Essential Role of the E3 Ubiquitin Ligase Cbl-b in T Cell Anergy Induction

Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements

Barnden, M., Allison, J., Heath, W. R., & Carbone, F. (1998) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.1998.00709.x · Cited by 1,491

T cell anergy

Schwartz, R. H. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141110 · Cited by 1,487

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo.

Kearney, E. R., Pape, K., Loh, D., & Jenkins, M. (1994) · Immunity · doi:10.1016/1074-7613(94)90084-1 · Cited by 1,126

The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase

Joazeiro, C. A. P., Wing, S. S., Huang, H.-K., Leverson, J. D., Hunter, T. R., & Liu, Y. (1999) · Science · doi:10.1126/science.286.5438.309 · Cited by 1,036

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

Pircher, H., Bürki, K., Lang, R., Hengartner, H., & Zinkernagel, R. M. (1989) · Nature · doi:10.1038/342559a0 · Cited by 1,019

Structure of a c-Cbl–UbcH7 Complex

Zheng, N., Wang, P., Jeffrey, P. D., & Pavletich, N. P. (2000) · Cell · doi:10.1016/s0092-8674(00)00057-x · Cited by 839

Transcriptional Mechanisms Underlying Lymphocyte Tolerance

Macián, F., Garcia-Cozar, F. J., Im, S., Horton, H. F., Byrne, M. C., & Rao, A. (2002) · Cell · doi:10.1016/s0092-8674(02)00767-5 · Cited by 687

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

Bachmaier, K., Krawczyk, C. M., Kozieradzki, I., Kong, Y., Sasaki, T., Oliveira-dos-Santos, A., Mariathasan, S., Bouchard, D., Wakeham, A. C., Itié, A., et al. (2000) · Nature · doi:10.1038/35003228 · Cited by 674

Cbl: many adaptations to regulate protein tyrosine kinases

Thien, C. B. F., & Langdon, W. Y. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35067100 · Cited by 628

Cbl-b regulates the CD28 dependence of T-cell activation

Chiang, Y. J., Kole, H. K., Brown, K. E., Naramura, M., Fukuhara, S., Hu, R.-J., Jang, I. K., Gutkind, J. S., Shevach, E. M., & Gu, H. (2000) · Nature · doi:10.1038/35003235 · Cited by 626

ZAP-70 Regulates Autoimmune Arthritis via Alterations in T Cell Activation and Apoptosis

Kugyelka, R., Prenek, L., Olasz, K., Kohl, Z., Botz, B., Glant, T. T., Berki, T., & Boldizsár, F. (2019) · Cells · doi:10.3390/cells8050504 · Cited by 17

CRISPR-Cas9-Based Gene Knockout of Immune Checkpoints in Expanded NK Cells

Gol, T. M., Kim, M., Sinn, R., Ureña-Bailén, G., Stegmeyer, S., Gratz, P. G., Zahedipour, F., Roig‐Merino, A., Antony, J. S., & Mezger, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216065 · Cited by 16

Peptide-induced immune regulation by a promiscuous and immunodominant CD4T-cell epitope of Timothy grass pollen: a role of Cbl-b and Itch in regulation

Till, S. J., Raynsford, E. J., Reynolds, C. J., Quigley, K. J., Grzybowska-Kowalczyk, A., Saggar, L. R., Goldstone, A., Maillère, B., Kwok, W. W., Altmann, D. M., et al. (2013) · Thorax · doi:10.1136/thoraxjnl-2013-204324 · Cited by 16

A novelCBL-Bflox/floxmouse model allows tissue-selective fully conditionalCBL/CBL-Bdouble-knockout: CD4-Cre mediatedCBL/CBL-Bdeletion occurs in both T-cells and hematopoietic stem cells

Goetz, B. T., An, W., Mohapatra, B. C., Zutshi, N., Iseka, F., Storck, M. D., Meza, J. L., Sheinin, Y. M., Band, V., & Band, H. (2016) · Oncotarget · doi:10.18632/oncotarget.9812 · Cited by 16

Overproduction of IL-2 by Cbl-b deficient CD4 + T cells provides resistance against regulatory T cells

Han, S., Chung, D. C., Paul, M. S., Liu, Z. Q., Garcia-Batres, C. R., Elford, A. R., Tran, C. W., Chapatte, L., & Ohashi, P. S. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1737368 · Cited by 16

