Cited by 1,861T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesPsoriasis: Treatment and Pathogenesis

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-bet Transcription Factor

Open access

Joshi, Nikhil S., Cui, Weiguo, Chandele, Anmol, Lee, Heung Kyu, Urso, David R., Hagman, James, Gapin, Laurent, Kaech, Susan M.·2007·Immunity

DOI 10.1016/j.immuni.2007.07.010PMC PMC2034442

Open this paper in CoChat — free account Open PDF

Abstract

As acute infections resolve, effector CD8(+) T cells differentiate into interleukin-7 receptor(lo) (IL-7R(lo)) short-lived effector cells (SLECs) and IL-7R(hi) memory precursor effector cells (MPECs) capable of generating long-lived memory CD8(+) T cells. By using another SLEC marker, KLRG1, we found that KLRG1(hi) effector cells began appearing early during infection and were committed to downregulating IL-7R. Unlike IL-7R(hi) MPECs, KLRG1(hi) IL-7R(lo) SLECs relied on IL-15, but IL-15 could not sustain their long-term maintenance or homeostatic turnover. The decision between SLEC and MPEC fates was regulated by the amount of inflammatory cytokines (i.e., IL-12) present during T cell priming. According to the amount of inflammation, a gradient of T-bet was created in which high T-bet expression induced SLECs and low expression promoted MPECs. These results elucidate a mechanism by which the innate immune system sets the relative amounts of a lineage-determining transcription factor in activated CD8(+) T cells and, correspondingly, regulates their memory cell potential.

Integrity signals

Registry

Crossref · 10.1016/j.immuni.2007.07.010

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846 · cited 2×
“…on the attribute examined, differ according to their localization, effector functions or potential to become protective memory CD8 T cells (de Bree et al., 2005; Huster et al., 2004; Kaech et al., 2003; Sallusto et al., 1999; Schluns et al., 2000; Voehringer et al., 2001; Wherry et al., 2003).”
Background
A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment
Szabo, S. J., Kim, S. T., Costa, G. L., Zhang, X., Fathman, C. G., & Glimcher, L. H. (2000) · Cell · doi:10.1016/s0092-8674(00)80702-3 · Cited by 3,589
CpG Motifs in Bacterial DNA and Their Immune Effects
Krieg, A. Μ. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064842 · Cited by 2,598
Lineage relationship and protective immunity of memory CD8 T cell subsets
Wherry, E. J., Teichgräber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni889 · Cited by 1,864
Self-citation
Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
Kaech, S. M., Tan, J. T., Wherry, E. J., Konieczny, B. T., Surh, C. D., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni1009 · Cited by 1,830 · cited 12×
“…on the attribute examined, differ according to their localization, effector functions or potential to become protective memory CD8 T cells (de Bree et al., 2005; Huster et al., 2004; Kaech et al., 2003; Sallusto et al., 1999; Schluns et al., 2000; Voehringer et al., 2001; Wherry et al., 2003).”
BackgroundMethodResultInfluentialSelf-citation
Immunological memory and protective immunity: understanding their relation
Ahmed, R., & Gray, D. (1996) · Science · doi:10.1126/science.272.5258.54 · Cited by 1,775 · cited 2×
“The “decreasing potential model” for the development of memory CD8 T cells suggests that “memory T cells can only arise under conditions in which the antigenic load is limited and the stimulation of precursors ceases before a point of no return” (Ahmed and Gray, 1996).”
Background
Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo
Schluns, K. S., Kieper, W. C., Jameson, S. C., & Lefrançois, L. (2000) · Nature Immunology · doi:10.1038/80868 · Cited by 1,619
Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties
Weaver, C. T., Harrington, L. E., Mangan, P. R., Gavrieli, M., & Murphy, K. M. (2006) · Immunity · doi:10.1016/j.immuni.2006.06.002 · Cited by 1,422
Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin
Intlekofer, A. M., Takemoto, N., Wherry, E. J., Longworth, S. A., Northrup, J. T., Palanivel, V., Mullen, A. C., Gasink, C. R., Kaech, S. M., Miller, J. D., et al. (2005) · Nature Immunology · doi:10.1038/ni1268 · Cited by 1,293
Self-citation
Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells
Langenkamp, A., Messi, M., Lanzavecchia, A., & Sallusto, F. (2000) · Nature Immunology · doi:10.1038/79758 · Cited by 1,140

