Cited by 167Proteoglycans and glycosaminoglycans researchCell Adhesion Molecules ResearchChemokine receptors and signaling

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Endothelial Heparan Sulfate Controls Chemokine Presentation in Recruitment of Lymphocytes and Dendritic Cells to Lymph Nodes

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Bao, Xingfeng, Moseman, E. Ashley, Saito, Hideo, Petryanik, Bronislawa, Thiriot, Aude, Hatakeyama, Shingo, Ito, Yuki, Kawashima, Hiroto, Yamaguchi, Yu, Lowe, John B., von Andrian, Ulrich H., Fukuda, Minoru·2010·Immunity

DOI 10.1016/j.immuni.2010.10.018PMC PMC2996097

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Abstract

Heparan sulfate can bind several adhesion molecules involved in lymphocyte trafficking. However, the in vivo function of endothelial heparan sulfate in lymphocyte homing and stimulation of the immune response has not been elucidated. Here, we generated mutant mice deficient in the enzyme Ext1, which is required for heparan sulfate synthesis, in a Tek-dependent and inducible manner. Chemokine presentation was diminished in the mutant mice, causing the lack of appropriate integrin-mediated adhesion, and resulted in a marked decrease in lymphocyte sticking to high endothelial venules and in recruitment of resident dendritic cells through lymphatic vessels to the lymph nodes. As a consequence, mutant mice displayed a severe impairment in lymphocyte homing and a compromised contact hypersensitivity response. By contrast, lymphocyte rolling was increased because of loss of electrostatic repulsion by heparan sulfate. These results demonstrate critical roles of endothelial heparan sulfate in immune surveillance and immune response generation.

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Authors: Bao, X., Moseman, E. A., Saito, H., Petryanik, B., Thiriot, A., Hatakeyama, S., Ito, Y., Kawashima, H., Yamaguchi, Y., Lowe, J. B., von Andrian, U. H., & Fukuda, M.
Affiliations: Sanford Burnham Prebys Medical Discovery Institute (US)
Harvard University (US)
Case Western Reserve University (US)
Corresponding author: Fukuda, Minoru
ORCID: Bao, Xingfeng
Moseman, E. Ashley
Thiriot, Aude
Hatakeyama, Shingo
Ito, Yuki
Kawashima, Hiroto
Yamaguchi, Yu
von Andrian, Ulrich H.
Fukuda, Minoru
Venue: Immunity
Publisher: Elsevier BV
Published: 2010-11
Volume: 33
Issue: 5
Pages: 817-829
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2010.10.018
PMC: PMC2996097
OpenAlex: W2037665285
Cited by: 167
References: 49
Citations by year: 2026: 7 · 2025: 10 · 2024: 6 · 2023: 6 · 2022: 9 · 2021: 14 · 2020: 4 · 2019: 14 · 2018: 16 · 2017: 10 · 2016: 10 · 2015: 10 · 2014: 13 · 2013: 13 · 2012: 14
FWCI: 4.97
Type: journal article
Language: en
Update notices: erratum (2011-05-27)
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1020 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Japan Society for the Promotion of Science (22659018, 21390023)
National Cancer Institute (P01CA071932)
National Institute of Allergy and Infectious Diseases (R01AI072252, R01AI069259)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Keywords: EXT1, lymphocyte homing, dendritic cell recruitment, lymph nodes, high endothelial venules, integrin-mediated adhesion, lymphatic vessels, contact hypersensitivity, immune surveillance, heparan sulfate synthesis
MeSH terms: Exostosin 1, Animals, Cell Adhesion, Dendritic Cells, Endothelium, Vascular, Heparan Sulfate, Lymph Nodes, Lymphocytes, Mice, Inbred C57BL, Venules, Integrins, N-Acetylglucosaminyltransferases, Chemokines, Mice

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Endothelial Heparan Sulfate Controls Chemokine Presentation in Recruitment of Lymphocytes and Dendritic Cells to Lymph Nodes

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