The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction

Molecular and cellular insights into T cell exhaustion

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Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

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Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

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Mitochondria as sensors and regulators of calcium signalling

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Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape

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Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development

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Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

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Combination cancer immunotherapy and new immunomodulatory targets

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Identification of a clinically efficacious CAR T cell subset in diffuse large B cell lymphoma by dynamic multidimensional single-cell profiling

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Targeting chromosomal instability in patients with cancer

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Regulation of mTOR, Metabolic Fitness, and Effector Functions by Cytokines in Natural Killer Cells

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Aberrant Expression of Peroxisome Proliferator-Activated Receptors in Colorectal Cancer and Their Association with Cancer Progression and Prognosis

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Hydrogen gas activates coenzyme Q10 to restore exhausted CD8+ T cells, especially PD‑1+Tim3+terminal CD8+ T cells, leading to better nivolumab outcomes in patients with lung cancer

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Amino acids and RagD potentiate mTORC1 activation in CD8 + T cells to confer antitumor immunity

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A novel strategy to fuel cancer immunotherapy: targeting glucose metabolism to remodel the tumor microenvironment

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Targeting T-cell metabolism to boost immune checkpoint inhibitor therapy

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Targeting MondoA–TXNIP restores antitumour immunity in lactic-acid-induced immunosuppressive microenvironment

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Oxygen-dependent regulation of immune checkpoint mechanisms

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T-cell Exhaustion in Organ Transplantation

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Immunotherapy: an emerging modality to checkmate brain metastasis

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TET2 regulates early and late transitions in exhausted CD8 + T cell differentiation and limits CAR T cell function

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Suppressing MDSC Infiltration in Tumor Microenvironment Serves as an Option for Treating Ovarian Cancer Metastasis

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Modulating the tumor immune microenvironment with nanoparticles: A sword for improving the efficiency of ovarian cancer immunotherapy

Xu, T., Liu, Z., Huang, L., Jing, J., & Liu, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1057850 · Cited by 38

Mitochondrial Metabolism in T-Cell Exhaustion

Li, F., Yu, F., Yin, Z., & Wang, Y. J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157400 · Cited by 42

Glucometabolic Reprogramming in the Hepatocellular Carcinoma Microenvironment: Cause and Effect

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Immunometabolic reprogramming, another cancer hallmark

Kumar, V., & Stewart, J. H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1125874 · Cited by 37

The Metabolic Profile of Tumor and Virally Infected Cells Shapes Their Microenvironment Counteracting T Cell Immunity

Magalhaes, I., Yogev, O., Mattsson, J., & Schurich, A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02309 · Cited by 34

The Ups and Downs of Metabolism during the Lifespan of a T Cell

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Spatial dynamics of tertiary lymphoid aggregates in head and neck cancer: insights into immunotherapy response

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Metabolic profiles of regulatory T cells in the tumour microenvironment

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BOXR1030, an anti-GPC3 CAR with exogenous GOT2 expression, shows enhanced T cell metabolism and improved anti-cell line derived tumor xenograft activity

Hickman, T. L., Choi, E., Whiteman, K. R., Muralidharan, S., Pai, T., Johnson, T., Parikh, A. B., Friedman, T., Gilbert, M., Shen, B., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0266980 · Cited by 36

Metabolic reprogramming of CAR T cells: a new frontier in cancer immunotherapy

Frlic, T., & Pavlin, M. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1688995 · Cited by 38

Mitochondria as Playmakers of CAR T-cell Fate and Longevity

Rostamian, H., Khakpoor-Koosheh, M., Fallah-Mehrjardi, K., Mirzaei, H. R., & Brown, C. E. (2021) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-21-0110 · Cited by 34

Mitochondrial regulation in the tumor microenvironment: targeting mitochondria for immunotherapy

Ahn, M., Ali, A., & Seo, J. H. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1453886 · Cited by 33

Insights Into the Role of Mitochondrial Ion Channels in Inflammatory Response

Ponnalagu, D., & Singh, H. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00258 · Cited by 32

Arming a killer: mitochondrial regulation of CD8+ T cell cytotoxicity

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Dual Effect of Combined Metformin and 2-Deoxy-D-Glucose Treatment on Mitochondrial Biogenesis and PD-L1 Expression in Triple-Negative Breast Cancer Cells

