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Cited by 17Nuclear Receptors and SignalingEstrogen and related hormone effectsRetinoids in leukemia and cellular processes

Role of NR4A family members in myeloid cells and leukemia

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Boulet, Salix, Le Corre, Laure, Odagiu, Livia, Labrecque, Nathalie·2022·Current Research in Immunology
DOI 10.1016/j.crimmu.2022.02.001PMC PMC9040138
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Abstract

The myeloid cellular compartment comprises monocytes, dendritic cells (DCs), macrophages and granulocytes. As diverse as this group of cells may be, they are all an important part of the innate immune system and are therefore linked by the necessity to be acutely sensitive to their environment and to rapidly and appropriately respond to any changes that may occur. The nuclear orphan receptors NR4A1, NR4A2 and NR4A3 are encoded by immediate early genes as their expression is rapidly induced in response to various signals. It is perhaps because of this characteristic that this family of transcription factors has many known roles in myeloid cells. In this review, we will regroup and discuss the diverse roles NR4As have in different myeloid cell subsets, including in differentiation, migration, activation, and metabolism. We will also highlight the importance these molecules have in the development of myeloid leukemia.

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  • NR4A1 and other NR4A family members have an immunomodulatory role in mature cell types, most commonly in T cells and macrophages.

    “NR4A1 and other NR4A family members are known for their immunomodulatory role in mature cell types, most commonly in T cell and macrophages [83,84].”

    From Clonal hematopoiesis and inflammation – the perpetual cycle (2023) · cites this paper as [83]

    The section ‘NR4As limit the inflammatory macrophage response’ describes how NR4A family members regulate macrophage inflammation, and the macrophage section mentions NR4A1’s role in regulatory T-cell development. The paper does not establish that T cells and macrophages are the cell types in which these roles occur most commonly; its discussion also covers other myeloid cells. Page numbers were not available in our copy. (LLM, conf=0.82)

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  1. Alitalo K. Winqvist R. Keski-Oja J. Ilvonen M. Saksela K. Alitalo R. Laiho M. Knuutila S. Chapelle A.D.L. Acute myelogenous leukemia with C-MYC amplification and double minute chromosomes Lancet 326 1985 1035 1039 10.1016/s0140-6736(85)90907-9 2865517 · DOI
  2. Arber D.A. Orazi A. Hasserjian R. Thiele J. Borowitz M.J. Beau M.M.L. Bloomfield C.D. Cazzola M. Vardiman J.W. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia Blood 127 2016 2391 2405 10.1182/blood-2016-03-643544 27069254 · DOI · Paper page
  3. Arkenbout E.K. Waard V. de Bragt M. van van Achterberg T.A.E. Grimbergen J.M. Pichon B. Pannekoek H. Vries C.J.M. de Protective function of transcription factor TR3 orphan receptor in atherogenesis Circulation 106 2002 1530 1535 10.1161/01.cir.0000028811.03056.bf 12234960 · DOI
