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Hematopoietic Stem Cells Are the Major Source of Multilineage Hematopoiesis in Adult Animals
Open accessAbstract
Hematopoietic stem cells (HSCs) sustain long-term reconstitution of hematopoiesis in transplantation recipients, yet their role in the endogenous steady-state hematopoiesis remains unclear. In particular, recent studies suggested that HSCs provide a relatively minor contribution to immune cell development in adults. We directed transgene expression in a fraction of HSCs that maintained reconstituting activity during serial transplantations. Inducible genetic labeling showed that transgene-expressing HSCs gave rise to other phenotypic HSCs, confirming their top position in the differentiation hierarchy. The labeled HSCs rapidly contributed to committed progenitors of all lineages and to mature myeloid cells and lymphocytes, but not to B-1a cells or tissue macrophages. Importantly, labeled HSCs gave rise to more than two-thirds of all myeloid cells and platelets in adult mice, and this contribution could be accelerated by an induced interferon response. Thus, classically defined HSCs maintain immune cell development in the steady state and during systemic cytokine responses.
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“Similarly, direct fluorescent labeling of mouse HSCs under steady state conditions illustrated a significant and continued contribution of HSCs to nearly all steady state hematopoiesis (Chapple et al., 2018; Sawai et al., 2016; Säwen et al., 2018).”
From Unraveling Hematopoiesis through the Lens of Genomics (2020) · cites this paper as Sawai et al., 2016
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InfluentialIFNα activates dormant haematopoietic stem cells in vivo
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Items 101–200 of 388
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BackgroundDimensions of neutrophil life and fate
Hidalgo, A., & Casanova-Acebes, M. (2021) · Seminars in Immunology · doi:10.1016/j.smim.2021.101506 · Cited by 47
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“, the generation of blood cells) relies on hematopoietic stem cells (HSCs), a rare cell population in the bone marrow [1].”
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Fujino, T., Asada, S., Goyama, S., & Kitamura, T. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04356-5 · Cited by 49
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“Pdzk1ip1-labled HSCs seem to be the major contributor of downstream progeny at steady state.(61) The exact reasons underlying these different conclusions remain to be clarified.”
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Nguyen, T. S., Lapidot, T., & Ruf, W. (2018) · Blood · doi:10.1182/blood-2017-12-768986 · Cited by 43
Contributions of Inflammation to Cardiometabolic Heart Failure with Preserved Ejection Fraction
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“Hematopoiesis is the process whereby the pool of all mature blood cells is replenished throughout an organism’s life time (Doulatov et al., 2012; Sawai et al., 2016).”
BackgroundNew Molecular Insights into Immune Cell Development
Cumano, A., Berthault, C., Ramond, C., Petit, M., Golub, R., Bandeira, A., & Pereira, P. (2019) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042718-041319 · Cited by 49
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Control of B-1a cell development by instructive BCR signaling
Kreslavsky, T., Wong, J. B., Fischer, M., Skok, J. A., & Busslinger, M. (2018) · Current Opinion in Immunology · doi:10.1016/j.coi.2018.01.001 · Cited by 42
Tracing human stem cell lineage during development using DNA methylationPreprint
Salas, L. A., Wiencke, J. K., Koestler, D. C., Zhang, Z., Christensen, B. C., & Kelsey, K. T. (2018) · Genome Research · doi:10.1101/gr.233213.117 · Cited by 41
“…using genetically labeled HSCs, which permits stem cell tracking without engraftment, have produced contrasting data on the relative contributions of HSCs and progenitors in steady-state hematopoiesis (Sun et al. 2014b; Busch et al. 2015; McKenna et al. 2016; Sawai et al. 2016; Säwén et al. 2016).”
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“HSCs are heterogeneous with respect to self-renewing and differentiation activity (8, 9).”
