The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Bee Venom Phospholipase A2 Induces a Primary Type 2 Response that Is Dependent on the Receptor ST2 and Confers Protective Immunity
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“As noted above, Palm et al. reported that immunization of mice with honeybee venom-derived bvPLA2, which represents approximately 10% of the dry weight of whole BV [106], can reduce the toxicity-related hypothermia induced by subsequent challenge with a high dose of the same allergen in an antibody- and FcεRIα-dependent manner [104].”
From Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy (2020) · cites this paper as [104]
In the citing paper
“Independently of our work, Palm et al. showed that mice immunized with the major allergen contained in honeybee venom, bee venom phospholipase A2 (bvPLA2), exhibited enhanced resistance to the ability of bvPLA2 to induce hypothermia upon its injection into mice, and also provided evidence that this enhanced immunity required B cells and was diminished significantly in mice which lacked the IgE”
From Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy (2020) · cites this paper as [104]
In the citing paper
“Taken together, these two initial studies [96, 104] support the hypothesis that one physiological function of IgE is to protect the host against noxious substances.”
From Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy (2020) · cites this paper as [104]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Immunological and inflammatory functions of the interleukin-1 family
Dinarello, C. A. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132612 · Cited by 3,466
Molecular mechanisms of necroptosis: an ordered cellular explosion
Vandenabeele, P., Galluzzi, L., Vanden Berghe, T., & Kroemer, G. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2970 · Cited by 2,382
Phospholipase A2 structure/function, mechanism, and signaling
Burke, J. E., & Dennis, E. A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800033-jlr200 · Cited by 933
Research works printed but not linked: 41
- Akahoshi, 2011, Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice, J. Clin. Invest., 121, 4180, 10.1172/JCI46139 · DOI · Paper page
- Allen, 2011, Evolution of Th2 immunity: a rapid repair response to tissue destructive pathogens, PLoS Pathog., 7, e1002003, 10.1371/journal.ppat.1002003 · DOI
- Besnard, 2011, IL-33-activated dendritic cells are critical for allergic airway inflammation, Eur. J. Immunol., 41, 1675, 10.1002/eji.201041033 · DOI
- Bircher, 2005, Systemic immediate allergic reactions to arthropod stings and bites, Dermatology (Basel), 210, 119, 10.1159/000082567 · DOI
- Chippaux, 1998, Venoms, antivenoms and immunotherapy, Toxicon, 36, 823, 10.1016/S0041-0101(97)00160-8 · DOI
- Dombrowicz, 1993, Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor alpha chain gene, Cell, 75, 969, 10.1016/0092-8674(93)90540-7 · DOI
- Donnelly, 2006, Proteases in helminth- and allergen- induced inflammatory responses, Chem. Immunol. Allergy, 90, 45
- Dudler, 1995, A link between catalytic activity, IgE-independent mast cell activation, and allergenicity of bee venom phospholipase A2, J. Immunol., 155, 2605, 10.4049/jimmunol.155.5.2605 · DOI
- Fry, 2009, The toxicogenomic multiverse: convergent recruitment of proteins into animal venoms, Annu. Rev. Genomics Hum. Genet., 10, 483, 10.1146/annurev.genom.9.081307.164356 · DOI
- Habermann, 1972, Bee and wasp venoms, Science, 177, 314, 10.1126/science.177.4046.314 · DOI · Paper page
- Higginbotham, 1965, Mast cells and local resistance to Russell’s viper venom, J. Immunol., 95, 867, 10.4049/jimmunol.95.5.867 · DOI · Paper page
- Higginbotham, 1971, The significance of the mast cell response to bee venom, J. Immunol., 106, 233, 10.4049/jimmunol.106.1.233 · DOI · Paper page
- Humphreys, 2008, IL-33, a potent inducer of adaptive immunity to intestinal nematodes, J. Immunol., 180, 2443, 10.4049/jimmunol.180.4.2443 · DOI
- Janeway, 1989, Approaching the asymptote? Evolution and revolution in immunology, Cold Spring Harb. Symp. Quant. Biol., 54, 1, 10.1101/SQB.1989.054.01.003 · DOI
- Kabarowski, 2001, Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A, Science, 293, 702, 10.1126/science.1061781 · DOI
- Kaczmarek, 2013, Necroptosis: the release of damage-associated molecular patterns and its physiological relevance, Immunity, 38, 209, 10.1016/j.immuni.2013.02.003 · DOI · Paper page
- Kakkar, 2012, Interleukin 33 as a mechanically responsive cytokine secreted by living cells, J. Biol. Chem., 287, 6941, 10.1074/jbc.M111.298703 · DOI
- Liew, 2012, IL-33: a Janus cytokine, Ann. Rheum. Dis., 71, i101, 10.1136/annrheumdis-2011-200589 · DOI
- Madero, 2009, Characterization of allergens in four South American snake species, Int. Arch. Allergy Immunol., 150, 307, 10.1159/000222684 · DOI
- Mesquita, 2008, Trypanosoma cruzi infection is enhanced by vector saliva through immunosuppressant mechanisms mediated by lysophosphatidylcholine, Infect. Immun., 76, 5543, 10.1128/IAI.00683-08 · DOI
- Metz, 2006, Mast cells can enhance resistance to snake and honeybee venoms, Science, 313, 526, 10.1126/science.1128877 · DOI · Paper page
- Mohammed, 1961, Immunity of bee keepers to some constituents of bee venom: phospholipase-A antibodies, Nature, 189, 837, 10.1038/189837b0 · DOI
- Mohrs, 2001, Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter, Immunity, 15, 303, 10.1016/S1074-7613(01)00186-8 · DOI
- Müller, 2010, Insect venoms, Chem. Immunol. Allergy, 95, 141, 10.1159/000315948 · DOI
- Oliphant, 2011, Insights into the initiation of type 2 immune responses, Immunology, 134, 378, 10.1111/j.1365-2567.2011.03499.x · DOI
- Ownby, 1997, Melittin and phospholipase A2 from bee (Apis mellifera) venom cause necrosis of murine skeletal muscle in vivo, Toxicon, 35, 67, 10.1016/S0041-0101(96)00078-5 · DOI
- Ozdemir, 2011, Mechanisms of immunotherapy to wasp and bee venom, Clinical and experimental allergy: journal of the British Society for Allergy and Clinical Immunology, 41, 1226, 10.1111/j.1365-2222.2011.03812.x · DOI · Paper page
- Palm, 2009, Pattern recognition receptors and control of adaptive immunity, Immunol. Rev., 227, 221, 10.1111/j.1600-065X.2008.00731.x · DOI
- Palm, 2012, Allergic host defences, Nature, 484, 465, 10.1038/nature11047 · DOI · Paper page
- Phillips, 2003, Basophils express a type 2 cytokine profile on exposure to proteases from helminths and house dust mites, J. Leukoc. Biol., 73, 165, 10.1189/jlb.0702356 · DOI
- Profet, 1991, The function of allergy: immunological defense against toxins, Q. Rev. Biol., 66, 23, 10.1086/417049 · DOI · Paper page
- Pulendran, 2012, New paradigms in type 2 immunity, Science, 337, 431, 10.1126/science.1221064 · DOI · Paper page
- Scalfone, 2013, Participation of MyD88 and IL-33 as innate drivers of Th2 immunity to Trichinella spiralis, Infect. Immun., 81, 1354, 10.1128/IAI.01307-12 · DOI
- Schmitz, 2005, IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines, Immunity, 23, 479, 10.1016/j.immuni.2005.09.015 · DOI
- Shakib, 2008, The molecular basis of allergenicity, Trends Immunol., 29, 633, 10.1016/j.it.2008.08.007 · DOI
- Sobotka, 1976, Allergy to insect stings. II. Phospholipase A: the major allergen in honeybee venom, J. Allergy Clin. Immunol., 57, 29, 10.1016/0091-6749(76)90076-2 · DOI
- Sokol, 2008, A mechanism for the initiation of allergen-induced T helper type 2 responses, Nat. Immunol., 9, 310, 10.1038/ni1558 · DOI
- Townsend, 2000, T1/ST2-deficient mice demonstrate the importance of T1/ST2 in developing primary T helper cell type 2 responses, J. Exp. Med., 191, 1069, 10.1084/jem.191.6.1069 · DOI
- Walker, 2013, Development and function of group 2 innate lymphoid cells, Curr. Opin. Immunol., 25, 148, 10.1016/j.coi.2013.02.010 · DOI
- Wills-Karp, 2010, New insights into innate immune mechanisms underlying allergenicity, Mucosal Immunol., 3, 104, 10.1038/mi.2009.138 · DOI
- Zhao, 2010, The enigmatic processing and secretion of interleukin-33, Cell. Mol. Immunol., 7, 260, 10.1038/cmi.2010.3 · DOI
Cited by
Sorted by citations
The interleukin-1 family: back to the future
Garlanda, C., Dinarello, C. A., & Mantovani, A. (2013) · Immunity · doi:10.1016/j.immuni.2013.11.010 · Cited by 1,945
“The adaptive Th2 response against PLA2 is also IL-33 and ST2 dependent.”
The 3 major types of innate and adaptive cell-mediated effector immunity
Annunziato, F., Romagnani, C., & Romagnani, S. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.11.001 · Cited by 818
Mast cells and IgE in defense against venoms: Possible “good side” of allergy?
Galli, S. J., Starkl, P., Marichal, T., & Tsai, M. (2016) · Allergology International · doi:10.1016/j.alit.2015.09.002 · Cited by 73
Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy
Galli, S. J., Metz, M., Starkl, P., Marichal, T., & Tsai, M. (2020) · Allergo Journal International · doi:10.1007/s40629-020-00118-6 · Cited by 57
Immunological Responses to Envenomation
Ryan, R. Y. M., Seymour, J., Loukas, A., Lopez, J. A., Ikonomopoulou, M. P., & Miles, J. J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.661082 · Cited by 49
Metadata
- Authors
- Palm, N. W., Rosenstein, R. K., Yu, S., Schenten, D. D., Florsheim, E., & Medzhitov, R.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 39
- Issue
- 5
- Pages
- 976-985
- ISSN
- 1074-7613
- PMC
- PMC3852615
- Cited by
- 214
- References
- 3
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Bee Venom Phospholipase A2 Induces a Primary Type 2 Response that Is Dependent on the Receptor ST2 and Confers Protective Immunity. https://app.cochat.ai/papers/10.1016/j.immuni.2013.10.006
- The paper
- Palm, N. W., Rosenstein, R. K., Yu, S., Schenten, D. D., Florsheim, E., & Medzhitov, R. (2013). Bee Venom Phospholipase A2 Induces a Primary Type 2 Response that Is Dependent on the Receptor ST2 and Confers Protective Immunity. Immunity. https://doi.org/10.1016/j.immuni.2013.10.006
