Cited by 196interferon and immune responsesImmune Response and InflammationCytokine Signaling Pathways and Interactions

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Interferons: Signaling, antiviral and viral evasion

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Bonjardim, Cláudio A., Ferreira, Paulo C.P., Kroon, Erna G.·2009·Immunology Letters

DOI 10.1016/j.imlet.2008.11.002PMC PMC7112942

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Abstract

Interferons (IFNs) were discovered as antiviral agents 50 years ago, and enormous progress has been made since then. Nowadays, IFNs (specifically type I IFNs), have been ascribed as the cytokines that bridge the innate and adaptive immunity soon after the recognition of pathogen-associated molecular patterns (PAMPs) by the infected host. Notably, a unifying mechanism for type I IFN production has been established upon innate immune detection. Thus, TLR 3, 4, 7 and 9 associate endosomal recognition of PAMPs to type I IFN responses, a mechanism that has been shown in plasmacytoid dendritic cells to be dependent on the PI3K/mTOR/S6K pathway. It is worth noting that pathogen recognition triggers a fine-tuned controlled program that not only includes the production of antiviral (IFN) and pro-inflammatory cytokines to initiate the antiviral response but also signals the cessation of the response through the induction of suppressors of cytokine signaling (SOCS). SOCS in turn is under tight regulation of the TAM receptors (protein tyrosine kinase receptors TYRO3, AXL and MER), and activation of which thereby protects the host from the threats of autoimmune diseases.

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Authors: Bonjardim, C. A., Ferreira, P. C. P., & Kroon, E. G.
Affiliations: Universidade Federal de Minas Gerais (BR)
Corresponding author: Bonjardim, Cláudio A.
ORCID: Bonjardim, Cláudio A.
Kroon, Erna G.
Venue: Immunology Letters
Publisher: Elsevier BV
Published: 2009-01
Volume: 122
Issue: 1
Pages: 1-11
ISSN: 0165-2478 (ISSN-L)
DOI: 10.1016/j.imlet.2008.11.002
PMC: PMC7112942
OpenAlex: W2020464368
Cited by: 196
References: 163
Citations by year: 2026: 3 · 2025: 4 · 2024: 7 · 2023: 5 · 2022: 11 · 2021: 5 · 2020: 6 · 2019: 10 · 2018: 2 · 2017: 11 · 2016: 11 · 2015: 15 · 2014: 16 · 2013: 19 · 2012: 23
FWCI: 1.10
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Immunology Letters (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Keywords: interferon, type I interferon, antiviral signaling, viral evasion, innate immunity, adaptive immunity, pathogen-associated molecular patterns, Toll-like receptors, plasmacytoid dendritic cells, suppressor of cytokine signaling, TAM receptors, autoimmune disease
MeSH terms: Animals, Humans, Immunity, Innate, Interferon Type I, Endosomes, Virus Diseases, Signal Transduction, Feedback, Physiological, Suppressor of Cytokine Signaling Proteins, Toll-Like Receptors, Host-Pathogen Interactions

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Interferons: Signaling, antiviral and viral evasion

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