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Purton, L. E. (2022) · Experimental Hematology · doi:10.1016/j.exphem.2022.10.005 · Cited by 39
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“The bipotent pre-megakaryocyte erythrocyte progenitor (Pre-MgE), which is upstream of the more committed erythroid-restricted progenitor (Pre-CFUe), the CFUe (colony forming unit erythroid) and erythroblasts (EB), have been suggested as the first cells in the hematopoietic tree to robustly express EPO-R during hematop…”
Essential role for Gata2 in modulating lineage output from hematopoietic stem cells in zebrafish
Gioacchino, E., Koyunlar, C., Zink, J., de Looper, H. W. J., de Jong, M. M. E., Dobrzycki, T., Mahony, C. B., Hoogenboezem, R. M., Bosch, D. A., van Strien, P. M. H., et al. (2021) · Blood Advances · doi:10.1182/bloodadvances.2020002993 · Cited by 36
“Hematopoietic stem cells (HSCs) have the capacity to self-renew and generate all lineages of the hematopoietic system.(1) The HSC pool is a heterogeneous population of cells that are tightly controlled by cell-intrinsic and -extrinsic cues to maintain a balance between myeloid and lymphoid cell commitment.”
BackgroundBone marrow niches orchestrate stem-cell hierarchy and immune tolerance
Furuhashi, K., Kakiuchi, M., Ueda, R., Oda, H., Ummarino, S., Ebralidze, A. K., Bassal, M. A., Chen, M., Sato, T., Lyu, J., et al. (2025) · Nature · doi:10.1038/s41586-024-08352-6 · Cited by 39
“Third, imaging analyses using a HSC reporter mouse model, Pdzk1ip1 creER ; Rosa26 tdTomato mice 37 , reproduced the results of CD150 staining (Fig.”
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“A recent lineage tracing experiment with the hematopoietic stem cell restricted Pdzk1ip1-CreER line in tamoxifen-treated adult mice revealed that the contribution of adult hematopoiesis to B1 cell subset is below 10% over a 40-week observation period [29].”
BackgroundYolk sac hematopoiesis: does it contribute to the adult hematopoietic system?
Wittamer, V., & Bertrand, J. Y. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03527-6 · Cited by 38
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Yolk-sac-derived macrophages progressively expand in the mouse kidney with age
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“, report of Pdzk1ip1-GFP-labeled HSCs as the ultimate source of continuous lymphopoiesis and myelopoiesis under steady-state conditions, which can be accelerated by a systemic interferon response (5).”
BackgroundThe complexities and caveats of lineage tracing in the mammary gland
Rios, A. C., Fu, N. Y., Cursons, J., Lindeman, G. J., & Visvader, J. E. (2016) · Breast Cancer Research · doi:10.1186/s13058-016-0774-5 · Cited by 38
Clonal dominance and transplantation dynamics in hematopoietic stem cell compartments
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Emameh, R. Z., Nosrati, H., Eftekhari, M., Falak, R., & Khoshmirsafa, M. (2020) · Biological Procedures Online · doi:10.1186/s12575-020-00127-3 · Cited by 33
Aging and Clonal Behavior of Hematopoietic Stem Cells
Yamashita, M., & Iwama, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23041948 · Cited by 36
“Pdzk1ipCreERT2::Rosa26-LSLtdTomato HSCs 30% [38]”
BackgroundInfluentialFast and furious: The neutrophil and its armamentarium in health and disease
Metzemaekers, M., Malengier‐Devlies, B., Gouwy, M., Somer, L. D., Cunha, F. Q., Opdenakker, G., & Proost, P. (2023) · Medicinal Research Reviews · doi:10.1002/med.21958 · Cited by 30
“Neutrophil development starts with undifferentiated hematopoietic stem cells (HSCs; “the stem cell pool”) that occupy specific niches in the bone marrow furnished by osteoclasts and endothelial cells.(14) Proliferating HSCs reside around hematopoietic cords between venous sinuses.”
