Cited by 1,861T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesPsoriasis: Treatment and Pathogenesis

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-bet Transcription Factor

Open access

Joshi, Nikhil S., Cui, Weiguo, Chandele, Anmol, Lee, Heung Kyu, Urso, David R., Hagman, James, Gapin, Laurent, Kaech, Susan M.·2007·Immunity

DOI 10.1016/j.immuni.2007.07.010PMC PMC2034442

Open this paper in CoChat — free account Open PDF

Abstract

As acute infections resolve, effector CD8(+) T cells differentiate into interleukin-7 receptor(lo) (IL-7R(lo)) short-lived effector cells (SLECs) and IL-7R(hi) memory precursor effector cells (MPECs) capable of generating long-lived memory CD8(+) T cells. By using another SLEC marker, KLRG1, we found that KLRG1(hi) effector cells began appearing early during infection and were committed to downregulating IL-7R. Unlike IL-7R(hi) MPECs, KLRG1(hi) IL-7R(lo) SLECs relied on IL-15, but IL-15 could not sustain their long-term maintenance or homeostatic turnover. The decision between SLEC and MPEC fates was regulated by the amount of inflammatory cytokines (i.e., IL-12) present during T cell priming. According to the amount of inflammation, a gradient of T-bet was created in which high T-bet expression induced SLECs and low expression promoted MPECs. These results elucidate a mechanism by which the innate immune system sets the relative amounts of a lineage-determining transcription factor in activated CD8(+) T cells and, correspondingly, regulates their memory cell potential.

Integrity signals

Registry

Crossref · 10.1016/j.immuni.2007.07.010

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846 · cited 2×
“…on the attribute examined, differ according to their localization, effector functions or potential to become protective memory CD8 T cells (de Bree et al., 2005; Huster et al., 2004; Kaech et al., 2003; Sallusto et al., 1999; Schluns et al., 2000; Voehringer et al., 2001; Wherry et al., 2003).”
Background
A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment
Szabo, S. J., Kim, S. T., Costa, G. L., Zhang, X., Fathman, C. G., & Glimcher, L. H. (2000) · Cell · doi:10.1016/s0092-8674(00)80702-3 · Cited by 3,589
CpG Motifs in Bacterial DNA and Their Immune Effects
Krieg, A. Μ. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064842 · Cited by 2,598
Lineage relationship and protective immunity of memory CD8 T cell subsets
Wherry, E. J., Teichgräber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni889 · Cited by 1,864
Self-citation
Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
Kaech, S. M., Tan, J. T., Wherry, E. J., Konieczny, B. T., Surh, C. D., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni1009 · Cited by 1,830 · cited 12×
“…on the attribute examined, differ according to their localization, effector functions or potential to become protective memory CD8 T cells (de Bree et al., 2005; Huster et al., 2004; Kaech et al., 2003; Sallusto et al., 1999; Schluns et al., 2000; Voehringer et al., 2001; Wherry et al., 2003).”
BackgroundMethodResultInfluentialSelf-citation
Immunological memory and protective immunity: understanding their relation
Ahmed, R., & Gray, D. (1996) · Science · doi:10.1126/science.272.5258.54 · Cited by 1,775 · cited 2×
“The “decreasing potential model” for the development of memory CD8 T cells suggests that “memory T cells can only arise under conditions in which the antigenic load is limited and the stimulation of precursors ceases before a point of no return” (Ahmed and Gray, 1996).”
Background
Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo
Schluns, K. S., Kieper, W. C., Jameson, S. C., & Lefrançois, L. (2000) · Nature Immunology · doi:10.1038/80868 · Cited by 1,619
Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties
Weaver, C. T., Harrington, L. E., Mangan, P. R., Gavrieli, M., & Murphy, K. M. (2006) · Immunity · doi:10.1016/j.immuni.2006.06.002 · Cited by 1,422
Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin
Intlekofer, A. M., Takemoto, N., Wherry, E. J., Longworth, S. A., Northrup, J. T., Palanivel, V., Mullen, A. C., Gasink, C. R., Kaech, S. M., Miller, J. D., et al. (2005) · Nature Immunology · doi:10.1038/ni1268 · Cited by 1,293
Self-citation
Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells
Langenkamp, A., Messi, M., Lanzavecchia, A., & Sallusto, F. (2000) · Nature Immunology · doi:10.1038/79758 · Cited by 1,140

