- Affiliations
- Universidade Federal de Minas Gerais (BR)
- Corresponding author
- Bonjardim, Cláudio A.
- Venue
- Immunology Letters
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 122
- Issue
- 1
- Pages
- 1-11
- ISSN
- 0165-2478 (ISSN-L)
- PMC
- PMC7112942
- OpenAlex
- W2020464368
- Cited by
- 196
- References
- 163
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 7 · 2023: 5 · 2022: 11 · 2021: 5 · 2020: 6 · 2019: 10 · 2018: 2 · 2017: 11 · 2016: 11 · 2015: 15 · 2014: 16 · 2013: 19 · 2012: 23
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Immunology Letters (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Keywords
- interferon, type I interferon, antiviral signaling, viral evasion, innate immunity, adaptive immunity, pathogen-associated molecular patterns, Toll-like receptors, plasmacytoid dendritic cells, suppressor of cytokine signaling, TAM receptors, autoimmune disease
- MeSH terms
- Animals, Humans, Immunity, Innate, Interferon Type I, Endosomes, Virus Diseases, Signal Transduction, Feedback, Physiological, Suppressor of Cytokine Signaling Proteins, Toll-Like Receptors, Host-Pathogen Interactions
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