Developmental and Molecular Characterization of Emerging β- and γδ-Selected Pre-T Cells in the Adult Mouse Thymus

Induction of T Cell Development from Hematopoietic Progenitor Cells by Delta-like-1 In Vitro

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Differential Requirements for Runx Proteins in CD4 Repression and Epigenetic Silencing during T Lymphocyte Development

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CD5 Expression Is Developmentally Regulated By T Cell Receptor (TCR) Signals and TCR Avidity

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Thymopoiesis independent of common lymphoid progenitors.

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T cell receptor δ gene mutant mice: Independent generation of αβ T cells and programmed rearrangements of γδ TCR genes

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Heterogeneity among DN1 prothymocytes reveals multiple progenitors with different capacities to generate T cell and non-T cell lineages.

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Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis

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Notch Activity Influences the αβ versus γδ T Cell Lineage Decision

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Inactivation of Notch1 Impairs VDJβ Rearrangement and Allows pre-TCR-Independent Survival of Early αβ Lineage Thymocytes

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Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo.Preprint

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c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphomaPreprint

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CD27 is a thymic determinant of the balance between interferon-γ- and interleukin 17–producing γδ T cell subsets

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Notch Signaling in the Immune System

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Launching the T-cell-lineage developmental programme

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Zoned Out: Functional Mapping of Stromal Signaling Microenvironments in the Thymus

Petrie, H. T., & Zúñiga-Pflücker, J. C. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115715 · Cited by 454

A critical role for TCF-1 in T-lineage specification and differentiation

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Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia

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Regulation of innate and adaptive immunity by Notch

Radtke, F., MacDonald, H. R., & Tacchini‐Cottier, F. (2013) · Nature reviews. Immunology · doi:10.1038/nri3445 · Cited by 416

Developmental gene networks: a triathlon on the course to T cell identity

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Decision checkpoints in the thymus

Carpenter, A. C., & Bosselut, R. (2010) · Nature Immunology · doi:10.1038/ni.1887 · Cited by 335

The multifaceted role of Notch in cancer

Roy, M., Pear, W. S., & Aster, J. C. (2006) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2006.12.001 · Cited by 292

Mechanisms of T Cell Development and Transformation

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The transcriptional landscape of αβ T cell differentiation

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Stage-Specific and Differential Notch Dependency at the αβ and γδ T Lineage Bifurcation

Ciofani, M., Knowles, G. C., Wiest, D. L., von Boehmer, H., & Zúñiga‐Pflücker, J. C. (2006) · Immunity · doi:10.1016/j.immuni.2006.05.010 · Cited by 257

Transcriptional Control of Early T and B Cell Developmental Choices

Rothenberg, E. V. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-100024 · Cited by 245

The Thymus as an Inductive Site for T Lymphopoiesis

Ciofani, M., & Zúñiga‐Pflücker, J. C. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123547 · Cited by 243

Visualization of the earliest steps of γδ T cell development in the adult thymus

Prinz, I., Sansoni, A., Kissenpfennig, A., Ardouin, L., Malissen, M., & MALISSEN, B. (2006) · Nature Immunology · doi:10.1038/ni1371 · Cited by 209

The requirement for Notch signaling at the β-selection checkpoint in vivo is absolute and independent of the pre–T cell receptor

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Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2APreprint

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E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment

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Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3

Taghon, T., Yui, M. A., & Rothenberg, E. V. (2007) · Nature Immunology · doi:10.1038/ni1486 · Cited by 195

Determining γδ versus αβ T cell development

Ciofani, M., & Zúñiga‐Pflücker, J. C. (2010) · Nature reviews. Immunology · doi:10.1038/nri2820 · Cited by 194

Functions of Notch Signaling in the Immune System: Consensus and Controversies

Yuan, J. S., Kousis, P. C., Suliman, S., Visan, I., & Guidos, C. J. (2010) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132719 · Cited by 180

Ablation of Ribosomal Protein L22 Selectively Impairs αβ T Cell Development by Activation of a p53-Dependent Checkpoint

Anderson, S. J., Lauritsen, J. P. H., Hartman, M. G., Foushee, A. M. D., Lefebvre, J. M., Shinton, S. A., Gerhardt, B., Hardy, R. R., Oravecz, T., & Wiest, D. L. (2007) · Immunity · doi:10.1016/j.immuni.2007.04.012 · Cited by 173

Development of Promyelocytic Zinc Finger and ThPOK-Expressing Innate γδ T Cells Is Controlled by Strength of TCR Signaling and Id3

Alonzo, E. S., Gottschalk, R. A., Das, J., Egawa, T., Hobbs, R. M., Pandolfi, P. P., Pereira, P., Nichols, K. E., Koretzky, G. A., Jordan, M. S., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0903218 · Cited by 157

Fine-Scale Staging of T Cell Lineage Commitment in Adult Mouse Thymus

Yui, M. A., Feng, N., & Rothenberg, E. V. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000679 · Cited by 152

γδ T Cells and Their Potential for Immunotherapy

Wu, Y., Ding, Y., Tanaka, Y., Shen, L.-W., Wei, C., Minato, N., & Zhang, W. (2014) · International Journal of Biological Sciences · doi:10.7150/ijbs.7823 · Cited by 166

Aryl Hydrocarbon Receptor Is Critical for Homeostasis of Invariant γδ T Cells in the Murine Epidermis

Kadow, S., Jux, B., Zahner, S. P., Wingerath, B., Chmill, S., Clausen, B. E., Hengstler, J. G., & Esser, C. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100912 · Cited by 150

Key factors in the organized chaos of early T cell development

Hayday, A., & Pennington, D. J. (2007) · Nature Immunology · doi:10.1038/ni1436 · Cited by 146

Thymic development beyond β-selection requires phosphatidylinositol 3-kinase activation by CXCR4

Janas, M. L., Varano, G., Gudmundsson, K. S., Noda, M., Nagasawa, T., & Turner, M. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20091430 · Cited by 140

The opposing roles of the transcription factor E2A and its antagonist Id3 that orchestrate and enforce the naive fate of T cells

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Akt1 and Akt2 are required for αβ thymocyte survival and differentiation

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E2A and HEB Are Required to Block Thymocyte Proliferation Prior to Pre-TCR Expression

Wojciechowski, J., Lai, A. Y., Kondo, M., & Zhuang, Y. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.9.5717 · Cited by 126

Acquisition of a Functional T Cell Receptor during T Lymphocyte Development Is Enforced by HEB and E2A Transcription Factors

Jones, M. E., & Zhuang, Y. (2007) · Immunity · doi:10.1016/j.immuni.2007.10.014 · Cited by 125

Prospects for chimeric antigen receptor (CAR) γδ T cells: A potential game changer for adoptive T cell cancer immunotherapy

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T cell receptor–instructed αβ versus γδ lineage commitment revealed by single-cell analysis

Kreslavsky, T., Garbe, A. I., Krueger, A., & von Boehmer, H. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072425 · Cited by 116

IL-7 coordinates proliferation, differentiation and Tcra recombination during thymocyte β-selection

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HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes

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Differential synergy of Notch and T cell receptor signaling determines αβ versus γδ lineage fate

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Notch/Delta signaling constrains reengineering of pro-T cells by PU.1

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Specific Notch receptor–ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength

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Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions

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An early decrease in Notch activation is required for human TCR-αβ lineage differentiation at the expense of TCR-γδ T cells

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T cell development requires constraint of the myeloid regulator C/EBP-α by the Notch target and transcriptional repressor Hes1

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NKAP Is a Transcriptional Repressor of Notch Signaling and Is Required for T Cell Development

Pajerowski, A. G., Nguyen, C. T. T., Aghajanian, H. K., Shapiro, M. J., & Shapiro, V. S. (2009) · Immunity · doi:10.1016/j.immuni.2009.02.011 · Cited by 101

Unequal Contribution of Akt Isoforms in the Double-Negative to Double-Positive Thymocyte Transition

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Molecular Dissection of Prethymic Progenitor Entry into the T Lymphocyte Developmental Pathway

Tydell, C. C., David-Fung, E.-S., Moore, J. E., Rowen, L., Taghon, T., & Rothenberg, E. V. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.1.421 · Cited by 99

Regulation of γδ T Cell Effector Diversification in the Thymus

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Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress

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A gene regulatory network armature for T lymphocyte specification

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Gamma Delta T Cells and Their Pathogenic Role in Psoriasis

Qi, C., Wang, Y., Li, P., & Zhao, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.627139 · Cited by 93

Distinct roles for Syk and ZAP-70 during early thymocyte development

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T-cell potential and development in vitro: the OP9-DL1 approach

de Pooter, R. F., & Zúñiga‐Pflücker, J. C. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.02.011 · Cited by 87

IL-7 Produced by Thymic Epithelial Cells Plays a Major Role in the Development of Thymocytes and TCRγδ+ Intraepithelial Lymphocytes

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Id3 Restricts the Developmental Potential of γδ Lineage during Thymopoiesis

Ueda‐Hayakawa, I., Mahlios, J., & Zhuang, Y. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804249 · Cited by 85

New insights into TCR β-selection

Dutta, A., Zhao, B., & Love, P. E. (2021) · Trends in Immunology · doi:10.1016/j.it.2021.06.005 · Cited by 83

Negotiation of the T Lineage Fate Decision by Transcription-Factor Interplay and Microenvironmental Signals

Rothenberg, E. V. (2007) · Immunity · doi:10.1016/j.immuni.2007.06.005 · Cited by 87

Notch signaling is required for proliferation but not for differentiation at a well-defined β-selection checkpoint during human T-cell development

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Runx proteins are involved in regulation of CD122, Ly49 family and IFN-γ expression during NK cell differentiation

Ohno, S., Sato, T., Kohu, K., Takeda, K., Okumura, K., Satake, M., & Habu, S. (2007) · International Immunology · doi:10.1093/intimm/dxm120 · Cited by 82

Notch dimerization is required for leukemogenesis and T-cell developmentPreprint

Liu, H., Chi, A. W. S., Arnett, K. L., Chiang, M. Y., Xu, L., Shestova, O. E., Wang, H., Li, Y., Bhandoola, A., Aster, J. C., et al. (2010) · Genes & Development · doi:10.1101/gad.1975210 · Cited by 82

T cell receptor signaling for γδT cell development

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Regulation of Notch signaling during T‐ and B‐cell development by O‐fucose glycans

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Cytokines, Transcription Factors, and the Initiation of T-Cell DevelopmentPreprint

Hosokawa, H., & Rothenberg, E. V. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028621 · Cited by 89

The Development of T Cells From Stem Cells in Mice and Humans

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The RNA-Binding Proteins Zfp36l1 and Zfp36l2 Enforce the Thymic β-Selection Checkpoint by Limiting DNA Damage Response Signaling and Cell Cycle Progression

Vogel, K., Bell, L. S., Galloway, A., Ahlfors, H., & Turner, M. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600854 · Cited by 75

Metabolic signaling directs the reciprocal lineage decisions of αβ and γδ T cells

Yang, K., Blanco, D. B., Chen, X. '., Dash, P., Neale, G. A. M., Rosencrance, C. D., Easton, J. B., Chen, W., Cheng, C., Dhungana, Y., et al. (2018) · Science Immunology · doi:10.1126/sciimmunol.aas9818 · Cited by 76

Dynamic Regulation of Notch 1 and Notch 2 Surface Expression during T Cell Development and Activation Revealed by Novel Monoclonal Antibodies

Fiorini, E., Merck, E., Wilson, A., Ferrero, I., Jiang, W., Koch, U., Auderset, F., Laurenti, E., Tacchini‐Cottier, F., Pierres, M., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0902432 · Cited by 74

Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development

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Distinct and temporary-restricted epigenetic mechanisms regulate human αβ and γδ T cell development

Roels, J., Kuchmiy, A. A., Decker, M. D., Strubbe, S., Lavaert, M., Liang, K. L., Leclercq, G., Vandekerckhove, B., Nieuwerburgh, F. V., Vlierberghe, P. V., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0747-9 · Cited by 77

T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymus

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Suppression of leukemia development caused by PTEN loss

Guo, W., Schubbert, S., Chen, J. Y., Valamehr, B. B., Mosessian, S., Shi, H., Dang, N. H., Garcia, C., Theodoro, M. F., Varella‐Garcia, M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006937108 · Cited by 73

αβ versus γδ fate choice: counting the T‐cell lineages at the branch point

Kreslavsky, T., Gleimer, M., Garbe, A. I., & von Boehmer, H. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00947.x · Cited by 77

Transcription factor expression dynamics of early T-lymphocyte specification and commitment

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Molecular mechanisms that control mouse and human TCR-αβ and TCR-γδ T cell development

Taghon, T., & Rothenberg, E. V. (2008) · Seminars in Immunopathology · doi:10.1007/s00281-008-0134-3 · Cited by 72

Chromatin remodeling complex NURF regulates thymocyte maturationPreprint

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Thymocyte Proliferation Induced by Pre-T Cell Receptor Signaling Is Maintained through Polycomb Gene Product Bmi-1-Mediated Cdkn2a Repression

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Chromatin Dynamics and the Development of the TCRα and TCRδ Repertoires

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GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate

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A Transcription Factor Map as Revealed by a Genome-Wide Gene Expression Analysis of Whole-Blood mRNA Transcriptome in Multiple Sclerosis

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The role of CD27 in anti-viral T-cell immunity

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