The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes
Open accessAbstract
Despite accumulating evidence suggesting local self-maintenance of tissue macrophages in the steady state, the dogma remains that tissue macrophages derive from monocytes. Using parabiosis and fate-mapping approaches, we confirmed that monocytes do not show significant contribution to tissue macrophages in the steady state. Similarly, we found that after depletion of lung macrophages, the majority of repopulation occurred by stochastic cellular proliferation in situ in a macrophage colony-stimulating factor (M-Csf)- and granulocyte macrophage (GM)-CSF-dependent manner but independently of interleukin-4. We also found that after bone marrow transplantation, host macrophages retained the capacity to expand when the development of donor macrophages was compromised. Expansion of host macrophages was functional and prevented the development of alveolar proteinosis in mice transplanted with GM-Csf-receptor-deficient progenitors. Collectively, these results indicate that tissue-resident macrophages and circulating monocytes should be classified as mononuclear phagocyte lineages that are independently maintained in the steady state.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Our findings are consistent with reports that macrophage progenitors develop from the primitive ectoderm of the yolk sac4 and give rise to tissue macrophages that do not have a monocytic progenitor16,17.”
From Identification of a unique TGF-β–dependent molecular and functional signature in microglia (2014) · cites this paper as [16]
In the citing paper
“In addition, the normal arterial intima of mice and humans, like any tissue of the mammalian body, contains tissue-resident macrophages, which arise from embryonic precursors and from bone-marrow-derived circulating monocytes immediately after birth144.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [144]
In the citing paper
“These macrophages self-renew and fulfil homeostatic and physiological functions in the tissue concerned144.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [144]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907
Protective and pathogenic functions of macrophage subsets
Murray, P. J., & Wynn, T. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3073 · Cited by 5,269
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175
Self-citationCCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
Qian, B.-Z., Li, J., Zhang, H., Kitamura, T., Zhang, J., Campion, L. R., Kaiser, E. A., Snyder, L. A., & Pollard, J. W. (2011) · Nature · doi:10.1038/nature10138 · Cited by 2,874
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578
Serbina, N. V., & Pamer, E. G. (2006) · Nature Immunology · doi:10.1038/ni1309 · Cited by 1,658
Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
Ajami, B., Bennett, J. L., Krieger, C., Tetzlaff, W., & Rossi, F. M. V. (2007) · Nature Neuroscience · doi:10.1038/nn2014 · Cited by 1,643
Inducible Gene Targeting in Mice
Kühn, R., Schwenk, F., Aguet, M., & Rajewsky, K. (1995) · Science · doi:10.1126/science.7660125 · Cited by 1,641
THE ORIGIN AND KINETICS OF MONONUCLEAR PHAGOCYTES
van Furth, R., & Cohn, Z. A. (1968) · The Journal of Experimental Medicine · doi:10.1084/jem.128.3.415 · Cited by 1,564
Jenkins, S. J., Rückerl, D., Cook, P. C., Jackson-Jones, L. H., Finkelman, F. D., van Rooijen, N., MacDonald, A. S., & Allen, J. E. (2011) · Science · doi:10.1126/science.1204351 · Cited by 1,404
Cited by
Sorted by citations
Items 701–800 of 1,007
Exploring cardiac macrophage heterogeneity in the healthy and diseased myocardium
Zaman, R., Hamidzada, H., & Epelman, S. (2021) · Current Opinion in Immunology · doi:10.1016/j.coi.2020.09.005 · Cited by 65
Monocyte-derived Alveolar Macrophages: The Dark Side of Lung Repair?
McQuattie‐Pimentel, A. C., Budinger, G. R. S., & Ballinger, M. N. (2017) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2017-0328ed · Cited by 70
Lax, S., Rayes, J., Wichaiyo, S., Haining, E. J., Lowe, K. L., Grygielska, B., Laloo, R., Flodby, P., Borok, Z., Crandall, E. D., et al. (2017) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00023.2017 · Cited by 64
“Cell populations from digested tissue were stained as previously described (18) or as stated in the text.”