Flagged first, then by citations

Show all 50 references

Sorted by citations

Items 101–200 of 1,005

The β1-adrenergic receptor links sympathetic nerves to T cell exhaustion
Globig, A.-M., Zhao, S., Roginsky, J., Maltez, V. I., Güiza, J., Avina-Ochoa, N., Heeg, M., Hoffmann, F. A., Chaudhary, O., Wang, J., et al. (2023) · Nature · doi:10.1038/s41586-023-06568-6 · Cited by 331
Self-citation
Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype
Demento, S. L., Cui, W., Criscione, J., Stern, E., Tulipan, J., Kaech, S., & Fahmy, T. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.03.041 · Cited by 287
Self-citation
Proinflammatory cytokine signaling required for the generation of natural killer cell memory
Sun, J. C.-Y., Madera, S., Bezman, N., Beilke, J. N., Kaplan, M. H., & Lanier, L. L. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20111760 · Cited by 308
A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy
Yuan, X., Paez-Cortez, J. R., Schmitt-Knosalla, I., D’Addio, F., Mfarrej, B. G., Donnarumma, M., Habicht, A., Clarkson, M. R., Iacomini, J., Glimcher, L. H., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20081937 · Cited by 306
Functional classification of memory CD8+ T cells by CX3CR1 expression
Böttcher, J. P., Beyer, M., Meissner, F., Abdullah, Z., Sander, J., Höchst, B., Eickhoff, S., Rieckmann, J. C., Russo, C., Bauer, T., et al. (2015) · Nature Communications · doi:10.1038/ncomms9306 · Cited by 292
Differential Expression of Ly6C and T-bet Distinguish Effector and Memory Th1 CD4+ Cell Properties during Viral Infection
Marshall, H. D., Chandele, A., Jung, Y. W., Meng, H., Poholek, A. C., Parish, I. A., Rutishauser, R. L., Cui, W., Kleinstein, S. H., Craft, J. E., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.08.016 · Cited by 299
Self-citation
T-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+ T Cells in HIV Infection
Buggert, M., Tauriainen, J., Yamamoto, T., Frederiksen, J., Ivarsson, M. A., Michaëlsson, J., Lund, O., Hejdeman, B., Jansson, M., Sönnerborg, A. B., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004251 · Cited by 293
The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway
Rankin, L. C., Groom, J. R., Chopin, M., Herold, M. J., Walker, J. A., Mielke, L. A., McKenzie, A. N. J., Carotta, S., Nutt, S. L., & Belz, G. T. (2013) · Nature Immunology · doi:10.1038/ni.2545 · Cited by 294
Transcription Factor Foxo1 Represses T-bet-Mediated Effector Functions and Promotes Memory CD8+ T Cell Differentiation
Rao, R. R., Li, Q., Bupp, M. G., & Shrikant, P. A. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.015 · Cited by 305
Influence of immune aging on vaccine responses
Gustafson, C. E., Kim, C., Weyand, C. M., & Goronzy, J. J. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.03.017 · Cited by 292
Generation of effector CD8 + T cells and their conversion to memory T cells
Cui, W., & Kaech, S. M. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00926.x · Cited by 299
Self-citation
Progressive Loss of Memory T Cell Potential and Commitment to Exhaustion during Chronic Viral Infection
Angelosanto, J., Blackburn, S. D., Crawford, A., & Wherry, E. J. (2012) · Journal of Virology · doi:10.1128/jvi.00889-12 · Cited by 285
PD-1-cis IL-2R agonism yields better effectors from stem-like CD8+ T cells
Deak, L. C., Nicolini, V., Hashimoto, M., Karagianni, M., Schwalie, P. C., Lauener, L., Varypataki, E. M., Richard, M., Bommer, E., Sam, J., et al. (2022) · Nature · doi:10.1038/s41586-022-05192-0 · Cited by 286
Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells
Pepper, M., Linehan, J. L., Pagán, A. J., Zell, T., Dileepan, T., Cleary, P. P., & Jenkins, M. K. (2009) · Nature Immunology · doi:10.1038/ni.1826 · Cited by 284
The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation in response to LCMV viral infection
Dominguez, C. X., Amezquita, R. A., Guan, T., Marshall, H. D., Joshi, N. S., Kleinstein, S. H., & Kaech, S. M. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20150186 · Cited by 275
Self-citation
Tissue-resident memory T cells at the center of immunity to solid tumors
Amsen, D., van Gisbergen, K. P. J. M., Hombrink, P., & van Lier, R. A. W. (2018) · Nature Immunology · doi:10.1038/s41590-018-0114-2 · Cited by 291