  4. Auffray C. Fogg D. Garfa M. Elain G. Join-Lambert O. Kayal S. Sarnacki S. Cumano A. Lauvau G. Geissmann F. Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior Science 317 2007 666 670 10.1126/science.1142883 17673663 · DOI · Paper page
  5. Baker K.D. Shewchuk L.M. Kozlova T. Makishima M. Hassell A. Wisely B. Caravella J.A. Lambert M.H. Reinking J.L. Krause H. Thummel C.S. Willson T.M. Mangelsdorf D.J. The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway Cell 113 2003 731 742 10.1016/s0092-8674(03)00420-3 12809604 · DOI
  6. Baratin M. Foray C. Demaria O. Habbeddine M. Pollet E. Maurizio J. Verthuy C. Davanture S. Azukizawa H. Flores-Langarica A. Dalod M. Lawrence T. Homeostatic NF-κB signaling in steady-state migratory dendritic cells regulates immune homeostasis and tolerance Immunity 42 2015 627 639 10.1016/j.immuni.2015.03.003 25862089 · DOI
  7. Barish G.D. Downes M. Alaynick W.A. Yu R.T. Ocampo C.B. Bookout A.L. Mangelsdorf D.J. Evans R.M. A nuclear receptor atlas: macrophage activation Mol. Endocrinol. 19 2005 2466 2477 10.1210/me.2004-0529 16051664 · DOI
  8. Blanchard V. Moussaoui S. Czech C. Touchet N. Bonici B. Planche M. Canton T. Jedidi I. Gohin M. Wirths O. Bayer T.A. Langui D. Duyckaerts C. Tremp G. Pradier L. Time sequence of maturation of dystrophic neurites associated with Aβ deposits in APP/PS1 transgenic mice Exp. Neurol. 184 2003 247 263 10.1016/s0014-4886(03)00252-8 14637096 · DOI · Paper page
  9. Block M.L. Zecca L. Hong J.-S. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms Nat. Rev. Neurosci. 8 2007 57 69 10.1038/nrn2038 17180163 · DOI · Paper page
  10. Bluteau D. Gilles L. Hilpert M. Antony-Debré I. James C. Debili N. Camara-Clayette V. Wagner-Ballon O. Cordette-Lagarde V. Robert T. Ripoche H. Gonin P. Swierczek S. Prchal J. Vainchenker W. Favier R. Raslova H. Down-regulation of the RUNX1-target gene NR4A3 contributes to hematopoiesis deregulation in familial platelet disorder/acute myelogenous leukemia Blood 118 2011 6310 6320 10.1182/blood-2010-12-325555 21725049 · DOI
  11. Bonta P.I. Matlung H.L. Vos M. Peters S.L.M. Pannekoek H. Bakker E.N.T.P. Vries C.J.M. de Nuclear receptor Nur77 inhibits vascular outward remodelling and reduces macrophage accumulation and matrix metalloproteinase levels Cardiovasc. Res. 87 2010 561 568 10.1093/cvr/cvq064 20189954 · DOI
  12. Bonta P.I. van Tiel C.M. Vos M. Pols T.W.H. van Thienen J.V. Ferreira V. Arkenbout E.K. Seppen J. Spek C.A. van der Poll T. Pannekoek H. de Vries C.J.M. Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses Arterioscler. Thromb. Vasc. Biol. 26 2006 2288 2294 10.1161/01.atv.0000238346.84458.5d 16873729 · DOI
  13. Boudreaux S.P. Duren R.P. Call S.G. Nguyen L. Freire P.R. Narayanan P. Redell M.S. Conneely O.M. Drug targeting of NR4A nuclear receptors for treatment of acute myeloid leukemia Leukemia 33 2019 52 63 10.1038/s41375-018-0174-1 29884904 PMC6286710 · DOI
  14. Boudreaux S.P. Ramirez-Herrick A.M. Duren R.P. Conneely O.M. Genome-wide profiling reveals transcriptional repression of MYC as a core component of NR4A tumor suppression in acute myeloid leukemia Oncogenesis 1 2012 10.1038/oncsis.2012.19 e19–e19 PMC3412651 23552735 · DOI