The cell biology of inflammation: From common traits to remarkable immunological adaptations
Weavers, H., & Martin, P. B. (2020) · The Journal of Cell Biology · doi:10.1083/jcb.202004003 · Cited by 68
Matsuda, M., & Seki, E. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111556 · Cited by 65
Functional heterogeneity of alveolar macrophage population based on expression of CXCL2
Xu-Vanpala, S., Deerhake, M. E., Wheaton, J. D., Parker, M. E., Juvvadi, P. R., MacIver, N. J., Ciofani, M., & Shinohara, M. L. (2020) · Science Immunology · doi:10.1126/sciimmunol.aba7350 · Cited by 64
Neuroimmune interactions and osteoarthritis pain: focus on macrophages
Geraghty, T., Winter, D. R., Miller, R. J., Miller, R. E., & Malfait, A. (2021) · PAIN Reports · doi:10.1097/pr9.0000000000000892 · Cited by 67
From proliferation to proliferation: monocyte lineage comes full circle
Świrski, F. K., Hilgendorf, I., & Robbins, C. S. (2014) · Seminars in Immunopathology · doi:10.1007/s00281-013-0409-1 · Cited by 69
“macrophages relies on M-CSF- and GM-CSF and is independent of IL-4 [91], replenishing macrophages during intestinal inflammation not only depends on IL-4 but may be indepen-”
BackgroundRole of microglia in fungal infections of the central nervous system
Koutsouras, G. W., Ramos, R. L., & Martinez, L. R. (2016) · Virulence · doi:10.1080/21505594.2016.1261789 · Cited by 64
Alveolar Macrophages Drive Hepatocellular Carcinoma Lung Metastasis by Generating Leukotriene B4
Nosaka, T., Baba, T., Tanabe, Y., Sasaki, S., Nishimura, T., Imamura, Y., Yurino, H., Hashimoto, S., Arita, M., Nakamoto, Y., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1700544 · Cited by 64
Casanova-Acebes, M., Menéndez-Gutierrez, M. P., Porcuna, J., Álvarez‐Errico, D., Lavin, Y., García, A. G., Kobayashi, S., Bérichel, J. L., Núñez, V., Were, F., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15371-0 · Cited by 63
Innate Immunomodulation in Food Animals: Evidence for Trained Immunity?
Byrne, K. A., Loving, C. L., & McGill, J. L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01099 · Cited by 65
Macrophage Plasticity and Function in the Eye and Heart
Wang, Z., Koenig, A. L., Lavine, K. J., & Apte, R. S. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.07.002 · Cited by 64
Macrophages in Lupus Nephritis: Exploring a potential new therapeutic avenue
Kwant, L. E., Vegting, Y., Tsang-A-Sjoe, M. W. P., Kwakernaak, A. J., Vogt, L., Voskuyl, A. E., van Vollenhoven, R., de Winther, M. P. J., Bemelman, F. J., Anders, H., et al. (2022) · Autoimmunity Reviews · doi:10.1016/j.autrev.2022.103211 · Cited by 64
Lercher, A., Cheong, J., Bale, M. J., Jiang, C., Hoffmann, H.-H., Ashbrook, A. W., Lewy, T., Yin, Y. S., Quirk, C., DeGrace, E. J., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.08.018 · Cited by 73
Alexander, K. A., Raggatt, L. J., Millard, S. M., Batoon, L., Wu, A., Chang, M., Hume, D. A., & Pettit, A. R. (2016) · Immunology and Cell Biology · doi:10.1038/icb.2016.74 · Cited by 63
The contributions of lung macrophage and monocyte heterogeneity to influenza pathogenesis
Duan, M., Hibbs, M. L., & Chen, W. (2016) · Immunology and Cell Biology · doi:10.1038/icb.2016.97 · Cited by 64
Lung surfactant metabolism: early in life, early in disease and target in cell therapy
López-Rodríguez, E., Gay-Jordi, G., Mucci, A., Lachmann, N., & Serrano‐Mollar, A. (2016) · Cell and Tissue Research · doi:10.1007/s00441-016-2520-9 · Cited by 65
Duru, N., Wolfson, B., & Zhou, Q. Y. (2016) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v7.i4.231 · Cited by 63
Rolot, M., & Dewals, B. G. (2018) · Journal of Immunology Research · doi:10.1155/2018/2790627 · Cited by 64
Nahrendorf, W., Ivens, A. C., & Spence, P. J. (2021) · eLife · doi:10.7554/elife.63838 · Cited by 57
Macrophages in cardiac repair: Environmental cues and therapeutic strategies
de Couto, G. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0269-4 · Cited by 64
Host Recovery from Respiratory Viral Infection
Wei, X., Narasimhan, H., Zhu, B., & Sun, J. (2023) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101921-040450 · Cited by 63
Beyond vascular inflammation—recent advances in understanding atherosclerosis
Wolf, D., Zirlik, A., & Ley, K. F. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1971-6 · Cited by 62
“Also, macrophages in other locations have been shown to proliferate in response to inflammation, presumably by innate immune signaling [44], and in steady state [45].”
