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Human dermal CD14(+) cells are a transient population of monocyte-derived macrophages
Open accessAbstract
Dendritic cells (DCs), monocytes, and macrophages are leukocytes with critical roles in immunity and tolerance. The DC network is evolutionarily conserved; the homologs of human tissue CD141(hi)XCR1⁺ CLEC9A⁺ DCs and CD1c⁺ DCs are murine CD103⁺ DCs and CD64⁻ CD11b⁺ DCs. In addition, human tissues also contain CD14⁺ cells, currently designated as DCs, with an as-yet unknown murine counterpart. Here we have demonstrated that human dermal CD14⁺ cells are a tissue-resident population of monocyte-derived macrophages with a short half-life of <6 days. The decline and reconstitution kinetics of human blood CD14⁺ monocytes and dermal CD14⁺ cells in vivo supported their precursor-progeny relationship. The murine homologs of human dermal CD14⁺ cells are CD11b⁺ CD64⁺ monocyte-derived macrophages. Human and mouse monocytes and macrophages were defined by highly conserved gene transcripts, which were distinct from DCs. The demonstration of monocyte-derived macrophages in the steady state in human tissue supports a conserved organization of human and mouse mononuclear phagocyte system.
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“This does indeed happen, for example in the gut or the dermis (53,54).”
From The impact of ageing on monocytes and macrophages (2021) · cites this paper as [54]
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Metadata
- Authors
- McGovern, N., Schlitzer, A., Gunawan, M., Jardine, L., Shin, A., Poyner, E., Green, K., Dickinson, R., Wang, X.-N., Low, D., Best, K., Covins, S., Milne, P., Pagan, S., Aljefri, K., Windebank, M., Miranda-Saavedra, D., Larbi, A., Wasan, P. S., Duan, K., Poidinger, M., Bigley, V., Ginhoux, F., Collin, M., & Haniffa, M.
- Affiliations
- Agency for Science, Technology and Research (SG)
- Newcastle University (GB)
- Corresponding author
- Collin, Matthew
- Haniffa, Muzlifah
- ORCID
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 41
- Issue
- 3
- Pages
- 465-477
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC4175180
- OpenAlex
- W2144829409
- Cited by
- 281
- References
- 54
- Citations by year
- 2026: 3 · 2025: 12 · 2024: 13 · 2023: 17 · 2022: 11 · 2021: 24 · 2020: 34 · 2019: 32 · 2018: 25 · 2017: 37 · 2016: 31 · 2015: 36 · 2014: 6
- FWCI
- 16.76
- Type
- journal article
- Language
- en
- Update notices
- erratum (2015-02-17)
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Immunity (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Apollo (University of Cambridge) (submittedVersion, cc-by)
- Apollo (cc-by)
- Funders
- Histiocytosis Association
- Wellcome Trust (101155/Z/13/Z, WT088555MA)
- British Skin Foundation
- Leukaemia and Lymphoma Research
- Newcastle University
- AXA Research Fund
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- CD14+ cells, monocyte-derived macrophages, dermal macrophages, monocytes, monocyte-to-macrophage differentiation, tissue-resident macrophages, reticuloendothelial system, CD11b, CD64, dendritic cells, CD1c+ dendritic cells, CD103+ dendritic cells, human-mouse comparison, macrophage turnover
- MeSH terms
- Animals, Cell Differentiation, Cell Movement, Cells, Cultured, Dendritic Cells, Female, Humans, Immunologic Memory, Macrophages, Mice, Transgenic, Skin, T-Lymphocytes, Receptors, IgG, Lipopolysaccharide Receptors, Cell Lineage, CD11b Antigen, Mice
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