BackgroundHuang, X., Ferris, S. T., Kim, S. K., Choudhary, M. N. K., Belk, J. A., Fan, C., Qi, Y., Sudan, R., Xia, Y., Desai, P., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.04.015 · Cited by 33
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mTOR Signaling as a Regulator of Hematopoietic Stem Cell Fate
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Airway Macrophage and Dendritic Cell Subsets in the Resting Human Lung
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“In a similar manner to the hippocampus, almost all types of circulating blood cells are permanently being generated and released from the bone marrow, where hematopoietic stem cells (HSC) reside (69).”
BackgroundSplenic hematopoietic stem cells display a pre‐activated phenotype
Coppin, E., Florentin, J., Vasamsetti, S. B., Arunkumar, A., Sembrat, J., Rojas, M. M., & Dutta, P. (2018) · Immunology and Cell Biology · doi:10.1111/imcb.12035 · Cited by 28
“Under physiological conditions bone marrow HSC are the main source of hematopoiesis.(25) However, the spleen plays a crucial role in “emergency hematopoiesis”.”
BackgroundMisexpression of genes lacking CpG islands drives degenerative changes during aging
Lee, J.-Y., Davis, I., Youth, E. H. H., Kim, J., Churchill, G. A., Godwin, J. W., Korstanje, R., & Beck, S. (2021) · Science Advances · doi:10.1126/sciadv.abj9111 · Cited by 27
Ikonomi, N., Werle, S. D., Schwab, J. D., & Kestler, H. A. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00848 · Cited by 29
“HSCs are a particular population of cells characterized by the ability to self-renew and to generate differentiated blood cells (Pietras et al., 2011; Sun et al., 2014; Busch et al., 2015; Sawai et al., 2016).”
BackgroundMiao, R., Chun, H., Feng, X., Gomes, A. C., Choi, J., & Pereira, J. P. (2022) · Nature Communications · doi:10.1038/s41467-022-32228-w · Cited by 29
“These findings and model are more easily compatible with studies showing that HSCs actively contribute to blood cell production during homeostasis (Sawai et al., 2016) than with other studies suggesting that HSCs contribute only during physiological stress conditions such as systemic infection or…”
ResultHow cell migration helps immune sentinels
Delgado, M., & Lennon‐Duménil, A. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.932472 · Cited by 27
“and supports blood and immune system regeneration during the entire organism life (Sawai et al., 2016; Säwen et al., 2018).”
BackgroundDysregulation of haematopoietic stem cell regulatory programs in acute myeloid leukaemia
Basilico, S., & Göttgens, B. (2017) · Journal of Molecular Medicine · doi:10.1007/s00109-017-1535-3 · Cited by 30
“Though mostly quiescent [1], HSCs actively contribute to steady state haematopoiesis [2], which in turn is largely driven by long-lived multipotent progenitor cells [3, 4].”
BackgroundLin28b controls a neonatal to adult switch in B cell positive selection
Vanhee, S., Åkerstrand, H., Kristiansen, T. A., Datta, S., Montano, G., Vergani, S., Lang, S., Ungerbäck, J., Doyle, A., Olsson, K., et al. (2019) · Science Immunology · doi:10.1126/sciimmunol.aax4453 · Cited by 27
The biology of hematopoietic stem cells and its clinical implications
Skulimowska, I., Sośniak, J., Gońka, M., Szade, A., Józkowicz, A., & Szade, K. (2021) · FEBS Journal · doi:10.1111/febs.16192 · Cited by 27
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Hematopoietic Stem Cells Self-Renew Symmetrically or Gradually Proceed to DifferentiationPreprint
Barile, M., Busch, K., Fanti, A.-K., Greco, A., Wang, X., Oguro, H., Zhang, Q., Morrison, S. J., Rodewald, H.-R., & Höfer, T. (2020) · SSRN Electronic Journal · doi:10.1101/2020.08.06.239186 · Cited by 24
“With a similar approach, Sawai et al. (2016) found an HSC-to-MPP differentiation rate that is of the same order of magnitude (2.6 % of HSCs per day differentiating into MPPs) as our estimate, and hence does not contradict the idea of infrequent HSC input to MPPs.”