Heterogenous Populations of Tissue-Resident CD8+ T Cells Are Generated in Response to Infection and Malignancy
Milner, J. J., Toma, C., He, Z., Kurd, N. S., Nguyen, Q., McDonald, B., Quezada, L. K., Widjaja, C. E., Witherden, D. A., Crowl, J. T., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.04.007 · Cited by 278
Initiation and regulation of T-cell responses in tuberculosis
Urdahl, K. B., Shafiani, S., & Ernst, J. (2011) · Mucosal Immunology · doi:10.1038/mi.2011.10 · Cited by 271
Contributions of humoral and cellular immunity to vaccine-induced protection in humans
Amanna, I. J., & Slifka, M. K. (2011) · Virology · doi:10.1016/j.virol.2010.12.016 · Cited by 263
Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics
Giles, J. R., Ngiow, S. F., Manne, S., Baxter, A. E., Khan, O., Wang, P., Staupe, R., Abdel-Hakeem, M. S., Huang, H., Mathew, D., et al. (2022) · Nature Immunology · doi:10.1038/s41590-022-01338-4 · Cited by 264
Transcriptional repressor ZEB2 promotes terminal differentiation of CD8+ effector and memory T cell populations during infection
Omilusik, K. D., Best, J. A., Yu, B., Goossens, S., Weidemann, A., Nguyen, J. V., Seuntjens, E., Stryjewska, A., Zweier, C., Roychoudhuri, R., et al. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20150194 · Cited by 260
Effector-like CD8+ T Cells in the Memory Population Mediate Potent Protective Immunity
Olson, J. A., McDonald-Hyman, C. S., Jameson, S. C., & Hamilton, S. E. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.009 · Cited by 262
Regulation of effector and memory T-cell functions by type I interferon
Huber, J. P., & Farrar, J. D. (2011) · Immunology · doi:10.1111/j.1365-2567.2011.03412.x · Cited by 261
Regional and mucosal memory T cells
Sheridan, B. S., & Lefrançois, L. (2011) · Nature Immunology · doi:10.1038/ni.2029 · Cited by 268
Costimulatory and Coinhibitory Receptor Pathways in Infectious Disease
Attanasio, J., & Wherry, E. J. (2016) · Immunity · doi:10.1016/j.immuni.2016.04.022 · Cited by 267
Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation
Yu, B., Zhang, K., Milner, J. J., Toma, C., Chen, R., Scott-Browne, J. P., Pereira, R. M., Crotty, S., Chang, J. T., Pipkin, M. E., et al. (2017) · Nature Immunology · doi:10.1038/ni.3706 · Cited by 248
T-bet+ Treg Cells Undergo Abortive Th1 Cell Differentiation due to Impaired Expression of IL-12 Receptor β2
Koch, M. A., Thomas, K. R., Perdue, N., Smigiel, K. S., Srivastava, S., & Campbell, D. (2012) · Immunity · doi:10.1016/j.immuni.2012.05.031 · Cited by 260
Immunity to Respiratory Viruses
Kohlmeier, J. E., & Woodland, D. L. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132625 · Cited by 262
IL-12 Produced by Dendritic Cells Augments CD8+ T Cell Activation through the Production of the Chemokines CCL1 and CCL17
Henry, C. J., Ornelles, D. A., Mitchell, L. M., Brzoza‐Lewis, K. L., & Hiltbold, E. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.12.8576 · Cited by 258
Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans
Yates, K. B., Tonnerre, P., Martin, G. E., Gerdemann, U., Abosy, R. A., Comstock, D. E., Weiss, S. A., Wolski, D., Tully, D. C., Chung, R. T., et al. (2021) · Nature Immunology · doi:10.1038/s41590-021-00979-1 · Cited by 257
T-bet in disease
Lazarevic, V., & Glimcher, L. H. (2011) · Nature Immunology · doi:10.1038/ni.2059 · Cited by 255
Polycomb Repressive Complex 2-Mediated Chromatin Repression Guides Effector CD8 + T Cell Terminal Differentiation and Loss of Multipotency
Gray, S. M., Amezquita, R. A., Guan, T., Kleinstein, S. H., & Kaech, S. M. (2017) · Immunity · doi:10.1016/j.immuni.2017.03.012 · Cited by 240
Self-citation
Memory T cell–driven differentiation of naive cells impairs adoptive immunotherapy
Klebanoff, C. A., Scott, C. D., Leonardi, A. J., Yamamoto, T. N., Cruz, A. C., Ouyang, C., Ramaswamy, M., Roychoudhuri, R., Ji, Y., Eil, R. L., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci81217 · Cited by 251
Early transcriptional and epigenetic regulation of CD8+ T cell differentiation revealed by single-cell RNA sequencing
Kakaradov, B., Arsenio, J., Widjaja, C. E., He, Z., Aigner, S., Metz, P. J., Yu, B., Wehrens, E. J., Lopez, J. M., Kim, S. H., et al. (2017) · Nature Immunology · doi:10.1038/ni.3688 · Cited by 231