BackgroundBiology and function of adipose tissue macrophages, dendritic cells and B cells
Ivanov, S., Merlin, J., Lee, M. K. S., Murphy, A. J., & Guinamard, R. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.01.018 · Cited by 65
Mass, E. (2018) · International Immunology · doi:10.1093/intimm/dxy044 · Cited by 64
Central metabolic interactions of immune cells and microbes: prospects for defeating infections
Traven, A., & Naderer, T. (2019) · EMBO Reports · doi:10.15252/embr.201947995 · Cited by 60
“However, several tissue-resident phagocytes, including alveolar macrophages, are of embryonic origin and self-renew independently of the bone marrow [72].”
Bone marrow-derived Ly6C− macrophages promote ischemia-induced chronic kidney disease
Yang, Q., Wang, Y., Pei, G., Deng, X., Jiang, H., Wu, J., Zhou, C., Guo, Y., Yao, Y., Zeng, R., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1531-3 · Cited by 65
Tay, T. L., Carrier, M., & Tremblay, M. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-9913-8_6 · Cited by 61
The Multiple Facets of Iron Recycling
Slusarczyk, P., & Mleczko‐Sanecka, K. (2021) · Genes · doi:10.3390/genes12091364 · Cited by 64
“The ResMφs of embryonic origin are proposed to maintain themselves due to their long-term self-renewal capacity, akin to that of stem cells [134].”
BackgroundFunctional diversity of cardiac macrophages in health and disease
Yang, S. H., Penna, V. R., & Lavine, K. J. (2025) · Nature Reviews Cardiology · doi:10.1038/s41569-024-01109-8 · Cited by 67
Glezeva, N., Horgan, S. J., & Baugh, J. A. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.10.029 · Cited by 62
Sauter, K. A. D., Pridans, C., Sehgal, A., Bain, C. C., Scott, C. L., Moffat, L., Rojo, R., Stutchfield, B. M., Davies, C. L., Donaldson, D. S., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105429 · Cited by 59
Redefining Myeloid Cell Subsets in Murine Spleen
Hey, Y. Y., Tan, J. K. H., & O'Neill, H. C. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00652 · Cited by 69
Smith, J. N. P., Kanwar, V. S., & MacNamara, K. C. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00330 · Cited by 62
Lafuse, W. P., Rajaram, M. V. S., Wu, Q., Moliva, J. I., Torrelles, J. B., Turner, J., & Schlesinger, L. S. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900495 · Cited by 61
Interactions between macrophages and helminths
Coakley, G., & Harris, N. L. (2020) · Parasite Immunology · doi:10.1111/pim.12717 · Cited by 59
Mariano, L. L., Rousseau, M., Varet, H., Legendre, R., Gentek, R., Coronilla, J. S., Bajénoff, M., Perdiguero, E. G., & Ingersoll, M. A. (2020) · Science Advances · doi:10.1126/sciadv.abc5739 · Cited by 60
Perinatal development of innate immune topology
Henneke, P., Kierdorf, K., Hall, L. J., Sperandio, M., & Hornef, M. W. (2021) · eLife · doi:10.7554/elife.67793 · Cited by 65
Biology of resident tissue macrophages
Lee, C., & Ginhoux, F. (2022) · Development · doi:10.1242/dev.200270 · Cited by 68
Self-citationHuman inherited CCR2 deficiency underlies progressive polycystic lung disease
Neehus, A., Carey, B. C., Landekic, M., Panikulam, P., Deutsch, G. H., Ogishi, M., Arango-Franco, C. A., Philippot, Q., Modaresi, M., Mohammadzadeh, I., et al. (2023) · Cell · doi:10.1016/j.cell.2023.11.036 · Cited by 64
Use of induced pluripotent stem cells to recapitulate pulmonary alveolar proteinosis pathogenesis.
Suzuki, T., Mayhew, C., Sallese, A., Chalk, C., Carey, B., Malik, P., Wood, R., & Trapnell, B. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201306-1039oc · Cited by 56
Macrophages: Key regulators of steady-state and demand-adapted hematopoiesis
McCabe, A. F., & MacNamara, K. C. (2016) · Experimental Hematology · doi:10.1016/j.exphem.2016.01.003 · Cited by 62
“a difference in developmental origin [8, 28].”
BackgroundInfluentialPohl, J.-M., Gutweiler, S., Thiebes, S., Volke, J., Klein-Hitpass, L., Zwanziger, D., Gunzer, M., Jung, S., Agace, W., Kurts, C., et al. (2017) · Gut · doi:10.1136/gutjnl-2017-313856 · Cited by 65
“25 26 However, intestinal Ly6C – macrophages have an exceptionally short half-life of 3 weeks 27 and are constantly replaced by blood-derived Ly6C + monocytes.”
BackgroundMacrophages Orchestrate Hematopoietic Programs and Regulate HSC Function During Inflammatory Stress
Seyfried, A. N., Maloney, J., & MacNamara, K. C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01499 · Cited by 61
Interleukin-33 Signaling Controls the Development of Iron-Recycling Macrophages
Lu, Y., Basatemur, G., Scott, I. C., Chiarugi, D., Clément, M., Harrison, J. E., Jugdaohsingh, R., Yu, X., Newland, S. A., Jolin, H. E., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.03.006 · Cited by 59
Targeting monocytes/macrophages in fibrosis and cancer diseases: Therapeutic approaches
Conte, E. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.108031 · Cited by 61
Chang, J., & Tang, C. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113056 · Cited by 66
Applying nanomedicine in maladaptive inflammation and angiogenesis
Alaarg, A., Pérez‐Medina, C., Metselaar, J. M., Nahrendorf, M., Fayad, Z. A., Storm, G., & Mulder, W. J. M. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.05.009 · Cited by 60
Song, S., Wang, S., Pigott, V. M., Jiang, T., Foley, L. M., Mishra, A., Nayak, R., Zhu, W., Begum, G., Shi, Y., et al. (2018) · Glia · doi:10.1002/glia.23456 · Cited by 57
Modeling radiation-induced lung injury: lessons learned from whole thorax irradiation
Beach, T. A., Groves, A. M., Williams, J. P., & Finkelstein, J. N. (2018) · International Journal of Radiation Biology · doi:10.1080/09553002.2018.1532619 · Cited by 60
Wei, Q., Boulais, P. E., Zhang, D., Pinho, S., Tanaka, M., & Frenette, P. S. (2019) · Blood · doi:10.1182/blood-2018-11-888180 · Cited by 59
Self-citationTu, J., Hong, W., Guo, Y.-W., Zhang, P., Fang, Y., Wang, X., Chen, X., Lu, S., & Wei, W. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01146 · Cited by 59
“A series of paper suggested that tissue macrophages stem from both embryonic precursors except circulating monocytes (5, 13, 15).”
