The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Designing Vaccines Based on Biology of Human Dendritic Cell Subsets
Open accessAbstract
The effective vaccines developed against a variety of infectious agents, including polio, measles and Hepatitis B, represent major achievements in medicine. These vaccines, usually composed of microbial antigens, are often associated with an adjuvant that activates dendritic cells (DCs). Many infectious diseases are still in need of an effective vaccine including HIV, malaria, hepatitis C and tuberculosis. In some cases, the induction of cellular rather than humoral responses may be more important as the goal is to control and eliminate the existing infection rather than to prevent it. Our increased understanding of the mechanisms of antigen presentation, particularly with the description of DC subsets with distinct functions, as well as their plasticity in responding to extrinsic signals, represent opportunities to develop novel vaccines. In addition, we foresee that this increased knowledge will permit us to design vaccines that will reprogram the immune system to intervene therapeutically in cancer, allergy and autoimmunity.
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Cites
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Cited by
Cancer immunotherapy comes of age
Mellman, I., Coukos, G., & Dranoff, G. (2011) · Nature · doi:10.1038/nature10673 · Cited by 3,893
Self-citationGalli, S. J., Borregaard, N., & Wynn, T. A. (2011) · Nature Immunology · doi:10.1038/ni.2109 · Cited by 1,055
Igyártó, B. Z., Haley, K., Ortner, D., Bobr, A., Gerami-Nejad, M., Edelson, B. T., Zurawski, S. M., Malissen, B., Zurawski, G., Berman, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.06.005 · Cited by 435
Dendritic Cell–Based Cancer Vaccines
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The Role of Indoleamine 2, 3-Dioxygenase in Immune Suppression and Autoimmunity
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“Studies aimed at understanding how Bin1 restricts tumor outgrowth identified the establishment of immune tolerance through deregulation of IDO1 as a likely explanation [108].”
Background
Metadata
- Authors
- Palucka, K., Banchereau, J., & Mellman, I.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 33
- Issue
- 4
- Pages
- 464-478
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2067015198
- Cited by
- 332
- References
- 18
- FWCI
- 15.81
- Type
- journal article
- Language
- en
- Open access
- bronze
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