Effector CD8 T Cell Development: A Balancing Act between Memory Cell Potential and Terminal Differentiation
Joshi, N. S., & Kaech, S. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.3.1309 · Cited by 245
Self-citation
Cellular networks controlling T cell persistence in adoptive cell therapy
Chan, J. D., Lai, J., Slaney, C. Y., Kallies, A., Beavis, P. A., & Darcy, P. K. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00539-6 · Cited by 253
Genetic and Epigenetic Regulation of PD-1 Expression
Bally, A. P. R., Austin, J. W., & Boss, J. M. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502643 · Cited by 254
Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche
Clever, D. C., Roychoudhuri, R., Constantinides, M. G., Askenase, M. H., Sukumar, M., Klebanoff, C. A., Eil, R. L., Hickman, H. D., Yu, Z., Pan, J. H., et al. (2016) · Cell · doi:10.1016/j.cell.2016.07.032 · Cited by 246
Visualizing Synaptic Transfer of Tumor Antigens among Dendritic Cells
Ruhland, M. K., Roberts, E. W., Cai, E., Mujal, A. M., Marchuk, K., Beppler, C., Nam, D., Serwas, N. K., Binnewies, M., & Krummel, M. F. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.05.002 · Cited by 241
Targeting memory T cell metabolism to improve immunity
Corrado, M., & Pearce, E. L. (2022) · Journal of Clinical Investigation · doi:10.1172/jci148546 · Cited by 250
pH-Responsive Poly(d,l-lactic-co-glycolic acid) Nanoparticles with Rapid Antigen Release Behavior Promote Immune Response
Liu, Q., Chen, X., Jia, J., Zhang, W., Yang, T., Wang, L., & Ma, G. (2015) · ACS Nano · doi:10.1021/nn5066793 · Cited by 233
Influence of Inflammation in the Process of T Lymphocyte Differentiation: Proliferative, Metabolic, and Oxidative Changes
Moro‐García, M. A., Mayo, J. C., Sainz, R. M., & Alonso‐Arias, R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00339 · Cited by 241
Differentiation of CD8 memory T cells depends on Foxo1
Michelini, R. H., Doedens, A. L., Goldrath, A. W., & Hedrick, S. Μ. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20130392 · Cited by 232
Intratumoral injection of a CpG oligonucleotide reverts resistance to PD-1 blockade by expanding multifunctional CD8 + T cells
Wang, S., Campos, J. S., Gallotta, M., Gong, M., Crain, C., Naik, E., Coffman, R. L., & Guiducci, C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1608555113 · Cited by 235
Memory CD4+ T Cells in Immunity and Autoimmune Diseases
Raphael, I., Robinson, R. R., & Forsthuber, T. G. (2020) · Cells · doi:10.3390/cells9030531 · Cited by 241
The precursors of CD8+ tissue resident memory T cells: from lymphoid organs to infected tissues
Kok, L., Masopust, D., & Schumacher, T. N. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-021-00590-3 · Cited by 230
Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival
Hand, T. W., Cui, W., Jung, Y. W., Sefik, E., Joshi, N. S., Chandele, A., Liu, Y., & Kaech, S. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003457107 · Cited by 232
Self-citation
Lineage relationship of effector and memory T cells
Restifo, N. P., & Gattinoni, L. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.09.003 · Cited by 245
Role of memory T cell subsets for adoptive immunotherapy
Busch, D. H., Fräßle, S. P., Sommermeyer, D., Buchholz, V. R., & Riddell, S. R. (2016) · Seminars in Immunology · doi:10.1016/j.smim.2016.02.001 · Cited by 232
Distinct Epigenetic Signatures Delineate Transcriptional Programs during Virus-Specific CD8+ T Cell Differentiation
Russ, B. E., Olshanksy, M., Smallwood, H. S., Li, J., Denton, A. E., Prier, J. E., Stock, A. T., McQuilten, H. A., Cullen, J. G., Nguyen, M. L. T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.11.001 · Cited by 220
Epigenetic signature of PD-1+ TCF1+ CD8 T cells that act as resource cells during chronic viral infection and respond to PD-1 blockade
Jadhav, R. R., Im, S. J., Hu, B., Hashimoto, M., Li, P., Lin, J., Leonard, W. J., Greenleaf, W. J., Ahmed, R., & Goronzy, J. J. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1903520116 · Cited by 224
Early precursors and molecular determinants of tissue-resident memory CD8 + T lymphocytes revealed by single-cell RNA sequencing
