The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction

Molecular and cellular insights into T cell exhaustion

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Combination cancer immunotherapy and new immunomodulatory targets

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Antitumor T-cell Reconditioning: Improving Metabolic Fitness for Optimal Cancer Immunotherapy

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CAR-T cell therapy for hematological malignancies: Limitations and optimization strategies

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Immune-resistant mechanisms in cancer immunotherapy

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Fever supports CD8 + effector T cell responses by promoting mitochondrial translation

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IL-21 from high-affinity CD4 T cells drives differentiation of brain-resident CD8 T cells during persistent viral infection

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Prospects and challenges for use of CAR T cell therapies in solid tumors

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Tumor microenvironmental influences on dendritic cell and T cell function: A focus on clinically relevant immunologic and metabolic checkpoints

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Emerging principles of brain immunology and immune checkpoint blockade in brain metastases

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A deubiquitination module essential for T reg fitness in the tumor microenvironment

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Metabolic Adaptations of CD4+ T Cells in Inflammatory Disease

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Metabolic programs drive function of therapeutic NK cells in hypoxic tumor environments

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Reenergizing T cell anti-tumor immunity by harnessing immunometabolic checkpoints and machineries

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Mitochondrial Redox Hubs as Promising Targets for Anticancer Therapy

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Enhancing CAR-T cell metabolism to overcome hypoxic conditions in the brain tumor microenvironment

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Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4

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Overcoming resistance to anti-PD-L1 immunotherapy: mechanisms, combination strategies, and future directions

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HBV Immune-Therapy: From Molecular Mechanisms to Clinical Applications

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Synergistic T cell signaling by 41BB and CD28 is optimally achieved by membrane proximal positioning within parallel chimeric antigen receptors

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Carbon Monoxide Activates PERK-Regulated Autophagy to Induce Immunometabolic Reprogramming and Boost Antitumor T-cell Function

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Fueling CARs: metabolic strategies to enhance CAR T-cell therapy

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Obesity and CD8 T cell metabolism: Implications for anti‐tumor immunity and cancer immunotherapy outcomes

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PGC-1α activator–induced fatty acid oxidation in tumor-infiltrating CTLs enhances effects of PD-1 blockade therapy in lung cancer

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Anti-PD-1/PD-L1 Based Combination Immunotherapy to Boost Antigen-Specific CD8+ T Cell Response in Hepatocellular Carcinoma

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Mitochondria during T cell aging

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Strategies for Dodging the Obstacles in CAR T Cell Therapy

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Metabolic regulation of T cells in the tumor microenvironment by nutrient availability and diet

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An Injectable Hydrogel to Modulate T Cells for Cancer Immunotherapy

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Spatiotemporal metabolomic approaches to the cancer-immunity panorama: a methodological perspective

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Recent Advances in the Clinical Development of Immune Checkpoint Blockade Therapy for Mismatch Repair Proficient (pMMR)/non-MSI-H Metastatic Colorectal Cancer

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Fueling the Revolution: Targeting Metabolism to Enhance Immunotherapy

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WAVE2 suppresses mTOR activation to maintain T cell homeostasis and prevent autoimmunity

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Supramolecular Biomaterials for Cancer Immunotherapy

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Immunometabolism of CD8+ T cell differentiation in cancer

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Immune-mediated anti-tumor effects of metformin; targeting metabolic reprogramming of T cells as a new possible mechanism for anti-cancer effects of metformin

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ACLY and ACSS2 link nutrient-dependent chromatin accessibility to CD8 T cell effector responses

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Use of Multi-Site Radiation Therapy for Systemic Disease Control

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T cell metabolism in homeostasis and cancer immunity

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β2-Adrenergic Receptor Mediated Inhibition of T Cell Function and Its Implications for CAR-T Cell Therapy

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Immunometabolism: A new target for improving cancer immunotherapy

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Adoptive Cell Therapy—Harnessing Antigen-Specific T Cells to Target Solid Tumours

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PPARγ signaling in hepatocarcinogenesis: Mechanistic insights for cellular reprogramming and therapeutic implications

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The immunometabolic ecosystem in cancer

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NR4A ablation improves mitochondrial fitness for long persistence in human CAR-T cells against solid tumors

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The role of mitochondria in tumor metastasis and advances in mitochondria-targeted cancer therapy

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Determinants of Tissue-Specific Metabolic Adaptation of T Cells

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Immunometabolism in the Tumor Microenvironment