  15. Boulet S. Daudelin J.-F. Odagiu L. Pelletier A.-N. Yun T.J. Lesage S. Cheong C. Labrecque N. The orphan nuclear receptor NR4A3 controls the differentiation of monocyte-derived dendritic cells following microbial stimulation Proc. Natl. Acad. Sci. Unit. States Am. 116 2019 15150 15159 10.1073/pnas.1821296116 PMC6660778 31285338 · DOI
  16. Briseño C.G. Haldar M. Kretzer N.M. Wu X. Theisen D.J. Kc W. Durai V. Grajales-Reyes G.E. Iwata A. Bagadia P. Murphy T.L. Murphy K.M. Distinct transcriptional programs control cross-priming in classical and monocyte-derived dendritic cells Cell Rep. 15 2016 2462 2474 10.1016/j.celrep.2016.05.025 27264183 PMC4941620 · DOI
  17. Bruning J.M. Wang Y. Oltrabella F. Tian B. Kholodar S.A. Liu H. Bhattacharya P. Guo S. Holton J.M. Fletterick R.J. Jacobson M.P. England P.M. Covalent modification and regulation of the nuclear receptor Nurr1 by a dopamine metabolite Cell Chem Biol 26 2019 674 685 10.1016/j.chembiol.2019.02.002 e6 30853418 PMC7185887 · DOI
  18. Call S.G. Duren R.P. Panigrahi A.K. Nguyen L. Freire P.R. Grimm S.L. Coarfa C. Conneely O.M. Targeting oncogenic super enhancers in MYC-dependent AML using a small molecule activator of NR4A nuclear receptors Sci. Rep. 10 2020 2851 10.1038/s41598-020-59469-3 32071334 PMC7029036 · DOI
  19. Carlin L.M. Stamatiades E.G. Auffray C. Hanna R.N. Glover L. Vizcay-Barrena G. Hedrick C.C. Cook H.T. Diebold S. Geissmann F. Nr4a1-Dependent Ly6Clo monocytes monitor endothelial cells and orchestrate their disposal Cell 153 2013 362 375 10.1016/j.cell.2013.03.010 23582326 PMC3898614 · DOI
  20. Chambon P. The nuclear receptor superfamily: a personal retrospect on the first two decades Mol. Endocrinol. 19 2005 1418 1428 10.1210/me.2005-0125 15914711 · DOI · Paper page
  21. Chao L.C. Soto E. Hong C. Ito A. Pei L. Chawla A. Conneely O.M. Tangirala R.K. Evans R.M. Tontonoz P. Bone marrow NR4A expression is not a dominant factor in the development of atherosclerosis or macrophage polarization in mice J. Lipid Res. 54 2013 806 815 10.1194/jlr.m034157 23288947 PMC3617954 · DOI
  22. Cheong C. Matos I. Choi J.-H. Dandamudi D.B. Shrestha E. Longhi M.P. Jeffrey K.L. Anthony R.M. Kluger C. Nchinda G. Koh H. Rodriguez A. Idoyaga J. Pack M. Velinzon K. Park C.G. Steinman R.M. Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209+ dendritic cells for immune T cell areas Cell 143 2010 416 429 10.1016/j.cell.2010.09.039 21029863 PMC3150728 · DOI
  23. Cros J. Cagnard N. Woollard K. Patey N. Zhang S.-Y. Senechal B. Puel A. Biswas S.K. Moshous D. Picard C. Jais J.-P. D'Cruz D. Casanova J.-L. Trouillet C. Geissmann F. Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors Immunity 33 2010 375 386 10.1016/j.immuni.2010.08.012 20832340 PMC3063338 · DOI
  24. Dehn S. Thorp E.B. Myeloid receptor CD36 is required for early phagocytosis of myocardial infarcts and induction of Nr4a1‐dependent mechanisms of cardiac repair Faseb. J. 32 2018 254 264 10.1096/fj.201700450r 28860151 PMC5731133 · DOI