The Role of the E3 Ligase Cbl-B in Murine Dendritic Cells

Wallner, S., Lutz‐Nicoladoni, C., Tripp, C. H., Gastl, G. A., Baier, G., Penninger, J. M., Stoitzner, P., & Wolf, D. G. F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065178 · Cited by 16

Ndfip1 Enforces a Requirement for CD28 Costimulation by Limiting IL-2 Production

Ramos-Hernández, N., Ramón, H. E., Beal, A. M., Laroche, A., Dekleva, E. A., & Oliver, P. M. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203571 · Cited by 16

Ubiquitylation as a Rheostat for TCR Signaling: From Targeted Approaches Toward Global Profiling

O’Leary, C. E., Lewis, E. L., & Oliver, P. M. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00618 · Cited by 15

Autoreactive CD8 T cells in NOD mice exhibit phenotypic heterogeneity but restricted TCR gene usage

Kasmani, M. Y., Ciecko, A. E., Brown, A. K., Петрова, Г. В., Gorski, J., Chen, Y., & Cui, W. (2022) · Life Science Alliance · doi:10.26508/lsa.202201503 · Cited by 14

CD4+ T Cell Subset Differentiation and Avidity Setpoint Are Dictated by the Interplay of Cytokine and Antigen Mediated Signals

Shiner, E. K., Holbrook, B. C., & Alexander‐Miller, M. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100175 · Cited by 15

The Ubiquitin E3 Ligase Cbl-b in T Cells Tolerance and Tumor Immunity

Loeser, S., & Penninger, J. M. (2007) · Cell Cycle · doi:10.4161/cc.6.20.4797 · Cited by 15

Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation

Tran, C. W., Saibil, S. D., Bihan, T. L., Hamilton, S. R., Lang, K. S., You, H., Lin, A. E., Garza, K. M., Elford, A. R., Tai, K., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1600396 · Cited by 15

The Anergy Induction of M3 Muscarinic Acetylcholine Receptor–Reactive CD4+ T Cells Suppresses Experimental Sialadenitis‐like Sjögren's Syndrome

Asashima, H., Tsuboi, H., Takahashi, H., Hirota, T., Iizuka, M., Kondo, Y., Matsui, M., Matsumoto, I., & Sumida, T. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39163 · Cited by 15

Therapeutic Blockade of T- Cell Antigen Receptor Signal Transduction and Costimulation in Autoimmune Disease

Podojil, J. R., Turley, D. M., & Miller, S. D. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-09789-3_18 · Cited by 15

Cbl‐family proteins as regulators of cytoskeleton‐dependent phenomena

Lee, H., & Tsygankov, A. Y. (2013) · Journal of Cellular Physiology · doi:10.1002/jcp.24412 · Cited by 14

Protein phosphatases regulate the liver microenvironment in the development of hepatocellular carcinoma

Yoon, J.-S., & Lee, C.-W. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00883-0 · Cited by 14

Gene Related to Anergy in Lymphocytes (GRAIL) Expression in CD4+ T Cells Impairs Actin Cytoskeletal Organization during T Cell/Antigen-presenting Cell Interactions

Schartner, J. M., Simonson, W. T., Wernimont, S. A., Nettenstrom, L. M., Anna Huttenlocher, A., & Seroogy, C. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.024497 · Cited by 14

Does Antigen Masking by Ubiquitin Chains Protect from the Development of Autoimmune Diseases?

Weil, R. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00262 · Cited by 14

E3 ubiquitin ligases and their control of T cell autoreactivity.

Bonnevier, J. L., Zhang, R., & Mueller, D. L. (2005) · Arthritis Research & Therapy · doi:10.1186/ar1842 · Cited by 14

CD43 regulates the threshold for T cell activation by targeting Cbl functions

Pedraza‐Alva, G., de Long, L. M., del Río, R., Fierro, N. A., Muñoz, M. E. C., Olivares, N., Melchy-Pérez, E., Igras, V., Holländer, G. A., Burakoff, S. J., et al. (2011) · IUBMB Life · doi:10.1002/iub.554 · Cited by 14

CBLB Constrains Inactivated Vaccine–Induced CD8+ T Cell Responses and Immunity against Lethal Fungal Pneumonia

Nanjappa, S. G., Mudalagiriyappa, S., Fites, J. S., Suresh, M., & Klein, B. S. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701241 · Cited by 13

E3 Ubiquitin Ligases as Immunotherapeutic Target in Atherosclerotic Cardiovascular Disease

Poels, K., Vos, W. G., Lutgens, E., & Seijkens, T. T. P. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00106 · Cited by 11

Program death-1 regulates peripheral T cell tolerance via an anergy-independent mechanism

Qiao, G., Yang, L., Li, Z., Ying, H., Hassen, Y., Yin, F., & Zhang, J. (2012) · Clinical Immunology · doi:10.1016/j.clim.2012.02.006 · Cited by 13

The Ubiquitin Ligase Adaptor NDFIP1 Selectively Enforces a CD8+ T Cell Tolerance Checkpoint to High-Dose Antigen

Wagle, M. V., Marchingo, J. M., Howitt, J. A., Tan, S., Goodnow, C. C., & Parish, I. A. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.06.060 · Cited by 12

E3 ubiquitin ligase Cbl-b potentiates the apoptotic action of arsenic trioxide by inhibiting the PI3K/Akt pathway

Li, Y., Qu, X., Qu, J., Ye, Z., Jing, L., Yuee, T., Hu, X., Hou, K., & Liu, Y. (2010) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2010007500142 · Cited by 12

c-Cbl expression levels regulate the functional responses of human central and effector memory CD4 T cells

Brembilla, N. C., Weber, J., Rimoldi, D., Pradervand, S., Schütz, F., Pantaleo, G., Rüegg, C., Quadroni, M., Harshman, K., & Doucey, M. (2008) · Blood · doi:10.1182/blood-2008-01-134486 · Cited by 12

Preservation of self: An overview of E3 ubiquitin ligases and T cell tolerance

Schartner, J. M., Fathman, C. G., & Seroogy, C. M. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.02.010 · Cited by 12

Lck Function and Modulation: Immune Cytotoxic Response and Tumor Treatment More Than a Simple Event

Sanctis, J. B. D., Garmendia, J. V., Duchová, H., Valentini, V., Puskasu, A., Kubíčková, A., & Hajdúch, M. (2024) · Cancers · doi:10.3390/cancers16152630 · Cited by 11

Foxp3 positive regulatory T cells: a functional regulation by the E3 ubiquitin ligase Itch

Su, J., & Liu, Y. (2010) · Seminars in Immunopathology · doi:10.1007/s00281-009-0192-1 · Cited by 12

Immune Dysregulation in Human ITCH Deficiency Successfully Treated with Hematopoietic Cell Transplantation

Patel, T., Henrickson, S. E., Moser, E. K., Field, N. S., Maurer, K., Dawany, N. B., Conrad, M. A., Bunin, N., Freedman, J. L., Heimall, J. R., et al. (2021) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2021.04.010 · Cited by 11

Discovery of diaminotriazine carboxamides as potent inhibitors of hematopoetic progenitor kinase 1

Zhou, L., Ye, X., Wang, K., Shen, H., Wang, T., Zhang, X., Jiang, S., Xiao, Y., & Zhang, K. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2023.106682 · Cited by 11

Embryonic Stem Cell-Derived Factors Inhibit T Effector Activation and Induce T Regulatory Cells by Suppressing PKC-θ Activation

Mohib, K., Al-Khamees, B., Zein, H. S., Allan, D., & Wang, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032420 · Cited by 11

Does our current understanding of the molecular basis of immune tolerance predict new therapies for autoimmune disease?

Tarner, I. H., & Fathman, C. G. (2006) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0272 · Cited by 11

Immunological Tolerance

Farhangnia, P., & Akbarpour, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818731-9.00165-8 · Cited by 15

Defining a Methylation Signature Associated With Operational Tolerance in Kidney Transplant Recipients

Rodríguez, R. M. A., Hernández-Fuentes, M. P., Corte-Iglesias, V., Sáiz, M. L., Lozano, J. J., Cortázar, A. R., Mendizabal, I., Suárez-Fernández, M. L., Coto, E., López‐Vázquez, A., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.709164 · Cited by 10

Cbl-b restrains priming of pathogenic Th17 cells via the inhibition of IL-6 production by macrophages

Zeng, Q., Tang, N., Ma, Y., Guo, H., Zhao, Y., Tang, R., Yan, C., Ouyang, S., Langdon, W. Y., Yang, H., et al. (2022) · iScience · doi:10.1016/j.isci.2022.105151 · Cited by 11

