Cited by 316T-cell and B-cell ImmunologyDevelopmental Biology and Gene RegulationPsoriasis: Treatment and Pathogenesis

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Developmental and Molecular Characterization of Emerging β- and γδ-Selected Pre-T Cells in the Adult Mouse Thymus

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Taghon, Tom, Yui, Mary A., Pant, Rashmi, Diamond, Rochelle A., Rothenberg, Ellen V.·2006·Immunity

DOI 10.1016/j.immuni.2005.11.012

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Abstract

The first checkpoint in T cell development, beta selection, has remained incompletely characterized for lack of specific surface markers. We show that CD27 is upregulated in DN3 thymocytes initiating beta selection, concomitant with intracellular TCR-beta expression. Clonal analysis determined that CD27high DN3 cells generate CD4+CD8+ progeny with more than 90% efficiency, faster and more efficiently than the CD27low majority. CD27 upregulation also occurs in gammadelta-selected DN3 thymocytes in TCR-beta-/- mice and in IL2-GFP transgenic reporter mice where GFP marks the earliest emerging TCR-gammadelta cells from DN3 thymocytes. With CD27 to distinguish pre- and postselection DN3 cells, a detailed gene expression analysis defined regulatory changes associated with checkpoint arrest, with beta selection, and with gammadelta selection. gammadelta selection induces higher CD5, Egr, and Runx3 expression as compared to beta selection, but it triggers less proliferation. Our results also reveal differences in Notch/Delta dependence at the earliest stages of divergence between developing alphabeta and gammadelta T-lineage cells.

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Authors: Taghon, T., Yui, M. A., Pant, R., Diamond, R. A., & Rothenberg, E. V.
Affiliations: California Institute of Technology (US)
Corresponding author: Rothenberg, Ellen V.
ORCID: Taghon, Tom
Yui, Mary A.
Diamond, Rochelle A.
Rothenberg, Ellen V.
Venue: Immunity
Publisher: Elsevier BV
Published: 2006-01
Volume: 24
Issue: 1
Pages: 53-64
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2005.11.012
OpenAlex: W2056429839
Cited by: 312
References: 58
Citations by year: 2026: 2 · 2025: 10 · 2024: 12 · 2023: 6 · 2022: 17 · 2021: 13 · 2020: 17 · 2019: 14 · 2018: 7 · 2017: 7 · 2016: 14 · 2015: 15 · 2014: 19 · 2013: 17 · 2012: 18
FWCI: 8.39
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2790 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Funders: National Cancer Institute (R01CA98925, R01CA90233, R01CA090233, R01CA098925)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords: beta-selection, γδ T cells, CD27, T cell development, TCR beta, CD5, Egr transcription factors, RUNX3, Delta-Notch signaling, thymus, clonal analysis
MeSH terms: Animals, Interleukin-2, Membrane Proteins, Mice, Mutant Strains, Stem Cells, Thymus Gland, CD4-Positive T-Lymphocytes, Up-Regulation, Receptors, Antigen, T-Cell, gamma-delta, Receptors, Antigen, T-Cell, alpha-beta, Tumor Necrosis Factor Receptor Superfamily, Member 7, CD8-Positive T-Lymphocytes, Gene Expression Regulation, Developmental, Cell Lineage, Transgenes, Gene Expression Profiling, Intracellular Signaling Peptides and Proteins, Mice, Receptors, Notch

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Developmental and Molecular Characterization of Emerging β- and γδ-Selected Pre-T Cells in the Adult Mouse Thymus

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