BackgroundResultInfluentialImaging and spatial analysis of hematopoietic stem cell niches
Gomariz, Á., Isringhausen, S., Helbling, P. M., & Nombela‐Arrieta, C. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14184 · Cited by 23
Tracking hematopoietic stem cells and their progeny using whole-genome sequencing
Lee-Six, H., & Kent, D. G. (2020) · Experimental Hematology · doi:10.1016/j.exphem.2020.01.004 · Cited by 26
Takahashi, M., Barile, M., Chapple, R. H., Tseng, Y.-J., Nakada, D., Busch, K., Fanti, A.-K., Säwén, P., Bryder, D., Höfer, T., et al. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.02.020 · Cited by 21
“…the upstream HSC population is at least five times smaller than the downstream HSC population, in agreement with the idea of a hematopoietic hierarchy where the relative size of progenitor populations tends to increase as one progresses down the hierarchy (Busch et al., 2015; Sawai et al., 2016).”
BackgroundMethodResultInfluentialThe ontogeny of murine B-1a cells
Yoshimoto, M. (2019) · International Journal of Hematology · doi:10.1007/s12185-019-02787-8 · Cited by 25
C/EBPβ is a critical mediator of IFN-α–induced exhaustion of chronic myeloid leukemia stem cells
Yokota, A., Hirai, H., Sato, R., Adachi, H., Sato, F., Hayashi, Y., Satō, A., Kamio, N., Miura, Y., Nakano, M., et al. (2019) · Blood Advances · doi:10.1182/bloodadvances.2018020503 · Cited by 24
Stem Cells, Hematopoiesis and Lineage Tracing: Transplantation-Centric Views and Beyond
Konturek-Cieśla, A., & Bryder, D. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.903528 · Cited by 24
To B1a or not to B1a: do hematopoietic stem cells contribute to tissue-resident immune cells?
Beaudin, A. E., & Forsberg, E. C. (2016) · Blood · doi:10.1182/blood-2016-10-697813 · Cited by 26
Impact of DNA methylation programming on normal and pre-leukemic hematopoiesis
Langstein, J., Milsom, M. D., & Lipka, D. B. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.09.008 · Cited by 25
“production under homeostatic conditions remains under debate, as seemingly contradictory results have been recently reported [48-50].”
ResultHematopoietic stem and progenitor cells as a reservoir for trained immunity
Tran, B. T., Jeyanathan, V., Cao, R., Kaufmann, E., & King, K. Y. (2025) · eLife · doi:10.7554/elife.106610 · Cited by 25
“For instance, some authors label ST-HSCs as positive for CD150 and CD48 ( Rathinam et al., 2011 ; Wang et al., 2013 ), whereas others label them as negative for those surface markers ( Pietras et al., 2015 ; Sawai et al., 2016 ).”
Ferrière, A., Santa, P., Garreau, A., Bandopadhyay, P., Blanco, P., Ganguly, D., & Sisirak, V. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.624256 · Cited by 24
“However, Kupffer cells are radioresistant and the contribution of bone marrow cells for their replenishment is low (56), therefore it is more likely that cGASSTING pathway is required in another cell type of hematopoietic origin for the development of NAFLD.”