Therapeutic Potential of Hyporesponsive CD4+ T Cells in Autoimmunity

Maggi, J., Schäfer, C., Ubilla-Olguín, G., Catalán, D., Schinnerling, K., & Aguillón, J. C. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00488 · Cited by 10

Mammary tumors with diverse immunological phenotypes show differing sensitivity to adoptively transferred CD8+ T cells lacking the Cbl-b gene

Yang, T., Martin, M. L., Nielsen, J. S., Milne, K., Wall, E. M., Lin, W., Watson, P. H., & Nelson, B. H. (2009) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-009-0698-3 · Cited by 10

An adenoviral vector encoding dominant negative Cbl lowers the threshold for T cell activation in post-thymic T cells

Zha, Y., & Gajewski, T. F. (2007) · Cellular Immunology · doi:10.1016/j.cellimm.2007.07.006 · Cited by 10

Biomarkers to Discern Transplantation Tolerance after Allogeneic Hematopoietic Cell Transplantation

Pidala, J., Bloom, G. C., Enkemann, S. A., Eschrich, S. A., Lancaster, J. M., & Anasetti, C. (2009) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2009.11.009 · Cited by 9

CARD11 is dispensable for homeostatic responses and suppressive activity of peripherally induced FOXP3+ regulatory T cells

Policheni, A. N., Horikawa, K., Milla, L., Kofler, J., Bouillet, P., Belz, G. T., O’Reilly, L. A., Goodnow, C. C., Strasser, A., & Gray, D. H. D. (2019) · Immunology and Cell Biology · doi:10.1111/imcb.12268 · Cited by 9

Immune Regulation by Ubiquitin Conjugation

Venuprasad, K., Yang, C., Shao, Y., Demydenko, D., Harada, Y., Jeon, M., & Liu, Y. (2007) · Springer eBooks · doi:10.1007/0-387-34132-3_15 · Cited by 9

E3 ubiquitin ligase Cbl‐b suppresses human ORMDL3 expression through STAT6 mediation

Yang, W., Jin, R., Jiang, C., Wang, X., Shu, J., Li, L., Zhu, L.-H., Zhuang, L., Gao, C., & Zhou, G.-P. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.06.015 · Cited by 9

Loss of the Surface Antigen 3G11 Characterizes a Distinct Population of Anergic/Regulatory T Cells in Experimental Autoimmune Encephalomyelitis

Zhang, G., Yu, S., Calida, D. M., Zhao, Z., Gran, B., Kamoun, M., & Rostami, A. M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.6.3366 · Cited by 9

T cell receptor-associated protein tyrosine kinases: The dynamics of tolerance regulation by phosphorylation and its role in systemic lupus erythematosus

Barrera‐Vargas, A., Gómez‐Martín, D., & Alcocer-Varela, J. C. (2014) · Human Immunology · doi:10.1016/j.humimm.2014.08.207 · Cited by 9

The E3 Ubiquitin Ligase Cbl-b Regulates Expansion but Not Functional Activity of Self-Reactive CD4 T Cells

Rose, M. S., Qui, H. Z., Bandyopadhyay, S., Mihalyo, M. A., Hagymasi, A. T., Clark, R. B., & Adler, A. J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901243 · Cited by 9

Innate (Over)immunity and Adaptive Autoimmune Disease

Recher, M., & Lang, K. S. (2006) · Current topics in microbiology and immunology · doi:10.1007/3-540-29714-6_5 · Cited by 9

Combinatorial immunotherapeutic approaches to restore the function of anergic tumor-reactive cytotoxic CD8+ T cells

Redmond, W. L., & Linch, S. N. (2016) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2016.1193277 · Cited by 9

NDRG1 is induced by antigen-receptor signaling but dispensable for B and T cell self-tolerance

Hodgson, R., Xu, X., Anzilotti, C., Deobagkar‐Lele, M., Crockford, T. L., Kepple, J. D., Cawthorne, E., Bhandari, A., Cebrian-Serrano, A., Wilcock, M. J., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-04118-w · Cited by 8

Regulation of T Cell Activation and Anergy by the Intensity of the Ca2+Signal in Cooperation with Other Signals

ADACHI, Y., Hattori, M., & Yoshida, T. (2010) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.100107 · Cited by 8

Cbl-b Deficiency in Mice Results in Exacerbation of Acute and Chronic Stages of Allergic Asthma

