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The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

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Iyer, Shankar S., He, Qiong, Janczy, John R., Elliott, Eric I., Zhong, Zhenyu, Olivier, Alicia K., Sadler, Jeffrey J., Knepper-Adrian, Vickie, Han, Renzhi, Qiao, Liang, Eisenbarth, Stephanie C., Nauseef, William M., Cassel, Suzanne L., Sutterwala, Fayyaz S.·2013·Immunity
DOI 10.1016/j.immuni.2013.08.001
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Abstract

Summary Nlrp3 inflammasome activation occurs in response to numerous agonists but the specific mechanism by which this takes place remains unclear. All previously evaluated activators of the Nlrp3 inflammasome induce the generation of mitochondrial reactive oxygen species (ROS), suggesting a model in which ROS is a required upstream mediator of Nlrp3 inflammasome activation. Here we have identified the oxazolidinone antibiotic, linezolid, as a Nlrp3 agonist that activates the Nlrp3 inflammasome independently of ROS. The pathways for ROS-dependent and ROS-independent Nlrp3 activation converged upon mitochondrial dysfunction and specifically the mitochondrial lipid cardiolipin. Cardiolipin bound to Nlrp3 directly and interference with cardiolipin synthesis specifically inhibited Nlrp3 inflammasome activation. Together these data suggest that mitochondria play a critical role in the activation of the Nlrp3 inflammasome through the direct binding of Nlrp3 to cardiolipin.

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Show all 14 references

Research works printed but not linked: 41

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Metadata

Authors
Iyer, S. S., He, Q., Janczy, J. R., Elliott, E. I., Zhong, Z., Olivier, A. K., Sadler, J. J., Knepper-Adrian, V., Han, R., Qiao, L., Eisenbarth, S. C., Nauseef, W. M., Cassel, S. L., & Sutterwala, F. S.
Venue
Immunity
Publisher
Elsevier BV
Published
2013-08
Volume
39
Issue
2
Pages
311-323
ISSN
1074-7613 (ISSN-L)
DOI
10.1016/j.immuni.2013.08.001
OpenAlex
W2067406680
Cited by
931
References
14
FWCI
18.69
Type
journal article
Language
en
Open access
bronze
Licence

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CoChat. (2026). Citation check: Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation. https://app.cochat.ai/papers/10.1016/j.immuni.2013.08.001
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Iyer, S. S., He, Q., Janczy, J. R., Elliott, E. I., Zhong, Z., Olivier, A. K., Sadler, J. J., Knepper-Adrian, V., Han, R., Qiao, L., Eisenbarth, S. C., Nauseef, W. M., Cassel, S. L., & Sutterwala, F. S. (2013). Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation. Immunity. https://doi.org/10.1016/j.immuni.2013.08.001

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