STOP floxing around: Specificity and leakiness of inducible Cre/loxP systems

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

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Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

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Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

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Tissue-Resident Macrophage Ontogeny and Homeostasis

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Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF

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Origin, fate and dynamics of macrophages at central nervous system interfaces

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A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

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C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

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The mononuclear phagocyte system: a new classification of macrophages, monocytes, and their precursor cells.

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Single-cell sequencing reveals dissociation-induced gene expression in tissue subpopulations

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Cell-type-specific isolation of ribosome-associated mRNA from complex tissues

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Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages

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Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

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Sall1 is a transcriptional regulator defining microglia identity and function

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Vagaries of conditional gene targeting

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Microglia turnover with aging and in an Alzheimer’s model via long-term in vivo single-cell imaging

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Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain

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Re-evaluating microglia expression profiles using RiboTag and cell isolation strategies

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Cre‐<i>lox</i>P‐Mediated Recombination: General Principles and Experimental Considerations

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Current issues in mouse genome engineering

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Tamoxifen-independent recombination of reporter genes limits lineage tracing and mosaic analysis using CreERT2 lines

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Conditional Gene-Targeting in Mice: Problems and Solutions

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Spontaneous recombinase activity of Cre–ERT2 in vivo

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Comparative analysis of CreER transgenic mice for the study of brain macrophages: A case study

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Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice.

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Identifying the variables that drive tamoxifen‐independent CreERT2 recombination: Implications for microglial fate mapping and gene deletions

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Sall1 regulates cortical neurogenesis and laminar fate specification, implications for neural abnormalities in Townes Brocks Syndrome

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Cre-lox: Target Sensitivity Matters

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The Specificity of Conditional Gene Targeting: A Case for Cre Reporters

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Comparative analysis of CreER transgenic mice for the study of brain macrophages – a case studyPreprint

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A new genetic strategy for targeting microglia in development and disease

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Cx3Cr1-Cre induction leads to microglial activation and IFN-1 signaling caused by DNA damage in early postnatal brain

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Fusion-independent satellite cell communication to muscle fibers during load-induced hypertrophy

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Early satellite cell communication creates a permissive environment for long-term muscle growth

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Adult microglial TGFβ1 is required for microglia homeostasis via an autocrine mechanism to maintain cognitive function in mice

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The CNS mononuclear phagocyte system in health and disease

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Cell type-specific roles of NLRP3, inflammasome-dependent and -independent, in host defense, sterile necroinflammation, tissue repair, and fibrosis

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What microglia depletion approaches tell us about the role of microglia on synaptic function and behavior

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Mechanisms of astrocyte aging in reactivity and disease

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Emerging role of astrocytes in oxytocin-mediated control of neural circuits and brain functions

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Off-Target Expression of Cre-Dependent Adeno-Associated Viruses in Wild-Type C57BL/6J Mice

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Glioblastoma preclinical models: Strengths and weaknesses

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Depletion of microglial BDNF increases susceptibility to the behavioral and synaptic effects of chronic unpredictable stress

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An inducible glycogen synthase-1 knockout halts but does not reverse Lafora disease progression in mice

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Targeting osteocytes vs osteoblasts

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A vascular smooth muscle-specific integrin-α8 Cre mouse for lymphatic contraction studies that allows male-female comparisons and avoids visceral myopathy

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Systematic optimization and prediction of cre recombinase for precise genome editing in mice

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Visualizing Cathepsin K‐Cre Expression at the Single‐Cell Level with GFP Reporters

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From lignocellulosic biomass to single cell oil for sustainable biomanufacturing: Current advances and prospects

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Dopaminergic neurons are not a major Sonic hedgehog ligand source for striatal cholinergic or PV interneurons

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Fate‐mapping studies in inbred mice: A model for understanding macrophage development and homeostasis?

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Clarifying the ability of NeuroD1 to convert mouse microglia into neurons

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Modelling the ageing dependence of cancer evolutionary trajectories

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Evidence for RNA or protein transport from somatic tissues to the male reproductive tract in mouse

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A novel mouse model for an inducible gene modification in the renal thick ascending limb

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Transgenic Targeting of Fcrls Creates a Highly Efficient Constitutively Active Microglia Cre Line with Differentiated Specificity

Kaiser, T., Dattero, J., Li, L., Chen, M., Jiang, M., Harrahill, A., Butovsky, O., & Feng, G. (2024) · eNeuro · doi:10.1523/eneuro.0549-23.2024 · Cited by 7 · see citing works

Deletion of SPI1 in microglia exacerbates amyloid pathology by impairing microglial response in Alzheimer’s disease models

Kim, B., Tate, M. D., Karahan, H., Wijeratne, H. R. S., Sharify, A. D., Wang, S. S., Kim, J. R., Al-Amin, M. M., Hartigan, K., Chung, S., et al. (2026) · Neuron · doi:10.1016/j.neuron.2026.03.011 · Cited by 6 · see citing works

Mouse Models to Study Peroxisomal Functions and Disorders: Overview, Caveats, and Recommendations

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Vaccination generates functional progenitor tumor-specific CD8 T cells and long-term tumor control

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An extragenital cell population contributes to urethra closure during mouse penis development

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Epiblast-derived CX3CR1+ progenitors generate cardiovascular cells during cardiogenesis

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Membrane tethering of CreER decreases uninduced cell labeling and cytotoxicity while maintaining recombination efficiency

Chen, M., Tian, X., Xu, L., Wu, R., He, H., Zhu, H., Xu, W., & Wei, C. (2022) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2022.01.022 · Cited by 3 · see citing works

Determining the optimal expression method for dual-color imaging

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Genome-Based Advances in Modeling Renal Ciliopathies and Enhancing Patient Care

Secondulfo, F., Blanco, F. D. V., Capolongo, G., Piluso, G., Nigro, V., Perna, A. F., Capasso, G., & Zacchia, M. (2025) · Kidney & Blood Pressure Research · doi:10.1159/000547131 · Cited by 2 · see citing works

Targeted Delivery of RNA-Based Therapeutics Enables Functional Analysis of Macrophage SubpopulationsPreprint

Rasmussen, R. K., Gudbergsson, J. M., Mathiesen, H., Strauss, L. M., Holten‐Møller, I., Thomsen, M. B., Kristensen, M. W., Andersen, M. N., & Etzerodt, A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.12.642907 · Cited by 2 · see citing works

Molecular characterization of humanized APOE mouse models reveals source and genotype dependent differences

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Rôle émergent des astrocytes dans le contrôle des circuits neuronaux et des fonctions cérébrales modulés par l’ocytocine

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Large-Scale Genome-Wide Optimization and Prediction of the Cre Recombinase System for Precise Genome Manipulation in MicePreprint

Hosur, V., Erhardt, V., Hartig, E., Lorenzo, K., Megathlin, H. R., & Tarchini, B. (2024) · Research Square · doi:10.21203/rs.3.rs-4595968/v1 · Cited by 1 · see citing works

Single-cell lineage tracing identifies hemogenic endothelial cells in the adult mouse bone marrowPreprint

Feng, J., Yang, M., Li, L., Li, C. C., Livák, F., Chen, J., Zhao, Y., Wang, D., Bhandoola, A., Taylor, N. N., et al. (2026) · eLife · doi:10.7554/elife.109553 · Cited by 1 · see citing works

Single-cell lineage tracing identifies hemogenic endothelial cells in the adult mouse bone marrowPreprint

Feng, J., Yang, M., Li, L., Li, C. C., Livák, F., Chen, J., Zhao, Y., Wang, D., Bhandoola, A., Taylor, N. N., et al. (2026) · eLife · doi:10.7554/elife.109553.2 · Cited by 1 · see citing works

Retooling conditional gene expression using a floxed exon

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Modern Methods for Unraveling Cell- and Circuit-Level Mechanisms of Neurophysiological Biomarkers in Psychiatry

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Single-cell lineage tracing identifies hemogenic endothelial cells in the adult mouse bone marrow

Feng, J., Yang, M., Li, L., Li, C., Livák, F., Chen, J., Zhao, Y., Wang, D., Bhandoola, A., Taylor, N. N., et al. (2026) · eLife · doi:10.7554/elife.109553.3

A chemically inducible, leakless Cre recombinase by split-protein-based efficient and enhanced degradation (SPEED)

Cai, D., Kawano, F., Otabe, T., Hashimoto, K., & Sato, M. (2025) · Communications Biology · doi:10.1038/s42003-025-09359-z

Single-cell lineage tracing identifies hemogenic endothelial cells in the adult mouse bone marrowPreprint

Feng, J., Yang, M., Li, L., Li, C. C., Livák, F., Chen, J., Zhao, Y., Wang, D., Bhandoola, A., Taylor, N. N., et al. (2026) · eLife · doi:10.7554/elife.109553.1

Exploration of the peptidergic modulation of pain

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Engineering a Membrane‐Anchored CreER Recombinase With Reduced Basal Activity for In Vitro Recombination

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UNC5B regulates epithelial-to-mesenchymal transition through a SRC-ZEB1 signaling axis to facilitate pancreatic cancer metastasis

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Comparative analysis of CreER transgenic mice for the study of brain macrophages: A case study

Chappell‐Maor, L., Kolesnikov, M., Kim, J., Shemer, A., Haimon, Z., Grozovski, J., Boura‐Halfon, S., Masuda, T., Prinz, M., & Jung, S. (2020) · European Journal of Immunology · doi:10.1002/eji.201948342 · Cited by 70 · see citing works

Identifying the variables that drive tamoxifen‐independent CreERT2 recombination: Implications for microglial fate mapping and gene deletions

Van Hove, H., Antunes, A. R. P., De Vlaminck, K., Scheyltjens, I., Van Ginderachter, J. A., & Movahedi, K. (2020) · European Journal of Immunology · doi:10.1002/eji.201948162 · Cited by 52 · see citing works

Cre Driver Mice Targeting Macrophages

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Promoter specificity and efficacy in conditional and inducible transgenic targeting of lung macrophages

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Comparative analysis of the efficiency and specificity of myeloid-Cre deleting strains using ROSA-EYFP reporter mice

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