BackgroundTian, S., Huang, P., Gu, Y., Yang, J., Wu, R., Zhao, J., Liu, A., & Zhang, W. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00408 · Cited by 22
Sarkaria, S. M., Decker, M., & Ding, L. (2018) · BioEssays · doi:10.1002/bies.201700190 · Cited by 22
Multiple waves of fetal‐derived immune cells constitute adult immune system
Kobayashi, M., & Yoshimoto, M. (2023) · Immunological Reviews · doi:10.1111/imr.13192 · Cited by 21
The influence of developmental timing on B cell diversity
Kristiansen, T. A., Vanhee, S., & Yuan, J. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.12.005 · Cited by 22
Essential cell-extrinsic requirement for PDIA6 in lymphoid and myeloid development
Choi, J. H., Zhong, X. Y., Zhang, Z., Su, L., McAlpine, W., Misawa, T., Liao, T.-C., Zhan, X., Russell, J. L., Ludwig, S. M., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20190006 · Cited by 21
“Lifelong generation of blood and immune cells from hematopoietic stem cells (HSCs) depends on the organized expression of lineage-specific transcriptional programs, and extrinsic regulation through cellular or molecular components of the microenvironment that support homeostasis of HSCs and immune cells (Osawa et al.,…”
BackgroundJaiswal, A. K., Makhija, S., Stahr, N. A., Sandey, M., Suryawanshi, A. S., Saxena, A., Dagur, P. K., McCoy, J. P., Levine, S. J., & Mishra, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00363 · Cited by 21
“In parallel our results demonstrate quantitative expansion of lineage-specific niche cells in the BM pool (38).”
ResultTo portray clonal evolution in blood cancer, count your stem cells
Lyne, A.-M., Laplane, L., & Perié, L. (2020) · Blood · doi:10.1182/blood.2020008407 · Cited by 26
Hoxb5 defines the heterogeneity of self-renewal capacity in the hematopoietic stem cell compartment
Sakamaki, T., Kao, K. S., Nishi, K., Chen, J. Y., Sadaoka, K., Fujii, M., Takaori‐Kondo, A., Weissman, I. L., & Miyanishi, M. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.12.077 · Cited by 21
Spiteri, A. G., Wishart, C. L., & King, N. J. C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.600822 · Cited by 31
Xu, Y., Murphy, A. J., & Fleetwood, A. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042234 · Cited by 23
“HSCs are now best understood as a heterogenous population of cells with distinct self-renewal abilities as well as potentially having inherent “biases” toward certain blood cell lineages [1,5,8,25].”
BackgroundBidirectional interplay between metabolism and epigenetics in hematopoietic stem cells and leukemia
Zhang, Y. W., Schönberger, K., & Cabezas‐Wallscheid, N. (2023) · The EMBO Journal · doi:10.15252/embj.2022112348 · Cited by 24
“%) resides in the resting phase, G0 (Cheshier et al , 1999; Zhang et al , 2022b), while the downstream multipotent progenitors are actively cycling to maintain daily turnover (Sun et al , 2014; Busch et al , 2015; Sawai et al , 2016).”
Elevated Oxidative Stress Impairs Hematopoietic Progenitor Function in C57BL/6 Substrains
Morales‐Hernández, A., Martinat, A., Chabot, A., Kang, G., & McKinney‐Freeman, S. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.06.011 · Cited by 20
“In addition, LT-HSCs contribute to maintaining the hematopoietic system throughout life (Nakamura-Ishizu et al., 2014; Sawai et al., 2016).”
BackgroundRadtke, S., Enstrom, M., Pande, D., Duke, E. R., Ojeda, E. F. C., Madhu, R., Owen, S., Kanestrom, G., Cui, M., Perez, A. M., et al. (2023) · Blood · doi:10.1182/blood.2022018564 · Cited by 19
Klose, M., Florian, M. C., Gerbaulet, A., Geiger, H., & Glauche, I. (2019) · Stem Cells · doi:10.1002/stem.3005 · Cited by 19
Deciphering the heterogeneity of myeloid cells during neuroinflammation in the single‐cell era
Borst, K., & Prinz, M. (2020) · Brain Pathology · doi:10.1111/bpa.12910 · Cited by 17
“Classical circulating monocytes are only sustained in the blood for a short time before they either infiltrate tissues and differentiate into tissue-resident macrophages/DCs or differentiate into nonclassical monocytes (165,200).”
