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Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22
Open accessAbstract
Endogenous tryptophan (Trp) metabolites have an important role in mammalian gut immune homeostasis, yet the potential contribution of Trp metabolites from resident microbiota has never been addressed experimentally. Here, we describe a metabolic pathway whereby Trp metabolites from the microbiota balance mucosal reactivity in mice. Switching from sugar to Trp as an energy source (e.g., under conditions of unrestricted Trp availability), highly adaptive lactobacilli are expanded and produce an aryl hydrocarbon receptor (AhR) ligand-indole-3-aldehyde-that contributes to AhR-dependent Il22 transcription. The resulting IL-22-dependent balanced mucosal response allows for survival of mixed microbial communities yet provides colonization resistance to the fungus Candida albicans and mucosal protection from inflammation. Thus, the microbiota-AhR axis might represent an important strategy pursued by coevolutive commensalism for fine tuning host mucosal reactivity contingent on Trp catabolism.
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“In Ido1−/− mice, which cannot produce the endogenous AhR ligand l-kynurenine, bacteria that are able to metabolize dietary tryptophan and produce indole derivatives gain a selective advantage due to the increased availability of tryptophan.”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Zelante et al., 2013
In the citing paper
“Indole derivatives produced by these bacteria can then compensate for the lack of endogenously produced AhR ligands, reflecting an interesting mutualistic balance between the needs of microbiome and host (Zelante et al., 2013).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Zelante et al., 2013
In the citing paper
“Activation of AhR by tryptophan metabolites promotes immune cell maturation and decreased pathogen colonization.89”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [89]
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Cites
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554
Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species
Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
Wikoff, W. R., Anfora, A. T., Liu, J., Schultz, P. G., Lesley, S. A., Peters, E. C., & Siuzdak, G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812874106 · Cited by 2,677
Innate lymphoid cells — a proposal for uniform nomenclature
Spits, H., Artis, D., Colonna, M., Diefenbach, A., Disanto, J. D., Eberl, G., Koyasu, S., Locksley, R., McKenzie, A., Mebius, R., et al. (2013) · Nature reviews. Immunology · doi:10.1038/nri3365 · Cited by 2,380
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
Opitz, C. A., Litzenburger, U. M., Sahm, F., Ott, M., Tritschler, I., Trump, S., Schumacher, T., Jestaedt, L., Schrenk, D., Weller, M., et al. (2011) · Nature · doi:10.1038/nature10491 · Cited by 1,898
Romani, L. (2011) · Nature Reviews Immunology · doi:10.1038/nri2939 · Cited by 1,793
Self-citationAn Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells
Mezrich, J. D., Fechner, J. H., Zhang, X., Johnson, B. P., Burlingham, W. J., & Bradfield, C. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903670 · Cited by 1,674
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation
Hashimoto, T., Perlot, T., Rehman, A., Trichereau, J., Ishiguro, H., Paolino, M., Sigl, V., Hanada, T., Hanada, R., Lipinski, S., et al. (2012) · Nature · doi:10.1038/nature11228 · Cited by 1,271
Sobel, J. D. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60917-9 · Cited by 1,270
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Items 101–200 of 1,009
Portune, K. J., Beaumont, M., Davila, A.-M., Tomé, D., Blachier, F., & Sanz, Y. (2016) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2016.08.011 · Cited by 356
Hendrikx, T., Duan, Y., Wang, Y., Oh, J., Alexander, L. M., Huang, W. J. M., Stärkel, P., Ho, S. B., Gao, B., Fiehn, O., et al. (2018) · Gut · doi:10.1136/gutjnl-2018-317232 · Cited by 376