BackgroundMicroglial Responses to Brain Injury and Disease: Functional Diversity and New Opportunities
Lyu, J., Jiang, X., Leak, R. K., Shi, Y., Hu, X., & Chen, J. (2020) · Translational Stroke Research · doi:10.1007/s12975-020-00857-2 · Cited by 63
The Role of Microglia in the Homeostasis of the Central Nervous System and Neuroinflammation
Gogoleva, V. S., Drutskaya, M. S., & Атретханы, К.-С. Н. (2019) · Molecular Biology · doi:10.1134/s0026893319050054 · Cited by 61
Wang, J., Lu, S., Yang, F., Guo, Y., Chen, Z., Yu, N., Yao, L., Huang, J., Fan, W., Xu, Z., et al. (2021) · Chinese Medicine · doi:10.1186/s13020-021-00466-7 · Cited by 60
Transcriptomic analysis of mononuclear phagocyte differentiation and activation
Hume, D. A., & Freeman, T. C. (2014) · Immunological Reviews · doi:10.1111/imr.12211 · Cited by 60
Hill, A. A., Anderson‐Baucum, E. K., Kennedy, A. J., Webb, C. D., Yull, F. E., & Hasty, A. H. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.07.005 · Cited by 68
Groves, A. M., Johnston, C. J., Misra, R. S., Williams, J. P., & Finkelstein, J. N. (2015) · Radiation Research · doi:10.1667/rr14178.1 · Cited by 58
The Innate Immune Response in Myocardial Infarction, Repair, and Regeneration
Gentek, R., & Hoeffel, G. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-57613-8_12 · Cited by 58
The varying roles of macrophages in kidney injury and repair
Wen, Y., & Crowley, S. D. (2020) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000595 · Cited by 59
Targeting immunometabolism in host defence against Mycobacterium tuberculosis
Sheedy, F. J., & Divangahi, M. (2020) · Immunology · doi:10.1111/imm.13276 · Cited by 62
Tissue-Resident Macrophages in Fungal Infections
Xu, S., & Shinohara, M. L. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01798 · Cited by 57
Collin, J., Gössl, M., Matsuo, Y., Cilluffo, R. R., Flammer, A. J., Loeffler, D. L., Lennon, R. J., Simari, R. D., Spoon, D. B., Erbel, R., et al. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.11.156 · Cited by 57
“In contrary to our findings, recent studies suggest only a minor amount of tissue-resident macrophages are derived from the bone marrow [33, 34].”
ResultProliferating macrophages prevail in atherosclerosis
Randolph, G. J. (2013) · Nature Medicine · doi:10.1038/nm.3316 · Cited by 57
Wild-type macrophages reverse disease in heme oxygenase 1-deficient mice
Kovtunovych, G., Ghosh, M. C., Ollivierre, W. H., Weitzel, R. P., Eckhaus, M., Tisdale, J. F., Yachie, A., & Rouault, T. A. (2014) · Blood · doi:10.1182/blood-2014-02-554162 · Cited by 57
Alveolar macrophage development in mice requires L-plastin for cellular localization in alveoli
Todd, E. M., Zhou, J. Y., Szasz, T. P., Deady, L. E., D’Angelo, J. A., Cheung, M. D., Kim, A. H. J., & Morley, S. C. (2016) · Blood · doi:10.1182/blood-2016-03-705962 · Cited by 59
A story of birth and death: Insights into the formation and dynamics of the microglial population
Askew, K. E., & Gómez‐Nicola, D. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.03.009 · Cited by 59
Oh, M. H., Collins, S. L., Sun, I., Tam, A. J., Patel, C. H., Arwood, M. L., Chan‐Li, Y., Powell, J. D., & Horton, M. R. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.046 · Cited by 58
“Unlike monocyte-derived macrophages, ResM4s maintain their numbers by self-renewal and have unique functions in their respective tissues (Hashimoto et al., 2013; Jenkins et al., 2011).”
Ahmed, I., & Ismail, N. (2020) · Journal of Cellular Immunology · doi:10.33696/immunology.2.029 · Cited by 64
Microglia as therapeutic target in central nervous system disorders
Fatoba, O., Itokazu, T., & Yamashita, T. (2020) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2020.07.004 · Cited by 57
Macrophage-derived cytokines in pneumonia: Linking cellular immunology and genetics
Dukhinova, M., Kokinos, E. K., Kuchur, P. D., Komissarov, A., & Штро, А. А. (2020) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2020.11.003 · Cited by 59
Alveolar Macrophages: Adaptation to Their Anatomic Niche during and after Inflammation
Martin, F. P., Jacqueline, C., Poschmann, J., & Roquilly, A. (2021) · Cells · doi:10.3390/cells10102720 · Cited by 56
“The last decades swept these old dogmas away by showing that embryonic macrophages colonize the lung during the first week of life in mice [1] and are in charge of the lung tissue homeostasis [2], where a microbiota naturally dwells [3].”
BackgroundInfluentialRole of macrophages in pulmonary arterial hypertension
Zhang, M., Wang, C., Pang, X., Shi, J.-Z., Li, H., Xie, X., Wang, Z., Zhang, H., Zhou, Y., Chen, J., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1152881 · Cited by 61
CD163+ macrophages monitor enhanced permeability at the blood–dorsal root ganglion barrier
Lund, H., Hunt, M. A., Kurtović, Z., Sándor, K., Kägy, P. B., Fereydouni, N., Julien, A., Göritz, C., Vázquez-Liébanas, E., Mäe, M. A., et al. (2023) · The Journal of Experimental Medicine · doi:10.1084/jem.20230675 · Cited by 62
“5 H), which supports the well-described self-sustainability of microglia (Schulz et al., 2012; Hashimoto et al., 2013; Ajami et al., 2007; Ginhoux et al., 2010).”
BackgroundMinireview: Emerging Concepts in Islet Macrophage Biology in Type 2 Diabetes
Morris, D. L. (2015) · Molecular Endocrinology · doi:10.1210/me.2014-1393 · Cited by 57
Murphy, A. J., Dragoljevic, D., & Tall, A. R. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00490 · Cited by 57
Anthony, D., McQualter, J. L., Bishara, M., Lim, E. X., Yatmaz, S., Seow, H. J., Hansen, M. J., Thompson, M. A., Hamilton, J. A., Irving, L. B., et al. (2014) · The FASEB Journal · doi:10.1096/fj.14-250332 · Cited by 56
The force awakens: insights into the origin and formation of microglia
Tay, T. L., Hagemeyer, N., & Prinz, M. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.04.003 · Cited by 59
Modelling microglial function with induced pluripotent stem cells: an update
Pocock, J. M., & Piers, T. M. (2018) · Nature reviews. Neuroscience · doi:10.1038/s41583-018-0030-3 · Cited by 59
The metabolic axis of macrophage and immune cell polarization
Hobson-Gutierrez, S., & Carmona‐Fontaine, C. (2018) · Disease Models & Mechanisms · doi:10.1242/dmm.034462 · Cited by 57
“Most, if not all, macrophages present at birth develop from yolk-sac-derived erythro-myeloid progenitors (Box 1) (Gomez Perdiguero et al., 2015), and emerge independently of the hematopoietic process (Hashimoto et al., 2013; Yona et al., 2013).”
Exosome and Macrophage Crosstalk in Sleep-Disordered Breathing-Induced Metabolic Dysfunction
Khalyfa, A., Gozal, D., & Gozal, D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113383 · Cited by 57
Schloer, S., Hübel, N., Masemann, D., Pajonczyk, D., Brunotte, L., Ehrhardt, C., Brandenburg, L., Ludwig, S., Gerke, V., & Rescher, U. (2019) · The FASEB Journal · doi:10.1096/fj.201901265r · Cited by 56
Prospects and challenges of imaging neuroinflammation beyond TSPO in Alzheimer’s disease
Faculty, O. B. O. T. M., Boche, D., Gerhard, A., & Rodriguez-Vieitez, E. (2019) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-019-04462-w · Cited by 55
Lyadova, I. V., Gerasimova, T., & Nenasheva, T. A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.640703 · Cited by 56
Zhang, L., Jiang, Y., He, J., Chen, J., Qi, R., Yuan, L., Shao, T., Zhao, H. J., Chen, C., Chen, Y., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39560-9 · Cited by 62
Morias, Y., Abels, C., Laoui, D., Overmeire, E. V., Guilliams, M., Schouppe, E., Tacke, F., de Vries, C. J. M., BAETSELIER, P. D., & Beschin, A. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004873 · Cited by 54
The Immunophysiology of Male Reproduction
Hedger, M. P. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00019-3 · Cited by 61
Krishnan, A., Bhavanam, S., & Zochodne, D. W. (2018) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nly072 · Cited by 55
Choi, K.-Y. G., Wu, B. C., Lee, A. H., Baquir, B., & Hancock, R. E. W. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00228 · Cited by 54
STOP floxing around: Specificity and leakiness of inducible Cre/loxP systems
Stifter, S. A., & Greter, M. (2020) · European Journal of Immunology · doi:10.1002/eji.202048546 · Cited by 48
Self-citationMicroglia and Microglia-Like Cells: Similar but Different
Cuadros, M. Á., Sepúlveda, M. R., Martín‐Oliva, D., Marín‐Teva, J. L., & Neubrand, V. E. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.816439 · Cited by 57
Mujal, A. M., Combes, A. J., Rao, A. A., Binnewies, M., Samad, B., Tsui, J., Boissonnas, A., Pollack, J. L., Argüello, R. J., Meng, M. V., et al. (2022) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-21-0588 · Cited by 52
Understanding macrophage diversity at the ontogenic and transcriptomic levels
Gautier, E. L., & Yvan‐Charvet, L. (2014) · Immunological Reviews · doi:10.1111/imr.12231 · Cited by 65
Mattar, C. N. Z., Gil-Fariña, I., Rosales, C., Johana, N. B., Tan, Y., McIntosh, J., Kaeppel, C., Waddington, S. N., Biswas, A., Choolani, M. A., et al. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.04.003 · Cited by 55
Hadland, B., & Yoshimoto, M. (2017) · Experimental Hematology · doi:10.1016/j.exphem.2017.12.008 · Cited by 52
Morisse, M. C., Jouannet, S., Dominguez‐Villar, M., Sanson, M., & Idbaïh, A. (2018) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2018.1510321 · Cited by 54
Venosa, A., Katzen, J. B., Tomer, Y., Kopp, M. C., Jamil, S., Russo, S. J., Mulugeta, S., & Beers, M. F. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900039 · Cited by 53
Tissue-specific expression of IgG receptors by human macrophages ex vivo
Bruggeman, C. W., Houtzager, J., Dierdorp, B., Kers, J., Pals, S. T., Lutter, R., van Gulik, T. M., den Haan, J. M. M., van den Berg, T. K., van Bruggen, R., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0223264 · Cited by 56
“After birth, blood monocytes may indeed migrate into the tissues and differentiate into macrophages in case of inflammation [6].”
CD116+ fetal precursors migrate to the perinatal lung and give rise to human alveolar macrophages
Evren, E., Ringqvist, E. E., Doisne, J., Thaller, A., Sleiers, N., Flavell, R. A., Santo, J. P. D., & Willinger, T. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20210987 · Cited by 60
Metadata
- Authors
- Hashimoto, D., Chow, A., Noizat, C., Teo, P., Beasley, M. B., Leboeuf, M., Becker, C. D., See, P., Price, J., Lucas, D., Greter, M., Mortha, A., Boyer, S. W., Forsberg, E. C., Tanaka, M., van Rooijen, N., García-Sastre, A., Stanley, E. R., Ginhoux, F., Frenette, P. S., & Merad, M.
- Affiliations
- Tisch Cancer Institute (US)
- Albert Einstein College of Medicine (US)
- Agency for Science, Technology and Research (SG)
- Icahn School of Medicine at Mount Sinai (US)
- University of Zurich (CH)
- University of California, Santa Cruz (US)
- Tokyo University of Pharmacy and Life Sciences (JP)
- ORCID
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 38
- Issue
- 4
- Pages
- 792-804
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC3853406
- OpenAlex
- W1973433801
- Cited by
- 2,311
- References
- 49
- Citations by year
- 2026: 132 · 2025: 151 · 2024: 158 · 2023: 168 · 2022: 204 · 2021: 211 · 2020: 219 · 2019: 185 · 2018: 179 · 2017: 188 · 2016: 152 · 2015: 155 · 2014: 148 · 2013: 47
- FWCI
- 92.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- California Institute for Regenerative Medicine
- California Institute of Regenerative Medicine
- National Institutes of Health
- Japan Society for the Promotion of Science (23390095)
- National Heart, Lung, and Blood Institute (HL097700, HL069438, R01HL116340, R01HL086899, R01HL097700, F30HL099028, R01HL069438, HL116340)
- National Cancer Institute (CA154947A, R01CA173861, R01CA154947)
- National Institute of General Medical Sciences (T32GM008646)
- National Institute of Allergy and Infectious Diseases (AI 089987, U19AI089987, AI10008)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK056638, DK056638)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- tissue-resident macrophages, macrophage self-renewal, monocytes, lung macrophages, macrophage colony-stimulating factor, GM-CSF, IL-4, pulmonary alveolar proteinosis, bone marrow transplantation, parabiosis, fate mapping
- MeSH terms
- Adult, Animals, Cell Survival, Cells, Cultured, Homeostasis, Humans, Lung, Macrophages, Mice, Mutant Strains, Parabiosis, Interleukin-4, Bone Marrow Transplantation, Macrophage Colony-Stimulating Factor, Granulocyte-Macrophage Colony-Stimulating Factor, Receptors, Granulocyte-Macrophage Colony-Stimulating Factor, Mice, Knockout, Cell Proliferation, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