Kurd, N. S., He, Z., Louis, T. L., Milner, J. J., Omilusik, K. D., Jin, W., Tsai, M. S., Widjaja, C. E., Kanbar, J. N., Olvera, J. G., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.aaz6894 · Cited by 219
Memory CD8+ T cell responses to cancer
Han, J., Khatwani, N., Searles, T. G., Turk, M. J., & Angeles, C. V. (2020) · Seminars in Immunology · doi:10.1016/j.smim.2020.101435 · Cited by 236
Optimal Generation of Tissue-Resident but Not Circulating Memory T Cells during Viral Infection Requires Crosspriming by DNGR-1 + Dendritic Cells
Iborra, S., Martínez‐López, M., Khouili, S. C., Enamorado, M., Cueto, F. J., Conde‐Garrosa, R., del Fresno, C., & Sancho, D. (2016) · Immunity · doi:10.1016/j.immuni.2016.08.019 · Cited by 224
The Transcription Factor Foxo1 Controls Central-Memory CD8+ T Cell Responses to Infection
Kim, M. V., Ouyang, W., Liao, W., Zhang, M. Q., & Li, M. O. (2013) · Immunity · doi:10.1016/j.immuni.2013.07.013 · Cited by 218
One naive T cell, multiple fates in CD8+ T cell differentiation
Gerlach, C., van Heijst, J. W. J., Swart, E., Sie, D., Armstrong, N. J., Kerkhoven, R. M., Zehn, D., Bevan, M. J., Schepers, K., & Schumacher, T. N. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20091175 · Cited by 215
BET bromodomain inhibition enhances T cell persistence and function in adoptive immunotherapy models
Kagoya, Y., Nakatsugawa, M., Yamashita, Y., Ochi, T., Guo, T., Anczurowski, M., Saso, K., Butler, M. O., Arrowsmith, C. H., & Hirano, N. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86437 · Cited by 218
Local antigen in nonlymphoid tissue promotes resident memory CD8+ T cell formation during viral infection
Khan, T. N., Mooster, J. L., Kilgore, A. M., Osborn, J. F., & Nolz, J. C. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20151855 · Cited by 218
The EGR2 targets LAG-3 and 4-1BB describe and regulate dysfunctional antigen-specific CD8+ T cells in the tumor microenvironment
Williams, J. B., Horton, B. L., Zheng, Y., Duan, Y., Powell, J. D., & Gajewski, T. F. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20160485 · Cited by 213
Programming for CD8 T Cell Memory Development Requires IL-12 or Type I IFN
Xiao, Z., Casey, K. A., Jameson, S. C., Curtsinger, J., & Mescher, M. F. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803484 · Cited by 213
Regulation of Effector and Memory CD8 T Cell Differentiation by IL-2—A Balancing Act
Kalia, V., & Sarkar, S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02987 · Cited by 217
Oncolytic virus–mediated expansion of dual-specific CAR T cells improves efficacy against solid tumors in mice
Evgin, L., Kottke, T., Tonne, J. M., Thompson, J., Huff, A. L., van Vloten, J. P., Moore, M. N., Michael, J., Driscoll, C. B., Pulido, J. S., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abn2231 · Cited by 213
In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer
Chen, Z., Arai, E., Khan, O., Zhang, Z., Ngiow, S. F., He, Y. M., Huang, H., Manne, S., Cao, Z., Baxter, A. E., et al. (2021) · Cell · doi:10.1016/j.cell.2021.02.019 · Cited by 210
Plasticity in programming of effector and memory CD8+ T‐cell formation
Arens, R., & Schoenberger, S. P. (2010) · Immunological Reviews · doi:10.1111/j.0105-2896.2010.00899.x · Cited by 213
Early specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene-expression analyses
Arsenio, J., Kakaradov, B., Metz, P. J., Kim, S. H., Yeo, G. W.-M., & Chang, J. T. (2014) · Nature Immunology · doi:10.1038/ni.2842 · Cited by 201
Developmental Origin Governs CD8+ T Cell Fate Decisions during Infection
Smith, N. L., Patel, R. K., Reynaldi, A., Grenier, J. K., Wang, J., Watson, N. B., Nzingha, K., Mon, K. J. Y., Peng, S. A., Grimson, A., et al. (2018) · Cell · doi:10.1016/j.cell.2018.05.029 · Cited by 202
Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation
Hertoghs, K. M. L., Moerland, P. D., van Stijn, A., Remmerswaal, E. B. M., Yong, S. L., van de Berg, P. J. E. J., van Ham, S. M., Baas, F., ten Berge, I. J. M., & van Lier, R. A. W. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42758 · Cited by 198
The Effects of TLR Activation on T-Cell Development and Differentiation
Jin, B., Sun, T., Yu, X., Yang, Y., & Yeo, A. E. T. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/836485 · Cited by 209
Tissue‐resident memory T cells
