Innate and Adaptive Interferons Suppress IL-1α and IL-1β Production by Distinct Pulmonary Myeloid Subsets during Mycobacterium tuberculosis Infection

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

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An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis

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TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection.

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Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

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Type I interferon: friend or foe?

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Microbial Stimulation Fully Differentiates Monocytes to DC-SIGN/CD209+ Dendritic Cells for Immune T Cell Areas

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Virulence of a Mycobacterium tuberculosis clinical isolate in mice is determined by failure to induce Th1 type immunity and is associated with induction of IFN-α/β

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Taurine transport is a critical modulator of ionic fluxes during NLRP3 inflammasome activation

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Type I interferons in tuberculosis pathogenesis and prevention

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Reduced thyroxine production in young household contacts of tuberculosis patients increases active tuberculosis disease risk

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Exploring the genetic factors behind the discrepancy in resistance to bovine tuberculosis between African zebu cattle and European taurine cattle

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Airway microbiome signature accurately discriminates Mycobacterium tuberculosis infection status

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Caspase-1 inhibits IFN-β production via cleavage of cGAS during M. bovis infection

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Host‐directed anti‐mycobacterial activity of colchicine, an anti‐gout drug, via strengthened host innate resistance reinforced by the IL‐1β/PGE2 axis

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Prediction of Th1 and Cytotoxic T Lymphocyte Epitopes of Mycobacterium tuberculosis and Evaluation of Their Potential in the Diagnosis of Tuberculosis in a Mouse Model and in Humans

Gong, W., Liang, Y., Wang, J., Liu, Y., Xue, Y., Mi, J., Li, P., Wang, X., Wang, L., & Wu, X. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.01438-22 · Cited by 10

Decreased IL-1 β Secretion as a Potential Predictor of Tuberculosis Recurrence in Individuals Diagnosed with HIV

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Inflammasome Activation and Function During Infection with Mycobacterium Tuberculosis

Ablasser, A., & Dorhoi, A. (2016) · Current topics in microbiology and immunology · doi:10.1007/978-3-319-41171-2_9 · Cited by 9

Subversion of mouse dendritic cell subset function by bacterial pathogens

Papadopoulos, A., & Gorvel, J. (2015) · Microbial Pathogenesis · doi:10.1016/j.micpath.2015.10.004 · Cited by 9

Divergent Functions of TLR2 on Hematopoietic and Nonhematopoietic Cells during Chronic Mycobacterium tuberculosis Infection

Konowich, J., Gopalakrishnan, A., Dietzold, J., Verma, S., Bhatt, K., Rafi, W., & Salgame, P. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1601651 · Cited by 9

Interleukin-1 receptor antagonist is a conserved factor for exacerbating tuberculosis susceptibilityPreprint

Lee, O. V., Pathak, E., Hernández-Bazán, S., Ji, D. X., Rosa, B. A., Jaye, D. L., Suliman, S., Mitreva, M., Gabay, C., Vance, R. E., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.27.564420 · Cited by 9

Cytokine and chemokine profiles in pulmonary tuberculosis with pre-diabetes

Rajamanickam, A., Kothandaraman, S. P., Kumar, N. P., Viswanathan, V., Shanmugam, S., Hissar, S. S., Nott, S., Kornfeld, H., & Babu, S. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1447161 · Cited by 10

Mycobacterium avium subsp. paratuberculosis antigens induce cellular immune responses in cattle without causing reactivity to tuberculin in the tuberculosis skin test

Gupta, S. K., Wilson, T., Maclean, P. H., Rehm, B. H. A., Heiser, A., Buddle, B. M., & Wedlock, D. N. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1087015 · Cited by 9

A TNF-IL-1 circuit controls Yersinia within intestinal pyogranulomas

Matsuda, R., Sorobetea, D., Zhang, J., Peterson, S. T., Grayczyk, J. P., Yost, W., Apenes, N., Kovalik, M. E., Herrmann, B. I., O’Neill, R. J., et al. (2024) · The Journal of Experimental Medicine · doi:10.1084/jem.20230679 · Cited by 8

Plasma LOX-Products and Monocyte Signaling Is Reduced by Adjunctive Cyclooxygenase-2 Inhibitor in a Phase I Clinical Trial of Tuberculosis Patients

Jørgensen, M. J., Nore, K. G., Aass, H. C. D., Layre, E., Nigou, J., Mortensen, R. J., Taskén, K., Kvale, D., Jenum, S., Tonby, K., et al. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.669623 · Cited by 9

