Cited by 349T-cell and B-cell ImmunologyImmune Response and InflammationImmunotherapy and Immune Responses

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Essential Role of the E3 Ubiquitin Ligase Cbl-b in T Cell Anergy Induction

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Jeon, Myung-Shin, Atfield, Alex, Venuprasad, K., Krawczyk, Connie, Sarao, Renu, Elly, Chris, Yang, Chun, Arya, Sudha, Bachmaier, Kurt, Su, Leon, Bouchard, Dennis, Jones, Russel, Gronski, Mathew, Ohashi, Pamela, Wada, Teiji, Bloom, Debra, Fathman, C.Garrison, Liu, Yun-Cai, Penninger, Josef M.·2004·Immunity

DOI 10.1016/j.immuni.2004.07.013

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Abstract

Antigen-specific immunotolerance limits the expansion of self-reactive T cells involved in autoimmune diseases. Here, we show that the E3 ubiquitin ligase Cbl-b is upregulated in T cells after tolerizing signals. Loss of Cbl-b in mice results in impaired induction of T cell tolerance both in vitro and in vivo. Importantly, rechallenge of Cbl-b mutant mice with the tolerizing antigen results in massive lethality. Moreover, ablation of Cbl-b resulted in exacerbated autoimmunity. Mechanistically, loss of Cbl-b rescues reduced calcium mobilization of anergic T cells, which was attributed to Cbl-b-mediated regulation of PLCgamma-1 phosphorylation. Our results show a critical role for Cbl-b in the regulation of peripheral tolerance and anergy of T cells.

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Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements
Barnden, M., Allison, J., Heath, W. R., & Carbone, F. (1998) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.1998.00709.x · Cited by 1,491
T cell anergy
Schwartz, R. H. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141110 · Cited by 1,487
Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo.
Kearney, E. R., Pape, K., Loh, D., & Jenkins, M. (1994) · Immunity · doi:10.1016/1074-7613(94)90084-1 · Cited by 1,126
The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase
Joazeiro, C. A. P., Wing, S. S., Huang, H.-K., Leverson, J. D., Hunter, T. R., & Liu, Y. (1999) · Science · doi:10.1126/science.286.5438.309 · Cited by 1,036
Self-citation
Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen
Pircher, H., Bürki, K., Lang, R., Hengartner, H., & Zinkernagel, R. M. (1989) · Nature · doi:10.1038/342559a0 · Cited by 1,019
Structure of a c-Cbl–UbcH7 Complex
Zheng, N., Wang, P., Jeffrey, P. D., & Pavletich, N. P. (2000) · Cell · doi:10.1016/s0092-8674(00)00057-x · Cited by 839
Transcriptional Mechanisms Underlying Lymphocyte Tolerance
Macián, F., Garcia-Cozar, F. J., Im, S., Horton, H. F., Byrne, M. C., & Rao, A. (2002) · Cell · doi:10.1016/s0092-8674(02)00767-5 · Cited by 687
Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b
Bachmaier, K., Krawczyk, C. M., Kozieradzki, I., Kong, Y., Sasaki, T., Oliveira-dos-Santos, A., Mariathasan, S., Bouchard, D., Wakeham, A. C., Itié, A., et al. (2000) · Nature · doi:10.1038/35003228 · Cited by 674
Self-citation
Cbl: many adaptations to regulate protein tyrosine kinases
Thien, C. B. F., & Langdon, W. Y. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35067100 · Cited by 628
Cbl-b regulates the CD28 dependence of T-cell activation
Chiang, Y. J., Kole, H. K., Brown, K. E., Naramura, M., Fukuhara, S., Hu, R.-J., Jang, I. K., Gutkind, J. S., Shevach, E. M., & Gu, H. (2000) · Nature · doi:10.1038/35003235 · Cited by 626

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Keane, 1995, Cloning and characterization of cbl-b, Oncogene, 10, 2367

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Chang, X., Chen, L., Wen, J., Godfrey, V., Qiao, G., Hussien, Y., Zhang, J., & Gao, J.-X. (2006) · Clinical Immunology · doi:10.1016/j.clim.2006.07.004 · Cited by 18
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Authors: Jeon, M.-S., Atfield, A., Venuprasad, K., Krawczyk, C., Sarao, R., Elly, C., Yang, C., Arya, S., Bachmaier, K., Su, L., Bouchard, D., Jones, R., Gronski, M., Ohashi, P., Wada, T., Bloom, D., Fathman, C. G., Liu, Y.-C., & Penninger, J. M.
Affiliations: La Jolla Institute for Immunology (US)
University of Toronto (CA)
Institute of Molecular Biotechnology (AT)
Stanford Medicine (US)
Corresponding author: Liu, Yun-Cai
Penninger, Josef M.
ORCID: Jeon, Myung-Shin
Venuprasad, K.
Krawczyk, Connie
Yang, Chun
Bachmaier, Kurt
Su, Leon
Ohashi, Pamela
Wada, Teiji
Fathman, C.Garrison
Liu, Yun-Cai
Penninger, Josef M.
Venue: Immunity
Publisher: Elsevier BV
Published: 2004-08
Volume: 21
Issue: 2
Pages: 167-177
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2004.07.013
OpenAlex: W2039096179
Cited by: 348
References: 33
Citations by year: 2026: 7 · 2025: 10 · 2024: 10 · 2023: 5 · 2022: 8 · 2021: 16 · 2020: 12 · 2019: 13 · 2018: 10 · 2017: 15 · 2016: 12 · 2015: 19 · 2014: 23 · 2013: 22 · 2012: 20
FWCI: 8.39
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3272 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ai050280-05)
U.S. Public Health Service (R0156558)
National Institute of Allergy and Infectious Diseases (R01 AI 50280)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: Cbl-b, E3 ubiquitin ligase, T cell anergy, T cell tolerance, antigen-specific tolerance, autoimmunity, calcium mobilization, peripheral tolerance, autoreactive T cells
MeSH terms: Animals, Antigens, Enterotoxins, Type C Phospholipases, T-Lymphocytes, Clonal Anergy, Adoptive Transfer, Ubiquitin-Protein Ligases, Adaptor Proteins, Signal Transducing, Proto-Oncogene Proteins c-cbl, Mice, Phospholipase C gamma, In Vitro Techniques

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Essential Role of the E3 Ubiquitin Ligase Cbl-b in T Cell Anergy Induction

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