Flagged first, then by citations

Show all 50 references

Sorted by citations

Items 701–800 of 1,005

Fatty acid metabolism in T-cell function and differentiation
Endo, Y., Kanno, T., & Nakajima, T. (2022) · International Immunology · doi:10.1093/intimm/dxac025 · Cited by 52
Insights into phenotypic and functional CD8 + TRM heterogeneity
Heeg, M., & Goldrath, A. W. (2023) · Immunological Reviews · doi:10.1111/imr.13218 · Cited by 45
MicroRNAs and Their Targets Are Differentially Regulated in Adult and Neonatal Mouse CD8+ T Cells
Wissink, E. M., Smith, N. L., Spektor, R., Rudd, B. D., & Grimson, A. (2015) · Genetics · doi:10.1534/genetics.115.179176 · Cited by 45
Sugar or Fat?—Metabolic Requirements for Immunity to Viral Infections
Shehata, H. M., Murphy, A. J., Lee, M. K. S., Gardiner, C. M., Crowe, S. M., Sanjabi, S., Finlay, D. K., & Palmer, C. S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01311 · Cited by 47
THE IMPACT OF TCR SIGNAL STRENGTH ON RESIDENT MEMORY T CELL FORMATION DURING INFLUENZA VIRUS INFECTION
Fiege, J. K., Stone, I. A., Fay, E. J., Markman, M., Wijeyesinghe, S. P., Macchietto, M., Shen, S. S., Masopust, D., & Langlois, R. (2019) · Journal of Immunology · doi:10.4049/jimmunol.1900093 · Cited by 43
Characterization of CD8+ T Cell Differentiation following SIVΔnef Vaccination by Transcription Factor Expression Profiling
Billingsley, J. M., Rajakumar, P. A., Connole, M., Salisch, N. C., Adnan, S., Kuzmichev, Y. V., Hong, H. S., Reeves, R. K., Kang, H., Li, W., et al. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004740 · Cited by 47
Early Decision: Effector and Effector Memory T Cell Differentiation in Chronic Infection
Opata, M. M., & Stephens, R. (2014) · Current Immunology Reviews · doi:10.2174/1573395509666131126231209 · Cited by 46
Generation of highly proliferative, rejuvenated cytotoxic T cell clones through pluripotency reprogramming for adoptive immunotherapy
Kawai, Y., Kawana‐Tachikawa, A., Kitayama, S., Ueda, T., Miki, S., Watanabe, A., & Kaneko, S. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.05.016 · Cited by 43
Enhancing T Cell Chemotaxis and Infiltration in Glioblastoma
Singh, K., Hotchkiss, K. M., Patel, K. K., Wilkinson, D. S., Mohan, A. A., Cook, S. L., & Sampson, J. H. (2021) · Cancers · doi:10.3390/cancers13215367 · Cited by 50
DNA Methylation and Immune Memory Response
Mittelstaedt, N. N., Becker, A. L., de Freitas, D. N., Zanin, R. F., Stein, R. T., & de Souza, A. P. D. (2021) · Cells · doi:10.3390/cells10112943 · Cited by 45
Immunoregulatory functions of KLRG1 cadherin interactions are dependent on forward and reverse signaling
Banh, C., Fugère, C., & Brossay, L. (2009) · Blood · doi:10.1182/blood-2009-06-228353 · Cited by 43
Primary Cytomegalovirus Phosphoprotein 65–Specific CD8+ T-Cell Responses and T-bet Levels Predict Immune Control During Early Chronic Infection in Lung Transplant Recipients
Pipeling, M. R., John, E. R., Orens, J. B., Lechtzin, N., & McDyer, J. F. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir624 · Cited by 43
Pathogenic virus-specific T cells cause disease during treatment with the calcineurin inhibitor FK506: implications for transplantation
Araki, K., Gangappa, S., Dillehay, D. L., Rouse, B. T., Larsen, C. P., & Ahmed, R. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100124 · Cited by 43
B7-H1 antibodies lose antitumor activity due to activation of p38 MAPK that leads to apoptosis of tumor-reactive CD8+ T cells
Liu, X., Wu, X., Cao, S., Harrington, S. M., Yin, P., Mansfield, A. S., & Dong, H. (2016) · Scientific Reports · doi:10.1038/srep36722 · Cited by 43
Eomes expression reports the progressive differentiation of IFN‐γ‐producing Th1‐like γδ T cells
Lino, C. N. R., Barros‐Martins, J., Oberdörfer, L., Walzer, T., & Prinz, I. (2017) · European Journal of Immunology · doi:10.1002/eji.201646753 · Cited by 43
Thioesterase PPT1 balances viral resistance and efficient T cell crosspriming in dendritic cells
Ou, P., Wen, L., Liu, X., Huang, J., Huang, X., Su, C., Wang, L., Ni, H., Reizis, B., & Yang, C. Y. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20190041 · Cited by 42
Monocyte-Derived Dendritic Cells Dictate the Memory Differentiation of CD8+ T Cells During Acute Infection