Microbiome-modulated metabolites at the interface of host immunity
Blacher, E., Levy, M., Tatirovsky, E., & Elinav, E. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601247 · Cited by 354
Gut Microbial Metabolites of Aromatic Amino Acids as Signals in Host–Microbe Interplay
Liu, Y., Hou, Y., Wang, G., Zheng, X., & Hao, H. (2020) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2020.02.012 · Cited by 364
Bifidobacterium mechanisms of immune modulation and tolerance
Gavzy, S. J., Kensiski, A., Lee, Z. L., Mongodin, E. F., Ma, B., & Bromberg, J. S. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2291164 · Cited by 392
Zhao, Z., Xin, F., Xue, Y., Hu, Z., Han, Y., Ma, F., Zhou, D., Liu, X., Cui, A., Liu, Z., et al. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0304-5 · Cited by 357
Interactions between Intestinal Microbiota and Host Immune Response in Inflammatory Bowel Disease
Zhang, M., Sun, K., Wu, Y., Yang, Y., Tso, P., & Wu, Z. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00942 · Cited by 347
d’Enfert, C., Kaune, A.-K., Alaban, L. R., Chakraborty, S., Cole, N. L., Delavy, M., Kosmala, D., Marsaux, B., Fróis-Martins, R., Morelli, M., et al. (2020) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaa060 · Cited by 377
(CONTAM), E. P. O. C. I. T. F. C., Knutsen, H. K., Alexander, J., Barregård, L., Bignami, M., Brüschweiler, B. J., Ceccatelli, S., Cottrill, B., Dinovi, M., Edler, L., et al. (2018) · EFSA Journal · doi:10.2903/j.efsa.2018.5333 · Cited by 378
Cancer Immunotherapy by Targeting IDO1/TDO and Their Downstream Effectors
Platten, M., Doeberitz, N. V. K., Oezen, I., Wick, W., & Ochs, K. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00673 · Cited by 348
Tryptophan (Trp) modulates gut homeostasis via aryl hydrocarbon receptor (AhR)
Sun, M., Ma, N., He, T., Johnston, L. J., & Ma, X. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1598334 · Cited by 345
The microbiome and regulation of mucosal immunity
McDermott, A. J., & Huffnagle, G. B. (2013) · Immunology · doi:10.1111/imm.12231 · Cited by 351
The Aryl Hydrocarbon Receptor: Connecting Immunity to the Microenvironment
Shinde, R. S., & McGaha, T. L. (2018) · Trends in Immunology · doi:10.1016/j.it.2018.10.010 · Cited by 340
Sassone‐Corsi, M., & Raffatellu, M. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1403169 · Cited by 346
Li, N., Wang, Q., Wang, Y., Sun, A., Lin, Y., Jin, Y., & Li, X. (2019) · Stress · doi:10.1080/10253890.2019.1617267 · Cited by 327
The mutual interplay of gut microbiota, diet and human disease
Illiano, P., Brambilla, R., & Parolini, C. (2020) · FEBS Journal · doi:10.1111/febs.15217 · Cited by 338
Crosstalk Between Gut Microbiota and Innate Immunity and Its Implication in Autoimmune Diseases
Jiao, Y., Wu, L., Huntington, N. D., & Zhang, X. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00282 · Cited by 321
Ye, L., Bae, M., Cassilly, C. D., Jabba, S. V., Thorpe, D. W., Martin, A. M., Lu, H.-Y., Wang, J., Thompson, J., Lickwar, C. R., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.11.011 · Cited by 338
The gut microbiota in obesity and weight management: microbes as friends or foe?
Hul, M. V., & Cani, P. D. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00794-0 · Cited by 353
The Intestine Harbors Functionally Distinct Homeostatic Tissue-Resident and Inflammatory Th17 Cells
Omenetti, S., Bussi, C., Metidji, A., Iseppon, A., Lee, S., Tolaini, M., Li, Y., Kelly, G., Chakravarty, P., Shoaie, S., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.05.004 · Cited by 317
Finding the Missing Links among Metabolites, Microbes, and the Host
Dorrestein, P. C., Mazmanian, S. K., & Knight, R. (2014) · Immunity · doi:10.1016/j.immuni.2014.05.015 · Cited by 317
Fong, W., Li, Q., Ji, F., Liang, W., Lau, H. C.-H., Kang, X., Liu, W., To, K. K. W., Zuo, Z., Li, X., et al. (2023) · Gut · doi:10.1136/gutjnl-2023-329543 · Cited by 329
Advancing human gut microbiota research by considering gut transit time
