The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22
Open accessAbstract
Endogenous tryptophan (Trp) metabolites have an important role in mammalian gut immune homeostasis, yet the potential contribution of Trp metabolites from resident microbiota has never been addressed experimentally. Here, we describe a metabolic pathway whereby Trp metabolites from the microbiota balance mucosal reactivity in mice. Switching from sugar to Trp as an energy source (e.g., under conditions of unrestricted Trp availability), highly adaptive lactobacilli are expanded and produce an aryl hydrocarbon receptor (AhR) ligand-indole-3-aldehyde-that contributes to AhR-dependent Il22 transcription. The resulting IL-22-dependent balanced mucosal response allows for survival of mixed microbial communities yet provides colonization resistance to the fungus Candida albicans and mucosal protection from inflammation. Thus, the microbiota-AhR axis might represent an important strategy pursued by coevolutive commensalism for fine tuning host mucosal reactivity contingent on Trp catabolism.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In Ido1−/− mice, which cannot produce the endogenous AhR ligand l-kynurenine, bacteria that are able to metabolize dietary tryptophan and produce indole derivatives gain a selective advantage due to the increased availability of tryptophan.”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Zelante et al., 2013
In the citing paper
“Indole derivatives produced by these bacteria can then compensate for the lack of endogenously produced AhR ligands, reflecting an interesting mutualistic balance between the needs of microbiome and host (Zelante et al., 2013).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Zelante et al., 2013
In the citing paper
“Activation of AhR by tryptophan metabolites promotes immune cell maturation and decreased pathogen colonization.89”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [89]
Citations
Cites
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554
Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species
Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
Wikoff, W. R., Anfora, A. T., Liu, J., Schultz, P. G., Lesley, S. A., Peters, E. C., & Siuzdak, G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812874106 · Cited by 2,677
Innate lymphoid cells — a proposal for uniform nomenclature
Spits, H., Artis, D., Colonna, M., Diefenbach, A., Disanto, J. D., Eberl, G., Koyasu, S., Locksley, R., McKenzie, A., Mebius, R., et al. (2013) · Nature reviews. Immunology · doi:10.1038/nri3365 · Cited by 2,380
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
Opitz, C. A., Litzenburger, U. M., Sahm, F., Ott, M., Tritschler, I., Trump, S., Schumacher, T., Jestaedt, L., Schrenk, D., Weller, M., et al. (2011) · Nature · doi:10.1038/nature10491 · Cited by 1,898
Romani, L. (2011) · Nature Reviews Immunology · doi:10.1038/nri2939 · Cited by 1,793
Self-citationAn Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells
Mezrich, J. D., Fechner, J. H., Zhang, X., Johnson, B. P., Burlingham, W. J., & Bradfield, C. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903670 · Cited by 1,674
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation
Hashimoto, T., Perlot, T., Rehman, A., Trichereau, J., Ishiguro, H., Paolino, M., Sigl, V., Hanada, T., Hanada, R., Lipinski, S., et al. (2012) · Nature · doi:10.1038/nature11228 · Cited by 1,271
Sobel, J. D. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60917-9 · Cited by 1,270
Cited by
Sorted by citations
Items 701–800 of 1,009
Postbiotics as the key mediators of the gut microbiota-host interactions
Ozma, M. A., Abbasi, A., Akrami, S., Lahouty, M., Shahbazi, N., Ganbarov, K., Pagliano, P., Sabahi, S., Köse, Ş., Yousefi, M., et al. (2022) · Infezioni in Medicina · doi:10.53854/liim-3002-3 · Cited by 61
Endocrine-disrupting chemicals and autoimmune diseases
Huang, R., Li, X., Wang, Y., Wu, H., Li, K.-D., Jin, X., Du, Y.-J., Wang, H., Qian, F., & Li, B. (2023) · Environmental Research · doi:10.1016/j.envres.2023.116222 · Cited by 61
Cao, C., Yue, S., Lü, A., & Liang, C. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107321 · Cited by 64
Fungal-bacterial interactions and their relevance in health
Arvanitis, M., & Mylonakis, E. E. (2015) · Cellular Microbiology · doi:10.1111/cmi.12493 · Cited by 56
Pathogen Resistance Mediated by IL-22 Signaling at the Epithelial–Microbiota Interface
Schreiber, F., Arasteh, J. M., & Lawley, T. D. (2015) · Journal of Molecular Biology · doi:10.1016/j.jmb.2015.10.013 · Cited by 57
Interactions between the microbiota and innate and innate-like lymphocytes
Constantinides, M. G. (2017) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ri0917-378r · Cited by 56
Boulé, L. A., Burke, C. G., Jin, G., & Lawrence, B. P. (2018) · Scientific Reports · doi:10.1038/s41598-018-20197-4 · Cited by 59
The causes and consequences of variation in human cytokine production in health
Schirmer, M., Kumar, V., Netea, M. G., & Xavier, R. J. (2018) · Current Opinion in Immunology · doi:10.1016/j.coi.2018.05.012 · Cited by 60
Microbiome control of innate reactivity
Chen, F., & Stappenbeck, T. S. (2019) · Current Opinion in Immunology · doi:10.1016/j.coi.2018.12.003 · Cited by 57
Ideal food pyramid for patients with rheumatoid arthritis: A narrative review
Rondanelli, M., Perdoni, F., Peroni, G., Caporali, R. F., Gasparri, C., Riva, A., Petrangolini, G., Faliva, M. A., Infantino, V., Naso, M., et al. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.08.020 · Cited by 62
Amino Acid Metabolism in Rheumatoid Arthritis: Friend or Foe?
Panfili, E., Gerli, R., Grohmann, U., & Pallotta, M. T. (2020) · Biomolecules · doi:10.3390/biom10091280 · Cited by 58
Gut Microbiota-Derived Metabolites in the Development of Diseases
Shen, G., Wu, J., Ye, B., & Qi, N. (2021) · Canadian Journal of Infectious Diseases and Medical Microbiology · doi:10.1155/2021/6658674 · Cited by 58
Li, L., Dai, Y., & Xia, Y. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114845 · Cited by 60
Gudkov, S. V., Burmistrov, D. E., Kondakova, E. V., Sarimov, R. M., Yarkov, R. S., Franceschi, C., & Vedunova, M. V. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101775 · Cited by 57
Xia, Y., Liu, C., Li, R., Zheng, M., Feng, B., Gao, J., Long, X., Li, L., Li, S., Zuo, X., et al. (2023) · iScience · doi:10.1016/j.isci.2023.108279 · Cited by 60
Urbauer, E., Aguanno, D., Mindermann, N., Omer, H., Metwaly, A., Krammel, T., Faro, T., Remke, M., Reitmeier, S., Bärthel, S., et al. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2024.06.013 · Cited by 57
What are the 100 most cited fungal genera?
Bhunjun, C. S., Chen, Y. J., Phukhamsakda, C., Boekhout, T., Groenewald, J. Z., McKenzi, E. H. C., Francisco, E. C., Frisvad, J. C., Groenewald, M., Hurdeal, V. G., et al. (2024) · Studies in Mycology · doi:10.3114/sim.2024.108.01 · Cited by 58
Zhang, Z., Zhao, J., Tian, C., Chen, X., Li, H., Wei, X., Lin, W., Zheng, N., Jiang, A., Feng, R., et al. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800941 · Cited by 56
Treatment with indigo naturalis for inflammatory bowel disease and other immune diseases
Naganuma, M. (2019) · Immunological Medicine · doi:10.1080/25785826.2019.1599158 · Cited by 56
The balance of power: innate lymphoid cells in tissue inflammation and repair
Castellanos, J. G., & Longman, R. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124617 · Cited by 57
The human gut chemical landscape predicts microbe-mediated biotransformation of foods and drugs
Guthrie, L., Wolfson, S. J., & Kelly, L. (2019) · eLife · doi:10.7554/elife.42866 · Cited by 57
Pathogenetic Impact of Bacterial–Fungal Interactions
Nogueira, F., Sharghi, S., Kuchler, K., & Lion, T. (2019) · Microorganisms · doi:10.3390/microorganisms7100459 · Cited by 62
The impact of maternal and early life malnutrition on health: a diet-microbe perspective
Forgie, A. J., Drall, K. M., Bourque, S. L., Field, C. J., Kozyrskyj, A. L., & Willing, B. P. (2020) · BMC Medicine · doi:10.1186/s12916-020-01584-z · Cited by 59
Update: Innate Lymphoid Cells in Inflammatory Bowel Disease
Luo, W., Tian, L., Tan, B., Shen, Z., Xiao, M., Wu, S., Meng, X., Wu, X., & Wang, X. (2021) · Digestive Diseases and Sciences · doi:10.1007/s10620-021-06831-8 · Cited by 56
Chen, G., Cao, Z., Shi, Z., Lei, H., Chen, C., Yuan, P., Wu, F., Liu, C., Dong, M., Song, Y., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111542 · Cited by 55
Dey, P., Chaudhuri, S. R., Efferth, T., & Pal, S. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.09.026 · Cited by 59
Önal, S., Sachadyn‐Król, M., & Kostecka, M. (2023) · Nutrients · doi:10.3390/nu15234852 · Cited by 57
Gut microbiota in regulatory T cell generation and function: mechanisms and health implications
Sharma, A., Sharma, G., & Im, S. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2516702 · Cited by 68
The Coevolution of IDO1 and AhR in the Emergence of Regulatory T-Cells in Mammals
Grohmann, U., & Puccetti, P. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00058 · Cited by 56
Self-citationThe Transcriptional Stress Response of Candida albicans to Weak Organic Acids
Cottier, F., Tan, A. S. M., Chen, J., Lum, J., Zolezzi, F., Poidinger, M., & Pavelka, N. (2015) · G3 Genes Genomes Genetics · doi:10.1534/g3.114.015941 · Cited by 57
Terra, W. R., Dias, R. O., de Oliveira, P. L., Ferreira, C., & Venâncio, T. M. (2018) · Current Opinion in Insect Science · doi:10.1016/j.cois.2018.05.015 · Cited by 56
Zhong, S., Zhou, Z., Liang, Y., Cheng, X., Li, Y., Teng, W., Zhao, M., Liu, C., Guan, M., & Zhao, C. (2019) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2019.1608905 · Cited by 56
Metabolism at the centre of the host–microbe relationship
Maslowski, K. M. (2019) · Clinical & Experimental Immunology · doi:10.1111/cei.13329 · Cited by 60
Microbial Metabolites and Intestinal Stem Cells Tune Intestinal Homeostasis
Xing, P. Y., Pettersson, S., & Kundu, P. (2020) · PROTEOMICS · doi:10.1002/pmic.201800419 · Cited by 55
Gut Microbial-Derived Metabolomics of Asthma
Lee‐Sarwar, K. A., Lasky-Su, J. A., Kelly, R. S., Litonjua, A. A., & Weiss, S. T. (2020) · Metabolites · doi:10.3390/metabo10030097 · Cited by 58
Cervicovaginal Microbiome Composition Is Associated with Metabolic Profiles in Healthy Pregnancy
Oliver, A. S., LaMere, B. J., Weihe, C., Wandro, S., Lindsay, K. L., Wadhwa, P. D., Mills, D. A., Pride, D. T., Fiehn, O., Northen, T. R., et al. (2020) · mBio · doi:10.1128/mbio.01851-20 · Cited by 56
Metabolic regulation in the immune response to cancer
Wu, Q., Yu, X., Li, J., Sun, S., & Tu, Y. (2021) · 癌症:英文版 · doi:10.1002/cac2.12182 · Cited by 57
Ferrara, J. L. M., & Chaudhry, M. S. (2018) · Blood Advances · doi:10.1182/bloodadvances.2018020214 · Cited by 55
Microbiome-intestine cross talk during acute graft-versus-host disease
Rafei, H., & Jenq, R. R. (2020) · Blood · doi:10.1182/blood.2019000950 · Cited by 59
Metabolic regulation on the immune environment of glioma through gut microbiota
Lyu, Y., Yang, H., & Liang, C. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.05.005 · Cited by 55
Microbiota-Associated Metabolites and Related Immunoregulation in Colorectal Cancer
Chen, Y., & Chen, Y. (2021) · Cancers · doi:10.3390/cancers13164054 · Cited by 54
Luo, H., Li, M., Wang, F., Yang, Y., Wang, Q. L., Zhao, Y., Du, F., Chen, Y., Shen, J., Zhao, Q., et al. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.72600 · Cited by 58
Dang, G., Wen, X., Zhong, R., Wu, W., Tang, S., Li, C., Yi, B., Chen, L., Zhang, H., & Schroyen, M. (2023) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-023-00838-z · Cited by 54
Gao, J., Yang, T., Song, B., Ma, X., Ma, Y., Lin, X., & Wang, H. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115395 · Cited by 58
The Role of the Kynurenine/AhR Pathway in Diseases Related to Metabolism and Cancer
Shadboorestan, A., Koual, M., Dairou, J., & Coumoul, X. (2023) · International Journal of Tryptophan Research · doi:10.1177/11786469231185102 · Cited by 58
Remote Sensing Between Liver and Intestine: Importance of Microbial Metabolites
Fu, Z. D., & Cui, J. Y. (2017) · Current Pharmacology Reports · doi:10.1007/s40495-017-0087-0 · Cited by 54
The Microbiota/Host Immune System Interaction in the Nose to Protect from COVID-19
Stadio, A. D., Costantini, C., Renga, G., Pariano, M., Ricci, G., & Romani, L. R. (2020) · Life · doi:10.3390/life10120345 · Cited by 55
Self-citationFrom intestinal dysbiosis to alcohol-associated liver disease
Mendes, B. G., & Schnabl, B. (2020) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2020.0086 · Cited by 57
Xie, J., Tian, S., Liu, J., Huang, S., Yang, M., Yang, X., Xu, R., Lin, J., Han, L., & Zhang, D. (2023) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2023/2894695 · Cited by 52
Kezer, G., Paramithiotis, S., Khwaldia, K., Harahap, I. A., Čagalj, M., Šimat, V., Smaoui, S., Elfalleh, W., Özoğul, F., & Esatbeyoglu, T. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1651965 · Cited by 61
Moyat, M., Bouzourène, H., Ouyang, W., Iovanna, J., Renauld, J., & Velin, D. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.38 · Cited by 55
Dynamic regulation of serum aryl hydrocarbon receptor agonists in MS
Rothhammer, V., Borucki, D. M., Sánchez, M. I. G., Mazzola, M. A., Hemond, C. C., Regev, K., Paul, A., Kivisäkk, P., Bakshi, R., Izquierdo, G., et al. (2017) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000359 · Cited by 56
Gastrointestinal host-pathogen interaction in the age of microbiome research
Tsolis, R. M., & Bäumler, A. J. (2020) · Current Opinion in Microbiology · doi:10.1016/j.mib.2020.03.002 · Cited by 56
Che, J., Shi, J., Fang, C., Zeng, X., Wu, Z., Du, Q., Tu, M., & Pan, D. (2024) · Microorganisms · doi:10.3390/microorganisms12040704 · Cited by 52
Zhao, Y., Wu, C., Zhu, Y. G., Zhou, C., Xiong, Z., Eweys, A. S., Zhou, H., Dong, Y., & Xiao, X. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109808 · Cited by 54
Mirhakkak, M. H., Schäuble, S., Klassert, T. E., Brunke, S., Brandt, P., Loos, D., Vazquez-Uribe, R., Lino, F. S. D. O., Ni, Y., Vylkova, S., et al. (2020) · The ISME Journal · doi:10.1038/s41396-020-00848-z · Cited by 54
Interleukin-22 Influences the Th1/Th17 Axis
Lindahl, H., & Olsson, T. P. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.618110 · Cited by 56
Yin, J., Song, Y., Hu, Y., Wang, Y., Zhang, B., Wang, J., Ji, X., & Wang, S. (2021) · Microorganisms · doi:10.3390/microorganisms9071511 · Cited by 52
Neonatal metabolome of caesarean section and risk of childhood asthma
Gürdeniz, G., Ernst, M., Rago, D., Kim, M. G., Courraud, J., Stokholm, J., Bønnelykke, K., Björkbom, A., Trivedi, U., Sørensen, S. J., et al. (2021) · European Respiratory Journal · doi:10.1183/13993003.02406-2021 · Cited by 54
The Gut-Brain-Immune Axis in Autism Spectrum Disorders: A State-of-Art Report
Puricelli, C., Rolla, R., Gigliotti, C. L., Boggio, E. M., Beltrami, E., Dianzani, U., & Keller, R. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.755171 · Cited by 64
Xu, H., Wang, X., Lackner, A. A., & Veazey, R. S. (2015) · The FASEB Journal · doi:10.1096/fj.15-276477 · Cited by 52
Phenotypic and Functional Plasticity of Murine Intestinal NKp46+ Group 3 Innate Lymphoid Cells
Verrier, T., Satoh‐Takayama, N., Serafini, N., Marie, S., Santo, J. P. D., & Vosshenrich, C. A. J. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502673 · Cited by 51
Environmental control of autoimmune inflammation in the central nervous system
Rothhammer, V., & Quintana, F. J. (2016) · Current Opinion in Immunology · doi:10.1016/j.coi.2016.09.002 · Cited by 52
Carpia, F. L., Wójczyk, B. S., Annavajhala, M. K., Rebbaa, A., Culp‐Hill, R., D’Alessandro, A., Freedberg, D. E., Uhlemann, A., & Hod, E. A. (2019) · npj Biofilms and Microbiomes · doi:10.1038/s41522-019-0097-2 · Cited by 54
Michaudel, C., Bataille, F., Maillet, I., Fauconnier, L., Colas, C., Sokol, H., Straube, M., Couturier-Maillard, A., Dumoutier, L., Snick, J. V., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00144 · Cited by 55
Özçam, M., Tocmo, R., Oh, J., Afrazi, A., Mezrich, J. D., Roos, S., Claesen, J., & van Pijkeren, J. (2018) · Applied and Environmental Microbiology · doi:10.1128/aem.01661-18 · Cited by 52
Tryptophan Metabolism, Regulatory T Cells, and Inflammatory Bowel Disease: A Mini Review
Ding, X., Bin, P., Wu, W., Chang, Y., & Zhu, G. (2020) · Mediators of Inflammation · doi:10.1155/2020/9706140 · Cited by 57
Huang, F., Liu, X., Xu, S., Hu, S., Wang, S., Shi, D., Wang, K., Wang, Z., Lin, Q., Li, S., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2021.805465 · Cited by 56
Li, Y., Liu, N., Ge, Y., Yang, Y., Ren, F., & Wu, Z. (2022) · European Journal of Immunology · doi:10.1002/eji.202149401 · Cited by 53
Lu, W., Qian, L., Fang, Z., Wang, H., Zhu, J., Lee, Y. K., Zhao, J., Zhang, H., & Chen, W. (2022) · Food & Function · doi:10.1039/d1fo03520g · Cited by 51
Zhao, C., Bao, L., Qiu, M., Feng, L., Chen, L., Liu, Z., Duan, S., Zhao, Y., Wu, K., Zhang, N., et al. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.00811-22 · Cited by 53
Metabolic control of innate lymphoid cells in health and disease
Zhou, L., Lin, Q., & Sonnenberg, G. F. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00685-8 · Cited by 53
Hui, Y., Zhao, J., Yu, Z., Wang, Y., Qin, Y., Zhang, Y., Xing, Y., Han, M., Wang, A., Guo, S., et al. (2023) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300218 · Cited by 53
Gut-liver axis: Pathophysiological concepts and medical perspective in chronic liver diseases
Rodrigues, S. G., der Merwe, V., Krag, A. A., & Wiest, R. (2024) · Seminars in Immunology · doi:10.1016/j.smim.2023.101859 · Cited by 51
Yang, G., Yu, J., Su, J.-H., Jiao, L.-G., Liu, X., & Zhu, Y. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00323 · Cited by 51
Role of gut microbiota in brain function and stress-related pathology
Sudo, N. (2019) · Bioscience of Microbiota Food and Health · doi:10.12938/bmfh.19-006 · Cited by 55
Dolciami, D., Ballarotto, M., Gargaro, M., Lopez-Cara, L. C., Fallarino, F., & Macchiarulo, A. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.111842 · Cited by 52
Self-citationCruel to Be Kind: Epithelial, Microbial, and Immune Cell Interactions in Gastrointestinal Cancers
Shalapour, S., & Karin, M. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-082019-081656 · Cited by 52
Pyridoxal 5′-Phosphate-Dependent Enzymes at the Crossroads of Host–Microbe Tryptophan Metabolism
Cellini, B., Zelante, T., Dindo, M., Bellet, M. M., Renga, G., Romani, L. R., & Costantini, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165823 · Cited by 54
Self-citationPeng, C., Wu, C., Xu, X., Pan, L., Lou, Z., Zhao, Y., Jiang, H., He, Z., & Ruan, B. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112638 · Cited by 51
Xiao, Y., Zhao, J., Zhang, H., Zhai, Q., & Chen, W. (2021) · Microbial Genomics · doi:10.1099/mgen.0.000581 · Cited by 54
Kovàcs, T., Mikó, E., Ujlaki, G., Yousef, H., Csontos, V., Uray, K., & Bai, P. (2021) · Cancer and Metastasis Reviews · doi:10.1007/s10555-021-10013-3 · Cited by 52
Koper, J. E. B., Troise, A. D., Loonen, L. M. P., Vitaglione, P., Capuano, E., Fogliano, V., & Wells, J. M. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c04145 · Cited by 53
Microbiota-mediated skewing of tryptophan catabolism modulates CD4+ T cells in lupus-prone mice
Brown, J., Abboud, G., Ma, L., Choi, S., Kanda, N., Zeumer-Spataro, L., Lee, J. Y. H., Peng, W., Cagmat, J. G., Faludi, T., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104241 · Cited by 50
Liu, G., Lu, J., Sun, W., Jia, G., Zhao, H. Y., Chen, X., Kim, I. H., Zhang, R., & Wang, J. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.919431 · Cited by 50
Charoensappakit, A., Sae‐khow, K., & Leelahavanichkul, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158223 · Cited by 52
Ma, M., Wang, Y., Fan, S., Huang, Y., Su, X., & Lu, C. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c00830 · Cited by 52
Gut microbial metabolism in Alzheimer's disease and related dementias
Kang, J. W., Vemuganti, V., Kuehn, J. F., Ulland, T. K., Rey, F. E., & Bendlin, B. B. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00470 · Cited by 53
Xu, H., Wang, Y., Liu, G., Zhu, Z., Shahbazi, M., Reis, R. L., Kundu, S. C., Shi, X., Zu, M., & Xiao, B. (2024) · Advanced Science · doi:10.1002/advs.202410011 · Cited by 55
Gut Microbiome Regulation of Gut Hormone Secretion
Chao, J. L., Coleman, R. A., Keating, D. J., & Martin, A. M. (2025) · Endocrinology · doi:10.1210/endocr/bqaf004 · Cited by 60
Huang, M., Ji, Q., Huang, H., Wang, X., & Wang, L. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2486519 · Cited by 53
Microbiota-derived metabolites: Key modulators of cancer immunotherapies
Perl, M., Fante, M. A., Herfeld, K., Scherer, J. N., Poeck, H., & Orberg, E. T. (2025) · Med · doi:10.1016/j.medj.2025.100773 · Cited by 57
Li, S., Heller, J. J., Bostick, J. W., Lee, A., Schjerven, H., Kastner, P., Chan, S. H., Chen, Z. E., & Zhou, L. (2016) · Immunity · doi:10.1016/j.immuni.2016.06.027 · Cited by 50
Microbial metabolites and graft versus host disease
Riwes, M. M., & Reddy, P. (2017) · American Journal of Transplantation · doi:10.1111/ajt.14443 · Cited by 52
Gut Biofactory—Neurocompetent Metabolites within the Gastrointestinal Tract. A Scoping Review
Skonieczna‐Żydecka, K., Jakubczyk, K., Maciejewska, D., Janda, K., Kaźmierczak-Siedlecka, K., Kaczmarczyk, M., Łoniewski, I., & Marlicz, W. M. (2020) · Nutrients · doi:10.3390/nu12113369 · Cited by 52
Immunomodulatory role of oral microbiota in inflammatory diseases and allergic conditions
Moreno, C. M., Boeree, E., Freitas, C. M. T., & Weber, K. S. (2023) · Frontiers in Allergy · doi:10.3389/falgy.2023.1067483 · Cited by 53
Protein Persulfidation: Recent Progress and Future Directions
Luo, S., Kong, C., Ye, D., Liu, X., Wang, Y., Meng, G., Han, Y., Xie, L., & Ji, Y. H. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0064 · Cited by 49
A cross talk between microbial metabolites and host immunity: Its relevance for allergic diseases
Losol, P., Wolska, M., Wypych, T. P., Yao, L., O’Mahony, L., & Sokołowska, M. (2024) · Clinical and Translational Allergy · doi:10.1002/clt2.12339 · Cited by 54
The microbiota drives diurnal rhythms in tryptophan metabolism in the stressed gut
Gheorghe, C. E., Leigh, S., Tofani, G. S. S., Bastiaanssen, T. F. S., Lyte, J. M., Gardellin, E., Govindan, A., Strain, C., Martínez-Herrero, S., Goodson, M. S., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114079 · Cited by 53
Angiogenesis, a key point in the association of gut microbiota and its metabolites with disease
Wang, Y., Bai, M., Peng, Q., Li, L., Tian, F., Guo, Y., & Jing, C. (2024) · European journal of medical research · doi:10.1186/s40001-024-02224-5 · Cited by 51
Metadata
- Authors
- Zelante, T., Iannitti, R. G., Cunha, C., De Luca, A., Giovannini, G., Pieraccini, G., Zecchi, R., D’Angelo, C., Massi-Benedetti, C., Fallarino, F., Carvalho, A., Puccetti, P., & Romani, L.
- Affiliations
- University of Perugia (IT)
- University of Florence (IT)
- Corresponding author
- Romani, Luigina
- ORCID
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 39
- Issue
- 2
- Pages
- 372-385
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2044216294
- Cited by
- 2,614
- References
- 56
- Citations by year
- 2026: 385 · 2025: 285 · 2024: 279 · 2023: 237 · 2022: 268 · 2021: 248 · 2020: 249 · 2019: 179 · 2018: 136 · 2017: 119 · 2016: 100 · 2015: 66 · 2014: 54 · 2013: 4
- FWCI
- 33.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Funders
- Associazione Italiana per la Ricerca sul Cancro
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- tryptophan catabolites, gut microbiota, aryl hydrocarbon receptor, indole-3-carboxaldehyde, IL-22, mucosal immunity, lactobacilli, Candida albicans, colonization resistance, commensalism, host-microbe interactions, dietary tryptophan
- MeSH terms
- Interleukin-22, Animals, Candida albicans, Candidiasis, Energy Metabolism, Female, Indoles, Interleukins, Mice, Inbred BALB C, Mice, Inbred C3H, Mice, Inbred C57BL, Tryptophan, Mice, SCID, Receptors, Aryl Hydrocarbon, Mice, Knockout, Probiotics, Interleukin-17, Gastrointestinal Tract, Indoleamine-Pyrrole 2,3,-Dioxygenase, Toll-Like Receptor 2, Mice, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins, Limosilactobacillus reuteri, Myeloid Differentiation Factor 88, Metagenome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review