  25. Dress R.J. Liu Z. Ginhoux F. Towards the better understanding of myelopoiesis using single-cell technologies Mol. Immunol. 122 2020 186 192 10.1016/j.molimm.2020.04.020 32388073 · DOI
  26. Duren R.P. Boudreaux S.P. Conneely O.M. Genome wide mapping of NR4A binding reveals cooperativity with ETS factors to promote epigenetic activation of distal enhancers in acute myeloid leukemia cells PLoS One 11 2016 e0150450 10.1371/journal.pone.0150450 PMC4777543 26938745 · DOI
  27. Dwyer D.F. Barrett N.A. Austen K.F. Dwyer D.F. Barrett N.A. Austen K.F. Kim E.Y. Brenner M.B. Shaw L. Yu B. Goldrath A. Mostafavi S. Regev A. Rhoades A. Moodley D. Yoshida H. Mathis D. Benoist C. Nabekura T. Lam V. Lanier L.L. Brown B. Merad M. Cremasco V. Turley S. Monach P. Dustin M.L. Li Y. Shinton S.A. Hardy R.R. Shay T. Qi Y. Sylvia K. Kang J. Fairfax K. Randolph G.J. Robinette M.L. Fuchs A. Colonna M. Expression profiling of constitutive mast cells reveals a unique identity within the immune system Nat. Immunol. 17 2016 878 887 10.1038/ni.3445 27135604 PMC5045264 · DOI
  28. Egarnes B. Blanchet M.-R. Gosselin J. Treatment with the NR4A1 agonist cytosporone B controls influenza virus infection and improves pulmonary function in infected mice PLoS One 12 2017 e0186639 10.1371/journal.pone.0186639 PMC5650162 29053748 · DOI
  29. Ericson J.A. Duffau P. Yasuda K. Ortiz-Lopez A. Rothamel K. Rifkin I.R. Monach P.A. Consortium I. Gene expression during the generation and activation of mouse neutrophils: implication of novel functional and regulatory pathways PLoS One 9 2014 e108553 10.1371/journal.pone.0108553 PMC4184787 25279834 · DOI
  30. Evans R.M. Mangelsdorf D.J. Nuclear receptors, RXR, and the big bang Cell 157 2014 255 266 10.1016/j.cell.2014.03.012 24679540 PMC4029515 · DOI · Paper page
  31. Fahrbach S.E. Smagghe G. Velarde R.A. Insect nuclear receptors Annu. Rev. Entomol. 57 2012 83 106 10.1146/annurev-ento-120710-100607 22017307 · DOI
  32. Flaig R. Greschik H. Peluso-Iltis C. Moras D. Structural basis for the cell-specific activities of the NGFI-B and the Nurr1 ligand-binding domain J. Biol. Chem. 280 2005 19250 19258 10.1074/jbc.m413175200 15716272 · DOI
  33. Förster R. Schubel A. Breitfeld D. Kremmer E. Renner-Müller I. Wolf E. Lipp M. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs Cell 99 1999 23 33 10.1016/s0092-8674(00)80059-8 10520991 · DOI
  34. Freire P.R. Conneely O.M. NR4A1 and NR4A3 restrict HSC proliferation via reciprocal regulation of C/EBPα and inflammatory signaling Blood 131 2018 1081 1093 10.1182/blood-2017-07-795757 29343483 PMC5863701 · DOI · Paper page
  35. Garcia-Faroldi G. Melo F.R. Bruemmer D. Conneely O.M. Pejler G. Lundequist A. Nuclear receptor 4a3 (Nr4a3) regulates murine mast cell responses and granule content PLoS One 9 2014 e89311 10.1371/journal.pone.0089311 PMC3930735 24586680 · DOI
  36. Geissmann F. Jung S. Littman D.R. Blood monocytes consist of two principal subsets with distinct migratory properties Immunity 19 2003 71 82 10.1016/s1074-7613(03)00174-2 12871640 · DOI
  37. Girardin S.E. Boneca I.G. Viala J. Chamaillard M. Labigne A. Thomas G. Philpott D.J. Sansonetti P.J. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection J. Biol. Chem. 278 2003 8869 8872 10.1074/jbc.c200651200 12527755 · DOI
