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Cellular Mechanisms of Fatal Early-Onset Autoimmunity in Mice with the T Cell-Specific Targeting of Transforming Growth Factor-β Receptor
Open accessAbstract
Transforming growth factor-beta (TGF-beta) has been implicated in the control of differentiation and proliferation of multiple cell types. However, a role for TGF-beta in the control of immune homeostasis is not fully understood because of its pleiotropic action. Here we report that complete ablation of the TGF-beta signaling in T cells engendered aggressive early-onset, multiorgan, autoimmune-associated lesions with 100% mortality. Peripheral CD4+ and CD8+ T cells with TGF-beta-receptor II (TGF-betaRII) deficiency activated cytolytic and T helper 1 (Th1) differentiation program in a cell-intrinsic T cell receptor (TCR)-specific fashion. Furthermore, TGF-betaRII deficiency blocked the development of canonical CD1d-restricted NKT cells. Instead, it facilitated generation of a highly pathogenic T cell subset exhibiting multiple hallmarks of NK cells and sharply elevated amounts of FasL, perforin, granzymes, and interferon-gamma. Thus, TGF-beta signaling in peripheral T cells is crucial in restraining TCR activation-dependent Th1, cytotoxic, and NK cell-like differentiation program which, when left unchecked, leads to rapidly progressing fatal autoimmunity.
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“and contribute to macrophage and neutrophil polarization towards a regenerative rather than inflammatory cell state58,63,82,145,172,173,218,219.”
From TGFβ biology in cancer progression and immunotherapy (2021) · cites this paper as [219]
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“These then functionally repress, through various activities, including TGF-β1 activation82,145, the tumor-killing activity of CD8+ T cells 58,63,82,145,218,219”
From TGFβ biology in cancer progression and immunotherapy (2021) · cites this paper as [219]
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Metadata
- Authors
- Marie, J. C., Liggitt, D., & Rudensky, A. Y.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of Washington (US)
- Corresponding author
- Marie, Julien C.
- Rudensky, Alexander Y.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2006-09
- Volume
- 25
- Issue
- 3
- Pages
- 441-454
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2055061339
- Cited by
- 480
- References
- 43
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 17 · 2023: 23 · 2022: 22 · 2021: 25 · 2020: 14 · 2019: 17 · 2018: 25 · 2017: 24 · 2016: 25 · 2015: 20 · 2014: 23 · 2013: 27 · 2012: 32
- FWCI
- 13.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- TGF-beta signaling, TGFBR2, autoimmunity, Th1 differentiation, cytotoxic T lymphocytes, NKT cells, immune homeostasis, T cell receptor stimulation, CD4+ T cells, CD8+ T cells, perforin, granzymes, interferon-gamma, Fas ligand
- MeSH terms
- Animals, Antigens, Surface, Autoimmune Diseases, Cells, Cultured, Immune Tolerance, Lymphocyte Depletion, Mice, Inbred C57BL, Mice, Transgenic, T-Lymphocytes, Time Factors, Receptors, Transforming Growth Factor beta, Mice, Knockout, Lectins, C-Type, Mice, NK Cell Lectin-Like Receptor Subfamily B
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