Shin, H., & Iwasaki, A. (2013) · Immunological Reviews · doi:10.1111/imr.12087 · Cited by 215
The precursors of memory: models and controversies
Ahmed, R., Bevan, M. J., Reiner, S. L., & Fearon, D. T. (2009) · Nature reviews. Immunology · doi:10.1038/nri2619 · Cited by 207
CD4 + T cell regulation of CD25 expression controls development of short-lived effector CD8 + T cells in primary and secondary responses
Obar, J. J., Molloy, M. J., Jellison, E. R., Stoklasek, T. A., Zhang, W., Usherwood, E. J., & Lefrançois, L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909945107 · Cited by 206
Repression of the DNA-binding inhibitor Id3 by Blimp-1 limits the formation of memory CD8+ T cells
Ji, Y., Pós, Z., Rao, M., Klebanoff, C. A., Yu, Z., Sukumar, M., Reger, R. N., Palmer, D. C., Borman, Z. A., Muranski, P. J., et al. (2011) · Nature Immunology · doi:10.1038/ni.2153 · Cited by 205
Tissue‐resident memory T cells in tissue homeostasis, persistent infection, and cancer surveillance
Gebhardt, T., Palendira, U., Tscharke, D. C., & Bedoui, S. (2018) · Immunological Reviews · doi:10.1111/imr.12650 · Cited by 208
The Transcription Factor Runx3 Establishes Chromatin Accessibility of cis-Regulatory Landscapes that Drive Memory Cytotoxic T Lymphocyte Formation
Wang, D., Diao, H., Getzler, A. J., Rogal, W., Frederick, M. A., Milner, J., Yu, B., Crotty, S., Goldrath, A. W., & Pipkin, M. E. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.028 · Cited by 201
Different T Cell Receptor Signals Determine CD8 + Memory Versus Effector Development
Teixeiro, E., Daniëls, M. A., Hamilton, S. E., Schrum, A. G., Bragado, R., Jameson, S. C., & Palmer, E. (2009) · Science · doi:10.1126/science.1163612 · Cited by 199
The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function
Wenes, M., Jaccard, A., Wyss, T., Maldonado‐Pérez, N., Teoh, S. T., Lepez, A., Renaud, F., Franco, F., Waridel, P., Maroun, C. Y., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.03.013 · Cited by 215
Central memory CD8+ T cells derive from stem-like Tcf7hi effector cells in the absence of cytotoxic differentiation
Ferreira, D. P., da Silva, J. G., Wyss, T., Marraco, S. A. F., Scarpellino, L., Charmoy, M., Maas, R. R., Siddiqui, I., Tang, L., Joyce, J. A., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.09.005 · Cited by 200
Transcriptional Regulation of Tissue-Resident Lymphocytes
Mackay, L. K., & Kallies, A. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.11.004 · Cited by 202
Interleukin-10 from CD4 + follicular regulatory T cells promotes the germinal center response
Laidlaw, B. J., Lu, Y., Amezquita, R. A., Weinstein, J. S., Heiden, J. A. V., Gupta, N. T., Kleinstein, S. H., Kaech, S. M., & Craft, J. E. (2017) · Science Immunology · doi:10.1126/sciimmunol.aan4767 · Cited by 203
Self-citation
Production of IL-10 by CD4+ regulatory T cells during the resolution of infection promotes the maturation of memory CD8+ T cells
Laidlaw, B. J., Cui, W., Amezquita, R. A., Gray, S. M., Guan, T., Lu, Y., Kobayashi, Y., Flavell, R. A., Kleinstein, S. H., Craft, J. E., et al. (2015) · Nature Immunology · doi:10.1038/ni.3224 · Cited by 199
Self-citation
Chemokine receptor CXCR3 facilitates CD8+ T cell differentiation into short-lived effector cells leading to memory degeneration
Kurachi, M., Kurachi, J., Suenaga, F., Tsukui, T., Abe, J., Ueha, S., Tomura, M., Sugihara, K., Takamura, S., Kakimi, K., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20102101 · Cited by 189
Opposing Effects of TGF-β and IL-15 Cytokines Control the Number of Short-Lived Effector CD8+ T Cells
Sanjabi, S., Mosaheb, M. M., & Flavell, R. A. (2009) · Immunity · doi:10.1016/j.immuni.2009.04.020 · Cited by 199
Asymmetric Proteasome Segregation as a Mechanism for Unequal Partitioning of the Transcription Factor T-bet during T Lymphocyte Division
Chang, J. T., Ciocca, M. L., Kinjyo, I., Palanivel, V., McClurkin, C. E., DeJong, C. S., Mooney, E. C., Kim, J. S., Steinel, N. C., Oliaro, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.017 · Cited by 189
KLRG1—more than a marker for T cell senescence
Henson, S. M., & Akbar, A. N. (2009) · AGE · doi:10.1007/s11357-009-9100-9 · Cited by 204
Expression of chemokine receptor CXCR3 on T cells affects the balance between effector and memory CD8 T-cell generation