  38. Glass C.K. Saijo K. Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells Nat. Rev. Immunol. 10 2010 365 376 10.1038/nri2748 20414208 · DOI · Paper page
  39. Gombart A.F. Hofmann W.-K. Kawano S. Takeuchi S. Krug U. Kwok S.H. Larsen R.J. Asou H. Miller C.W. Hoelzer D. Koeffler H.P. Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein α in myelodysplastic syndromes and acute myeloid leukemias Blood 99 2002 1332 1340 10.1182/blood.v99.4.1332 11830484 · DOI
  40. Grajales-Reyes G.E. Iwata A. Albring J. Wu X. Tussiwand R. Kc W. Kretzer N.M. Briseño C.G. Durai V. Bagadia P. Haldar M. Schönheit J. Rosenbauer F. Murphy T.L. Murphy K.M. Batf3 maintains autoactivation of Irf8 for commitment of a CD8α+ conventional DC clonogenic progenitor Nat. Immunol. 16 2015 708 717 10.1038/ni.3197 26054719 PMC4507574 · DOI
  41. Grimes C.L. Ariyananda L.D.Z. Melnyk J.E. O'Shea E.K. The innate immune protein Nod2 binds directly to MDP, a bacterial cell wall fragment J. Am. Chem. Soc. 134 2012 13535 13537 10.1021/ja303883c 22857257 PMC3424850 · DOI
  42. Gronemeyer H. Gustafsson J.-Å. Laudet V. Principles for modulation of the nuclear receptor superfamily Nat. Rev. Drug Discov. 3 2004 950 964 10.1038/nrd1551 15520817 · DOI
  43. Guilliams M. Mildner A. Yona S. Developmental and functional heterogeneity of monocytes Immunity 49 2018 595 613 10.1016/j.immuni.2018.10.005 30332628 · DOI · Paper page
  44. Hamers A.A.J. van Dam L. Duarte J.M.T. Vos M. Marinković G. van Tiel C.M. Meijer S.L. van Stalborch A.-M. Huveneers S. Te Velde A.A. de Jonge W.J. de Vries C.J.M. Deficiency of nuclear receptor Nur77 aggravates mouse experimental colitis by increased NFκB activity in macrophages PLoS One 10 2015 e0133598 10.1371/journal.pone.0133598 PMC4524678 26241646 · DOI
  45. Hamers A.A.J. Vos M. Rassam F. Marinković G. Marincovic G. Kurakula K. Gorp P.J. van Winther M.P.J. de Gijbels M.J.J. Waard V. de Vries C.J.M. de Bone marrow–specific deficiency of nuclear receptor Nur77 enhances atherosclerosis Circ. Res. 110 2012 428 438 10.1161/circresaha.111.260760 22194623 · DOI
  46. Hanna R.N. Carlin L.M. Hubbeling H.G. Nackiewicz D. Green A.M. Punt J.A. Geissmann F. Hedrick C.C. The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C− monocytes Nat. Immunol. 12 2011 778 785 10.1038/ni.2063 21725321 PMC3324395 · DOI · Paper page
  47. Hanna R.N. Cekic C. Sag D. Tacke R. Thomas G.D. Nowyhed H. Herrley E. Rasquinha N. McArdle S. Wu R. Peluso E. Metzger D. Ichinose H. Shaked I. Chodaczek G. Biswas S.K. Hedrick C.C. Patrolling monocytes control tumor metastasis to the lung Science 350 2015 985 990 10.1126/science.aac9407 26494174 PMC4869713 · DOI
  48. Hanna R.N. Shaked I. Hubbeling H.G. Punt J.A. Wu R. Herrley E. Zaugg C. Pei H. Geissmann F. Ley K. Hedrick C.C. NR4A1 (Nur77) deletion polarizes macrophages toward an inflammatory phenotype and increases atherosclerosis Circ. Res. 110 2012 416 427 10.1161/circresaha.111.253377 22194622 PMC3309661 · DOI
  49. Helft J. Böttcher J. Chakravarty P. Zelenay S. Huotari J. Schraml B.U. Goubau D. Reis e Sousa C. GM-CSF mouse bone marrow cultures comprise a heterogeneous population of CD11c+MHCII+ macrophages and dendritic cells Immunity 42 2015 1197 1211 10.1016/j.immuni.2015.05.018 26084029 · DOI
  50. Heng T.S.P. Painter M.W. Consortium T.I.G.P. The Immunological Genome Project: networks of gene expression in immune cells Nat. Immunol. 9 2008 1091 1094 10.1038/ni1008-1091 18800157 · DOI · Paper page
  51. Hilgendorf I. Gerhardt L. Tan T.C. Winter C. Holderried T.A.W. Chousterman B.G. Iwamoto Y. Liao R. Zirlik A. Scherer-Crosbie M. Hedrick C.C. Libby P. Nahrendorf M. Weissleder R. Swirski F.K. Ly-6Chigh monocytes depend on Nr4a1 to balance both inflammatory and reparative phases in the infarcted myocardium Circ. Res. 114 2014 1611 1622 10.1161/circresaha.114.303204 24625784 PMC4017349 · DOI
  52. Hnisz D. Abraham B.J. Lee T.I. Lau A. Saint-André V. Sigova A.A. Hoke H.A. Young R.A. Super-enhancers in the control of cell identity and disease Cell 155 2013 934 947 10.1016/j.cell.2013.09.053 24119843 PMC3841062 · DOI · Paper page
  53. Hoffman B. Amanullah A. Shafarenko M. Liebermann D.A. The proto-oncogene c-myc in hematopoietic development and leukemogenesis Oncogene 21 2002 3414 3421 10.1038/sj.onc.1205400 12032779 · DOI
  54. Huang H.-Y. Chang H.-F. Tsai M.-J. Chen J.-S. Wang M.-J. 6-Mercaptopurine attenuates tumor necrosis factor-α production in microglia through Nur77-mediated transrepression and PI3K/Akt/mTOR signaling-mediated translational regulation J. Neuroinflammation 13 2016 78 10.1186/s12974-016-0543-5 27075886 PMC4831152 · DOI
  55. Inaba K. Inaba M. Romani N. Aya H. Deguchi M. Ikehara S. Muramatsu S. Steinman R.M. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor J. Exp. Med. 176 1992 1693 1702 10.1084/jem.176.6.1693 1460426 PMC2119469 · DOI
  56. Ingersoll M.A. Spanbroek R. Lottaz C. Gautier E.L. Frankenberger M. Hoffmann R. Lang R. Haniffa M. Collin M. Tacke F. Habenicht A.J.R. Ziegler-Heitbrock L. Randolph G.J. Comparison of gene expression profiles between human and mouse monocyte subsets Blood 115 2010 10.1182/blood-2009-07-235028 e10–e19 PMC2810986 19965649 · DOI
  57. Ipseiz N. Uderhardt S. Scholtysek C. Steffen M. Schabbauer G. Bozec A. Schett G. Krönke G. The nuclear receptor Nr4a1 mediates anti-inflammatory effects of apoptotic cells J. Immunol. 192 2014 4852 4858 10.4049/jimmunol.1303377 24740500 · DOI
  58. Jakubzick C. Gautier E.L. Gibbings S.L. Sojka D.K. Schlitzer A. Johnson T.E. Ivanov S. Duan Q. Bala S. Condon T. van Rooijen N. Grainger J.R. Belkaid Y. Ma’ayan A. Riches D.W.H. Yokoyama W.M. Ginhoux F. Henson P.M. Randolph G.J. Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes Immunity 39 2013 599 610 10.1016/j.immuni.2013.08.007 24012416 PMC3820017 · DOI
  59. Jang Y. Kim W. Leblanc P. Kim C.-H. Kim K.-S. Potent synthetic and endogenous ligands for the adopted orphan nuclear receptor Nurr1 Exp. Mol. Med. 53 2021 19 29 10.1038/s12276-021-00555-5 33479411 PMC8080818 · DOI
  60. Jha A.K. Huang S.C.-C. Sergushichev A. Lampropoulou V. Ivanova Y. Loginicheva E. Chmielewski K. Stewart K.M. Ashall J. Everts B. Pearce E.J. Driggers E.M. Artyomov M.N. Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization Immunity 42 2015 419 430 10.1016/j.immuni.2015.02.005 25786174 · DOI · Paper page
