Cited by 480T-cell and B-cell ImmunologyTGF-β signaling in diseasesPsoriasis: Treatment and Pathogenesis

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Cellular Mechanisms of Fatal Early-Onset Autoimmunity in Mice with the T Cell-Specific Targeting of Transforming Growth Factor-β Receptor

Open access

Marie, Julien C., Liggitt, Denny, Rudensky, Alexander Y.·2006·Immunity

DOI 10.1016/j.immuni.2006.07.012

Open this paper in CoChat — free account Open PDF

Abstract

Transforming growth factor-beta (TGF-beta) has been implicated in the control of differentiation and proliferation of multiple cell types. However, a role for TGF-beta in the control of immune homeostasis is not fully understood because of its pleiotropic action. Here we report that complete ablation of the TGF-beta signaling in T cells engendered aggressive early-onset, multiorgan, autoimmune-associated lesions with 100% mortality. Peripheral CD4+ and CD8+ T cells with TGF-beta-receptor II (TGF-betaRII) deficiency activated cytolytic and T helper 1 (Th1) differentiation program in a cell-intrinsic T cell receptor (TCR)-specific fashion. Furthermore, TGF-betaRII deficiency blocked the development of canonical CD1d-restricted NKT cells. Instead, it facilitated generation of a highly pathogenic T cell subset exhibiting multiple hallmarks of NK cells and sharply elevated amounts of FasL, perforin, granzymes, and interferon-gamma. Thus, TGF-beta signaling in peripheral T cells is crucial in restraining TCR activation-dependent Th1, cytotoxic, and NK cell-like differentiation program which, when left unchecked, leads to rapidly progressing fatal autoimmunity.

Integrity signals

Registry

Crossref · 10.1016/j.immuni.2006.07.012

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Smad-dependent and Smad-independent pathways in TGF-β family signalling
Derynck, R., & Zhang, Y. E. (2003) · Nature · doi:10.1038/nature02006 · Cited by 5,498
Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3
Chen, W., Jin, W., Hardegen, N. J., Lei, K.-J., Li, L., Marinos, N. J., McGrady, G., & Wahl, S. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030152 · Cited by 4,678
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121
Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease
Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., et al. (1992) · Nature · doi:10.1038/359693a0 · Cited by 2,985
Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3
Fontenot, J. D., Rasmussen, J. P., Williams, L. M., Dooley, J., Farr, A. G., & Rudensky, A. Y. (2005) · Immunity · doi:10.1016/j.immuni.2005.01.016 · Cited by 2,302
Self-citation
Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.
Kulkarni, A. B., Huh, C. G., Becker, D., Geiser, A., Lyght, M., Flanders, K. C., Roberts, A. B., Sporn, M. B., Ward, J. M., & Karlsson, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.2.770 · Cited by 1,967
REGULATION OF IMMUNE RESPONSES BY TGF-β
Letterio, J. J., & Roberts, A. B. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.137 · Cited by 1,894
Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment
Wherry, E. J., Blattman, J. N., Murali‐Krishna, K., der Most, R. G. V., & Ahmed, R. (2003) · Journal of Virology · doi:10.1128/jvi.77.8.4911-4927.2003 · Cited by 1,645
TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance
Thomas, D. A., & Massagué, J. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.10.012 · Cited by 1,355
Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin
Intlekofer, A. M., Takemoto, N., Wherry, E. J., Longworth, S. A., Northrup, J. T., Palanivel, V., Mullen, A. C., Gasink, C. R., Kaech, S. M., Miller, J. D., et al. (2005) · Nature Immunology · doi:10.1038/ni1268 · Cited by 1,293
A Critical Role for Dnmt1 and DNA Methylation in T Cell Development, Function, and Survival
Lee, P. P., Fitzpatrick, D. R., Beard, C., Jessup, H. K., Lehar, S. M., Makar, K. W., Pérez‐Melgosa, M., Sweetser, M. T., Schlissel, M. S., Nguyen, S., et al. (2001) · Immunity · doi:10.1016/s1074-7613(01)00227-8 · Cited by 1,282
Requirement for V α 14 NKT Cells in IL-12-Mediated Rejection of Tumors
Cui, J., Shin, T., Kawano, T., Sato, H., Kondo, E., Toura, I., Kaneko, Y., Koseki, H., Kanno, M., & Taniguchi, M. (1997) · Science · doi:10.1126/science.278.5343.1623 · Cited by 1,237
Cutting Edge: TGF-β Induces a Regulatory Phenotype in CD4+CD25− T Cells through Foxp3 Induction and Down-Regulation of Smad7
Fantini, M. C., Becker, C., Monteleone, G., Pallone, F., Galle, P. R., & Neurath, M. F. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.9.5149 · Cited by 1,158
Control of Effector CD8 + T Cell Function by the Transcription Factor Eomesodermin
Pearce, E. L., Mullen, A. C., Martins, G. A., Krawczyk, C. M., Hutchins, A. S., Zediak, V. P., Banica, M., DiCioccio, C. B., Gross, D. A., Mao, C.-A., et al. (2003) · Science · doi:10.1126/science.1090148 · Cited by 1,014
TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells
Marie, J. C., Letterio, J. J., Gavin, M. A., & Rudensky, A. Y. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042276 · Cited by 986
Self-citation
Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease
Gorelik, L., & Flavell, R. A. (2000) · Immunity · doi:10.1016/s1074-7613(00)80170-3 · Cited by 959
Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signals in vivo
Chen, M.-L., Pittet, M. J., Gorelik, L., Flavell, R. A., Weissleder, R., von Boehmer, H., & Khazaie, K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408197102 · Cited by 806
CD1d1 Mutant Mice Are Deficient in Natural T Cells That PromptlyProduce IL-4
Mendiratta, S. K., Martin, W. D., Hong, S., Boesteanu, A. C., Joyce, S., & Kaer, L. V. (1997) · Immunity · doi:10.1016/s1074-7613(00)80290-3 · Cited by 595
Abnormal angiogenesis but intact hematopoietic potential in TGF‐β type I receptor‐deficient mice
Larsson, J., Goumans, M., Sjöstrand, L. J., van Rooijen, M. A., Ward, D., Levéen, P., Xu, X., ten Dijke, P., Mummery, C. L., & Karlsson, S. (2001) · The EMBO Journal · doi:10.1093/emboj/20.7.1663 · Cited by 563
Mechanism of Transforming Growth Factor β–induced Inhibition of T Helper Type 1 Differentiation
Gorelik, L., Constant, S. L., & Flavell, R. A. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20012076 · Cited by 544
T cells that cannot respond to TGF-β escape control by CD4+CD25+ regulatory T cells
Fahlén, L., Read, S., Gorelik, L., Hurst, S. D., Coffman, R. L., Flavell, R. A., & Powrie, F. M. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20040685 · Cited by 516
Maternal Rescue of Transforming Growth Factor-β 1 Null Mice
Letterio, J. J., Geiser, A. G., Kulkarni, A. B., Roche, N. S., Sporn, M. B., & Roberts, A. B. (1994) · Science · doi:10.1126/science.8009224 · Cited by 495
TGF-β regulates in vivo expansion of Foxp3-expressing CD4 + CD25 + regulatory T cells responsible for protection against diabetes
Peng, Y., Laouar, Y., Li, M. O., Green, E. A., & Flavell, R. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400810101 · Cited by 417
