Cited by 1,861T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesPsoriasis: Treatment and Pathogenesis

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Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-bet Transcription Factor

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Joshi, Nikhil S., Cui, Weiguo, Chandele, Anmol, Lee, Heung Kyu, Urso, David R., Hagman, James, Gapin, Laurent, Kaech, Susan M.·2007·Immunity

DOI 10.1016/j.immuni.2007.07.010PMC PMC2034442

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Abstract

As acute infections resolve, effector CD8(+) T cells differentiate into interleukin-7 receptor(lo) (IL-7R(lo)) short-lived effector cells (SLECs) and IL-7R(hi) memory precursor effector cells (MPECs) capable of generating long-lived memory CD8(+) T cells. By using another SLEC marker, KLRG1, we found that KLRG1(hi) effector cells began appearing early during infection and were committed to downregulating IL-7R. Unlike IL-7R(hi) MPECs, KLRG1(hi) IL-7R(lo) SLECs relied on IL-15, but IL-15 could not sustain their long-term maintenance or homeostatic turnover. The decision between SLEC and MPEC fates was regulated by the amount of inflammatory cytokines (i.e., IL-12) present during T cell priming. According to the amount of inflammation, a gradient of T-bet was created in which high T-bet expression induced SLECs and low expression promoted MPECs. These results elucidate a mechanism by which the innate immune system sets the relative amounts of a lineage-determining transcription factor in activated CD8(+) T cells and, correspondingly, regulates their memory cell potential.

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Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846 · cited 2×
“…on the attribute examined, differ according to their localization, effector functions or potential to become protective memory CD8 T cells (de Bree et al., 2005; Huster et al., 2004; Kaech et al., 2003; Sallusto et al., 1999; Schluns et al., 2000; Voehringer et al., 2001; Wherry et al., 2003).”
Background
A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment
Szabo, S. J., Kim, S. T., Costa, G. L., Zhang, X., Fathman, C. G., & Glimcher, L. H. (2000) · Cell · doi:10.1016/s0092-8674(00)80702-3 · Cited by 3,589
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Lineage relationship and protective immunity of memory CD8 T cell subsets
Wherry, E. J., Teichgräber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni889 · Cited by 1,864
Self-citation
Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
Kaech, S. M., Tan, J. T., Wherry, E. J., Konieczny, B. T., Surh, C. D., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni1009 · Cited by 1,830 · cited 12×
“…on the attribute examined, differ according to their localization, effector functions or potential to become protective memory CD8 T cells (de Bree et al., 2005; Huster et al., 2004; Kaech et al., 2003; Sallusto et al., 1999; Schluns et al., 2000; Voehringer et al., 2001; Wherry et al., 2003).”
BackgroundMethodResultInfluentialSelf-citation
Immunological memory and protective immunity: understanding their relation
Ahmed, R., & Gray, D. (1996) · Science · doi:10.1126/science.272.5258.54 · Cited by 1,775 · cited 2×
“The “decreasing potential model” for the development of memory CD8 T cells suggests that “memory T cells can only arise under conditions in which the antigenic load is limited and the stimulation of precursors ceases before a point of no return” (Ahmed and Gray, 1996).”
Background
Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo
Schluns, K. S., Kieper, W. C., Jameson, S. C., & Lefrançois, L. (2000) · Nature Immunology · doi:10.1038/80868 · Cited by 1,619
Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties
Weaver, C. T., Harrington, L. E., Mangan, P. R., Gavrieli, M., & Murphy, K. M. (2006) · Immunity · doi:10.1016/j.immuni.2006.06.002 · Cited by 1,422
Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin
Intlekofer, A. M., Takemoto, N., Wherry, E. J., Longworth, S. A., Northrup, J. T., Palanivel, V., Mullen, A. C., Gasink, C. R., Kaech, S. M., Miller, J. D., et al. (2005) · Nature Immunology · doi:10.1038/ni1268 · Cited by 1,293
Self-citation
Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells
Langenkamp, A., Messi, M., Lanzavecchia, A., & Sallusto, F. (2000) · Nature Immunology · doi:10.1038/79758 · Cited by 1,140

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Mon, K. J. Y., Kim, S., Dai, Z., West, J. D., Zhu, H., Jain, R., Grimson, A., Rudd, B. D., & Singh, A. K. (2024) · Nature Nanotechnology · doi:10.1038/s41565-024-01649-7 · Cited by 32
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Opata, M. M., Carpio, V. H., Ibitokou, S. A., Dillon, B., Obiero, J. M., & Stephens, R. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1403216 · Cited by 30
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Dutta, A., Miaw, S., Yu, J.-S., Chen, T., Lin, C., Lin, Y., Chang, C., He, Y.-C., Chuang, S.-H., Yen, M.-I., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202434 · Cited by 30
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Simonetta, F., Hua, S., Lécuroux, C., Gérard, S., Boufassa, F., Sáez‐Cirión, A., Pancino, G., Goujard, C., Lambotte, O., Venet, A., et al. (2014) · Journal of Virology · doi:10.1128/jvi.02013-14 · Cited by 28
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Sumida, H., & Cyster, J. G. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00660 · Cited by 30
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Authors: Joshi, N. S., Cui, W., Chandele, A., Lee, H. K., Urso, D. R., Hagman, J., Gapin, L., & Kaech, S. M.
Affiliations: Yale University (US)
National Jewish Health (US)
Corresponding author: Kaech, Susan M.
ORCID: Joshi, Nikhil S.
Cui, Weiguo
Chandele, Anmol
Lee, Heung Kyu
Hagman, James
Gapin, Laurent
Kaech, Susan M.
Venue: Immunity
Publisher: Elsevier BV
Published: 2007-08
Volume: 27
Issue: 2
Pages: 281-295
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2007.07.010
PMC: PMC2034442
OpenAlex: W1985294654
Cited by: 1,861
References: 50
Citations by year: 2026: 77 · 2025: 99 · 2024: 94 · 2023: 112 · 2022: 108 · 2021: 137 · 2020: 125 · 2019: 105 · 2018: 99 · 2017: 73 · 2016: 105 · 2015: 110 · 2014: 106 · 2013: 117 · 2012: 102
FWCI: 25.67
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2213 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Wellcome Trust
National Institute of Allergy and Infectious Diseases (P01AI022295, R01AI057485, R01AI054661, P01 AI22295, T32AI055403, R01AI056322, R01AI066232)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords: CD8+ T cells, short-lived effector cells, memory precursor effector cells, T-bet, IL-7 receptor, KLRG1, IL-15, IL-12, inflammation, T cell differentiation, memory T cell generation, innate immune regulation
MeSH terms: T-bet Transcription Factor, Animals, Immunologic Memory, Infections, Inflammation, Interferon-gamma, Mice, Mutant Strains, Receptors, Immunologic, Biomarkers, Cytokines, CD8-Positive T-Lymphocytes, Interleukin-12, Interleukin-15, Receptors, Interleukin-7, T-Box Domain Proteins, Lectins, C-Type, Mice

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Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-bet Transcription Factor

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