The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Developmental and Molecular Characterization of Emerging β- and γδ-Selected Pre-T Cells in the Adult Mouse Thymus
Open accessAbstract
The first checkpoint in T cell development, beta selection, has remained incompletely characterized for lack of specific surface markers. We show that CD27 is upregulated in DN3 thymocytes initiating beta selection, concomitant with intracellular TCR-beta expression. Clonal analysis determined that CD27high DN3 cells generate CD4+CD8+ progeny with more than 90% efficiency, faster and more efficiently than the CD27low majority. CD27 upregulation also occurs in gammadelta-selected DN3 thymocytes in TCR-beta-/- mice and in IL2-GFP transgenic reporter mice where GFP marks the earliest emerging TCR-gammadelta cells from DN3 thymocytes. With CD27 to distinguish pre- and postselection DN3 cells, a detailed gene expression analysis defined regulatory changes associated with checkpoint arrest, with beta selection, and with gammadelta selection. gammadelta selection induces higher CD5, Egr, and Runx3 expression as compared to beta selection, but it triggers less proliferation. Our results also reveal differences in Notch/Delta dependence at the earliest stages of divergence between developing alphabeta and gammadelta T-lineage cells.
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“Commitment to the T cell lineage is complete at the DN3 stage where the cells undergo extensive DNA rearrangements at the β, γ and δ TCR loci in order to express functional TCR chains and make a choice between two developmental programs, one generating αβ T cell subsets and one generating the distinct characteristics and functions of γδ T cells [4], [5].”
From The Transcription Factor PU.1 Regulates γδ T Cell Homeostasis (2011) · cites this paper as [5]
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Cites
Induction of T Cell Development from Hematopoietic Progenitor Cells by Delta-like-1 In Vitro
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CD5 Expression Is Developmentally Regulated By T Cell Receptor (TCR) Signals and TCR Avidity
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Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis
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Notch Activity Influences the αβ versus γδ T Cell Lineage Decision
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Regulation of early human T cell development
Ma, K. (2018) · theses.fr (ABES) · doi:10.70675/ded079e3z40b0z48a5z80a8z517848109870
CD28 : nouvelles données sur un récepteur majeur de la costimulation lymphocytaire T
Morin, S. O. (2017) · theses.fr (ABES) · doi:10.70675/cb01635fz2f63z43e2zad0cz210485c4c5cf
Transcriptional Control of NK and iNKT Cell Development
Zhang, J. (2020) · theses.fr (ABES) · doi:10.70675/073dcbf5z7332z40c0zbba4z555a9ace31a5
Wang, H., Rajan, V., Wong, A., Epelman, S., & Zúñiga‐Pflücker, J. C. (2026) · eLife · doi:10.7554/elife.109219.2
Schwarz, B. A., & Bhandoola, A. (2009) · Springer eBooks · doi:10.1007/978-0-387-85816-6_7
Metadata
- Authors
- Taghon, T., Yui, M. A., Pant, R., Diamond, R. A., & Rothenberg, E. V.
- Affiliations
- California Institute of Technology (US)
- Corresponding author
- Rothenberg, Ellen V.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2006-01
- Volume
- 24
- Issue
- 1
- Pages
- 53-64
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2056429839
- Cited by
- 312
- References
- 58
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 12 · 2023: 6 · 2022: 17 · 2021: 13 · 2020: 17 · 2019: 14 · 2018: 7 · 2017: 7 · 2016: 14 · 2015: 15 · 2014: 19 · 2013: 17 · 2012: 18
- FWCI
- 8.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Funders
- National Cancer Institute (R01CA98925, R01CA90233, R01CA090233, R01CA098925)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- beta-selection, γδ T cells, CD27, T cell development, TCR beta, CD5, Egr transcription factors, RUNX3, Delta-Notch signaling, thymus, clonal analysis
- MeSH terms
- Animals, Interleukin-2, Membrane Proteins, Mice, Mutant Strains, Stem Cells, Thymus Gland, CD4-Positive T-Lymphocytes, Up-Regulation, Receptors, Antigen, T-Cell, gamma-delta, Receptors, Antigen, T-Cell, alpha-beta, Tumor Necrosis Factor Receptor Superfamily, Member 7, CD8-Positive T-Lymphocytes, Gene Expression Regulation, Developmental, Cell Lineage, Transgenes, Gene Expression Profiling, Intracellular Signaling Peptides and Proteins, Mice, Receptors, Notch
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