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Adoptive T cell therapy: Boosting the immune system to fight cancer

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The role of mitochondria in the resistance of melanoma to PD-1 inhibitors

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Magnetic Metal–Organic Framework-Based Nanoplatform with Platelet Membrane Coating as a Synergistic Programmed Cell Death Protein 1 Inhibitor against Hepatocellular Carcinoma

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Foxp3 confers long-term efficacy of chimeric antigen receptor-T cells via metabolic reprogramming

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Exploring Non-Metabolic Functions of Glycolytic Enzymes in Immunity

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Checkpoint molecules coordinately restrain hyperactivated effector T cells in the tumor microenvironment

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Epithelial Ovarian Cancer and the Immune System: Biology, Interactions, Challenges and Potential Advances for Immunotherapy

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CD73 Ectonucleotidase Restrains CD8+ T Cell Metabolic Fitness and Anti-tumoral Activity

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Metabolic Reprogramming in the Tumor Microenvironment With Immunocytes and Immune Checkpoints

Xu, Y., He, L., Fu, Q., & Hu, J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.759015 · Cited by 51

Targeting Metabolism to Control Immune Responses in Cancer and Improve Checkpoint Blockade Immunotherapy

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Gene expression signatures identify biologically and clinically distinct tuberculosis endotypes

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Structure, Health Benefits, Mechanisms, and Gut Microbiota of Dendrobium officinale Polysaccharides: A Review

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Decoding the metabolic dialogue in the tumor microenvironment: from immune suppression to precision cancer therapies

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Cancer, obesity and immunometabolism – Connecting the dots

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Metabolic Checkpoints: Novel Avenues for Immunotherapy of Cancer

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Optical Control of CD8+ T Cell Metabolism and Effector Functions

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Pathway signatures derived from on-treatment tumor specimens predict response to anti-PD1 blockade in metastatic melanoma

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Redirecting glucose flux during in vitro expansion generates epigenetically and metabolically superior T cells for cancer immunotherapy

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Immunocytes in the tumor microenvironment: recent updates and interconnections

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Transcriptional and epigenetic regulation of T cell hyporesponsiveness

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Tuberculosis endotypes to guide stratified host-directed therapy

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IL6 Induces an IL22+ CD8+ T-cell Subset with Potent Antitumor Function

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Interrupting the nitrosative stress fuels tumor-specific cytotoxic T lymphocytes in pancreatic cancer

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Prospects of mitochondrial transplantation in clinical medicine: Aspirations and challenges

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Exhausted T cells hijacking the cancer-immunity cycle: Assets and liabilities

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Cell metabolism-based optimization strategy of CAR-T cell function in cancer therapy

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The Role of Tumor Metabolic Reprogramming in Tumor Immunity

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Metabolites as agents and targets for cancer immunotherapy

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A Comprehensive Analysis of METTL1 to Immunity and Stemness in Pan-Cancer

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The Role of the Hypoxia-Related Unfolded Protein Response (UPR) in the Tumor Microenvironment

Bartoszewska, S., Collawn, J. F., & Bartoszewski, R. (2022) · Cancers · doi:10.3390/cancers14194870 · Cited by 43

Altered cancer metabolism and implications for next-generation CAR T-cell therapies

Ramapriyan, R., Vykunta, V. S., Vandecandelaere, G., Richardson, L. G., Sun, J. M., Curry, W. T., & Choi, B. D. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108667 · Cited by 48

Engineering Vaccines to Reprogram Immunity against Head and Neck Cancer

Tan, Y. S., Sansanaphongpricha, K., Prince, M. E., Sun, D., Wolf, G. T., & Lei, Y. L. (2018) · Journal of Dental Research · doi:10.1177/0022034518764416 · Cited by 44

T cell metabolism in chronic viral infection

Pallett, L. J., Schmidt, N. M., & Schurich, A. (2019) · Clinical & Experimental Immunology · doi:10.1111/cei.13308 · Cited by 44

Mitochondria orchestrate T cell fate and function

Liu, X., & Peng, G. (2021) · Nature Immunology · doi:10.1038/s41590-020-00861-6 · Cited by 43

T-cell dysfunction in chronic lymphocytic leukemia from an epigenetic perspective

Peters, F. S., Strefford, J. C., Eldering, E., & Kater, A. P. (2021) · Haematologica · doi:10.3324/haematol.2020.267914 · Cited by 43

Cellular stress responses and metabolic reprogramming in cancer progression and dormancy

Payne, K. K. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.06.004 · Cited by 42

Early methionine availability attenuates T cell exhaustion

Sharma, P., Guo, A., Poudel, S., Boada-Romero, E., Verbist, K., Palacios, G., Immadisetty, K., Chen, J., Haydar, D., Mishra, A., et al. (2025) · Nature Immunology · doi:10.1038/s41590-025-02223-6 · Cited by 45

Mitochondrial dysfunction defines T cell exhaustion

Soto‐Heredero, G., Desdín-Micó, G., & Mittelbrunn, M. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.02.010 · Cited by 43

Combination bezafibrate and nivolumab treatment of patients with advanced non–small cell lung cancer

Tanaka, K., Chamoto, K., Saeki, S., Hatae, R., Ikematsu, Y., Sakai, K., Ando, N., Sonomura, K., Kojima, S., Taketsuna, M., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abq0021 · Cited by 41

Manipulating T-cell metabolism to enhance immunotherapy in solid tumor

Chen, C., Wang, Z., Ding, Y., & Qin, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1090429 · Cited by 43

Metabolic rewiring and communication in cancer immunity

Chapman, N. M., & Chi, H. (2024) · Cell chemical biology · doi:10.1016/j.chembiol.2024.02.001 · Cited by 44

Reprogrammed immuno-metabolic environment of cancer: the driving force of ferroptosis resistance

Bhowmick, S., Banerjee, S., Shridhar, V., & Mondal, S. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02337-3 · Cited by 46

Early effector maturation of naïve human CD8+ T cells requires mitochondrial biogenesis

Fischer, M., Bantug, G. R., Dimeloe, S., Gubser, P. M., Burgener-Gasser, A.-V., Grählert, J., Balmer, M. L., Develioglu, L., Steiner, R., Unterstab, G., et al. (2018) · European Journal of Immunology · doi:10.1002/eji.201747443 · Cited by 41

Targeting Mitochondria in Tumor-Associated Macrophages using a Dendrimer-Conjugated TSPO Ligand that Stimulates Antitumor Signaling in Glioblastoma

Sharma, A., Liaw, K., Sharma, R. B., Thomas, A. G., Slusher, B. S., Kannan, S., & Kannan, R. M. (2020) · Biomacromolecules · doi:10.1021/acs.biomac.0c01033 · Cited by 41

Barriers to Immunotherapy in Ovarian Cancer: Metabolic, Genomic, and Immune Perturbations in the Tumour Microenvironment

Johnson, R. L., Cummings, M., Thangavelu, A., Theophilou, G., Jong, D. D., & Orsi, N. M. (2021) · Cancers · doi:10.3390/cancers13246231 · Cited by 39

Metabolic dynamics instruct CD8 + T‐cell differentiation and functions

Bevilacqua, A., Li, Z., & Ho, P. (2022) · European Journal of Immunology · doi:10.1002/eji.202149486 · Cited by 41

Metabolic advantages of regulatory T cells dictated by cancer cells

Kondo, M., Kumagai, S., & Nishikawa, H. (2023) · International Immunology · doi:10.1093/intimm/dxad035 · Cited by 42

Unlocking potential: the role of the electron transport chain in immunometabolism

Zotta, A., O'Neill, L. A. J., & Yin, M. (2024) · Trends in Immunology · doi:10.1016/j.it.2024.02.002 · Cited by 47

NETosis in tumour microenvironment of liver: From primary to metastatic hepatic carcinoma

Yang, Y. C., Yu, S., Lv, C., & Tian, Y. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102297 · Cited by 42

Abstract IA08: Identifying and overcoming metabolic checkpoints to antitumor immunity

Delgoffe, G. M. (2016) · Cancer Immunology Research · doi:10.1158/2326-6066.imm2016-ia08

Dysfunctional T cell metabolism in the tumor microenvironment

Beckermann, K. E., Dudzinski, S. O., & Rathmell, J. C. (2017) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2017.04.003 · Cited by 165

Immunometabolic requirements of T cell activation and exhaustion

Scharping, N. E. (2019) · D-Scholarship@Pitt (University of Pittsburgh)

Metabolic Barriers to T Cell Function in Tumors

Sugiura, A., & Rathmell, J. C. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701041 · Cited by 208

Abstract 632: The metabolic requirements for effective immunotherapy

Scharping, N. E., Menk, A. V., & Delgoffe, G. M. (2018) · Cancer Research · doi:10.1158/1538-7445.am2018-632