Carson, W. F., Guernsey, L. A., Singh, A., Secor, E. R., Wohlfert, E. A., Clark, R. B., Schramm, C. M., Kunkel, S. L., & Thrall, R. S. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00592 · Cited by 8

T Cell Anergy: Where It's LAT

Lineberry, N. B., & Fathman, C. G. (2006) · Immunity · doi:10.1016/j.immuni.2006.05.002 · Cited by 8

T cell specific deletion of Casitas B lineage lymphoma-b reduces atherosclerosis, but increases plaque T cell infiltration and systemic T cell activation

Vos, W. G., van Os, B. W., den Toom, M., Beckers, L., van Roomen, C. P. A. A., van Tiel, C. M., Mohapatra, B. C., Band, H., Nitz, K., Weber, C., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1297893 · Cited by 7

Cbl-b-deficient mice express alterations in trafficking-related molecules but retain sensitivity to the multiple sclerosis therapeutic agent, FTY720

Fujiwara, M., Anstadt, E. J., Khanna, K. M., & Clark, R. B. (2015) · Clinical Immunology · doi:10.1016/j.clim.2015.03.018 · Cited by 7

Cbl-b gene silencing in splenic T lymphocytes as a therapeutic strategy to target the prostate cancer RM-1 cell tumors in immune competent mice.

Zd, S., Xf, L., Hao, L., Zhao, Y., Yx, W., Dong, B.-Z., Wh, C., Zg, Z., Ym, W., Fu, Q., et al. (2014) · PubMed · Cited by 7

Regulation of Lymphatic GM-CSF Expression by the E3 Ubiquitin Ligase Cbl-b

Peer, S., Cappellano, G., Hermann‐Kleiter, N., Albrecht-Schgoer, K., Hinterleitner, R., Baier, G., & Gruber, T. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02311 · Cited by 7

Manipulating the TCR signaling network for cellular immunotherapy: Challenges & opportunities

Matson, C. A., & Singh, N. J. (2020) · Molecular Immunology · doi:10.1016/j.molimm.2020.04.007 · Cited by 7

Rational design, optimization, and biological evaluation of novel pyrrolo-pyridone derivatives as potent and orally active Cbl-b inhibitors

Zhang, Y., Guan, X., Chai, Y., Lu, T., An, N., Lin, X., & Liao, X. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.117488 · Cited by 6

Cbl-b inhibitor NX-1607 activates MAPK/ERK signaling pathway and enhances T-cell activation

Zhu, W., Lu, S., Jia, L., Liu, B., Song, S., Bao, X., Yu, T. Y., Zhang, Y., Miao, Z., & He, J. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-011180 · Cited by 6

CNOT4 suppresses non-small cell lung cancer progression and is required for effector cytolytic T lymphocytes cell responses to lung cancer cells

Zhang, B., & Chen, S. (2021) · Molecular Immunology · doi:10.1016/j.molimm.2020.12.020 · Cited by 6

An affinity prediction approach for the ligand of E3 ligase Cbl-b and an insight into substrate binding pattern

Hu, L.-B., Hu, X.-Q., Zhang, Q., You, Q., & Jiang, Z. (2021) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2021.116130 · Cited by 6

Immune Regulation by Ubiquitin Tagging as Checkpoint Code

Zeng, P., Ma, J., Yang, R., & Liu, Y. (2017) · Current topics in microbiology and immunology · doi:10.1007/82_2017_64 · Cited by 6

CAR T cell therapy drives endogenous locoregional T cell dynamics in a responding patient with glioblastomaPreprint

Jönsson, V. D., Ng, R. H., Dullerud, N., Wong, R. A., Hibbard, J. C., Wang, D., Aguilar, B., Starr, R., Weng, L., Alizadeh, D., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.22.460392 · Cited by 6

SIRT2-mediated deacetylation of LCK governs the magnitude of T cell receptor signaling

Hamaidi, I., Cheng, P., Jun, S. Y., Manna, A., Wang, M.-H., Nguyen, A., Can, İ., Zhang, M., Taylor, O. O., Lopez-Bailon, L. U., et al. (2026) · Nature Immunology · doi:10.1038/s41590-025-02377-3 · Cited by 5

The Role of Ubiquitin-Proteasome System (UPS) in Asthma Pathology

Deng, S., Ding, L., Qian, Y., & Huang, X. (2025) · Journal of Asthma and Allergy · doi:10.2147/jaa.s490039 · Cited by 6

E3 Ubiquitin ligases Cbl-b and c-Cbl maintain the homeostasis of macrophages by regulating the M-CSF/M-CSFR signaling axis

Xu, F., Tan, C., Tang, K., Qiao, G., Shao, Y., Li, X., Zhou, J. Y., Zhu, P., Wu, M., Cai, J., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08047-4 · Cited by 5

E3 Ligases in T Helper 2-mediated Pathogenesis

Sahoo, A. (2014) · Immunome Research · doi:10.4172/1745-7580.1000086 · Cited by 5

Ubiquitin ligase Cbl‐b acts as a negative regulator in discoidin domain receptor 2 signaling via modulation of its stability

Yu, J., Zhao, H., Zhang, Y., Liu, Y., Yao, L., Li, X., & Su, J. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.03.003 · Cited by 5

Animal Models: Systemic Autoimmune Diseases

Mizui, M., & Tsokos, G. C. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-812102-3.00029-4 · Cited by 5

Dendritic Cell Immune Therapy to Break or Induce Tolerance

Amodio, G., Annoni, A., & Gregori, S. (2015) · Current Stem Cell Reports · doi:10.1007/s40778-015-0024-2 · Cited by 5

Mechanisms of self-inactivation in anergic T cells

Valdor, R., & Macián, F. (2010) · Inmunología · doi:10.1016/s0213-9626(10)70008-1 · Cited by 7

CARD19, a Novel Regulator of the TAK1/NF-κB Pathway in Self-Reactive B Cells

Zheng, Y., Yu, M., Chen, Y., Xue, L., Zhu, W., Fu, G., Morris, S. W., Wen, R., & Wang, D. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2200639 · Cited by 4

Establishing an evaluation system for T cell activation and anergy based on CD25 expression levels as an indicator

Seo, S., Hattori, M., & Yoshida, T. (2024) · Cytotechnology · doi:10.1007/s10616-024-00651-0 · Cited by 4

Post-Translational Modification Profiling-Functional Proteomics for the Analysis of Immune Regulation

Eisenberg‐Lerner, A., Regev, I., & Merbl, Y. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7201-2_9 · Cited by 4

E3 ubiquitin ligases: structural diversity, dysregulation in disease, and their emerging role in targeted therapeutic strategies

Sriram, S., Krishnakumar, P., & Sudandiradoss, C. (2026) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2026.1745654 · Cited by 3

Cbl-b inhibition promotes less differentiated phenotypes of T cells with enhanced cytokine production

Wang, J., Han, X., Hao, Y., Chen, S., Pang, B., Zou, L., Han, X., Wang, W., Liu, L.-Z., Shen, M., et al. (2024) · Cellular Immunology · doi:10.1016/j.cellimm.2024.104863 · Cited by 3

E3 ubiquitin ligase casitas B-lineage lymphoma-b modulates T-cell anergic resistance via phosphoinositide 3-kinase signaling in patients with immune thrombocytopenia

Liu, L., Xiang, Y., Shao, L., Yuan, C., Song, X., Sun, M., Liu, Y., Zhang, X., Du, S., Hou, M., et al. (2024) · Journal of Thrombosis and Haemostasis · doi:10.1016/j.jtha.2023.12.032 · Cited by 3

Mechanisms of Cbl-Mediated Ubiquitination of Proteins in T and Natural Killer Cells and Effects on Immune Cell Functions

Nath, P. R., & Isakov, N. (2024) · Life · doi:10.3390/life14121592 · Cited by 3

Unleashing the Therapeutic Potential of Dendritic and T Cell Therapies Using RNA Interference

Sioud, M. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-0290-4_15 · Cited by 3

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Shiheido, H., Aoyama, T., Takahashi, H., Hanaoka, K., Abe, T., Nishida, E., Chen, C., Koga, O., Hikida, M., Shibagaki, Y., et al. (2014) · European Journal of Immunology · doi:10.1002/eji.201344146 · Cited by 3

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JoAnn Trial, L. A. P. (2014) · Inflammation and Cell Signaling · doi:10.14800/ics.146 · Cited by 3

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Tomar, N., & De, R. K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080918 · Cited by 3

