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Foxp3+ Regulatory T Cells Promote T Helper 17 Cell Development In Vivo through Regulation of Interleukin-2
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“The cytokines (e.g., IL-23, IL-6) secreted by macrophages, along with their antigen-presenting functions, can promote the differentiation and activation of T cells (e.g., Th1 and Th17 cells)48–50.”
From Macrophage INSIG1 deficiency drives psoriasiform dermatitis via the SREBP2-STAT1 axis (2026) · cites this paper as [50]
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Transforming growth factor-β induces development of the TH17 lineage
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Kanno, Y., Vahedi, G., Hirahara, K., Singleton, K., & O'Shea, J. J. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075058 · Cited by 342
“It is well established that IL-2 inhibits Th17 differentiation and by acting as IL-2 “sinks” Treg cells can promote Th17 differentiation (110-112).”
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Macrophage INSIG1 deficiency drives psoriasiform dermatitis via the SREBP2-STAT1 axis
Li, X., Zang, Y., Li, X., Sheng, T., Liu, S., Chen, L., Xu, X., Wang, L., Long, R., Zhang, M., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-73278-8 · Cited by 1
Metadata
- Authors
- Chen, Y., Haines, C. J., Gutcher, I., Hochweller, K., Blumenschein, W. M., McClanahan, T., Hämmerling, G., Li, M. O., Cua, D. J., & McGeachy, M. J.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 34
- Issue
- 3
- Pages
- 409-421
- ISSN
- 1074-7613
- Cited by
- 123
- References
- 4
- Language
- en
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