The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Interleukin-2-Dependent Allergen-Specific Tissue-Resident Memory Cells Drive Asthma
Open accessAbstract
Exposure to inhaled allergens generates T helper 2 (Th2) CD4+ T cells that contribute to episodes of inflammation associated with asthma. Little is known about allergen-specific Th2 memory cells and their contribution to airway inflammation. We generated reagents to understand how endogenous CD4+ T cells specific for a house dust mite (HDM) allergen form and function. After allergen exposure, HDM-specific memory cells persisted as central memory cells in the lymphoid organs and tissue resident memory (Trm) cells in the lung. Experimental blockade of lymphocyte migration demonstrated that lung resident cells were sufficient to induce airway hyper-responsiveness, which depended upon CD4+ T cells. Investigation into the differentiation of pathogenic Trm cells revealed that interleukin-2 (IL-2) signaling was required for residency and directed a program of tissue homing migrational cues. These studies thus identify IL-2-dependent resident Th2 memory cells as drivers of lung allergic responses.
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Citations
Cites
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
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“Circulating memory T cells exist in two subsets: central memory (Tcm) and effector memory (Tem) T cells (Sallusto et al., 1999).”
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“Very few of the cells expressed CD103, which is expressed on some CD8 Trm (data not shown) (Mackay et al., 2013; Schenkel and Masopust, 2014).”
CD69 acts downstream of interferon-α/β to inhibit S1P1 and lymphocyte egress from lymphoid organs
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Self-citationHow are TH2-type immune responses initiated and amplified?
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Cited by
T follicular helper cell biology: a decade of discovery and diseases
Crotty, S. (2019) · Immunity · doi:10.1016/j.immuni.2019.04.011 · Cited by 1,591
Human T cell development, localization, and function throughout life
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CD49a Expression Defines Tissue-Resident CD8 + T Cells Poised for Cytotoxic Function in Human Skin
Cheuk, S., Schlums, H., Gallais Sérézal, I., Martini, E., Chiang, S. C., Marquardt, N., Gibbs, A., Detlofsson, E., Introini, A., Forkel, M., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.01.009 · Cited by 678
“While such local immune responses contribute to immu- nity (Gebhardt et al., 2009; Glennie et al., 2015; Jiang et al., 2012; Naik et al., 2012), aberrant activation might cause disease (Hondowicz et al., 2016; Jabri and Abadie, 2015; Park and Kupper, 2015).”
Biology and regulation of IL-2: from molecular mechanisms to human therapy
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Location, location, location: Tissue resident memory T cells in mice and humans
Szabo, P. A., Miron, M., & Farber, D. L. (2019) · Science Immunology · doi:10.1126/sciimmunol.aas9673 · Cited by 651
Metadata
- Authors
- Hondowicz, B. D., An, D., Schenkel, J. M., Kim, K. S., Steach, H. R., Krishnamurty, A. T., Keitany, G. J., Garza, E. N., Fraser, K. A., Moon, J. J., Altemeier, W. A., Masopust, D., & Pepper, M.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 44
- Issue
- 1
- Pages
- 155-166
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2203802767
- Cited by
- 293
- References
- 59
- FWCI
- 13.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hondowicz, B. D., An, D., Schenkel, J. M., Kim, K. S., Steach, H. R., Krishnamurty, A. T., Keitany, G. J., Garza, E. N., Fraser, K. A., Moon, J. J., Altemeier, W. A., Masopust, D., & Pepper, M. (2016). Interleukin-2-Dependent Allergen-Specific Tissue-Resident Memory Cells Drive Asthma. Immunity. https://doi.org/10.1016/j.immuni.2015.11.004
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
