Cited by 418Tuberculosis Research and EpidemiologyImmune Response and Inflammationinterferon and immune responses

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Innate and Adaptive Interferons Suppress IL-1α and IL-1β Production by Distinct Pulmonary Myeloid Subsets during Mycobacterium tuberculosis Infection

Open access

Mayer-Barber, Katrin D., Andrade, Bruno B., Barber, Daniel L., Hieny, Sara, Feng, Carl G., Caspar, Patricia, Oland, Sandy, Gordon, Siamon, Sher, Alan·2011·Immunity

DOI 10.1016/j.immuni.2011.12.002PMC PMC3246221

Open this paper in CoChat — free account Open PDF

Abstract

Interleukin-1 (IL-1) receptor signaling is necessary for control of Mycobacterium tuberculosis (Mtb) infection, yet the role of its two ligands, IL-1α and IL-1β, and their regulation in vivo are poorly understood. Here, we showed that both IL-1α and IL-1β are critically required for host resistance and identified two multifunctional inflammatory monocyte-macrophage and DC populations that coexpressed both IL-1 species at the single-cell level in lungs of Mtb-infected mice. Moreover, we demonstrated that interferons (IFNs) played important roles in regulating IL-1 production by these cells in vivo. Type I interferons inhibited IL-1 production by both subsets whereas CD4(+) T cell-derived IFN-γ selectively suppressed monocyte-macrophages. These data provide a cellular basis for both the anti-inflammatory effects of IFNs and probacterial functions of type I IFNs during Mtb infection and reveal differential regulation of IL-1 production by distinct cell populations as an additional layer of complexity in the activity of IL-1 in vivo.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.immuni.2011.12.002

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
Biswas, S. K., & Mantovani, A. (2010) · Nature Immunology · doi:10.1038/ni.1937 · Cited by 3,840
Immunological and inflammatory functions of the interleukin-1 family
Dinarello, C. A. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132612 · Cited by 3,466
An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis
Berry, M. P. R., Graham, C. M., McNab, F. W., Xu, Z., Bloch, S. A. A., Oni, T., Wilkinson, K. A., Banchereau, R., Skinner, J., Wilkinson, R. J., et al. (2010) · Nature · doi:10.1038/nature09247 · Cited by 1,898
TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection.
Serbina, N., Salazar-Mather, T. P., Biron, C., Kuziel, W., & Pamer, E. (2003) · Immunity · doi:10.1016/s1074-7613(03)00171-7 · Cited by 1,293
Immunology of tuberculosis.
Flynn, J., & Chan, J. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.93 · Cited by 1,144
Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation
Guarda, G., Braun, M., Staehli, F., Tardivel, A., Mattmann, C., Förster, I., Farlik, M., Decker, T., Pasquier, R. D., Romero, P. J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.02.006 · Cited by 924
Type I interferon: friend or foe?
Trinchieri, G. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20101664 · Cited by 838
I mmunity to T uberculosis
North, R. J., & Jung, Y. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104635 · Cited by 677
Microbial Stimulation Fully Differentiates Monocytes to DC-SIGN/CD209+ Dendritic Cells for Immune T Cell Areas
Cheong, C., de Matos, I. G., Choi, J., Dandamudi, D. B., Shrestha, E., Longhi, M. P., Jeffrey, K. L., Anthony, R. M., Kluger, C., Nchinda, G., et al. (2010) · Cell · doi:10.1016/j.cell.2010.09.039 · Cited by 640
Virulence of a Mycobacterium tuberculosis clinical isolate in mice is determined by failure to induce Th1 type immunity and is associated with induction of IFN-α/β
Manca, C., Tsenova, L., Bergtold, A., Freeman, S. L., Tovey, M. G., Musser, J. M., Barry, C. E., Freedman, V. H., & Kaplan, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091096998 · Cited by 590
Mycobacterium tuberculosis Infects Dendritic Cells with High Frequency and Impairs Their Function In Vivo
Wolf, A. J., Linas, B. S., Trevejo-Nuñez, G., Kincaid, E., Tamura, T., Takatsu, K., & Ernst, J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.4.2509 · Cited by 558
Unravelling mononuclear phagocyte heterogeneity
Geissmann, F., Gordon, S., Hume, D. A., Mowat, A. M., & Randolph, G. J. (2010) · Nature reviews. Immunology · doi:10.1038/nri2784 · Cited by 554
Self-citation
The role of IL-10 in immune regulation during M. tuberculosis infection
Redford, P. S., Murray, P. J., & O’Garra, A. (2011) · Mucosal Immunology · doi:10.1038/mi.2011.7 · Cited by 480
Cutting Edge: Caspase-1 Independent IL-1β Production Is Critical for Host Resistance to Mycobacterium tuberculosis and Does Not Require TLR Signaling In Vivo
Mayer-Barber, K. D., Barber, D. L., Shenderov, K., White, S., Wilson, M. S., Cheever, A. W., Kugler, D. G., Hieny, S. E., Caspar, P., Núñez, G., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904189 · Cited by 472
Self-citation
Increase in TNF-α and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a)
Lowes, M. A., Chamian, F. N., Abello, M. V., Fuentes‐Duculan, J., Lin, S., Nussbaum, R., Novitskaya, I., Carbonaro, H., Cardinale, I. R., Kikuchi, T., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509736102 · Cited by 458
CCR2+ Monocyte-Derived Dendritic Cells and Exudate Macrophages Produce Influenza-Induced Pulmonary Immune Pathology and Mortality
Lin, K. L., Suzuki, Y. A., Nakano, H., Ramsburg, E. A., & Gunn, M. D. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2562 · Cited by 453
The Type I IFN Response to Infection with Mycobacterium tuberculosis Requires ESX-1-Mediated Secretion and Contributes to Pathogenesis
Stanley, S. A., Johndrow, J. E., Manzanillo, P. S., & Cox, J. S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.5.3143 · Cited by 439
Gr1+ Inflammatory Monocytes Are Required for Mucosal Resistance to the Pathogen Toxoplasma gondii
Dunay, I. R., DaMatta, R. A., Fux, B., Presti, R. M., Greco, S., Colonna, M., & Sibley, L. D. (2008) · Immunity · doi:10.1016/j.immuni.2008.05.019 · Cited by 433
IFN-γ Suppresses IL-10 Production and Synergizes with TLR2 by Regulating GSK3 and CREB/AP-1 Proteins
Hu, X., Paik, P. K., Chen, J., Yarilina, A., Kockeritz, L. K., Lu, T. T., Woodgett, J. R., & Ivashkiv, L. B. (2006) · Immunity · doi:10.1016/j.immuni.2006.02.014 · Cited by 414
IL-1 Receptor-Mediated Signal Is an Essential Component of MyD88-Dependent Innate Response to Mycobacterium tuberculosis Infection
Fremond, C., Togbe, D., Doz, E., Rose, S., Vasseur, V., Maillet, I., Jacobs, M., Ryffel, B., & Quesniaux, V. F. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.2.1178 · Cited by 339
Role of innate cytokines in mycobacterial infection
Cooper, A. M., Mayer-Barber, K. D., & Sher, A. (2011) · Mucosal Immunology · doi:10.1038/mi.2011.13 · Cited by 309
Self-citation
Caspase 1–independent activation of interleukin‐1β in neutrophil‐predominant inflammation
Gumá, M., Ronacher, L., Liu‐Bryan, R., Takai, S., Karin, M., & Corr, M. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24959 · Cited by 305
Inflammatory arthritis in caspase 1 gene–deficient mice: Contribution of proteinase 3 to caspase 1–independent production of bioactive interleukin‐1β
Joosten, L. A. B., Netea, M. G., Fantuzzi, G., Koenders, M. I., Helsen, M. M. A., Sparrer, H., Pham, C. T. N., van der Meer, J. W. M., Dinarello, C. A., & van den Berg, W. B. (2009) · Arthritis & Rheumatism · doi:10.1002/art.25006 · Cited by 304
Hypervirulent M. tuberculosis W/Beijing Strains Upregulate Type I IFNs and Increase Expression of Negative Regulators of the Jak-Stat Pathway
Manca, C., Tsenova, L., Freeman, S. L., Barczak, A. K., Tovey, M. G., Murray, P. J., Barry, C. E., & Kaplan, G. (2005) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2005.25.694 · Cited by 295
Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population
Antonelli, L. R. D. V., Rothfuchs, A. G., Gonçalves, R., Roffê, E., Cheever, A. W., Báfica, A. L. B., Salazar, A. Μ., Feng, C. G., & Sher, A. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40817 · Cited by 292
Self-citation
In Vivo IL-10 Production Reactivates Chronic Pulmonary Tuberculosis in C57BL/6 Mice
Turner, J., Juarrero, M. G., Ellis, D. L., Basaraba, R. J., Kipnis, A., Orme, I. M., & Cooper, A. M. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.11.6343 · Cited by 277
T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes
Guarda, G., Dostert, C., Staehli, F., Cabalzar, K., Castillo, R., Tardivel, A., Schneider, P., & Tschopp, J. (2009) · Nature · doi:10.1038/nature08100 · Cited by 250
Mycobacterium tuberculosis Triggers Host Type I IFN Signaling To Regulate IL-1β Production in Human Macrophages
Novikov, A., Cardone, M., Thompson, R. W., Shenderov, K., Kirschman, K. D., Mayer-Barber, K. D., Myers, T. G., Rabin, R. L., Trinchieri, G., Sher, A., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100926 · Cited by 246
Self-citation
Enhanced protection to Mycobacterium tuberculosis infection in IL‐10‐deficient mice is accompanied by early and enhanced Th1 responses in the lung
Redford, P. S., Boonstra, A., Read, S., Pitt, J. M., Graham, C. M., Stavropoulos, E., Bancroft, G. J., & O’Garra, A. (2010) · European Journal of Immunology · doi:10.1002/eji.201040433 · Cited by 239
Cutting Edge: Involvement of the Type I IFN Production and Signaling Pathway in Lipopolysaccharide-Induced IL-10 Production
Chang, E. Y., Guo, B., Doyle, S. E., & Cheng, G. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.6705 · Cited by 228
Induction of IFN-αβ enables Listeria monocytogenes to suppress macrophage activation by IFN-γ
Rayamajhi, M., Humann, J., Penheiter, K. L., Andreasen, K., & Lenz, L. L. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20091746 · Cited by 209
Tim3 binding to galectin-9 stimulates antimicrobial immunity
Jayaraman, P., Sada‐Ovalle, I., Beladi, S., Anderson, A. C., Dardalhon, V., Hotta, C., Kuchroo, V. K., & Behar, S. M. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100687 · Cited by 201
iNOS-Producing Inflammatory Dendritic Cells Constitute the Major Infected Cell Type during the Chronic Leishmania major Infection Phase of C57BL/6 Resistant Mice
Trez, C. D., Magez, S., Akira, S., Ryffel, B., Carlier, Y., & Muraille, É. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000494 · Cited by 194
Division of labor between dendritic cell subsets of the lung
GeurtsvanKessel, C. H., & Lambrecht, B. N. (2008) · Mucosal Immunology · doi:10.1038/mi.2008.39 · Cited by 186
Granuloma Formation and Host Defense in Chronic Mycobacterium tuberculosis Infection Requires PYCARD/ASC but Not NLRP3 or Caspase-1
McElvania, E., Allen, I. C., Hulseberg, P. D., Sullivan, J. T., McCann, J. R., Sándor, M., Braunstein, M., & Ting, J. P. ‐. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012320 · Cited by 159
The Detrimental Effects of IFN-α on Vasculogenesis in Lupus Are Mediated by Repression of IL-1 Pathways: Potential Role in Atherogenesis and Renal Vascular Rarefaction
Thacker, S. G., Berthier, C. C., Mattinzoli, D., Rastaldi, M. P., Kretzler, M., & Kaplan, M. J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001782 · Cited by 137
Induction of circulating IL-1 receptor antagonist by IFN treatment
Tilg, H., Mier, J. W., Vogel, W., Aulitzky, W. E., Wiedermann, C. J., Vannier, E. G., Huber, C. H., & Dinarello, C. A. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.10.4687 · Cited by 136
Origins and tissue‐context‐dependent fates of blood monocytes
Varol, C., Yona, S., & Jung, S. (2008) · Immunology and Cell Biology · doi:10.1038/icb.2008.90 · Cited by 135
Damping Excessive Inflammation and Tissue Damage in Mycobacterium tuberculosis Infection by Toll IL-1 Receptor 8/Single Ig IL-1-Related Receptor, a Negative Regulator of IL-1/TLR Signaling
Garlanda, C., Liberto, D. D., Vecchi, A., Manna, M. P. L., Buracchi, C., Caccamo, N., Salerno, A., Dieli, F., & Mantovani, A. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.5.3119 · Cited by 119
Tuberculosis Triggers a Tissue-Dependent Program of Differentiation and Acquisition of Effector Functions by Circulating Monocytes
Sköld, M., & Behar, S. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.9.6349 · Cited by 102
Regulation of interleukin‐1β by interferon‐γ is species specific, limited by suppressor of cytokine signalling 1 and influences interleukin‐17 production
Masters, S. L., Mielke, L. A., Cornish, A. L., Sutton, C. E., O’Donnell, J. A., Cengia, L. H., Roberts, A. W., Wicks, I. P., Mills, K. H. G., & Croker, B. A. (2010) · EMBO Reports · doi:10.1038/embor.2010.93 · Cited by 76
Blocking IL-1α but not IL-1β increases susceptibility to chronic Mycobacterium tuberculosis infection in mice
Guler, R., Parihar, S. P., Spohn, G., Johansen, P., Brombacher, F., & Bachmann, M. F. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.10.045 · Cited by 68
Antagonistic crosstalk between type I and II interferons and increased host susceptibility to bacterial infections
Rayamajhi, M., Humann, J., Kearney, S. J., Hill, K. K., & Lenz, L. L. (2010) · Virulence · doi:10.4161/viru.1.5.12787 · Cited by 66
T cell-derived tumour necrosis factor is essential, but not sufficient, for protection againstMycobacterium tuberculosisinfection
Saunders, B. M., Briscoe, H., & Britton, W. J. (2004) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2004.02518.x · Cited by 62
How interleukin‐1β induces gouty arthritis
Dinarello, C. A. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27663 · Cited by 59
Homeostatic Role of Interferons Conferred by Inhibition of IL-1-Mediated Inflammation and Tissue Destruction
Hu, X., Ho, H. H., Lou, O., Hidaka, C., & Ivashkiv, L. B. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.1.131 · Cited by 52
NALP3 is not necessary for early protection against experimental tuberculosis
Walter, K., Hölscher, C., Tschopp, J., & Ehlers, S. (2010) · Immunobiology · doi:10.1016/j.imbio.2010.05.015 · Cited by 47
Interferons as inhibitors of interleukin 1 induced interleukin 1 synthesis.
Schindler, R., Ghezzi, P., & Dinarello, C. (1989) · PubMed · Cited by 14

Flagged first, then by citations

Sorted by citations

Inflammasomes: mechanism of assembly, regulation and signalling
Broz, P., & Dixit, V. M. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.58 · Cited by 3,500
Regulation of type I interferon responses
Ivashkiv, L. B., & Donlin, L. T. (2013) · Nature reviews. Immunology · doi:10.1038/nri3581 · Cited by 3,442
Type I interferons in infectious disease
McNab, F., Mayer-Barber, K., Sher, A., Wack, A., & O'Garra, A. (2015) · Nature Reviews Immunology · doi:10.1038/nri3787 · Cited by 2,780
Self-citation
The Immune Response in Tuberculosis
O’Garra, A., Redford, P. S., McNab, F. W., Bloom, C. I., Wilkinson, R. J., & Berry, M. P. R. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095939 · Cited by 1,400
IL-10 Family Cytokines IL-10 and IL-22: from Basic Science to Clinical Translation
Ouyang, W., & O’Garra, A. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.020 · Cited by 1,141

See all 418

Authors: Mayer-Barber, K. D., Andrade, B. B., Barber, D. L., Hieny, S., Feng, C. G., Caspar, P., Oland, S., Gordon, S., & Sher, A.
Affiliations: National Institutes of Health (US)
University of Oxford (GB)
Corresponding author: Mayer-Barber, Katrin D.
Sher, Alan
ORCID: Mayer-Barber, Katrin D.
Andrade, Bruno B.
Barber, Daniel L.
Feng, Carl G.
Gordon, Siamon
Sher, Alan
Venue: Immunity
Publisher: Elsevier BV
Published: 2011-12
Volume: 35
Issue: 6
Pages: 1023-1034
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2011.12.002
PMC: PMC3246221
OpenAlex: W2023478821
Cited by: 418
References: 48
Citations by year: 2026: 16 · 2025: 26 · 2024: 25 · 2023: 31 · 2022: 33 · 2021: 18 · 2020: 27 · 2019: 31 · 2018: 23 · 2017: 31 · 2016: 38 · 2015: 37 · 2014: 31 · 2013: 37 · 2012: 14
FWCI: 17.77
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 594 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (Z99 AI999999)
National Cancer Institute
National Institute of Allergy and Infectious Diseases (Y99 AI999999)
Topics: Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Keywords: Mycobacterium tuberculosis infection, interleukin-1 alpha, IL-1β, type I interferon, innate immunity, adaptive immunity, monocytes/macrophages, dendritic cells, host resistance, IL-1 signaling, single-cell analysis
MeSH terms: Animals, Antigens, Ly, Dendritic Cells, Humans, Interferons, Lung, Mice, Inbred C57BL, Mycobacterium tuberculosis, Phagocytes, Tuberculosis, Pulmonary, Signal Transduction, CD4-Positive T-Lymphocytes, Mice, Knockout, Myeloid Cells, CD11b Antigen, Mice, Interleukin-1alpha, Interleukin-1beta, Interleukin-12 Subunit p40

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Innate and Adaptive Interferons Suppress IL-1α and IL-1β Production by Distinct Pulmonary Myeloid Subsets during Mycobacterium tuberculosis Infection

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks