The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Innate and Adaptive Interferons Suppress IL-1α and IL-1β Production by Distinct Pulmonary Myeloid Subsets during Mycobacterium tuberculosis Infection
Open accessAbstract
Interleukin-1 (IL-1) receptor signaling is necessary for control of Mycobacterium tuberculosis (Mtb) infection, yet the role of its two ligands, IL-1α and IL-1β, and their regulation in vivo are poorly understood. Here, we showed that both IL-1α and IL-1β are critically required for host resistance and identified two multifunctional inflammatory monocyte-macrophage and DC populations that coexpressed both IL-1 species at the single-cell level in lungs of Mtb-infected mice. Moreover, we demonstrated that interferons (IFNs) played important roles in regulating IL-1 production by these cells in vivo. Type I interferons inhibited IL-1 production by both subsets whereas CD4(+) T cell-derived IFN-γ selectively suppressed monocyte-macrophages. These data provide a cellular basis for both the anti-inflammatory effects of IFNs and probacterial functions of type I IFNs during Mtb infection and reveal differential regulation of IL-1 production by distinct cell populations as an additional layer of complexity in the activity of IL-1 in vivo.
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“IL-1β is massively induced upon infection of macrophages with M. tuberculosis, and it appears to play important roles in anti-mycobacterial immune defenses because knockout mice are more susceptible to this infection (98)”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [98]
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Cites
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
Biswas, S. K., & Mantovani, A. (2010) · Nature Immunology · doi:10.1038/ni.1937 · Cited by 3,840
Immunological and inflammatory functions of the interleukin-1 family
Dinarello, C. A. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132612 · Cited by 3,466
An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis
Berry, M. P. R., Graham, C. M., McNab, F. W., Xu, Z., Bloch, S. A. A., Oni, T., Wilkinson, K. A., Banchereau, R., Skinner, J., Wilkinson, R. J., et al. (2010) · Nature · doi:10.1038/nature09247 · Cited by 1,898
TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection.
Serbina, N., Salazar-Mather, T. P., Biron, C., Kuziel, W., & Pamer, E. (2003) · Immunity · doi:10.1016/s1074-7613(03)00171-7 · Cited by 1,293
Flynn, J., & Chan, J. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.93 · Cited by 1,144
Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation
Guarda, G., Braun, M., Staehli, F., Tardivel, A., Mattmann, C., Förster, I., Farlik, M., Decker, T., Pasquier, R. D., Romero, P. J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.02.006 · Cited by 924
Type I interferon: friend or foe?
Trinchieri, G. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20101664 · Cited by 838
North, R. J., & Jung, Y. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104635 · Cited by 677
Cheong, C., de Matos, I. G., Choi, J., Dandamudi, D. B., Shrestha, E., Longhi, M. P., Jeffrey, K. L., Anthony, R. M., Kluger, C., Nchinda, G., et al. (2010) · Cell · doi:10.1016/j.cell.2010.09.039 · Cited by 640
Manca, C., Tsenova, L., Bergtold, A., Freeman, S. L., Tovey, M. G., Musser, J. M., Barry, C. E., Freedman, V. H., & Kaplan, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091096998 · Cited by 590
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Inflammasomes: mechanism of assembly, regulation and signalling
Broz, P., & Dixit, V. M. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.58 · Cited by 3,500
Regulation of type I interferon responses
Ivashkiv, L. B., & Donlin, L. T. (2013) · Nature reviews. Immunology · doi:10.1038/nri3581 · Cited by 3,442
Type I interferons in infectious disease
McNab, F., Mayer-Barber, K., Sher, A., Wack, A., & O'Garra, A. (2015) · Nature Reviews Immunology · doi:10.1038/nri3787 · Cited by 2,780
Self-citationThe Immune Response in Tuberculosis
O’Garra, A., Redford, P. S., McNab, F. W., Bloom, C. I., Wilkinson, R. J., & Berry, M. P. R. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095939 · Cited by 1,400
IL-10 Family Cytokines IL-10 and IL-22: from Basic Science to Clinical Translation
Ouyang, W., & O’Garra, A. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.020 · Cited by 1,141
Metadata
- Authors
- Mayer-Barber, K. D., Andrade, B. B., Barber, D. L., Hieny, S., Feng, C. G., Caspar, P., Oland, S., Gordon, S., & Sher, A.
- Affiliations
- National Institutes of Health (US)
- University of Oxford (GB)
- Corresponding author
- Mayer-Barber, Katrin D.
- Sher, Alan
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 35
- Issue
- 6
- Pages
- 1023-1034
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC3246221
- OpenAlex
- W2023478821
- Cited by
- 418
- References
- 48
- Citations by year
- 2026: 16 · 2025: 26 · 2024: 25 · 2023: 31 · 2022: 33 · 2021: 18 · 2020: 27 · 2019: 31 · 2018: 23 · 2017: 31 · 2016: 38 · 2015: 37 · 2014: 31 · 2013: 37 · 2012: 14
- FWCI
- 17.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99 AI999999)
- National Cancer Institute
- National Institute of Allergy and Infectious Diseases (Y99 AI999999)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Keywords
- Mycobacterium tuberculosis infection, interleukin-1 alpha, IL-1β, type I interferon, innate immunity, adaptive immunity, monocytes/macrophages, dendritic cells, host resistance, IL-1 signaling, single-cell analysis
- MeSH terms
- Animals, Antigens, Ly, Dendritic Cells, Humans, Interferons, Lung, Mice, Inbred C57BL, Mycobacterium tuberculosis, Phagocytes, Tuberculosis, Pulmonary, Signal Transduction, CD4-Positive T-Lymphocytes, Mice, Knockout, Myeloid Cells, CD11b Antigen, Mice, Interleukin-1alpha, Interleukin-1beta, Interleukin-12 Subunit p40
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