Spotted Fever Group Rickettsia Trigger Species-Specific Alterations in Macrophage Proteome Signatures with Different Impacts in Host Innate Inflammatory Responses

Curto, P., Santa, C., Cortes, L., Manadas, B. J., & Simões, I. (2021) · Microbiology Spectrum · doi:10.1128/spectrum.00814-21 · Cited by 8

Cytosolic serpins act in a cytoprotective feedback loop that limits ESX-1-dependent death of Mycobacterium marinum -infected macrophages

Nobs, E., Laschanzky, K., Munke, K., Movert, E., Valfridsson, C., & Carlsson, F. (2024) · mBio · doi:10.1128/mbio.00384-24 · Cited by 7

For Better or Worse: Type I Interferon Responses in Bacterial Infection

Xia, A., Li, X., Zhao, C., Meng, X., Kari, G., & Wang, Y. (2025) · Pathogens · doi:10.3390/pathogens14030229 · Cited by 7

Cytotoxic granules and effector molecules from immune cells in tuberculosis: Mechanisms of host defense and therapeutic potential

Qin, Y., Xu, J., Wang, Q., & Shi, J. (2025) · Virulence · doi:10.1080/21505594.2025.2542466 · Cited by 9

A protective role for type I interferon signaling following infection with Mycobacterium tuberculosis carrying the rifampicin drug resistance-conferring RpoB mutation H445Y

Bobba, S., Chauhan, K. S., Akter, S., Das, S., Mittal, E., Mathema, B., Philips, J. A., & Khader, S. A. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1012137 · Cited by 7

Filarial Coinfection Is Associated With Higher Bacterial Burdens and Altered Plasma Cytokine and Chemokine Responses in Tuberculous Lymphadenitis

Kathamuthu, G. R., Munisankar, S., Banurekha, V. V., Nair, D., Sridhar, R., & Babu, S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00706 · Cited by 7

High Lethality of Mycobacterium tuberculosis Infection in Mice Lacking the Phagocyte Oxidase and Caspase1/11

Thomas, S. M., & Olive, A. J. (2023) · Infection and Immunity · doi:10.1128/iai.00060-23 · Cited by 6

Dichotomous roles of RIPK3 in regulating the IFN response and NLRP3 inflammasome in human monocytes

Yang, C., Yuan, R., Brauner, C., Du, Y., Kioon, M. D. A., Barrat, F. J., & Ivashkiv, L. B. (2023) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiad095 · Cited by 7

Gr1int/high Cells Dominate the Early Phagocyte Response to Mycobacterial Lung Infection in Mice

Ryder, B. M., Sandford, S., Manners, K. M., Dalton, J. P., Wiles, S., & Kirman, J. R. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00402 · Cited by 7

Clinical isolates of Mycobacterium tuberculosis with different genotypes exhibit distinct host macrophage responses in vitro

Liang, C., Li, X., Li, Q., Zhang, X., Ren, W., Yao, C., Pang, Y., Liu, Y., Li, C., & Tang, S. (2022) · Journal of Medical Microbiology · doi:10.1099/jmm.0.001604 · Cited by 6

Type I Interferon and Interleukin-1 Driven Inflammatory Pathways as Targets for HDT in Tuberculosis

Mayer-Barber, K. D., & Sassetti, C. M. (2020) · Springer eBooks · doi:10.1007/978-3-030-56905-1_14 · Cited by 6

Mycobacterium tuberculosis carrying the rifampicin drug-resistance-conferring rpoB mutation H445Y is associated with suppressed immunity through type I interferons

Bobba, S., Howard, N. C., Das, S., Ahmed, M., Tang, L., Thirunavukkarasu, S., Larsen, M. H., Mathema, B., Divangahi, M., & Khader, S. A. (2023) · mBio · doi:10.1128/mbio.00946-23 · Cited by 6

The Cyclooxygenase 2 Inhibitor Etoricoxib as Adjunctive Therapy in Tuberculosis Impairs Macrophage Control of Mycobacterial Growth

Nore, K. G., Louet, C., Bugge, M., Gidon, A., Jørgensen, M. J., Jenum, S., Dyrhol‐Riise, A. M., Tonby, K., & Flo, T. H. (2023) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiad390 · Cited by 6

Targeted Gene Expression Profiling of Human Myeloid Cells From Blood and Lung Compartments of Patients With Tuberculosis and Other Lung Diseases

Kotzé, L. A., van der Spuy, G. D., Leonard, B., Penn‐Nicholson, A., Musvosvi, M., McAnda, S., Malherbe, S. T., Erasmus, M., Scriba, T. J., Koegelenberg, C. F. N., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.839747 · Cited by 6

Pleural fluid mononuclear cells (PFMCs) from tuberculous pleurisy can migrate in vitro in response to CXCL10

Wu, C. Y., Ma, J., Xu, Y., Zhang, X., Lao, S., & Yang, B. (2013) · Tuberculosis · doi:10.1016/j.tube.2013.10.008 · Cited by 6

Interferon α and β induce differential transcriptional and functional metabolic phenotypes in human macrophages and blunt glycolysis in response to antigenic stimuli

Leisching, G. R., Yennemadi, A. S., Gogan, K. M., & Keane, J. (2024) · European Journal of Immunology · doi:10.1002/eji.202451032 · Cited by 5

Differential requirement of formyl peptide receptor 1 in macrophages and neutrophils in the host defense against Mycobacterium tuberculosis Infection

Nafiz, T. N., Sankar, P., MISHRA, L., Rousseau, R. P., Saqib, M., Subbian, S., Parihar, S. P., & Mishra, B. B. (2024) · Scientific Reports · doi:10.1038/s41598-024-71180-1 · Cited by 5

Alveolar epithelial cells shape lipopolysaccharide‐induced inflammatory responses and reprogramming of alveolar macrophages

Jiang, W., Chen, Y., Yu, C., Zou, B., Lu, Y., Yang, Q., Tang, Z., Mao, W., Li, J., Han, H., et al. (2024) · European Journal of Immunology · doi:10.1002/eji.202350378 · Cited by 5

Vaccination Strategies Against Mycobacterium tuberculosis: BCG and Beyond

Ferluga, J., Yasmin, H., Bhakta, S., & Kishore, U. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-67452-6_10 · Cited by 5

Epidemiological and genetic aspects of pulmonary tuberculosis in Kazakhstan

Yerezhepov, D., Gabdulkayum, A., Akhmetova, A., Abilova, Z., Rakhimova, S., Kairov, U., Akilzhanova, A. R., & Kozhamkulov, U. A. (2024) · Journal of Infection and Public Health · doi:10.1016/j.jiph.2024.102540 · Cited by 5

Inflammasomes and Obesity

Deng, T., Cui, J., Lyon, C. J., Zhang, N., Wang, H. Y., Wang, R., & Hsueh, W. A. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6819-6_2 · Cited by 5

IL-1R1-Dependent Signals Improve Control of Cytosolic Virulent Mycobacteria In Vivo

van der Niet, S., van Zon, M., de Punder, K., Grootemaat, A. E., Rutten, S., Moorlag, S. J. C. F. M., Houben, D., van der Sar, A. M., Bitter, W., Brosch, R., et al. (2021) · mSphere · doi:10.1128/msphere.00153-21 · Cited by 5

Immunität gegen Mycobacterium tuberculosis

Nowag, A., & Hartmann, P. (2016) · Der Internist · doi:10.1007/s00108-015-0016-4 · Cited by 5

Systematic deconstruction of myeloid cell signaling in tuberculosis granulomas reveals IFN-γ, TGF-β, and time are associated with conserved myeloid diversityPreprint

Peters, J. M., Gideon, H. P., Hughes, T. K., Gunnarsson, C., Maiello, P. A., Mugahid, D., Nyquist, S. K., Bromley, J. D., Blainey, P. C., Junecko, B. A. F., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.24.595747 · Cited by 4

NLRP3 mediates trophoblastic inflammasome activation and protects against Listeria monocytogenes infection during pregnancy

Gao, Y., Zhou, M., Zhang, W., Jiang, J., Ouyang, Z., Zhu, Y., & Li, N. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-4120 · Cited by 4

Salmonella Typhimurium infection inhibits macrophage IFNβ signaling in a TLR4-dependent manner

Shuster, M., Lyu, Z., Augenstreich, J., Mathur, S., Ganesh, A., Ling, J., & Briken, V. (2024) · Infection and Immunity · doi:10.1128/iai.00098-24 · Cited by 4

Working in negative space: Type I interferon mediated immuno-modulation through transcriptional suppression in disease and homeostasis

Hoffmann, G. B., & Perkins, D. J. (2025) · Innate Immunity · doi:10.1177/17534259251367263 · Cited by 4

Type I interferons and Mycobacterium tuberculosis whole cell lysate induce distinct transcriptional responses in M. tuberculosis infection

Mutua, F., Su, R., Mesa, C., Lopez, C., Ball, T. B., & Kiazyk, S. A. K. (2023) · Tuberculosis · doi:10.1016/j.tube.2023.102409 · Cited by 4

MDA5 signaling induces type 1 IFN- and IL-1-dependent lung vascular permeability which protects mice from opportunistic fungal infection

Davis, M. J., Martin, R. E., Pinheiro, G. M., Hoke, E. S., Moyer, S., Mayer-Barber, K. D., Chang, Y. C., & Kwon-Chung, K. J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.931194 · Cited by 4

Single-cell analysis reveals an important role of CD137L+ macrophages in the host response to uropathogenic Escherichia coli infection in the bladder

Liu, Y., Yang, Z., Xiang, Y., Cheng, G., Chen, L., Wang, S., Zang, M., Zhou, N., Zhang, X., Chen, R., et al. (2025) · PLoS Pathogens · doi:10.1371/journal.ppat.1013543 · Cited by 3

B cells and iBALT in TB immunity & pathogenesis

Dutt, T. S., Krause, R. G. E., Hertz, D., Henao-Tamayo, M. I., Leslie, A. J., & Schneider, B. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1743572 · Cited by 3

Alveolar macrophages shape tuberculosis susceptibility by delaying protective immunity

Micheli, C., Oliveira, A. R. G., Millan, B., Cardoso, M. S., Araújo, M. R., Duarte‐Oliveira, C., Mendes‐Frias, A., Silvestre, R., Cunha, C., Carvalho, A., et al. (2026) · Mucosal Immunology · doi:10.1016/j.mucimm.2026.02.006 · Cited by 4

Mycobacterium tuberculosis Rv3435c regulates inflammatory cytokines and promotes the intracellular survival of recombinant Mycobacteria

Zhao, D., Song, Y.-H., Li, D., Zhang, R., Xu, J., Shi, K., Li, J., Leng, X., Zong, Y., Zeng, F.-L., et al. (2023) · Acta Tropica · doi:10.1016/j.actatropica.2023.106974 · Cited by 3

Identification of SP110 in horse (Equus caballus): Isolation of novel splice variants and evidence of activation effects on macrophages

Chen, Q., Tong, Q., Ge, H., Li, W., Liu, J., Wang, Y., Guo, Z., Quan, F., & Zhang, Y. (2016) · Tuberculosis · doi:10.1016/j.tube.2016.08.007 · Cited by 3

Immunoregulatory macrophages induced by mycobacterial nonpolar lipids

Petrilli, J. D., Estevão, P., Araújo, L. E. D., Müller, I., Yoshinaga, M. Y., Ramos, P. I. P., Chaves‐Filho, A. B., Horta, T., Sorgi, C. A., Miyamoto, S., et al. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkae058 · Cited by 2

Transcriptomic insights into Mycobacterium orygis infection-associated pulmonary granulomas reveal multicellular immune networks and tuberculosis biomarkers in cattle

Kumar, R., Gandham, S., Bhaskar, V., Praharaj, M. R., Maity, H. K., Sarkar, U., & Dey, B. (2025) · Veterinary Quarterly · doi:10.1080/01652176.2025.2509503 · Cited by 2

Drugs Used in the Treatment of Viral Infections for the Prevention of Airway Remodeling in Asthma

Wieczfińska, J., & Pawliczak, R. (2025) · Mediators of Inflammation · doi:10.1155/mi/5526526 · Cited by 2

Type I interferons in bacterial diseases: myeloid cells at the crossroads of protection and pathology

Lyadova, I. V. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1717370 · Cited by 2

From Cytokines to Tuberculosis and Back: My Journey to Understanding the Immune Response to Infection

O’Garra, A. (2025) · Annual Review of Immunology · doi:10.1146/annurev-immunol-010824-041601 · Cited by 2

CHARACTERISTICS OF IMMUNOREACTIVITY IN PATIENTS WITH VARIOUS FORMS OF DIABETIC FOOT ULCER

Mykhaylichenko, V., Kaibov, I., Bondarenko, N., Parshin, D., & Пучкина, Г. (2022) · Archiv Euromedica · doi:10.35630/2199-885x/2022/12/3.17 · Cited by 2

Mycobacterium tuberculosis inhibits autocrine type I interferon signaling to increase intracellular survivalPreprint

Banks, D. A., Ahlbrand, S. E., Hughitt, V. K., Shah, S., Vogel, S. N., El-Sayed, N. M., & Briken, V. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/425116 · Cited by 2

Evaluation of IL-1 blockade as an adjunct to linezolid therapy for tuberculosis in mice and macaquesPreprint

Winchell, C. G., Mishra, B. B., Phuah, J. Y., Saqib, M., Nelson, S. J., Maiello, P. A., Causgrove, C. M., Ameel, C. L., Stein, B., Borish, H. J., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/792390 · Cited by 1

Inflammasome activation dictates the efficacy of antimycobacterial activity of frontline TB drugsPreprint

Rao, V., Singh, A., Bisht, K., Yadav, N., & Nanda, R. K. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.02.646750 · Cited by 2

Type I interferon responses contribute to immune protection against mycobacterial infectionPreprint

Szydlo-Shein, A., de Estrada, B. S.-M. D., Rosenheim, J., Turner, C. T., Chandran, A., Tsaliki, E., Lipman, M. C. I., Kunst, H., Pollara, G., Elks, P. M., et al. (2025) · eLife · doi:10.7554/elife.106799.1 · Cited by 2

Lyl1-deficiency promotes inflammatory responses and increases mycobacterial burden in response to Mycobacterium tuberculosis infection in mice

Jones, S.-S., Ozturk, M., Kieswetter, N. S., Poswayo, S. K., Hazra, R., Tamgue, O., Parihar, S. P., Suzuki, H., Brombacher, F., & Guler, R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.948047 · Cited by 1

Crosstalk between interferon and interleukin-1 antiviral signaling in cancer cells: implications for immune evasion and therapeutic resistance

Gjerstorff, M. F. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1219870 · Cited by 1

Intersecting epidemics: immune dysregulation associated with HIV and tuberculosis syndemic contribute to increased risk of hypertensive disease in Sub-Saharan Africa

Letuka, P., & Zulu, M. Z. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1717609 · Cited by 1

Exposure to polyhexamethylene guanidine, a humidifier disinfectant, disrupts protective immunity and accelerates tuberculosis progression via type I IFN signaling and neutrophil influx in mice

Kim, H., Shin, Y., Choi, H., Kim, K., Kim, H., Kim, H., Lee, W., & Shin, S. J. (2025) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2025.111884 · Cited by 1

Strong, sustained type I IFN signaling acts cell intrinsically to impair IFNγ responses and cause tuberculosis susceptibility

Fattinger, S. A., Bianca, P., Chavez, R. A., Fairgrieve, M. R., Lee, O. V., Witt, K. C., Rodriguez, J. J., Turcotte, E. A., Brydon, E. C., Dhaliwal, H. S., et al. (2026) · Cell Host & Microbe · doi:10.1016/j.chom.2026.07.014 · Cited by 1

Regulation of Host Response to Mycobacteria by Type I Interferons

Stifter, S. A., Coleman, M. C., & Feng, C. G. (2014) · Springer eBooks · doi:10.1007/978-3-319-09498-4_10 · Cited by 1

Long term dietary vitamin D3 supplementation impacts both microbicidal and inflammatory responses to ex-vivo Mycobacterium bovis BCG challenge in dairy calves

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Anti-tumor Necrosis Factor-α Antagonists and Tuberculosis

Lim, R., Fisher, D. A., & Field, S. K. (2023) · Integrated science · doi:10.1007/978-3-031-15955-8_32 · Cited by 1

Investigation of the relationship between chronic hepatitis B and tuberculosis using bioinformatics and systems biology approaches

He, J., Zhou, X., Zhang, D. D., Cai, Y., Pan, H., Huang, T., & He, F. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1519216 · Cited by 1

Local Immune Responses in Tuberculosis

Iványi, J. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-415847-4.00095-1 · Cited by 1

Interferon-β controls non-tuberculous mycobacterial infection in mice

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Float Like Bacilli, STING Like a B: Type I Interferons in Tuberculosis

Ernst, J. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201712-2368ed · Cited by 1

Interleukin-1 receptor antagonist mediates type I interferon-driven susceptibility to Mycobacterium tuberculosisPreprint

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Neutrophils reprograms the bone marrow to impair T-cell immunity during tuberculosisPreprint

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