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In Vitro Modeling of Tumor–Immune System Interaction

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Regulation of T cell exhaustion and stemness: molecular mechanisms and implications for cancer immunotherapy

Chen, Z., Zhu, Z., Hu, T., Yao, C., & Wu, T. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01378-4 · Cited by 37

Metabolic and Mitochondrial Functioning in Chimeric Antigen Receptor (CAR)—T Cells

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Complement C1q binding protein regulates T cells’ mitochondrial fitness to affect their survival, proliferation, and anti–tumor immune function

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Drug delivery for metabolism targeted cancer immunotherapy

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Evolving CAR-T-Cell Therapy for Cancer Treatment: From Scientific Discovery to Cures

Majumder, A. (2023) · Cancers · doi:10.3390/cancers16010039 · Cited by 35

Single‐cell transcriptomics identify TNFRSF1B as a novel T‐cell exhaustion marker for ovarian cancer

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Glut3 overexpression improves environmental glucose uptake and antitumor efficacy of CAR-T cells in solid tumors

Hu, W., Li, F., Liang, Y., Liu, S., Wang, S., Shen, C., Zhao, Y., Wang, H., & Zhang, Y. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-010540 · Cited by 32

Tumour microenvironment on mitochondrial dynamics and chemoresistance in cancer

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Mitochondrial-Linked De Novo Pyrimidine Biosynthesis Dictates Human T-Cell Proliferation but Not Expression of Effector Molecules

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P2RX7 Enhances Tumor Control by CD8+ T Cells in Adoptive Cell Therapy

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Coengineering specificity, safety, and function into T cells for cancer immunotherapy

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Reprogramming the immunosuppressive tumor microenvironment: exploiting angiogenesis and thrombosis to enhance immunotherapy

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Perspectives in immunotherapy: meeting report from the “Immunotherapy Bridge 2018” (28–29 November, 2018, Naples, Italy)

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The future of cryoablation: An abscopal effect

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Harnessing Metabolic Reprogramming to Improve Cancer Immunotherapy

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Innate and Adaptive Immune Cell Metabolism in Tumor Microenvironment

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Genetically engineering glycolysis in T cells increases their antitumor function

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A Mitochondrial Polymorphism Alters Immune Cell Metabolism and Protects Mice from Skin Inflammation

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LDHB Overexpression Can Partially Overcome T Cell Inhibition by Lactic Acid

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Effects of ginger extract and its major component 6‐gingerol on anti‐tumor property through mitochondrial biogenesis in CD8 + T cells

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Synthetic Biology: Immunotherapy by Design

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PA suppresses antitumor immunity of T cells by disturbing mitochondrial activity through Akt/mTOR-mediated Ca2+ flux

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Syndecan-1 inhibition promotes antitumor immune response and facilitates the efficacy of anti-PD1 checkpoint immunotherapy

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Quercetin-derived microbial metabolite DOPAC potentiates CD8+ T cell anti-tumor immunity via NRF2-mediated mitophagy

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Engineering Metabolism of Chimeric Antigen Receptor (CAR) Cells for Developing Efficient Immunotherapies

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Reversing the mitochondrial stress-induced exhaustion of CD8+ T cells for improving cancer immunotherapy

Qian, C., & Cao, X. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00709-5 · Cited by 26

Impact of Drp1-Mediated Mitochondrial Dynamics on T Cell Immune Modulation

Song, J., Yi, X., Gao, R.-L., Sun, L., Wu, Z., Zhang, S., Huang, L., Han, C., & Ma, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.873834 · Cited by 29

LEF1 Drives a Central Memory Program and Supports Antitumor Activity of Natural Killer T Cells

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Filling the Tank: Keeping Antitumor T Cells Metabolically Fit for the Long Haul

Delgoffe, G. M. (2016) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-16-0244 · Cited by 26

Tumor Immune Microenvironment in Gynecologic Cancers

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Metabolic plasticity of T cell fate decision

Pan, X., Wang, J., Zhang, L., Li, G., & Huang, B. (2023) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002989 · Cited by 26

CD8+ T-cell exhaustion: Impediment to triple-negative breast cancer (TNBC) immunotherapy

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Methylmalonic acid induces metabolic abnormalities and exhaustion in CD8+ T cells to suppress anti-tumor immunity

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Harnessing Immune Rejuvenation: Advances in Overcoming T Cell Senescence and Exhaustion in Cancer Immunotherapy

Admasu, T. D., & Yu, J. S. (2025) · Aging Cell · doi:10.1111/acel.70055 · Cited by 30

Barriers and solutions for CAR-T therapy in solid tumors

Tu, Z., Chen, Y., Zhang, Z., Meng, W., & Li, L. (2025) · Cancer Gene Therapy · doi:10.1038/s41417-025-00931-7 · Cited by 32

Receptor signaling, transcriptional, and metabolic regulation of T cell exhaustion

Balkhi, M. Y. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1747349 · Cited by 26

Tinkering under the Hood: Metabolic Optimisation of CAR-T Cell Therapy

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Transflammation in tissue regeneration and response to injury: How cell-autonomous inflammatory signaling mediates cell plasticity

Cooke, J. P., & Lai, L. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115118 · Cited by 25

Prospects of molecular hydrogen in cancer prevention and treatment

Zhou, W., Zhang, J., Chen, W., & Miao, C. (2024) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-024-05685-7 · Cited by 25

Understanding and overcoming resistance to immunotherapy in genitourinary cancers

Evans, S. T., Jani, Y. C., Jansen, C. S., Yıldırım, A., Kalemoglu, E., & Bilen, M. A. (2024) · Cancer Biology & Therapy · doi:10.1080/15384047.2024.2342599 · Cited by 24

T cell exhaustion and senescence for ovarian cancer immunotherapy

Zhao, J., Wang, Z., Tian, Y., Ning, J., & Ye, H. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.07.001 · Cited by 26

The redox sensor KEAP1 facilitates adaptation of T cells to chronic antigen stimulation by preventing hyperactivation

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Metabolic immunoengineering approaches to enhance CD8+ T cell-based cancer immunotherapy

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Dysfunctional CD11c − CD21 − extrafollicular memory B cells are enriched in the periphery and tumors of patients with cancer

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Antitumour effect of the mitochondrial complex III inhibitor Atovaquone in combination with anti-PD-L1 therapy in mouse cancer models

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Current Advances and Challenges in CAR-T Therapy for Hematological and Solid Tumors

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The multifaceted impact of stress on immune function

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T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

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Translating In Vitro T Cell Metabolic Findings to In Vivo Tumor Models of Nutrient Competition

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Resistance mechanisms in melanoma to immuneoncologic therapy with checkpoint inhibitors

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Directing T-Cell Immune Responses for Cancer Vaccination and Immunotherapy

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Regulation of immune cell metabolism in health and disease: Special focus on T and B cell subsets

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C1QBP regulates mitochondrial plasticity to impact tumor progression and antitumor immune response

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Enhancing chimeric antigen receptor T cell therapy by modulating the p53 signaling network with Δ133p53α

Roselle, C., Horikawa, I., Chen, L., Kelly, A. R., Gonzales, D. M., Da, T., Wellhausen, N., Rommel, P. C., Baker, D., Suhoski, M. M., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2317735121 · Cited by 24

Nicotinamide Inhibits T Cell Exhaustion and Increases Differentiation of CD8 Effector T Cells

Alavi, S., Emran, A. A., Tseng, H., Tiffen, J. C., McGuire, H. M., & Hersey, P. (2022) · Cancers · doi:10.3390/cancers14020323 · Cited by 22

Metabolism heterogeneity in melanoma fuels deactivation of immunotherapy: Predict before protect

Zhang, X., Tai, Z., Miao, F., Huang, H., Zhu, Q., Bao, L., & Chen, Z. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1046102 · Cited by 22

mWTX-330, an IL-12 INDUKINE Molecule, Activates and Reshapes Tumor-Infiltrating CD8+ T and NK Cells to Generate Antitumor Immunity

Nirschl, C. J., Brodkin, H. R., Domonkos, C., Dwyer, C. J., Hicklin, D. J., Ismail, N. S., Seidel‐Dugan, C., Steiner, P., Steuert, Z., Sullivan, J. M., et al. (2023) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-22-0705 · Cited by 22

Metformin is associated with improved clinical outcomes in patients with melanoma: a retrospective, multi-institutional study

Augustin, R. C., Huang, Z., Ding, F., Zhai, S., McArdle, J., Santisi, A., Davis, M., Sander, C., Davar, D., Kirkwood, J. M., et al. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1075823 · Cited by 24

Prognostic value of fatty acid metabolism-related genes in colorectal cancer and their potential implications for immunotherapy

Huang, X., Sun, Y., Song, J., Huang, Y., Shi, H., Qian, A., Cao, Y., Zhou, Y., & Wang, Q. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1301452 · Cited by 22

Spatial Regulation of Mitochondrial Heterogeneity by Stromal Confinement in Micropatterned Tumor Models

Begum, H. M., Ta, H. P., Zhou, H., Ando, Y., Kang, D. S., Nemes, K., Mariano, C. F., Hao, J., Yu, M., & Shen, K. (2019) · Scientific Reports · doi:10.1038/s41598-019-47593-8 · Cited by 22

The tumor immune microenvironment and T-cell-related immunotherapies in colorectal cancer

Liu, C., Qifeng, J., & Shaolei, Y. (2024) · Discover Oncology · doi:10.1007/s12672-024-01117-7 · Cited by 22

Focusing on CD8+ T-cell phenotypes: improving solid tumor therapy

Yao, Z., Zeng, Y., Liu, C., Jin, H., Wang, H., Zhang, Y., Ding, C., Chen, G., & Wu, D. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-03195-5 · Cited by 27

Cholesterol homeostasis and lipid raft dynamics at the basis of tumor-induced immune dysfunction in chronic lymphocytic leukemia

Jacobs, C. F., Peters, F. S., Camerini, E., Cretenet, G., Rietveld, J. M., Schomakers, B. V., van Weeghel, M., Hahn, N., Verberk, S. G. S., den Bossche, J. V., et al. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01262-1 · Cited by 23

Reprogramming T-Cell Metabolism for Better Anti-Tumor Immunity

Ping, Y., Shen, C., Huang, B., & Zhang, Y. (2022) · Cells · doi:10.3390/cells11193103 · Cited by 22

Modulation of T cell function and survival by the tumor microenvironment

Mani, N. L., Andrews, D., & Obeng, R. C. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1191774 · Cited by 22

Leveraging immune resistance archetypes in solid cancer to inform next-generation anticancer therapies

Anderson, K. G., Braun, D. A., Buqué, A., Gitto, S. B., Guerriero, J. L., Horton, B. L., Keenan, B. P., Kim, T. S., Overacre-Delgoffe, A. E., Ruella, M., et al. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-006533 · Cited by 22

Human T cells loaded with superparamagnetic iron oxide nanoparticles retain antigen-specific TCR functionality

Pfister, F., Dörrie, J., Schaft, N., Buchele, V., Unterweger, H., Carnell, L. R., Schreier, P., Stein, R. A., Kubánková, M., Guck, J. R., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1223695 · Cited by 21

Advances in reprogramming of energy metabolism in tumor T cells

Xuekai, L., Yan, S., Chu, J., Yifei, S., Wu, X., Wenyuan, Z., Han, S., & Xi, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1347181 · Cited by 23

Stem‐like T cells in cancer and autoimmunity

Schnell, A. (2024) · Immunological Reviews · doi:10.1111/imr.13356 · Cited by 22

Mitochondrial metabolism: Inducer or therapeutic target in tumor immune-resistance?

Kopecka, J., Gazzano, E., Castella, B., Salaroglio, I. C., Mungo, E., Massaia, M., & Riganti, C. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.05.008 · Cited by 21

Abstract IA08: Identifying and overcoming metabolic checkpoints to antitumor immunity

Delgoffe, G. M. (2016) · Cancer Immunology Research · doi:10.1158/2326-6066.imm2016-ia08

Dysfunctional T cell metabolism in the tumor microenvironment

Beckermann, K. E., Dudzinski, S. O., & Rathmell, J. C. (2017) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2017.04.003 · Cited by 165

Immunometabolic requirements of T cell activation and exhaustion

Scharping, N. E. (2019) · D-Scholarship@Pitt (University of Pittsburgh)

Metabolic Barriers to T Cell Function in Tumors

Sugiura, A., & Rathmell, J. C. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701041 · Cited by 208

Abstract 632: The metabolic requirements for effective immunotherapy

Scharping, N. E., Menk, A. V., & Delgoffe, G. M. (2018) · Cancer Research · doi:10.1158/1538-7445.am2018-632