Procházková, N., Falony, G., Dragsted, L. O., Licht, T. R., Raes, J., & Roager, H. M. (2022) · Gut · doi:10.1136/gutjnl-2022-328166 · Cited by 349
Modulation of immune development and function by intestinal microbiota
Kabat, A. M., Srinivasan, N., & Maloy, K. J. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.07.010 · Cited by 320
Venken, K., Jacques, P., Mortier, C., Labadia, M. E., Decruy, T., Coudenys, J., Hoyt, K., Wayne, A. L., Hughes, R. O., Turner, M. S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07911-6 · Cited by 320
Ehrlich, A. M., Pacheco, A. R., Henrick, B. M., Taft, D. H., Xu, G., Huda, M. N., Mishchuk, D. O., Goodson, M. L., Slupsky, C. M., Barile, D., et al. (2020) · BMC Microbiology · doi:10.1186/s12866-020-02023-y · Cited by 326
Wang, G., Fan, Y., Zhang, G., Cai, S., Ma, Y., Yang, L., Wang, Y., Yu, H., Qiao, S., & Zeng, X. (2024) · Microbiome · doi:10.1186/s40168-024-01750-y · Cited by 325
Gut microbiota injury in allogeneic haematopoietic stem cell transplantation
Shono, Y., & van den Brink, M. R. M. (2018) · Nature reviews. Cancer · doi:10.1038/nrc.2018.10 · Cited by 320
Koh, A., & Bäckhed, F. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.03.005 · Cited by 322
Alterations of gut microbiome in autoimmune hepatitis
Wei, Y., Li, Y., Li, Y., Sun, C., Miao, Q., Wang, Q., Xiao, X., Lian, M., Li, B., Chen, Y., et al. (2019) · Gut · doi:10.1136/gutjnl-2018-317836 · Cited by 310
Metabolite-Sensing G Protein–Coupled Receptors—Facilitators of Diet-Related Immune Regulation
Tan, J. K., McKenzie, C. I., Mariño, E., Macia, L., & Mackay, C. R. (2017) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052235 · Cited by 305
Zhang, L., Nichols, R. G., Correll, J. B., Murray, I. A., Tanaka, N., Smith, P. B. W., Hubbard, T. D., Sebastian, A., Albert, I. U., Hatzakis, E., et al. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1409055 · Cited by 307
Bridging intestinal immunity and gut microbiota by metabolites
Wang, G., Huang, S., Wang, Y., Cai, S., Yu, H., Liu, H., Zeng, X., Zhang, G., & Qiao, S. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03190-6 · Cited by 305
Tryptophan in health and disease
Comai, S., Bertazzo, A., Brughera, M., & Crotti, S. (2020) · Advances in clinical chemistry · doi:10.1016/bs.acc.2019.08.005 · Cited by 306
Food, immunity, and the microbiome
Tilg, H., & Moschen, A. R. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.12.036 · Cited by 292
A review of metabolic potential of human gut microbiome in human nutrition
Yadav, M., Verma, M. K., & Chauhan, N. S. (2017) · Archives of Microbiology · doi:10.1007/s00203-017-1459-x · Cited by 295
Gut microbial metabolites in depression: understanding the biochemical mechanisms
Caspani, G., Kennedy, S. H., Foster, J. A., & Swann, J. R. (2019) · Microbial Cell · doi:10.15698/mic2019.10.693 · Cited by 289
Intestinal epithelial cells: At the interface of the microbiota and mucosal immunity
Soderholm, A. T., & Pedicord, V. A. (2019) · Immunology · doi:10.1111/imm.13117 · Cited by 281
Dual Role of Indoles Derived From Intestinal Microbiota on Human Health
Ye, X., Li, H., Anjum, K., Zhong, X., Miao, S., Zheng, G., Liu, W., & Li, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.903526 · Cited by 288
Ma, N., & Ma, X. (2018) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12401 · Cited by 285
Fang, Z., Pan, T., Li, L., Wang, H., Zhu, J., Zhang, H., Zhao, J., Chen, W., & Lu, W. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2044723 · Cited by 273
Xue, H., Chen, X., Yu, C., Deng, Y., Zhang, Y., Shen, C., Chen, X., Chen, K., Yang, Y., & Ling, W. (2022) · Circulation Research · doi:10.1161/circresaha.122.321253 · Cited by 283
The nutrition‐gut microbiome‐physiology axis and allergic diseases
McKenzie, C. I., Tan, J., Macia, L., & Mackay, C. R. (2017) · Immunological Reviews · doi:10.1111/imr.12556 · Cited by 281
The Mouse Microbiome Is Required for Sex-Specific Diurnal Rhythms of Gene Expression and Metabolism
Weger, B. D., Gobet, C., Yeung, J., Martin, E., Jimenez, S., Betrisey, B., Foata, F., Berger, B., Balvay, A., Foussier, A., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.09.023 · Cited by 269
Regulation of the Immune System by the Resident Intestinal Bacteria
Kamada, N., & Núñez, G. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.01.060 · Cited by 285
Effector T Helper Cell Subsets in Inflammatory Bowel Diseases
Imam, T., Park, S., Kaplan, M. H., & Olson, M. R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01212 · Cited by 280
Choi, S.-C., Brown, J., Gong, M., Ge, Y., Zadeh, M., Li, W., Croker, B. P., Michailidis, G., Garrett, T. J., Mohamadzadeh, M., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aax2220 · Cited by 266
The microbiome in inflammatory bowel diseases: from pathogenesis to therapy
Liu, S., Zhao, W., Lan, P., & Mou, X. (2020) · Protein & Cell · doi:10.1007/s13238-020-00745-3 · Cited by 279
The Role of Microbiota in Infant Health: From Early Life to Adulthood
Yao, Y., Cai, X. T., Ye, Y., Wang, F., Chen, F., & Zheng, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.708472 · Cited by 271
Gut Microbial Dysbiosis in the Pathogenesis of Gastrointestinal Dysmotility and Metabolic Disorders
Singh, R., Zogg, H., Wei, L., Bartlett, A., Ghoshal, U. C., Rajender, S., & Ro, S. (2020) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm20149 · Cited by 274
Metabolism impacts upon Candida immunogenicity and pathogenicity at multiple levels
Brown, A. J. P., Brown, G. D., Netea, M. G., & Gow, N. A. R. (2014) · Trends in Microbiology · doi:10.1016/j.tim.2014.07.001 · Cited by 258
Yu, J., Luo, Y., Zhu, Z., Zhou, Y., Sun, L., Gao, J., Sun, J., Wang, G., Yao, X., & Li, W. S. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.11.036 · Cited by 262
The impact of diet on asthma and allergic diseases
Julia, V., Macia, L., & Dombrowicz, D. (2015) · Nature reviews. Immunology · doi:10.1038/nri3830 · Cited by 265
Zhang, Z., Tang, H., Chen, P., Xie, H., & Tao, Y. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0074-5 · Cited by 263
Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity
Dong, F., Hao, F., Murray, I. A., Smith, P. B. W., Koo, I., Tindall, A. M., Kris‐Etherton, P. M., Gowda, K., Amin, S., Patterson, A. D., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1788899 · Cited by 252
Microbiota-mediated inflammation and antimicrobial defense in the intestine
Caballero, S., & Pamer, E. G. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120238 · Cited by 238
Prediction and quantification of bioactive microbiota metabolites in the mouse gut
Sridharan, G. V., Choi, K., Klemashevich, C. L., Wu, C., Prabakaran, D., Pan, L. B., Steinmeyer, S. H., Mueller, C., Yousofshahi, M., Alaniz, R. C., et al. (2014) · Nature Communications · doi:10.1038/ncomms6492 · Cited by 247
Microbiome-based interventions to modulate gut ecology and the immune system
Hitch, T. C. A., Hall, L. J., Walsh, S. K., Leventhal, G. E., Slack, E. M. C., de Wouters, T., Walter, J., & Clavel, T. (2022) · Mucosal Immunology · doi:10.1038/s41385-022-00564-1 · Cited by 268
Sun, J., Zhang, Y., Kong, Y., Ye, T., Yu, Q., Kumaran Satyanarayanan, S., Su, K.-P., & Liu, J. (2022) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2022.08.003 · Cited by 255
Gut Mycobiota in Immunity and Inflammatory Disease
Li, X. V., Leonardi, I., & Iliev, I. D. (2019) · Immunity · doi:10.1016/j.immuni.2019.05.023 · Cited by 246
Dehhaghi, M., Panahi, H. K. S., & Guillemin, G. J. (2019) · International Journal of Tryptophan Research · doi:10.1177/1178646919852996 · Cited by 245
Interactions Between the Gut Microbiota and the Host Innate Immune Response Against Pathogens
Cheng, H.-Y., Ning, M.-X., Chen, D.-K., & Ma, W.-T. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00607 · Cited by 244
Microbiota Metabolites in Health and Disease
McCarville, J. L., Chen, G. Y., Cuevas, V. D., Troha, K., & Ayres, J. S. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-071219-125715 · Cited by 255
Impacts of microbiome metabolites on immune regulation and autoimmunity
Haase, S., Haghikia, A., Wilck, N., Müller, D. N., & Linker, R. A. (2018) · Immunology · doi:10.1111/imm.12933 · Cited by 239
Hoefs, S., Mogavero, S., & Hube, B. (2016) · The Journal of Microbiology · doi:10.1007/s12275-016-5514-0 · Cited by 251
Hosseinkhani, F., Heinken, A., Thiele, I., Lindenburg, P. W., Harms, A. C., & Hankemeier, T. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1882927 · Cited by 249
Tryptophan Dietary Impacts Gut Barrier and Metabolic Diseases
Taleb, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02113 · Cited by 236
Role of indoleamine 2,3-dioxygenase in health and disease
Yeung, A. W. S., Terentis, A. C., King, N. J. C., & Thomas, S. R. (2015) · Clinical Science · doi:10.1042/cs20140392 · Cited by 244
The neuropeptide VIP confers anticipatory mucosal immunity by regulating ILC3 activity
Seillet, C., Luong, K., Tellier, J., Jacquelot, N., Shen, R. D., Hickey, P. F., Wimmer, V. C., Whitehead, L. W., Rogers, K. L., Smyth, G. K., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0567-y · Cited by 242
The microbiome and autoimmunity: a paradigm from the gut–liver axis
Li, B., Selmi, C. F., Tang, R., Gershwin, M. E., & Ma, X. (2018) · Cellular and Molecular Immunology · doi:10.1038/cmi.2018.7 · Cited by 237
Oh, J., Alexander, L. M., Pan, M., Schueler, K. L., Keller, M. P., Attie, A., Walter, J., & van Pijkeren, J. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2018.11.016 · Cited by 235
Environmental risk factors for inflammatory bowel diseases: Evidence based literature review
Abegunde, A. T., Muhammad, B. H., Bhatti, O. I., & Ali, T. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i27.6296 · Cited by 250
Ji, Y. S., Yin, Y., Li, Z., & Zhang, W. (2019) · Nutrients · doi:10.3390/nu11081712 · Cited by 235
The microbiota-immune axis as a central mediator of gut-brain communication
Fung, T. C. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104714 · Cited by 234
Jacobs, J. P., Goudarzi, M., Singh, N., Tong, M., McHardy, I. H., Ruegger, P. M., Asadourian, M., Moon, B., Ayson, A., Borneman, J., et al. (2016) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2016.06.004 · Cited by 225
New Insights Into Gut-Bacteria-Derived Indole and Its Derivatives in Intestinal and Liver Diseases
Li, X., Zhang, B., Hu, Y., & Zhao, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.769501 · Cited by 244
Zhang, Z., Mu, X., Cao, Q., Shi, Y., Hu, X., & Zheng, H. (2022) · Nature Communications · doi:10.1038/s41467-022-29760-0 · Cited by 246
Mechanisms of Tolerance Induction by Dendritic Cells In Vivo
Hasegawa, H., & Matsumoto, T. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00350 · Cited by 240
Neutrophils: from IBD to the gut microbiota
Danne, C., Skerniškytė, J., Marteyn, B., & Sokol, H. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00871-3 · Cited by 242
Sasabe, J., Miyoshi, Y., Rakoff-Nahoum, S., Zhang, T., Mita, M., Davis, B. M., Hamase, K., & Waldor, M. K. (2016) · Nature Microbiology · doi:10.1038/nmicrobiol.2016.125 · Cited by 229
Clinical importance of IL-22 cascade in IBD
Mizoguchi, A., Yano, A., Himuro, H., Ezaki, Y., Sadanaga, T., & Mizoguchi, E. (2017) · Journal of Gastroenterology · doi:10.1007/s00535-017-1401-7 · Cited by 226
Hou, Y., Li, J., & Ying, S. (2023) · Metabolites · doi:10.3390/metabo13111166 · Cited by 244
Islam, J., Sato, A., Watanabe, K., Watanabe, T., Ardiansyah, A., Hirahara, K., Aoyama, Y., Tomita, S., Aso, H., Komai, M., et al. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.12.019 · Cited by 223
Bosi, A., Banfi, D., Bistoletti, M., Giaroni, C., & Baj, A. (2020) · International Journal of Tryptophan Research · doi:10.1177/1178646920928984 · Cited by 221
Neuroimmune circuits in inter-organ communication
Huh, J. R., & Veiga‐Fernandes, H. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0247-z · Cited by 216
Liu, J., Miao, H., Deng, D.-Q., Vaziri, N. D., Li, P., & Zhao, Y. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03645-1 · Cited by 220
Alterations of the Skin and Gut Microbiome in Psoriasis and Psoriatic Arthritis
Olejniczak‐Staruch, I., Ciążyńska, M. A., Sobolewska-Sztychny, D., Narbutt, J., Skibińska, M., & Lesiak, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083998 · Cited by 234
Shi, C., Han, X., Guo, W., Wu, Q., Yang, X., Wang, Y., Tang, G., Wang, S., Wang, Z., Liu, Y., et al. (2022) · Environment International · doi:10.1016/j.envint.2022.107273 · Cited by 219
Commensal bacteria mediated defenses against pathogens
Abt, M. C., & Pamer, E. G. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.03.003 · Cited by 223
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Han, J., Tao, Z., Wang, J., Zhang, L., Yu, C., Kang, Z., Xie, Y., Li, J., Lu, S., Cui, Y., et al. (2023) · Nature Microbiology · doi:10.1038/s41564-023-01363-5 · Cited by 223
Gryp, T., Paepe, K. D., Vanholder, R. C., Kerckhof, F., Biesen, W. V., de Wiele, T. V., Verbeke, F., Speeckaert, M. M., Joossens, M., Couttenye, M. M., et al. (2020) · Kidney International · doi:10.1016/j.kint.2020.01.028 · Cited by 219
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Lionakis, M. S., & Levitz, S. M. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053318 · Cited by 209
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Rosati, D., Bruno, M., Jaeger, M., ten Oever, J., & Netea, M. G. (2020) · Microorganisms · doi:10.3390/microorganisms8020144 · Cited by 206
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Connell, E., Le Gall, G., Pontifex, M. G., Sami, S., Cryan, J. F., Clarke, G., Müller, M., & Vauzour, D. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00548-6 · Cited by 208
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Beaumont, M., Neyrinck, A. M., Olivares, M., Rodriguez, J., Nédélec, A., Roumain, M., Bindels, L. B., Cani, P. D., Evenepoel, P., Muccioli, G. G., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201800544 · Cited by 214
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Leibovitzh, H., Lee, S.-H., Xue, M., Garay, J. A. R., Hernández-Rocha, C., Madsen, K. L., Meddings, J. B., Guttman, D. S., Espin‐Garcia, O., Smith, M. I., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.07.004 · Cited by 213
Wrzosek, L., Ciocan, D. M., Hugot, C., Spatz, M., Dupeux, M., Houron, C., Moal, V. L.-L., Puchois, V., Ferrere, G., Trainel, N., et al. (2020) · Gut · doi:10.1136/gutjnl-2020-321565 · Cited by 206
Metadata
- Authors
- Zelante, T., Iannitti, R. G., Cunha, C., De Luca, A., Giovannini, G., Pieraccini, G., Zecchi, R., D’Angelo, C., Massi-Benedetti, C., Fallarino, F., Carvalho, A., Puccetti, P., & Romani, L.
- Affiliations
- University of Perugia (IT)
- University of Florence (IT)
- Corresponding author
- Romani, Luigina
- ORCID
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 39
- Issue
- 2
- Pages
- 372-385
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2044216294
- Cited by
- 2,614
- References
- 56
- Citations by year
- 2026: 385 · 2025: 285 · 2024: 279 · 2023: 237 · 2022: 268 · 2021: 248 · 2020: 249 · 2019: 179 · 2018: 136 · 2017: 119 · 2016: 100 · 2015: 66 · 2014: 54 · 2013: 4
- FWCI
- 33.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Funders
- Associazione Italiana per la Ricerca sul Cancro
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- tryptophan catabolites, gut microbiota, aryl hydrocarbon receptor, indole-3-carboxaldehyde, IL-22, mucosal immunity, lactobacilli, Candida albicans, colonization resistance, commensalism, host-microbe interactions, dietary tryptophan
- MeSH terms
- Interleukin-22, Animals, Candida albicans, Candidiasis, Energy Metabolism, Female, Indoles, Interleukins, Mice, Inbred BALB C, Mice, Inbred C3H, Mice, Inbred C57BL, Tryptophan, Mice, SCID, Receptors, Aryl Hydrocarbon, Mice, Knockout, Probiotics, Interleukin-17, Gastrointestinal Tract, Indoleamine-Pyrrole 2,3,-Dioxygenase, Toll-Like Receptor 2, Mice, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins, Limosilactobacillus reuteri, Myeloid Differentiation Factor 88, Metagenome
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