Hu, J. K., Kagari, T., Clingan, J. M., & Matloubian, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1101881108 · Cited by 183
Tissue-resident memory CD8+ T cells shape local and systemic secondary T cell responses
Behr, F. M., Parga-Vidal, L., Kragten, N. A. M., van Dam, T. J. P., Wesselink, T. H., Sheridan, B. S., Arens, R., van Lier, R. A. W., Stark, R., & van Gisbergen, K. P. J. M. (2020) · Nature Immunology · doi:10.1038/s41590-020-0723-4 · Cited by 184
Characterization of T-Bet and Eomes in Peripheral Human Immune Cells
Knox, J. J., Cosma, G. L., Betts, M. R., & McLane, L. M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00217 · Cited by 199
T-bet and Eomesodermin Are Required for T Cell-Mediated Antitumor Immune Responses
Zhu, Y., Ju, S., Chen, E., Dai, S., Li, C., Morel, P. A., Liu, L., Zhang, X., & Lu, B. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000749 · Cited by 189
Bcl-6 directly represses the gene program of the glycolysis pathway
Oestreich, K. J., Read, K. A., Gilbertson, S. E., Hough, K. P., McDonald, P. W., Krishnamoorthy, V., & Weinmann, A. S. (2014) · Nature Immunology · doi:10.1038/ni.2985 · Cited by 192
The metabolic life and times of a T‐cell
Michalek, R. D., & Rathmell, J. C. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00911.x · Cited by 186
“One proposed mechanism is the selective upregulation of IL-7Ra on a subset of T cells, which may allow these cells to maintain some homeostatic regulation of nutrient uptake and metabolism (55, 114, 115).”
Background
The Third Signal Cytokine IL-12 Rescues the Anti-Viral Function of Exhausted HBV-Specific CD8 T Cells
Schurich, A., Pallett, L. J., Lubowiecki, M., Singh, H. D., Gill, U. S., Kennedy, P. T. F., Nastouli, E., Tanwar, S., Rosenberg, W. M., & Maini, M. K. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003208 · Cited by 194
The activation of the adaptive immune system: Cross-talk between antigen-presenting cells, T cells and B cells
den Haan, J. M. M., Arens, R., & van Zelm, M. C. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.10.011 · Cited by 205
A molecular threshold for effector CD8+ T cell differentiation controlled by transcription factors Blimp-1 and T-bet
Xin, A., Masson, F., Liao, Y., Preston, S., Guan, T., Gloury, R., Olshansky, M., Lin, J., Li, P., Speed, T. P., et al. (2016) · Nature Immunology · doi:10.1038/ni.3410 · Cited by 191
Self-citation
Insights from a 30-year journey: function, regulation and therapeutic modulation of PD1
Chamoto, K., Yaguchi, T., Tajima, M., & Honjo, T. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-023-00867-9 · Cited by 185
Role of PI3K/Akt signaling in memory CD8 T cell differentiation
Kim, E. H., & Suresh, M. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00020 · Cited by 185
The function and dysfunction of memory CD 8+ T cells in tumor immunity
Reading, J. L., Gálvez‐Cancino, F., Swanton, C., Lladser, Á., Peggs, K. S., & Quezada, S. A. (2018) · Immunological Reviews · doi:10.1111/imr.12657 · Cited by 186
BATF regulates progenitor to cytolytic effector CD8+ T cell transition during chronic viral infection
Chen, Y., Zander, R., Wu, X., Schauder, D., Kasmani, M. Y., Shen, J., Zheng, S., Burns, R., Taparowsky, E. J., & Cui, W. (2021) · Nature Immunology · doi:10.1038/s41590-021-00965-7 · Cited by 183
Self-citation
Increased HIV-specific CD8+ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression
Hersperger, A. R., Martin, J. N., Shin, L. Y., Sheth, P. M., Kovacs, C. M., Cosma, G. L., Makedonas, G., Pereyra, F., Walker, B. D., Kaul, R., et al. (2011) · Blood · doi:10.1182/blood-2010-12-322727 · Cited by 180
Distinct functions of antigen-specific CD4 T cells during murine Mycobacterium tuberculosis infection
Reiley, W. W., Shafiani, S., Wittmer, S. T., Tucker-Heard, G., Moon, J. J., Jenkins, M. K., Urdahl, K. B., Winslow, G. M., & Woodland, D. L. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006298107 · Cited by 179
Constitutive Activation of Wnt Signaling Favors Generation of Memory CD8 T Cells
Zhao, D., Yu, S., Zhou, X., Haring, J. S., Held, W., Badovinac, V. P., Harty, J. T., & Xue, H. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901199 · Cited by 176

