Cited by 281Immunotherapy and Immune ResponsesImmune cells in cancerImmune Response and Inflammation

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Human dermal CD14(+) cells are a transient population of monocyte-derived macrophages

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McGovern, Naomi, Schlitzer, Andreas, Gunawan, Merry, Jardine, Laura, Shin, Amanda, Poyner, Elizabeth, Green, Kile, Dickinson, Rachel, Wang, Xiao-nong, Low, Donovan, Best, Katie, Covins, Samuel, Milne, Paul, Pagan, Sarah, Aljefri, Khadija, Windebank, Martin, Miranda-Saavedra, Diego, Larbi, Anis, Wasan, Pavandip Singh, Duan, Kaibo, Poidinger, Michael, Bigley, Venetia, Ginhoux, Florent, Collin, Matthew, Haniffa, Muzlifah·2014·Immunity

DOI 10.1016/j.immuni.2014.08.006PMC PMC4175180

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Abstract

Dendritic cells (DCs), monocytes, and macrophages are leukocytes with critical roles in immunity and tolerance. The DC network is evolutionarily conserved; the homologs of human tissue CD141(hi)XCR1⁺ CLEC9A⁺ DCs and CD1c⁺ DCs are murine CD103⁺ DCs and CD64⁻ CD11b⁺ DCs. In addition, human tissues also contain CD14⁺ cells, currently designated as DCs, with an as-yet unknown murine counterpart. Here we have demonstrated that human dermal CD14⁺ cells are a tissue-resident population of monocyte-derived macrophages with a short half-life of <6 days. The decline and reconstitution kinetics of human blood CD14⁺ monocytes and dermal CD14⁺ cells in vivo supported their precursor-progeny relationship. The murine homologs of human dermal CD14⁺ cells are CD11b⁺ CD64⁺ monocyte-derived macrophages. Human and mouse monocytes and macrophages were defined by highly conserved gene transcripts, which were distinct from DCs. The demonstration of monocyte-derived macrophages in the steady state in human tissue supports a conserved organization of human and mouse mononuclear phagocyte system.

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Authors: McGovern, N., Schlitzer, A., Gunawan, M., Jardine, L., Shin, A., Poyner, E., Green, K., Dickinson, R., Wang, X.-N., Low, D., Best, K., Covins, S., Milne, P., Pagan, S., Aljefri, K., Windebank, M., Miranda-Saavedra, D., Larbi, A., Wasan, P. S., Duan, K., Poidinger, M., Bigley, V., Ginhoux, F., Collin, M., & Haniffa, M.
Affiliations: Agency for Science, Technology and Research (SG)
Newcastle University (GB)
Corresponding author: Collin, Matthew
Haniffa, Muzlifah
ORCID: McGovern, Naomi
Schlitzer, Andreas
Jardine, Laura
Poyner, Elizabeth
Green, Kile
Dickinson, Rachel
Best, Katie
Milne, Paul
Larbi, Anis
Duan, Kaibo
Poidinger, Michael
Bigley, Venetia
Ginhoux, Florent
Collin, Matthew
Haniffa, Muzlifah
Venue: Immunity
Publisher: Elsevier BV
Published: 2014-09
Volume: 41
Issue: 3
Pages: 465-477
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2014.08.006
PMC: PMC4175180
OpenAlex: W2144829409
Cited by: 281
References: 54
Citations by year: 2026: 3 · 2025: 12 · 2024: 13 · 2023: 17 · 2022: 11 · 2021: 24 · 2020: 34 · 2019: 32 · 2018: 25 · 2017: 37 · 2016: 31 · 2015: 36 · 2014: 6
FWCI: 16.76
Type: journal article
Language: en
Update notices: erratum (2015-02-17)
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/3.0/ (vor)
Locations: Immunity (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Apollo (University of Cambridge) (submittedVersion, cc-by)
Apollo (cc-by)
Funders: Histiocytosis Association
Wellcome Trust (101155/Z/13/Z, WT088555MA)
British Skin Foundation
Leukaemia and Lymphoma Research
Newcastle University
AXA Research Fund
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: CD14+ cells, monocyte-derived macrophages, dermal macrophages, monocytes, monocyte-to-macrophage differentiation, tissue-resident macrophages, reticuloendothelial system, CD11b, CD64, dendritic cells, CD1c+ dendritic cells, CD103+ dendritic cells, human-mouse comparison, macrophage turnover
MeSH terms: Animals, Cell Differentiation, Cell Movement, Cells, Cultured, Dendritic Cells, Female, Humans, Immunologic Memory, Macrophages, Mice, Transgenic, Skin, T-Lymphocytes, Receptors, IgG, Lipopolysaccharide Receptors, Cell Lineage, CD11b Antigen, Mice

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Human dermal CD14(+) cells are a transient population of monocyte-derived macrophages

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