Shin, K.-S., Jeon, I., Kim, B. S., Kim, I., Park, Y.-J., Koh, C., Song, B., Lee, J., Lim, J., Bae, E., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01887 · Cited by 43
SLAMF6 deficiency augments tumor killing and skews toward an effector phenotype revealing it as a novel T cell checkpoint
Hajaj, E., Eisenberg, G., Klein, S., Frankenburg, S., Merims, S., David, I. B., Eisenhaure, T., Henrickson, S. E., Villani, A., Hacohen, N., et al. (2020) · eLife · doi:10.7554/elife.52539 · Cited by 43
Peripheral Blood–Derived Virus-Specific Memory Stem T Cells Mature to Functional Effector Memory Subsets with Self-Renewal Potency
Schmueck‐Henneresse, M., Sharaf, R., Vogt, K., Weist, B. J. D., Landwehr-Kenzel, S., Fuehrer, H., Jurisch, A., Babel, N., Rooney, C. M., Reinke, P., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402090 · Cited by 44
Functional CD8 T Cell Memory Responding to Persistent Latent Infection Is Maintained for Life
Lang, A. M., & Nikolich‐Žugich, J. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100666 · Cited by 44
T cell exhaustion in human cancers
Kang, K., Lin, X., Chen, P., Liu, H., Liu, F., Xiong, W., Li, G., Yi, M., Li, X., Wang, H., et al. (2024) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189162 · Cited by 49
Regulation of Asymmetric Division and CD8+ T Lymphocyte Fate Specification by Protein Kinase Cζ and Protein Kinase Cλ/ι
Metz, P. J., Arsenio, J., Kakaradov, B., Kim, S. H., Remedios, K. A., Oakley, K., Akimoto, K., Ohno, S., Yeo, G. W.-M., & Chang, J. T. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1401652 · Cited by 42
Cutting Edge: Rapid Boosting of Cross-Reactive Memory CD8 T Cells Broadens the Protective Capacity of the Flumist Vaccine
Slütter, B., Pewe, L. L., Lauer, P., & Harty, J. T. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202790 · Cited by 42
Use it or lose it: establishment and persistence of T cell memory
Kedzierska, K., Valkenburg, S. A., Doherty, P. C., Davenport, M. P., & Venturi, V. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00357 · Cited by 41
Activated iNKT Cells Promote Memory CD8+ T Cell Differentiation during Viral Infection
Reilly, E. C., Thompson, E. A., Aspeslagh, S., Wands, J. R., Elewaut, D. S., & Brossay, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037991 · Cited by 42
miR-150-Mediated Foxo1 Regulation Programs CD8+ T Cell Differentiation
Ban, Y. H., Oh, S., Seo, S. H., Kim, S., Choi, I.-P., Greenberg, P. D., Chang, J., Kim, T., & Ha, S. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.065 · Cited by 42
A metabolic switch to memory CAR T cells: Implications for cancer treatment
Rostamian, H., Fallah-Mehrjardi, K., Khakpoor-Koosheh, M., Pawelek, J. M., Hadjati, J., Brown, C. E., & Mirzaei, H. R. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.12.004 · Cited by 44
Single-Cell Transcriptomics Reveals Core Regulatory Programs That Determine the Heterogeneity of Circulating and Tissue-Resident Memory CD8+ T Cells
Chen, Y., Shen, J., Kasmani, M. Y., Topchyan, P., & Cui, W. (2021) · Cells · doi:10.3390/cells10082143 · Cited by 40
Self-citation
Differential expression of CD26 on virus‐specific CD8+ T cells during active, latent and resolved infection
Ibegbu, C., Xu, Y., Fillos, D., Radziewicz, H., Grakoui, A., & Kourtis, A. P. (2008) · Immunology · doi:10.1111/j.1365-2567.2008.02899.x · Cited by 42
E2A-regulated epigenetic landscape promotes memory CD8 T cell differentiation
Schauder, D. M., Shen, J., Chen, Y., Kasmani, M. Y., Kudek, M. R., Burns, R., & Cui, W. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2013452118 · Cited by 40
Self-citation
T‐cell memory in tissues
van Gisbergen, K. P. J. M., Zens, K. D., & Münz, C. (2021) · European Journal of Immunology · doi:10.1002/eji.202049062 · Cited by 39
Expression of KLRG1 and CD127 defines distinct CD8+ subsets that differentially impact patient outcome in follicular lymphoma
Wu, H., Tang, X., Kim, H. J., Jalali, S., Pritchett, J. C., Villasboas, J. C., Novak, A. J., Yang, Z.-Z., & Ansell, S. M. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-002662 · Cited by 41
Role of PARP Inhibitors in Cancer Immunotherapy: Potential Friends to Immune Activating Molecules and Foes to Immune Checkpoints
Franzese, O., & Graziani, G. (2022) · Cancers · doi:10.3390/cancers14225633 · Cited by 44