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Iwata, Y., Matsushita, T., Narushima, Y., Harada, A., Sakamoto, Y., Sakamoto, A., Ikegami, H., Mishima, M., & Suzuki, H. (2025) · Journal of Applied Toxicology · doi:10.1002/jat.4812 · Cited by 2

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Leibbrandt, A., & Penninger, J. M. (2009) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2009.02215.x · Cited by 2

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Juan, M. (2016) · MOJ Immunology · doi:10.15406/moji.2016.04.00113 · Cited by 2

Suboptimal stimulation by weak agonist epitope variants does not drive dysfunction of HIV-1-specific cytotoxic T lymphocyte clones

Grossman, M. A., Hofmann, C., Ng, H. L., & Yang, O. O. (2019) · AIDS · doi:10.1097/qad.0000000000002259 · Cited by 2

CIMT 2019: report on the 17th Annual Meeting of the Association for Cancer Immunotherapy

Beck, J. D., Birtel, M., Haefner, E. S., Keil, I. S., Reidenbach, D., Salomon, N., Yildiz, I., & Diken, M. (2019) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2019.1675459 · Cited by 2

Three-dimensional genome structure and chromatin accessibility reorganization during in vivo induction of human T cell tolerancePreprint

Li, R., Guo, H., Hou, Y., Liu, S., Wang, M., Peng, T., Zhao, X., Lu, L., Han, Y., Shao, Y., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.11.988253 · Cited by 2

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Victora, G. D., Chudnovskiy, A., Nakandakari-Higa, S., Castro, T. B. R., Cui, A., Lin, C., Sade-Feldman, M., Phillips, B. K., Pae, J., Mesin, L., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-2152423/v1 · Cited by 2

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Heissmeyer, V., Tanasă, B., & RAO, A. (2007) · Elsevier eBooks · doi:10.1016/b978-012369454-6/50088-1 · Cited by 2

Combination of Cbl-b inhibitor NX-1607 and CDK4/6 inhibitor abemaciclib enhances anti-tumor immunity through PLCγ1/ERK-mediated T cell activation

Lu, S., Zhu, W.-T., Song, S.-S., Bao, X., Yu, T. Y., Zhang, Y., Miao, Z., & He, J. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.112051 · Cited by 1

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Li, Y., Tang, H., Shi, W., Zhou, Y., Wen, J., Zhu, J., Gao, M., Xu, T., & Xie, H. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.116026 · Cited by 1

Post‐Translational Regulation of CD8 + T Cell Fate and Dysfunction in Tumor Immunity

Zhou, Z., Chen, X., Li, N., Zou, M., Lin, Y., Lin, P., Feng, W., Zhao, X., & Cui, L. (2026) · Advanced Science · doi:10.1002/advs.74807 · Cited by 1

Tolerance and Autoimmunity: T Cells

Gronski, M. A., & Ohashi, P. S. (2006) · Elsevier eBooks · doi:10.1016/b978-012595961-2/50011-1 · Cited by 1

Differences in phosphorylation patterns of intracellular signaling proteins in T cells from kidney transplant patients with different outcomes

Ortiz, Y. M., García, L. F., & Álvarez, C. M. (2012) · Clinical Transplantation · doi:10.1111/j.1399-0012.2012.01683.x · Cited by 1

The Role of NDFIP1 in T Cell Tolerance

Hernández, R., & Natalia, M. (2013) · Cited by 1

Discoidin Domain Receptor Signalling Networks

Iwai, L. K., Payne, L. S., Allam, D., & Huang, P. H. (2016) · Springer eBooks · doi:10.1007/978-1-4939-6383-6_11 · Cited by 1

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Wang, B., Zhou, J., & An, N. (2024) · PeerJ · doi:10.7717/peerj.17280 · Cited by 1

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Xiao, X., Xie, R., Zhang, Y., Yin, Y., Chen, Y., Sun, N., Cheng, Z., & Zhang, G. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167765 · Cited by 1

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Atfield, A. (2005) · TSpace (University of Toronto)

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Rose, M. S., Qui, H. Z., Bandyopadhyay, S., Mihalyo, M. A., Hagymasi, A. T., Clark, R. B., & Adler, A. J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901243 · Cited by 9

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Kitaura, Y., Jang, I. K., Wang, Y., Han, Y.-C., Inazu, T., Cadera, E. J., Schlissel, M. S., Hardy, R. R., & Gu, H. (2007) · Immunity · doi:10.1016/j.immuni.2007.03.015 · Cited by 134