BackgroundMacrophage, a potential targeted therapeutic immune cell for cardiomyopathy
Chen, G., Jiang, H., Yao, Y., Tao, Z., Chen, W., Huang, F., & Chen, X. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.908790 · Cited by 18
The slippery slope of hematopoietic stem cell aging
Wahlestedt, M., & Bryder, D. (2017) · Experimental Hematology · doi:10.1016/j.exphem.2017.09.008 · Cited by 18
An Overview of Autophagy in Hematopoietic Stem Cell Transplantation
Montazersaheb, S., Ehsani, A., Fathi, E., Farahzadi, R., & Vietor, I. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.849768 · Cited by 18
Tseng, Y.-J., Kageyama, Y., Murdaugh, R. L., Kitano, A., Kim, J. H., Hoegenauer, K. A., Tiessen, J., Smith, M. H., Uryu, H., Takahashi, K., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-44718-0 · Cited by 21
“This study provides additional support for a role for TET2 in non-myeloid hematopoietic cells, such as erythroid lineages.”
Tang, W., He, J., Huang, T., Bai, Z., Wang, C., Wang, H., Yang, R., Ni, Y., Hou, J. W., Wang, J., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.728057 · Cited by 17
Liver Regeneration by Hematopoietic Stem Cells: Have We Reached the End of the Road?
Siapati, E. K., Roubelakis, M. G., & Vassilopoulos, G. (2022) · Cells · doi:10.3390/cells11152312 · Cited by 19
“A finely regulated balance between differentiation and self-renewal generates all the blood cell lineages in the adult hematopoietic system and frequently replenishes short-lived blood lineages, such as neutrophils and platelets, to sustain blood system homeostasis [39].”
BackgroundExtrinsic regulation of hematopoietic stem cells in development, homeostasis and diseases
Lee, Y., Decker, M., Lee, H. J., & Ding, L. (2017) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.279 · Cited by 20
“More recently developed genetically encoded fluorescent markers have also allowed detailed studies of HSC localization.(16,17) The advancement of other imaging techniques such as intra-vital live imaging and tissue clearing technology has provided even more comprehensive views of the natural environment of HSCs in the…”
BackgroundRole of NR4A family members in myeloid cells and leukemia
Boulet, S., Le Corre, L., Odagiu, L., & Labrecque, N. (2022) · Current Research in Immunology · doi:10.1016/j.crimmu.2022.02.001 · Cited by 17
“While monocytes can differentiate into macrophages upon stimulation, the majority of tissue macrophages are of embryonic origin (Gin-houx and Jung, 2014; Sawai et al., 2016).”
The chromatin-associated Sin3B protein is required for hematopoietic stem cell functions in mice
Cantor, D. J., & David, G. (2016) · Blood · doi:10.1182/blood-2016-06-721746 · Cited by 16
Bmi1 Maintains the Self-Renewal Property of Innate-like B Lymphocytes
Kobayashi, M., Lin, Y., Mishra, A., Shelly, C., Gao, R., Reeh, C., Wang, Z. P., Xi, R., Liu, Y., Wenzel, P. L., et al. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000030 · Cited by 17
“without being replenished by adult HSC-derived progenitors (9).”
BackgroundClones assemble! The clonal complexity of blood during ontogeny and disease
Ganuza, M., Hall, T., Obeng, E. A., & McKinney‐Freeman, S. (2020) · Experimental Hematology · doi:10.1016/j.exphem.2020.01.009 · Cited by 17
Mast Cell Repopulating Ability Is Lost During the Transition From Pre-HSC to FL HSC
Yoshimoto, M., Kosters, A., Cornelius, S. A., Valiente, N., Cheng, H., Latorre, A., Nishida, C., Ghosn, E., & Kobayashi, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.896396 · Cited by 14
“FL MPP subpopulations have not been characterized well, therefore, LSKCD150CD48 cells or KSL CD201(EPCR)CD48 cells were referred to as MPP in the FL (19).”
BackgroundLymphoid cell development from fetal hematopoietic progenitors and human pluripotent stem cells
Sun, S., Wijanarko, K. J., Liani, O., Strumila, K. A., Ng, E. S., Elefanty, A. G., & Stanley, E. G. (2023) · Immunological Reviews · doi:10.1111/imr.13197 · Cited by 14
Stem cell decoupling underlies impaired lymphoid development during aging
Jang, G., Contreras, S., Esteva, E., Upadhaya, S., Feng, J., Adams, N. M., Richard, É., Awatramani, R. B., Sawai, C. M., & Reizis, B. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2302019120 · Cited by 19
“1 I ), reflecting the differentiation of originally labeled “top-level” HSCs into downstream HSCs as described (21).”
BackgroundGenome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation
Tiniakou, I., Hsu, P.-F., López-Zepeda, L. S., Garipler, G., Esteva, E., Adams, N. M., Jang, G., Soni, C., Lau, C. M., Liu, F., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.adi1023 · Cited by 15
“5D and 6D) is consistent with the lack of BM progenitor input to LCs ( 71 ).”
BackgroundNew genetic tools for the in vivo study of hematopoietic stem cell function
Upadhaya, S., Reizis, B., & Sawai, C. M. (2018) · Experimental Hematology · doi:10.1016/j.exphem.2018.02.004 · Cited by 15
“Finally, we recently generated Pdzk1ip1-GFP transgenic animals and found reporter expression in the subset of HSCs with the phenotype of the least differentiated cells [37].”
BackgroundMethod
Metadata
- Authors
- Sawai, C. M., Babovic, S., Upadhaya, S., Knapp, D. J. H. F., Lavin, Y., Lau, C. M., Goloborodko, A., Feng, J., Fujisaki, J., Ding, L., Mirny, L. A., Merad, M., Eaves, C. J., & Reizis, B.
- Affiliations
- NYU Langone Health (US)
- BC Cancer Agency (CA)
- Columbia University Irving Medical Center (US)
- Tisch Cancer Institute (US)
- Massachusetts Institute of Technology (US)
- Corresponding author
- Sawai, Catherine M.
- Reizis, Boris
- ORCID
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 45
- Issue
- 3
- Pages
- 597-609
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC5054720
- OpenAlex
- W2517782886
- Cited by
- 381
- References
- 50
- Citations by year
- 2026: 13 · 2025: 22 · 2024: 33 · 2023: 35 · 2022: 45 · 2021: 36 · 2020: 55 · 2019: 54 · 2018: 49 · 2017: 33 · 2016: 6
- FWCI
- 45.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-nd)
- PMC
- Funders
- National Institutes of Health
- Canadian Institutes of Health Research
- National Institute on Aging (R01AG049074)
- National Heart, Lung, and Blood Institute (R21HL113678, R01HL132074, R01HL129506)
- National Cancer Institute (R01CA173861, R01CA190400, R01CA154947, P30CA016087)
- National Institute of General Medical Sciences (T32GM008224)
- National Institute of Allergy and Infectious Diseases (R01AI072571, R21AI115382, T32AI100853, R37AI072571)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD055165)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Hematology › Blood disorders and treatments
- Keywords
- hematopoietic stem cells, multilineage hematopoiesis, steady-state hematopoiesis, myeloid cell development, lymphocyte development, megakaryopoiesis, interferon response, serial transplantation, B-1a cells, tissue macrophages
- MeSH terms
- Animals, B-Lymphocytes, Blood Platelets, Cell Differentiation, Hematopoiesis, Hematopoietic Stem Cells, Interferons, Macrophages, Mice, Inbred C57BL, Hematopoietic Stem Cell Transplantation, Cell Lineage, Myeloid Cells, Mice
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