Divergent metabolic programmes control two populations of MAIT cells that protect the lung
Riffelmacher, T., Murray, M. P., Wientjens, C., Chandra, S., Castelan, V. O. C., Chou, T.-F., McArdle, S., Dillingham, C. H., Devereaux, J., Nilsen, A., et al. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01152-6 · Cited by 42
Control of nutrient uptake by IRF4 orchestrates innate immune memory
Santosa, E. K., Kim, H., Rückert, T., Luduec, J.-B. L., Abbasi, A. J., Wingert, C. K., Peters, L., Frost, J. N., Hsu, K. C., Romagnani, C., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01620-z · Cited by 40
CD8+ T-cell differentiation and dysfunction inform treatment response in acute myeloid leukemia
Mazziotta, F., Biavati, L., Rimando, J. C., Rutella, S., Borcherding, N. C., Parbhoo, S., Mukhopadhyay, R., Chowdhury, S., Knaus, H. A., Valent, P., et al. (2024) · Blood · doi:10.1182/blood.2023021680 · Cited by 41
The role of KLRG1: a novel biomarker and new therapeutic target
Zhang, Y., Chen, S., Tang, X., Yu, P., Jiang, T., Zhang, X., Li, J., Liu, Y., & Yang, Z. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01714-7 · Cited by 41
IFN-γ Regulates CD8+ Memory T Cell Differentiation and Survival in Response to Weak, but Not Strong, TCR Signals
Stoycheva, D., Deiser, K., Stärck, L., Nishanth, G., Schlüter, D., Uckert, W., & Schüler, T. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1402058 · Cited by 40
Histone Methyltransferase and Histone Methylation in Inflammatory T-Cell Responses
He, S., Tong, Q., Bishop, D. K., & Zhang, Y. (2013) · Immunotherapy · doi:10.2217/imt.13.101 · Cited by 41
Mogamulizumab, an Anti-CCR4 Antibody, Targets Human T-Lymphotropic Virus Type 1–infected CD8+and CD4+T Cells to Treat Associated Myelopathy
Yamauchi, J., Coler-Reilly, A. L. G., Sato, T., Araya, N., Yagishita, N., Ando, H., Kunitomo, Y., Takahashi, K., Tanaka, Y., Shibagaki, Y., et al. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu438 · Cited by 41
Critical Role for All-trans Retinoic Acid for Optimal Effector and Effector Memory CD8 T Cell Differentiation
Allie, S. R., Zhang, W., Tsai, C.-Y., Noelle, R. J., & Usherwood, E. J. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1201945 · Cited by 40
Double-negative T resident memory cells of the lung react to influenza virus infection via CD11chi dendritic cells
Neyt, K., GeurtsvanKessel, C. H., & Lambrecht, B. N. (2015) · Mucosal Immunology · doi:10.1038/mi.2015.91 · Cited by 41
TCR stimulation strength is inversely associated with establishment of functional brain-resident memory CD8 T cells during persistent viral infection
Maru, S. Y., Jin, G., Schell, T. D., & Lukacher, A. E. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006318 · Cited by 43
T Cells Primed by Live Mycobacteria Versus a Tuberculosis Subunit Vaccine Exhibit Distinct Functional Properties
Lindenstrøm, T., Moguche, A. O., Damborg, M., Agger, E. M., Urdahl, K. B., & Andersen, P. L. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.12.004 · Cited by 39
RUNX3 and T-Bet in Immunopathogenesis of Ankylosing Spondylitis—Novel Targets for Therapy?
Vecellio, M. L., Cohen, C., Roberts, A. R., Wordsworth, P. B., & Kenna, T. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03132 · Cited by 41
Barriers to Immunotherapy in Ovarian Cancer: Metabolic, Genomic, and Immune Perturbations in the Tumour Microenvironment
Johnson, R. L., Cummings, M., Thangavelu, A., Theophilou, G., Jong, D. D., & Orsi, N. M. (2021) · Cancers · doi:10.3390/cancers13246231 · Cited by 39
Epigenetics and CD8+ T cell memory*
Montacchiesi, G., & Pace, L. (2021) · Immunological Reviews · doi:10.1111/imr.13057 · Cited by 43
Nature and nurture: T‐cell receptor‐dependent and T‐cell receptor‐independent differentiation cues in the selection of the memory T‐cell pool
Kim, C., & Williams, M. A. (2010) · Immunology · doi:10.1111/j.1365-2567.2010.03338.x · Cited by 41
The contribution of epigenetic memory to immunologic memory
Zediak, V. P., Wherry, E. J., & Berger, S. L. (2011) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2011.01.016 · Cited by 41
mRNA Structural Constraints on EBNA1 Synthesis Impact on In Vivo Antigen Presentation and Early Priming of CD8+ T Cells
Tellam, J., Zhong, J., Lekieffre, L., Bhat, P., Irizarry, M. M. M., Croft, N. P., Kaplan, W. H., Tellam, R. L., & Khanna, R. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004423 · Cited by 41
