The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Professional Memory CD4+ T Lymphocytes Preferentially Reside and Rest in the Bone Marrow
Open accessAbstract
CD4(+) T lymphocytes are key to immunological memory. Here we show that in the memory phase of specific immune responses, most of the memory CD4(+) T lymphocytes had relocated into the bone marrow (BM) within 3-8 weeks after their generation-a process involving integrin alpha2. Antigen-specific memory CD4(+) T lymphocytes highly expressed Ly-6C, unlike most splenic CD44(hi)CD62L(-) CD4(+) T lymphocytes. In adult mice, more than 80% of Ly-6C(hi)CD44(hi)CD62L(-) memory CD4(+) T lymphocytes were in the BM. In the BM, they associated to IL-7-expressing VCAM-1(+) stroma cells. Gene expression and proliferation were downregulated, indicating a resting state. Upon challenge with antigen, they rapidly expressed cytokines and CD154 and efficiently induced the production of high-affinity antibodies by B lymphocytes. Thus, in the memory phase of immunity, memory helper T cells are maintained in BM as resting but highly reactive cells in survival niches defined by IL-7-expressing stroma cells.
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“They have been defined as independent populations by tissue retention in parabiosis experiments [239, 240], by distinguishing transcriptional profiles [230, 241-245], by exclusive Ag receptor repertoires and specificities [243, 244, 246], and by exclusive persistence in transplanted tissues [247, 248].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [243]
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Cites
CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes
Janssen, E. M., Lemmens, E. E., Wolfe, T., Christen, U., von Herrath, M. G., & Schoenberger, S. P. (2003) · Nature · doi:10.1038/nature01441 · Cited by 1,635
Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice
Kennedy, M. K., Glaccum, M. B., Brown, S. N., Butz, E. A., Viney, J. L., Embers, M. E., Matsuki, N., Charrier, K., Sedger, L. M., Willis, C. R., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.5.771 · Cited by 1,635
Diehl, K., Hull, R., Morton, D. B., Pfister, R., Rabemampianina, Y., Smith, D. W., Vidal, J., & Vorstenbosch, C. V. D. (2001) · Journal of Applied Toxicology · doi:10.1002/jat.727 · Cited by 1,570
Requirement for CD4 T Cell Help in Generating Functional CD8 T Cell Memory
Shedlock, D. J., & Shen, H. (2003) · Science · doi:10.1126/science.1082305 · Cited by 1,450
IL-15 Receptor Maintains Lymphoid Homeostasis by Supporting Lymphocyte Homing and Proliferation
Lodolce, J. P., Boone, D. L., Chai, S., Swain, R. E., Dassopoulos, T., Trettin, S., & Ma, A. I. (1998) · Immunity · doi:10.1016/s1074-7613(00)80664-0 · Cited by 1,302
Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help
Sun, J. C., & Bevan, M. J. (2003) · Science · doi:10.1126/science.1083317 · Cited by 1,213
Competence and competition: the challenge of becoming a long-lived plasma cell
Radbruch, A., Muehlinghaus, G., Luger, E., Inamine, A., Smith, K. G. C., Dörner, T., & Hiepe, F. (2006) · Nature reviews. Immunology · doi:10.1038/nri1886 · Cited by 1,033
Self-citationThe Vaccine Adjuvant Monophosphoryl Lipid A as a TRIF-Biased Agonist of TLR4
Mata‐Haro, V., Cekic, C., Martin, M., Chilton, P. M., Casella, C. R., & Mitchell, T. C. (2007) · Science · doi:10.1126/science.1138963 · Cited by 901
Cytokine control of memory T-cell development and survival
Schluns, K. S., & Lefrançois, L. (2003) · Nature reviews. Immunology · doi:10.1038/nri1052 · Cited by 879
Lifetime of plasma cells in the bone marrow
Manz, R. A., Thiel, A., & Radbruch, A. (1997) · Nature · doi:10.1038/40540 · Cited by 866
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Zhu, J., Yamane, H., & Paul, W. E. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101212 · Cited by 3,452
Human memory T cells: generation, compartmentalization and homeostasis
Farber, D. L., Yudanin, N. A., & Restifo, N. P. (2014) · Nature Reviews Immunology · doi:10.1038/nri3567 · Cited by 897
Development and Function of Dendritic Cell Subsets
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Ectopic lymphoid-like structures in infection, cancer and autoimmunity
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Location, location, location: Tissue resident memory T cells in mice and humans
Szabo, P. A., Miron, M., & Farber, D. L. (2019) · Science Immunology · doi:10.1126/sciimmunol.aas9673 · Cited by 651
Metadata
- Authors
- Tokoyoda, K., Zehentmeier, S., Hegazy, A. N., Albrecht, I., Grün, J. R., Löhning, M., & Radbruch, A.
- Affiliations
- German Rheumatism Research Centre (DE)
- Corresponding author
- Tokoyoda, Koji
- ORCID
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 30
- Issue
- 5
- Pages
- 721-730
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2065708749
- Cited by
- 352
- References
- 48
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 4 · 2023: 4 · 2022: 11 · 2021: 18 · 2020: 15 · 2019: 31 · 2018: 27 · 2017: 24 · 2016: 27 · 2015: 22 · 2014: 23 · 2013: 32 · 2012: 22
- FWCI
- 13.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1538 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- memory CD4+ T cells, bone marrow, T cell homing, integrin alpha2, Ly6C, CD44, L-selectin, IL-7, VCAM-1, stromal cells, T cell proliferation, CD154, antibody production, immunological memory
- MeSH terms
- Animals, Antigens, Ly, B-Lymphocytes, Bone Marrow, Immunologic Memory, CD4-Positive T-Lymphocytes, Down-Regulation, Interleukin-7, Gene Expression, Stromal Cells, Oligonucleotide Array Sequence Analysis, Integrin alpha2, Mice
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