Cited by 186Hepatitis B Virus StudiesT-cell and B-cell ImmunologyLiver physiology and pathology

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Oscillating CD8+ T Cell Effector Functions after Antigen Recognition in the Liver

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Isogawa, Masanori, Furuichi, Yoshihiro, Chisari, Francis V.·2005·Immunity

DOI 10.1016/j.immuni.2005.05.005

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Abstract

When hepatitis B virus (HBV)-specific CD8(+) cytotoxic T lymphocytes (CTLs) are adoptively transferred into HBV transgenic mice, they enter the liver, recognize antigen, secrete interferon gamma (IFNgamma), inhibit viral replication, and kill their target cells, causing hepatitis. In the current study, we examined the impact of antigen recognition on the evolution of the activation phenotype, antiviral effector functions, expansion and contraction kinetics, and compartmentalization of the transferred CTLs. The results reveal that noncytolytic and cytolytic effector functions and expansion-contraction kinetics of the CTLs are regulated asynchronously and in an oscillatory manner as a consequence of antigen recognition in the liver and in association with PD-1 upregulation. We suggest that such oscillations maximize viral clearance and minimize tissue injury during HBV infection and that poor coordination of these events could lead to viral persistence and chronic liver disease.

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Background
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MethodSelf-citation
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Result
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Background
Dynamical Modeling and Qualitative Analysis of a Delayed Model for CD8 T Cells in Response to Viral Antigens
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Background

Authors: Isogawa, M., Furuichi, Y., & Chisari, F. V.
Affiliations: Scripps Research Institute (US)
Corresponding author: Chisari, Francis V.
ORCID: Isogawa, Masanori
Furuichi, Yoshihiro
Chisari, Francis V.
Venue: Immunity
Publisher: Elsevier BV
Published: 2005-07
Volume: 23
Issue: 1
Pages: 53-63
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2005.05.005
OpenAlex: W2047908014
Cited by: 186
References: 0
Citations by year: 2026: 3 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 8 · 2020: 6 · 2019: 8 · 2018: 10 · 2017: 9 · 2016: 7 · 2015: 9 · 2014: 11 · 2013: 11 · 2012: 11
FWCI: 10.76
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2974 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (CA40489)
Topics: Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Keywords: hepatitis B virus, CD8+ cytotoxic T lymphocytes, antigen recognition, PD-1, interferon-gamma, viral clearance, liver, chronic hepatitis B, viral persistence, chronic liver disease, HBV transgenic mice
MeSH terms: Animals, Hepatitis B, Hepatitis B Surface Antigens, Immunologic Memory, Interferon-gamma, Liver, Mice, Transgenic, Receptors, Antigen, T-Cell, Serine Endopeptidases, Spleen, T-Lymphocytes, Cytotoxic, Viral Envelope Proteins, Adoptive Transfer, Mice, Granzymes

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Oscillating CD8+ T Cell Effector Functions after Antigen Recognition in the Liver

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