Origin of CD8+ effector and memory T cell subsets.
Stemberger, C., Neuenhahn, M., Buchholz, V. R., & Busch, D. H. (2007) · PubMed · Cited by 41
Lentiviral vector induces high-quality memory T cells via dendritic cells transduction
Ku, M., Authié, P., Névo, F., Souque, P., Bourgine, M., Romano, M., Charneau, P., & Majlessi, L. (2021) · Communications Biology · doi:10.1038/s42003-021-02251-6 · Cited by 38
The CD8 T-cell Road to Immunotherapy of Toxoplasmosis
Bhadra, R., Gigley, J. P., & Khan, I. A. (2011) · Immunotherapy · doi:10.2217/imt.11.68 · Cited by 39
Protecting and rescuing the effectors: roles of differentiation and survival in the control of memory T cell development
Kurtuluş, S., Tripathi, P., & Hildeman, D. A. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00404 · Cited by 40
Persistence in Temporary Lung Niches: A Survival Strategy of Lung-Resident Memory CD8 + T Cells
Takamura, S. (2017) · Viral Immunology · doi:10.1089/vim.2017.0016 · Cited by 38
Developmental Regulation of Effector and Resident Memory T Cell Generation during Pediatric Viral Respiratory Tract Infection
Connors, T. J., Baird, J. S., Yopes, M. C., Zens, K. D., Pethe, K., Ravindranath, T. M., Ho, S., & Färber, D. L. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800396 · Cited by 39
The Transcription Factor Runx2 Is Required for Long-Term Persistence of Antiviral CD8+ Memory T Cells
Olesin, E., Nayar, R., Lakshmi, P. S., & Berg, L. J. (2018) · ImmunoHorizons · doi:10.4049/immunohorizons.1800046 · Cited by 40
Diverse Roles of Akt in T cells
Abdullah, L., Hills, L. B., Winter, E. B., & Huang, Y. H. (2021) · Immunometabolism · doi:10.20900/immunometab20210007 · Cited by 42
Lipid-nanoparticle-encapsulated mRNA vaccines induce protective memory CD8 T cells against a lethal viral infection
Knudson, C. J., Alves-Peixoto, P., Muramatsu, H., Stotesbury, C., Tang, L., Lin, P. J. C., Tam, Y. K., Weissman, D., Pardi, N., & Sigal, L. J. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.05.011 · Cited by 39
CD49a Identifies Polyfunctional Memory CD8 T Cell Subsets that Persist in the Lungs After Influenza Infection
Reilly, E. C., Sportiello, M., Emo, K. L., Amitrano, A. M., Jha, R., Kumar, A. B. R., Laniewski, N. G., Yang, H., Kim, M., & Topham, D. J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.728669 · Cited by 39
Tumor-Reactive CD8+ Early Effector T Cells Identified at Tumor Site in Primary and Metastatic Melanoma
Anichini, A., Molla, A., Vegetti, C., Bersani, I., Zappasodi, R., Arienti, F., Ravagnani, F., Maurichi, A., Patuzzo, R., Santinami, M., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-2028 · Cited by 40
Microbiota-derived butyrate promotes a FOXO1-induced stemness program and preserves CD8+ T cell immunity against melanoma
Bachem, A., Clarke, M. V., Kong, G., Tarasova, I., Dryburgh, L., Kosack, L., Lee, A. R., Newland, L. G. M., Wagner, T., Bawden, E., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.10.004 · Cited by 46
NKT cell-targeted vaccination plus anti-4–1BB antibody generates persistent CD8 T cell immunity against B cell lymphoma
Kobayashi, T., Doff, B. L., Rearden, R. C., Leggatt, G. R., & Mattarollo, S. R. (2015) · OncoImmunology · doi:10.4161/2162402x.2014.990793 · Cited by 39
Modulation of the CD4+ T cell response after acellular pertussis vaccination in the presence of TLR4 ligation
Brummelman, J., Helm, K., Hamstra, H.-J., van der Ley, P., Boog, C. J. P., Han, W. G. H., & van Els, C. A. C. M. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.01.063 · Cited by 39
Exploiting differential expression of the IL-7 receptor on memory T cells to modulate immune responses
Zaunders, J., Lévy, Y., & Seddiki, N. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.07.012 · Cited by 39
An emerging role for Serine Protease Inhibitors in T lymphocyte immunity and beyond
Ashton‐Rickardt, P. G. (2013) · Immunology Letters · doi:10.1016/j.imlet.2013.04.004 · Cited by 40
NKG2D Induces Mcl-1 Expression and Mediates Survival of CD8 Memory T Cell Precursors via Phosphatidylinositol 3-Kinase
Wensveen, F. M., Lenartić, M., Jelenčić, V., Lemmermann, N. A. W., ten Brinke, A., Jonjić, S., & Polić, B. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300670 · Cited by 39
