The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4 + T Cells
Open accessAbstract
Critical Mediators: Helper T cells are the immune system's ringmasters, having a multiplicity of functions that mediate the body's immune responses to infections. Depending on the type of infection, CD4 + helper T cells respond by secreting specific patterns of cytokines, which provide important cues to other subsets of immune cells. CD4 + T cells with distinct cytokine profiles have been viewed classically as separate lineages; however, there is mounting evidence that these cells may not be terminally differentiated but are in fact quite plastic. O'Shea and Paul (p. 1098 ) review the current understanding of CD4 + T cell subset differentiation and the underlying mechanisms that drive cell-lineage commitment.
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Metadata
- Authors
- O’Shea, J. J., & Paul, W. E.
- Venue
- Science
- Published
- 2010-02-26
- Volume
- 327
- Issue
- 5969
- Pages
- 1098-1102
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2052998574
- Cited by
- 1,336
- References
- 10
- FWCI
- 44.61
- Type
- journal article
- Language
- en
- Open access
- green
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