Induction of foxP3 + Regulatory T Cells in the Periphery of T Cell Receptor Transgenic Mice Tolerized to Transplants
Cobbold, S. P., Castejón, R., Adams, E., Zélénika, D., Graça, L., Humm, S., & Waldmann, H. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.10.6003 · Cited by 410
IL-21 in Synergy with IL-15 or IL-18 Enhances IFN-γ Production in Human NK and T Cells
Strengell, M., Matikainen, S., Sirén, J., Lehtonen, A., Foster, D., Julkunen, I., & Sareneva, T. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.11.5464 · Cited by 397
Regulation of NKT cell development by SAP, the protein defective in XLP
Nichols, K. E., Hom, J., Gong, S., Ganguly, A. A., Ma, C. S., Cannons, J. L., Tangye, S. G., Schwartzberg, P. L., Koretzky, G. A., & Stein, P. L. (2005) · Nature Medicine · doi:10.1038/nm1189 · Cited by 390
Ability of the hydrophobic FGF and basic TAT peptides to promote cellular uptake of recombinant Cre recombinase: A tool for efficient genetic engineering of mammalian genomes
Peitz, M., Pfannkuche, K., Rajewsky, K., & Edenhofer, F. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032068699 · Cited by 340
Inactivation of Notch1 in immature thymocytes does not perturb CD4 or CD8 T cell development
Wolfer, A., Bakker, T. R., Wilson, A., Nicolas, M., Ioannidis, V., Littman, D. R., Wilson, C. B., Held, W., MacDonald, H. R., & Radtke, F. (2001) · Nature Immunology · doi:10.1038/85294 · Cited by 300
T-bet is required for optimal proinflammatory CD4+ T-cell trafficking
Lord, G. M. (2005) · Blood · doi:10.1182/blood-2005-04-1393 · Cited by 270
Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable
Levéen, P., Larsson, J., Ehinger, M., Cilio, C., Sundler, M., Sjöstrand, L. J., Holmdahl, R., & Karlsson, S. (2002) · Blood · doi:10.1182/blood.v100.2.560 · Cited by 259
Disruption of T Cell Homeostasis in Mice Expressing a T Cell–Specific Dominant Negative Transforming Growth Factor β II Receptor
Lucas, P. J., Kim, S., Melby, S. J., & Gress, R. E. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.7.1187 · Cited by 244
Differential dependence of CD4 + CD25 + regulatory and natural killer-like T cells on signals leading to NF-κB activation
Schmidt‐Supprian, M., Tian, J. Y., Grant, E. P., Pasparakis, M., Maehr, R., Ovaa, H., Ploegh, H. L., Coyle, A. J., & Rajewsky, K. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400885101 · Cited by 232
Deficient Positive Selection of CD4 T Cells in Mice Displaying Altered Repertoires of MHC Class II–Bound Self-Peptides
Grubin, C. E., Kovats, S., DeRoos, P. C., & Rudensky, A. Y. (1997) · Immunity · doi:10.1016/s1074-7613(00)80523-3 · Cited by 207
Self-citation
Autoimmune manifestations in the transforming growth factor-beta 1 knockout mouse
Yaswen, L. R., Kulkarni, A. B., Fredrickson, T. N., Mittleman, B. B., Schiffman, R. M., Payne, S., Longenecker, G., Mozes, E., & Karlsson, S. (1996) · Blood · doi:10.1182/blood.v87.4.1439.bloodjournal8741439 · Cited by 204
Linking innate and acquired immunity: divergent role of CD46 cytoplasmic domains in T cell–induced inflammation
Marie, J. C., Astier, A., Rivailler, P., Rabourdin‐Combe, C., Wild, T., & Horvat, B. (2002) · Nature Immunology · doi:10.1038/ni810 · Cited by 177
Self-citation
TGF-β1 Uses Distinct Mechanisms to Inhibit IFN-γ Expression in CD4+ T Cells at Priming and at Recall: Differential Involvement of Stat4 and T-bet
Lin, J. T., Martin, S. L., Xia, L., & Gorham, J. D. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.10.5950 · Cited by 170
Targeted Disruption of Smad4 in Cardiomyocytes Results in Cardiac Hypertrophy and Heart Failure
Wang, J., Xu, N., Feng, X., Hou, N., Zhang, J., Cheng, X., Chen, Y., Zhang, Y., & Yang, X. Y. (2005) · Circulation Research · doi:10.1161/01.res.0000185833.42544.06 · Cited by 146
TGF‐β receptors
Massagué, J., Andres, J., Attisano, L., Cheifetz, S., López‐Casillas, F., Ohtsuki, M., & Wrana, J. L. (1992) · Molecular Reproduction and Development · doi:10.1002/mrd.1080320204 · Cited by 135
T-bet Binding to Newly Identified Target Gene Promoters Is Cell Type-independent but Results in Variable Context-dependent Functional Effects
Beima, K. M., Miazgowicz, M. M., Lewis, M. D., Yan, P. S., Huang, T. H. ‐., & Weinmann, A. S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513613200 · Cited by 135
Conditional Expression of Smad7 in Pancreatic β Cells Disrupts TGF-β Signaling and Induces Reversible Diabetes Mellitus
Smart, N. G., Apelqvist, Å., Gu, X., Harmon, E. B., Topper, J. N., MacDonald, R. J., & Kim, S. K. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040039 · Cited by 123
Acquisition of anergic and suppressive activities in transforming growth factor- -costimulated CD4+CD25- T cells
Park, H.-B. (2004) · International Immunology · doi:10.1093/intimm/dxh123 · Cited by 115
The C10/CCL6 Chemokine and CCR1 Play Critical Roles in the Pathogenesis of IL-13-Induced Inflammation and Remodeling
Ma, B., Zhu, Z., Homer, R., Gerard, C. J., Strieter, R. M., & Elias, J. A. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.3.1872 · Cited by 111
TGF-β type II receptor–deficient thymocytes develop normally but demonstrate increased CD8+ proliferation in vivo
Levéen, P., Carlsén, M., Makowska, A., Oddsson, S. J., Larsson, J., Goumans, M., Cilio, C., & Karlsson, S. (2005) · Blood · doi:10.1182/blood-2005-05-1871 · Cited by 40

Sorted by citations

Differentiation of Effector CD4 T Cell Populations
Zhu, J., Yamane, H., & Paul, W. E. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101212 · Cited by 3,452
Regulatory T cells: mechanisms of differentiation and function
Josefowicz, S. Z., Lu, L.-F., & Rudensky, A. Y. (2012) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141623 · Cited by 2,866
Self-citation
Cytokines in inflammatory bowel disease
Neurath, M. F. (2014) · Nature Reviews Immunology · doi:10.1038/nri3661 · Cited by 2,706
Transforming Growth Factor-β Signaling in Immunity and Cancer
Batlle, E., & Massagué, J. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.024 · Cited by 2,366
TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis
Tauriello, D. V. F., Palomo-Ponce, S., Stork, D., Berenguer-Llergo, A., Badia-Ramentol, J., Iglesias, M., Sevillano, M., Ibiza, S., Cañellas, A., Hernando-Momblona, X., et al. (2018) · Nature · doi:10.1038/nature25492 · Cited by 1,851

See all 480

Authors: Marie, J. C., Liggitt, D., & Rudensky, A. Y.
Affiliations: Howard Hughes Medical Institute (US)
University of Washington (US)
Corresponding author: Marie, Julien C.
Rudensky, Alexander Y.
ORCID: Marie, Julien C.
Liggitt, Denny
Rudensky, Alexander Y.
Venue: Immunity
Publisher: Elsevier BV
Published: 2006-09
Volume: 25
Issue: 3
Pages: 441-454
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2006.07.012
OpenAlex: W2055061339
Cited by: 480
References: 43
Citations by year: 2026: 7 · 2025: 12 · 2024: 17 · 2023: 23 · 2022: 22 · 2021: 25 · 2020: 14 · 2019: 17 · 2018: 25 · 2017: 24 · 2016: 25 · 2015: 20 · 2014: 23 · 2013: 27 · 2012: 32
FWCI: 13.28
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2511 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords: TGF-beta signaling, TGFBR2, autoimmunity, Th1 differentiation, cytotoxic T lymphocytes, NKT cells, immune homeostasis, T cell receptor stimulation, CD4+ T cells, CD8+ T cells, perforin, granzymes, interferon-gamma, Fas ligand
MeSH terms: Animals, Antigens, Surface, Autoimmune Diseases, Cells, Cultured, Immune Tolerance, Lymphocyte Depletion, Mice, Inbred C57BL, Mice, Transgenic, T-Lymphocytes, Time Factors, Receptors, Transforming Growth Factor beta, Mice, Knockout, Lectins, C-Type, Mice, NK Cell Lectin-Like Receptor Subfamily B

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cellular Mechanisms of Fatal Early-Onset Autoimmunity in Mice with the T Cell-Specific Targeting of Transforming Growth Factor-β Receptor

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks