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Cited by 866

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation

Open access
Nakaya, Mako, Xiao, Yichuan, Zhou, Xiaofei, Chang, Jae-Hoon, Chang, Mikyoung, Cheng, Xuhong, Blonska, Marzenna, Lin, Xin, Sun, Shao-Cong·2014·Immunity
DOI 10.1016/j.immuni.2014.04.007
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Abstract

Glutamine has been implicated as an immunomodulatory nutrient, but how glutamine uptake is mediated during T-cell activation is poorly understood. We have shown that naïve T-cell activation is coupled with rapid glutamine uptake, which depended on the amino acid transporter ASCT2. ASCT2 deficiency impaired the induction of T helper-1 (Th1) and Th17 cells and attenuated inflammatory T-cell responses in mouse models of immunity and autoimmunity. Mechanistically, ASCT2 was required for T cell receptor (TCR)-stimulated activation of the metabolic kinase mTORC1. We have further shown that TCR-stimulated glutamine uptake and mTORC1 activation also required a TCR signaling complex composed of the scaffold protein CARMA1, the adaptor molecule BCL10, and the paracaspase MALT1. This function was independent of IKK kinase, a major downstream target of the CARMA1 complex. These findings highlight a mechanism of T-cell activation involving ASCT2-dependent integration of the TCR signal and a metabolic signaling pathway.

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Metadata

Authors
Nakaya, M., Xiao, Y., Zhou, X., Chang, J.-H., Chang, M., Cheng, X., Blonska, M., Lin, X., & Sun, S.-C.
Venue
Immunity
Publisher
Elsevier BV
Published
2014-05
Volume
40
Issue
5
Pages
692-705
ISSN
1074-7613 (ISSN-L)
DOI
10.1016/j.immuni.2014.04.007
OpenAlex
W2003398132
Cited by
866
References
10
FWCI
18.02
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation. https://app.cochat.ai/papers/10.1016/j.immuni.2014.04.007
The paper
Nakaya, M., Xiao, Y., Zhou, X., Chang, J.-H., Chang, M., Cheng, X., Blonska, M., Lin, X., & Sun, S.-C. (2014). Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation. Immunity. https://doi.org/10.1016/j.immuni.2014.04.007

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.