Authors: Joshi, N. S., Cui, W., Chandele, A., Lee, H. K., Urso, D. R., Hagman, J., Gapin, L., & Kaech, S. M.
Affiliations: Yale University (US)
National Jewish Health (US)
Corresponding author: Kaech, Susan M.
ORCID: Joshi, Nikhil S.
Cui, Weiguo
Chandele, Anmol
Lee, Heung Kyu
Hagman, James
Gapin, Laurent
Kaech, Susan M.
Venue: Immunity
Publisher: Elsevier BV
Published: 2007-08
Volume: 27
Issue: 2
Pages: 281-295
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2007.07.010
PMC: PMC2034442
OpenAlex: W1985294654
Cited by: 1,861
References: 50
Citations by year: 2026: 77 · 2025: 99 · 2024: 94 · 2023: 112 · 2022: 108 · 2021: 137 · 2020: 125 · 2019: 105 · 2018: 99 · 2017: 73 · 2016: 105 · 2015: 110 · 2014: 106 · 2013: 117 · 2012: 102
FWCI: 25.67
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2213 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Wellcome Trust
National Institute of Allergy and Infectious Diseases (P01AI022295, R01AI057485, R01AI054661, P01 AI22295, T32AI055403, R01AI056322, R01AI066232)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords: CD8+ T cells, short-lived effector cells, memory precursor effector cells, T-bet, IL-7 receptor, KLRG1, IL-15, IL-12, inflammation, T cell differentiation, memory T cell generation, innate immune regulation
MeSH terms: T-bet Transcription Factor, Animals, Immunologic Memory, Infections, Inflammation, Interferon-gamma, Mice, Mutant Strains, Receptors, Immunologic, Biomarkers, Cytokines, CD8-Positive T-Lymphocytes, Interleukin-12, Interleukin-15, Receptors, Interleukin-7, T-Box Domain Proteins, Lectins, C-Type, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-bet Transcription Factor

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks