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Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22
Open accessAbstract
Endogenous tryptophan (Trp) metabolites have an important role in mammalian gut immune homeostasis, yet the potential contribution of Trp metabolites from resident microbiota has never been addressed experimentally. Here, we describe a metabolic pathway whereby Trp metabolites from the microbiota balance mucosal reactivity in mice. Switching from sugar to Trp as an energy source (e.g., under conditions of unrestricted Trp availability), highly adaptive lactobacilli are expanded and produce an aryl hydrocarbon receptor (AhR) ligand-indole-3-aldehyde-that contributes to AhR-dependent Il22 transcription. The resulting IL-22-dependent balanced mucosal response allows for survival of mixed microbial communities yet provides colonization resistance to the fungus Candida albicans and mucosal protection from inflammation. Thus, the microbiota-AhR axis might represent an important strategy pursued by coevolutive commensalism for fine tuning host mucosal reactivity contingent on Trp catabolism.
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“In Ido1−/− mice, which cannot produce the endogenous AhR ligand l-kynurenine, bacteria that are able to metabolize dietary tryptophan and produce indole derivatives gain a selective advantage due to the increased availability of tryptophan.”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Zelante et al., 2013
In the citing paper
“Indole derivatives produced by these bacteria can then compensate for the lack of endogenously produced AhR ligands, reflecting an interesting mutualistic balance between the needs of microbiome and host (Zelante et al., 2013).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Zelante et al., 2013
In the citing paper
“Activation of AhR by tryptophan metabolites promotes immune cell maturation and decreased pathogen colonization.89”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [89]
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Cites
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554
Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species
Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
Wikoff, W. R., Anfora, A. T., Liu, J., Schultz, P. G., Lesley, S. A., Peters, E. C., & Siuzdak, G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812874106 · Cited by 2,677
Innate lymphoid cells — a proposal for uniform nomenclature
Spits, H., Artis, D., Colonna, M., Diefenbach, A., Disanto, J. D., Eberl, G., Koyasu, S., Locksley, R., McKenzie, A., Mebius, R., et al. (2013) · Nature reviews. Immunology · doi:10.1038/nri3365 · Cited by 2,380
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
Opitz, C. A., Litzenburger, U. M., Sahm, F., Ott, M., Tritschler, I., Trump, S., Schumacher, T., Jestaedt, L., Schrenk, D., Weller, M., et al. (2011) · Nature · doi:10.1038/nature10491 · Cited by 1,898
Romani, L. (2011) · Nature Reviews Immunology · doi:10.1038/nri2939 · Cited by 1,793
Self-citationAn Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells
Mezrich, J. D., Fechner, J. H., Zhang, X., Johnson, B. P., Burlingham, W. J., & Bradfield, C. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903670 · Cited by 1,674
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation
Hashimoto, T., Perlot, T., Rehman, A., Trichereau, J., Ishiguro, H., Paolino, M., Sigl, V., Hanada, T., Hanada, R., Lipinski, S., et al. (2012) · Nature · doi:10.1038/nature11228 · Cited by 1,271
Sobel, J. D. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60917-9 · Cited by 1,270
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Gow, N. A. R., & Netea, M. G. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0462 · Cited by 78
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Shi, Z., Lei, H., Chen, G., Yuan, P., Cao, Z., Ser, H.-L., Zhu, X., Wu, F., Liu, C., Dong, M., et al. (2021) · mSystems · doi:10.1128/msystems.00985-20 · Cited by 71
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Wang, F., Zou, J., Xu, H., Huang, W., Zhang, X., Wei, Z., Li, X., Liu, Y., Zou, J., Liu, F., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.820939 · Cited by 75
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Wei, Z., Li, F., & Pi, G. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.812596 · Cited by 80
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Metadata
- Authors
- Zelante, T., Iannitti, R. G., Cunha, C., De Luca, A., Giovannini, G., Pieraccini, G., Zecchi, R., D’Angelo, C., Massi-Benedetti, C., Fallarino, F., Carvalho, A., Puccetti, P., & Romani, L.
- Affiliations
- University of Perugia (IT)
- University of Florence (IT)
- Corresponding author
- Romani, Luigina
- ORCID
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 39
- Issue
- 2
- Pages
- 372-385
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2044216294
- Cited by
- 2,614
- References
- 56
- Citations by year
- 2026: 385 · 2025: 285 · 2024: 279 · 2023: 237 · 2022: 268 · 2021: 248 · 2020: 249 · 2019: 179 · 2018: 136 · 2017: 119 · 2016: 100 · 2015: 66 · 2014: 54 · 2013: 4
- FWCI
- 33.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Funders
- Associazione Italiana per la Ricerca sul Cancro
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- tryptophan catabolites, gut microbiota, aryl hydrocarbon receptor, indole-3-carboxaldehyde, IL-22, mucosal immunity, lactobacilli, Candida albicans, colonization resistance, commensalism, host-microbe interactions, dietary tryptophan
- MeSH terms
- Interleukin-22, Animals, Candida albicans, Candidiasis, Energy Metabolism, Female, Indoles, Interleukins, Mice, Inbred BALB C, Mice, Inbred C3H, Mice, Inbred C57BL, Tryptophan, Mice, SCID, Receptors, Aryl Hydrocarbon, Mice, Knockout, Probiotics, Interleukin-17, Gastrointestinal Tract, Indoleamine-Pyrrole 2,3,-Dioxygenase, Toll-Like Receptor 2, Mice, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins, Limosilactobacillus reuteri, Myeloid Differentiation Factor 88, Metagenome
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