Enhancing adoptive T cell immunotherapy with microRNA therapeutics
Ji, Y., Hocker, J. D., & Gattinoni, L. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.11.006 · Cited by 40
Short-Lived Antigen Recognition but Not Viral Infection at a Defined Checkpoint Programs Effector CD4 T Cells To Become Protective Memory
Bautista, B., Devarajan, P., McKinstry, K. K., Strutt, T. M., Vong, A. M., Jones, M. C., Kuang, Y., Mott, D., & Swain, S. L. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600838 · Cited by 39
Long-lived tissue resident HIV-1 specific memory CD8+ T cells are generated by skin immunization with live virus vectored microneedle arrays
Zaric, M., Becker, P. D., Hervouet, C., Kalcheva, P., Yus, B. I., Cocita, C., O'Neill, L. A., Kwon, S., & Klavinskis, L. S. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.10.026 · Cited by 39
Effector CD4 T cells with progenitor potential mediate chronic intestinal inflammation
Shin, B., Kress, R. L., Kramer, P. A., Darley-Usmar, V. M., Bellis, S. L., & Harrington, L. E. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20172335 · Cited by 39
Peripheral tissue chemokines: homeostatic control of immune surveillance T cells.
McCully, M. L., Kouzeli, A., & Moser, B. (2018) · Trends in Immunology · doi:10.1016/j.it.2018.06.003 · Cited by 37
B cell adaptor for PI3-kinase (BCAP) modulates CD8+ effector and memory T cell differentiation
Singh, M. D., Ni, M., Sullivan, J. M., Hamerman, J. A., & Campbell, D. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20171820 · Cited by 38
pH-responsive Astragalus polysaccharides-loaded poly(lactic-co-glycolic acid) nanoparticles and their in vitro immunogenicity
Xu, S., Wusiman, A., Liu, Z., Gu, P., Ni, H., Zhang, Y., Hu, Y., Liu, J., Wu, Y., & Wang, D. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.12.156 · Cited by 40
IL-6 Receptor α Defines Effector Memory CD8+ T Cells Producing Th2 Cytokines and Expanding in Asthma
Lee, N., You, S., Shin, M. S., Lee, W., Kang, K. S., Kim, S., Kim, W., Homer, R., Kang, M., Montgomery, R. R., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201403-0601oc · Cited by 38
Regulation of CD8 T cell by B-cells: A narrative review
Meerhaeghe, T. V., Néel, A., Brouard, S., & Degauque, N. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1125605 · Cited by 42
The Survival of Memory CD8 T Cells That Is Mediated by IL-15 Correlates with Sustained Protection Against Malaria
Zarling, S., Berenzon, D. P., Dalai, S. K., Liepinsh, D. J., Steers, N., & Krzych, U. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203396 · Cited by 38
Every Breath You Take: The Impact of Environment on Resident Memory CD8 T Cells in the Lung
Shane, H. L., & Klonowski, K. D. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00320 · Cited by 38
Regulation of effector and memory CD8+ T cell function by inflammatory cytokines
Valbon, S. F., Condotta, S. A., & Richer, M. J. (2015) · Cytokine · doi:10.1016/j.cyto.2015.11.013 · Cited by 36
T-bet Is Required for the Rapid Clearance of Attenuated Rabies Virus from Central Nervous System Tissue
Lebrun, A., Portocarrero, C. P., Kean, R. B., Barkhouse, D. A., Faber, M., & Hooper, D. C. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1501274 · Cited by 38
Identification of Nascent Memory CD8 T Cells and Modeling of Their Ontogeny.
Crauste, F., Mafille, J., Boucinha, L., Djebali, S., Gandrillon, O., Marvel, J., & Arpin, C. (2017) · Cell Systems · doi:10.1016/j.cels.2017.01.014 · Cited by 42
Multidomain Control Over TEC Kinase Activation State Tunes the T Cell Response
Andreotti, A. H., Joseph, R. E., Conley, J. M., Iwasa, J., & Berg, L. J. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053344 · Cited by 38
Cutting Edge: Transcription Factor BCL6 Is Required for the Generation, but Not Maintenance, of Memory CD8+ T Cells in Acute Viral Infection
Liu, Z., Guo, Y., Tang, S., Zhou, L., Huang, C., Cao, Y., Huang, H., Wu, X., Meng, D., Ye, L., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900014 · Cited by 37
Bromodomain protein BRD4 directs and sustains CD8 T cell differentiation during infection
Milner, J. J., Toma, C., Quon, S., Omilusik, K. D., Scharping, N. E., Dey, A., Reina‐Campos, M., Nguyen, H., Getzler, A. J., Diao, H., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20202512 · Cited by 38
Differences in the Transduction of Canonical Wnt Signals Demarcate Effector and Memory CD8 T Cells with Distinct Recall Proliferation Capacity
Boudousquié, C., Danilo, M., Pousse, L., Jeevan-Raj, B. P., Angelov, G. S., Chennupati, V., Zehn, D., & Held, W. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400465 · Cited by 38
IL‐2 and IL‐15 regulate CD8+ memory T‐cell differentiation but are dispensable for protective recall responses
Mathieu, C., Beltra, J., Charpentier, T., Bourbonnais, S., Santo, J. P. D., Lamarre, A., & Decaluwe, H. (2015) · European Journal of Immunology · doi:10.1002/eji.201546000 · Cited by 38
Antigen-Specific Naive CD8+ T Cells Produce a Single Pulse of IFN-γ In Vivo within Hours of Infection, but without Antiviral Effect
Hosking, M., Flynn, C. T., & Whitton, J. L. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400348 · Cited by 38
Differential Sensitivity to IL-12 Drives Sex-Specific Differences in the CD8+ T Cell Response to Infection
Mon, K. J. Y., Goldsmith, E. W., Watson, N. B., Wang, J., Smith, N. L., & Rudd, B. D. (2019) · ImmunoHorizons · doi:10.4049/immunohorizons.1800066 · Cited by 37
Sepsis-induced changes in differentiation, maintenance, and function of memory CD8 T cell subsets
Heidarian, M., Griffith, T. S., & Badovinac, V. P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1130009 · Cited by 41
Polarized Cells, Polarized Views: Asymmetric Cell Division in Hematopoietic Cells
Pham, K., Sacirbegovic, F., & Russell, S. M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00026 · Cited by 38
Transfer of CD8+ T Cell Memory Using Bcl-2 as a Marker
Dunkle, A. D., Dzhagalov, I. L., Gordy, C. L., & He, Y.-W. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103481 · Cited by 37
Phenotypic and Functional Characterization of Herpes Simplex Virus Glycoprotein B Epitope-Specific Effector and Memory CD8+T Cells from Symptomatic and Asymptomatic Individuals with Ocular Herpes
Khan, A. A., Srivastava, R., Spencer, D., Garg, S., Fremgen, D. M., Vahed, H., Lopes, P. P., Pham, T. T. M., Hewett, C., Kuang, J., et al. (2015) · Journal of Virology · doi:10.1128/jvi.03419-14 · Cited by 37
Fuel and brake of memory T cell inflation
Welten, S. P. M., Baumann, N. S., & Oxenius, A. (2019) · Medical Microbiology and Immunology · doi:10.1007/s00430-019-00587-9 · Cited by 36
Poly(I:C) Potentiates T Cell Immunity to a Dendritic Cell Targeted HIV-Multiepitope Vaccine
Apostólico, J. D. S., Lunardelli, V. A. S., Yamamoto, M. M., Cunha‐Neto, E., Boscardin, S. B., & Rosa, D. S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00843 · Cited by 37
CD19-CAR-T Cells Bearing a KIR/PD-1-Based Inhibitory CAR Eradicate CD19+HLA-C1− Malignant B Cells While Sparing CD19+HLA-C1+ Healthy B Cells
Tao, L., Farooq, M. A., Gao, Y., Zhang, L., Niu, C., Ajmal, I., Zhou, Y. Y., He, C., Zhao, G., Yao, J., et al. (2020) · Cancers · doi:10.3390/cancers12092612 · Cited by 39
Programming Multifaceted Pulmonary T Cell Immunity by Combination Adjuvants
Marinaik, C. B., Kingstad-Bakke, B. A., Lee, W., Hatta, M., Sonsalla, M. M., Larsen, A., Neldner, B., Gasper, D. J., Kedl, R. M., Kawaoka, Y., et al. (2020) · Cell Reports Medicine · doi:10.1016/j.xcrm.2020.100095 · Cited by 37
Loss of E protein transcription factors E 2 A and HEB delays memory‐precursor formation during the CD 8+ T ‐cell immune response
D’Cruz, L. M., Lind, K. C., Wu, B. B., Fujimoto, J., & Goldrath, A. W. (2012) · European Journal of Immunology · doi:10.1002/eji.201242497 · Cited by 37
Interleukin 27 inhibits cytotoxic T-lymphocyte-mediated platelet destruction in primary immune thrombocytopenia
Zhou, H., Qiu, J., Wang, T., Yu, Y., Liu, X., Li, X., Wang, Y., Hou, Y., Li, L.-Z., Liu, X., et al. (2014) · Blood · doi:10.1182/blood-2014-06-580084 · Cited by 37
An MHC class Ib–restricted CD8 T cell response confers antiviral immunity
Swanson, P. A., Pack, C. D., Hadley, A., Wang, C.-R., Stroynowski, I., Jensen, P. E., & Lukacher, A. E. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080570 · Cited by 37
Modulating numbers and phenotype of CD8+ T cells in secondary immune responses
Wirth, T. C., Harty, J. T., & Badovinac, V. P. (2010) · European Journal of Immunology · doi:10.1002/eji.201040310 · Cited by 37

Authors: Joshi, N. S., Cui, W., Chandele, A., Lee, H. K., Urso, D. R., Hagman, J., Gapin, L., & Kaech, S. M.
Affiliations: Yale University (US)
National Jewish Health (US)
Corresponding author: Kaech, Susan M.
ORCID: Joshi, Nikhil S.
Cui, Weiguo
Chandele, Anmol
Lee, Heung Kyu
Hagman, James
Gapin, Laurent
Kaech, Susan M.
Venue: Immunity
Publisher: Elsevier BV
Published: 2007-08
Volume: 27
Issue: 2
Pages: 281-295
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2007.07.010
PMC: PMC2034442
OpenAlex: W1985294654
Cited by: 1,861
References: 50
Citations by year: 2026: 77 · 2025: 99 · 2024: 94 · 2023: 112 · 2022: 108 · 2021: 137 · 2020: 125 · 2019: 105 · 2018: 99 · 2017: 73 · 2016: 105 · 2015: 110 · 2014: 106 · 2013: 117 · 2012: 102
FWCI: 25.67
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2213 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Wellcome Trust
National Institute of Allergy and Infectious Diseases (P01AI022295, R01AI057485, R01AI054661, P01 AI22295, T32AI055403, R01AI056322, R01AI066232)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords: CD8+ T cells, short-lived effector cells, memory precursor effector cells, T-bet, IL-7 receptor, KLRG1, IL-15, IL-12, inflammation, T cell differentiation, memory T cell generation, innate immune regulation
MeSH terms: T-bet Transcription Factor, Animals, Immunologic Memory, Infections, Inflammation, Interferon-gamma, Mice, Mutant Strains, Receptors, Immunologic, Biomarkers, Cytokines, CD8-Positive T-Lymphocytes, Interleukin-12, Interleukin-15, Receptors, Interleukin-7, T-Box Domain Proteins, Lectins, C-Type, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-bet Transcription Factor

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks