Essential Role of the E3 Ubiquitin Ligase Cbl-b in T Cell Anergy Induction

Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements

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The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase

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Structure of a c-Cbl–UbcH7 Complex

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Transcriptional Mechanisms Underlying Lymphocyte Tolerance

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Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

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Cbl: many adaptations to regulate protein tyrosine kinases

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Cbl-b regulates the CD28 dependence of T-cell activation

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Investigation of T cell signalling events regulating immunity and tolerance in vivo

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E3 Ubiquitin Ligase CBL-B

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Roquin binds to ICOS mRNA for P body-dependent and miRNA-independent posttranscriptional gene silencing

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CD4+ T Cell Responses: A Complex Network of Activating and Tolerizing Signals as Revealed by Gene Expression Analysis: A Dissertation

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Uso e limitações da tolerância imunológica periférica em modelo de asma experimental

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Probing lymphocyte responses to modulation of the F0F1-ATPase by BZ-423

Wang, L. (2009) · Deep Blue (University of Michigan)

Cbl-b: its role of expression and regulation in T-lymphocyte activation and ageing

Xu, Z. (2007) · Texas ScholarWorks (Texas Digital Library)

CIMT 2014: Next waves in cancer immunotherapy - Report on the 12th annual meeting of the Association for Cancer Immunotherapy

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Modulation of TCR signals reprograms immune tolerance in transplantation and type-1 diabetes

Khattar, M. (2012) · OhioLink ETD Center (Ohio Library and Information Network)

Chapter 1 Digestive System and Autoimmunity

Mix, H., & Manns, M. P. (2008) · Technical report · doi:10.1016/s1571-5078(07)00001-3

Regulation of calcium signaling and cellular localization of NFAT in CD8+ anergic T cells.

Srinivasan, M. (2008) · University Libraries (University of Maryland)

Staying calm under provocation

Minton, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1466

Mechanistic studies on long peptide based vaccins for the use in cancer therapy.

Bijker, M. S. (2007) · Leiden Repository (Leiden University)

The biology of CD4+ T cells in the blood and central nervous system

Voice, M. A. (2015) · University of Birmingham Institutional Research Archive (University of Birmingham)

Signaling Pathways of Cbl-b and Its Role in Peripheral T Cell Tolerance

Venuprasad, K. (2013) · Springer eBooks · doi:10.1007/978-94-007-6211-4_8

Role of Ubiquitination Promoted During Restimulation in the Induction of T Cell Anergy

Mizuguchi, Y., Yamamoto, A., Hattori, M., & Yoshida, T. (2010) · Springer eBooks · doi:10.1007/978-90-481-3892-0_38

T Cell Fate in the Tumor Microenvironment

Crespo, J., Kryczek, I., Welling, T. H., Wei, S., & Zou, W. (2015) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-3-319-21167-1_3

Cbl in Epidermal Growth Factor Receptor trafficking

Hagen, B. S. (2013) · NORA - Norwegian Open Research Archives

Digestive System and Autoimmunity

Mix, H., & Manns, M. P. (2017) · Technical report · doi:10.1016/b978-0-444-63707-9.00001-5

Defective Immune Regulation in Multiple Sclerosis: E3 Ubiquitin Ligase Cbl-b and TLR Tolerance

Fujiwara, M. (2017) · OpenCommons - UConn (University of Connecticut)

Autoimmunity and Inflammation

Mulay, S. R., Kulkarni, O. P., Rupanagudi, K. V., & Anders, H. (2017) · Wiley-VCH eBooks · doi:10.1002/9783527692156.ch40

Decoding the role of CBLB for innate immune responses regulating systemic dissemination during Non-Tuberculous Mycobacteria infectionPreprint

Mudalagiriyappa, S., Sharma, J., Abdelaal, H. F. M., Kelly, T. C., Choi, W., Vieson, M. D., Talaat, A. M., & Nanjappa, S. G. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.28.117663

Faculty Opinions recommendation of CD5 signalosome coordinates antagonist TCR signals to control the generation of Treg cells induced by foreign antigens.

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Faculty Opinions recommendation of K33-linked polyubiquitination of T cell receptor-zeta regulates proteolysis-independent T cell signaling.

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T Lymphocytes

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Faculty Opinions recommendation of Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction.

Rouse, B. T. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.735164832.793558437

CD28

Okkenhaug, K. (2005) · AfCS-Nature Molecule Pages · doi:10.1038/mp.a000548.01

E3 Ubiquitin Ligase CBL-B

Tang, J., & Zhang, J. (2016) · Springer eBooks · doi:10.1007/978-1-4614-6438-9_101569-1

Faculty Opinions recommendation of CD5 signalosome coordinates antagonist TCR signals to control the generation of Treg cells induced by foreign antigens.

Altman, A. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.737996780.793575542

Animal Models

Mizui, M., & Tsokos, G. C. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-384929-8.00030-7

E3 ligase casitas B-lineage lymphoma-b modulates peripheral T-cell tolerance via PI3K signaling in patients with immune thrombocytopeniaPreprint

Liu, L., Xiang, Y., Shao, L., Yuan, C., Song, X., Liu, Y., Zhang, X., Hou, M., Peng, J., & Shi, Y. (2023) · Research Square · doi:10.21203/rs.3.rs-2741491/v1

Ablation of Cbl-b and c-Cbl in macrophages causes severe spontaneous lung inflammation via enhancing the M-CSFR signaling pathwayPreprint

Zhang, J., Xu, F., Tan, C., Tang, K., Qiao, G., Shao, Y., Li, X., Zhou, J. Y., Zhu, P., Wu, M., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-5497778/v1

Polymersome-mediated Cbl-b silencing activates T cells against solid tumors

Cui, G., Shao, Y., Wang, J., Xu, C., Zhang, J., & Zhong, Z. (2025) · Biomaterials Science · doi:10.1039/d5bm00001g

Lenalidomide targets the T-cell co-stimulatory pathway to mediate immune modulation

McDaniel, J. M. (2012) · Digital Commons - University of South Florida (University of South Florida)

The Role of Notch Signaling in T Cell-mediated Immune Disorders.

Sandy, A. R. (2013) · Deep Blue (University of Michigan)

Inhibiting ubiquitin ligases: a case study on the discovery, mechanism, and optimization of Cbl-b inhibitors

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Implication de ROQUIN dans la physiopathologie du lymphome T angio-immunoblastique

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Optimisation de l’activité de l’alpha-galactosylcéramide, ligand des lymphocytes T Natural Killer invariants

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Analyses moléculaire, cellulaire et fonctionnelle des protéines de signalisation CD5 et Themis1 dans les lymphocytes T

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Normal and pathological functions of the T cell signaling protein, THEMIS, in CD4+ T cells

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CD8 T Cell Sensing of Type I Interferon Impacts Anergy

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The T cell receptor associated transmembrane adaptor 1 regulates the threshold for activation of naïve human CD4+ T cells

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BindingDB Entry 50013903: An affinity prediction approach for the ligand of E3 ligase Cbl-b and an insight into substrate binding pattern.

BindingDB (2022) · UC San Diego · doi:10.7270/q2dj5kd5

BindingDB Entry 50021619: Rising Star in Immunotherapy: Development and Therapeutic Potential of Small-Molecule Inhibitors Targeting Casitas B Cell Lymphoma-b (Cbl-b).

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BindingDB Entry 50023739: Rational design, optimization, and biological evaluation of novel pyrrolo-pyridone derivatives as potent and orally active Cbl-b inhibitors.

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Egr-2 and PD-1 Are Required for Induction and Maintenance of T Cell Anergy: A Dissertation

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REGULATION AND FUNCTION OF MARCH1: MODULATION OF IMMUNITY THROUGH UBIQUITINATION

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E3 ubiquitin ligases and immune tolerance: Targeting the immune synapse from within?

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Development and Partial Characterization of Agonistic OX40 Aptamer anti-CBLB siRNA Conjugates

Seales, D. (2012)

The E3 ubiquitin ligase Cbl-b is essential for the induction of in vivo T-cell anergy

Atfield, A. (2005) · TSpace (University of Toronto)

The E3 Ubiquitin Ligase Cbl-b Regulates Expansion but Not Functional Activity of Self-Reactive CD4 T Cells

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Signaling Pathways of Cbl-b and Its Role in Peripheral T Cell Tolerance

Venuprasad, K. (2013) · Springer eBooks · doi:10.1007/978-94-007-6211-4_8

Regulation of peripheral T cell tolerance by the E3 ubiquitin ligase Cbl-b

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Control of the B Cell-Intrinsic Tolerance Programs by Ubiquitin Ligases Cbl and Cbl-b

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