  61. Jung S. Aliberti J. Graemmel P. Sunshine M.J. Kreutzberg G.W. Sher A. Littman D.R. Analysis of fractalkine receptor CX3CR1 function by targeted deletion and green fluorescent protein reporter gene insertion Mol. Cell Biol. 20 2000 4106 4114 10.1128/mcb.20.11.4106-4114.2000 10805752 PMC85780 · DOI · Paper page
  62. Karthaus N. Hontelez S. Looman M.W.G. Spriel A.B. van Ansems M. Adema G.J. Nuclear receptor expression patterns in murine plasmacytoid and conventional dendritic cells Mol. Immunol. 55 2013 409 417 10.1016/j.molimm.2013.03.020 23597769 · DOI
  63. Koenis D.S. Medzikovic L. Loenen P.B. van Weeghel M. van Huveneers S. Vos M. Gogh I.J.E. Bossche J.V. den Speijer D. Kim Y. Wessels L. Zelcer N. Zwart W. Kalkhoven E. Vries C.J. de Nuclear receptor Nur77 limits the macrophage inflammatory response through transcriptional reprogramming of mitochondrial metabolism Cell Rep. 24 2018 2127 2140 10.1016/j.celrep.2018.07.065 e7 30134173 PMC6113932 · DOI
  64. Lamb J. Crawford E.D. Peck D. Modell J.W. Blat I.C. Wrobel M.J. Lerner J. Brunet J.-P. Subramanian A. Ross K.N. Reich M. Hieronymus H. Wei G. Armstrong S.A. Haggarty S.J. Clemons P.A. Wei R. Carr S.A. Lander E.S. Golub T.R. The connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease Science 313 2006 1929 1935 10.1126/science.1132939 17008526 · DOI · Paper page
  65. Land R.H. Rayne A.K. Vanderbeck A.N. Barlowe T.S. Manjunath S. Gross M. Eiger S. Klein P.S. Cunningham N.R. Huang J. Emerson S.G. Punt J.A. The orphan nuclear receptor NR4A1 specifies a distinct subpopulation of quiescent myeloid‐biased long‐term HSCs Stem Cell. 33 2015 278 288 10.1002/stem.1852 PMC4270858 25284014 · DOI · Paper page
  66. Le W. Xu P. Jankovic J. Jiang H. Appel S.H. Smith R.G. Vassilatis D.K. Mutations in NR4A2 associated with familial Parkinson disease Nat. Genet. 33 2003 85 89 10.1038/ng1066 12496759 · DOI
  67. Lehtonen A. Ahlfors H. Veckman V. Miettinen M. Lahesmaa R. Julkunen I. Gene expression profiling during differentiation of human monocytes to macrophages or dendritic cells J. Leukoc. Biol. 82 2007 710 720 10.1189/jlb.0307194 17595377 · DOI
  68. Li H. Kolluri S.K. Gu J. Dawson M.I. Cao X. Hobbs P.D. Lin B. Chen G. Lu J. Lin F. Xie Z. Fontana J.A. Reed J.C. Zhang X. Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3 Science 289 2000 1159 1164 10.1126/science.289.5482.1159 10947977 · DOI
  69. Li L. Liu Y. Chen H. Li F. Wu J. Zhang H. He J. Xing Y. Chen Y. Wang W. Tian X. Li A. Zhang Q. Huang P. Han J. Lin T. Wu Q. Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation Nat. Chem. Biol. 11 2015 339 346 10.1038/nchembio.1788 25822914 · DOI
  70. Lin B. Kolluri S.K. Lin F. Liu W. Han Y.-H. Cao X. Dawson M.I. Reed J.C. Zhang X. Conversion of bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3 Cell 116 2004 527 540 10.1016/s0092-8674(04)00162-x 14980220 · DOI
  71. Lu L. McCaslin D. Starzl T.E. Thomson A.W. Bone marrow-derived dendritic cell progenitors (NLDC 145+, MHC CLASS II+, B7-1dim, B7-2−) induce alloantigen-specific hyporesponsiveness in murine T lymphocytes Transplantation 60 1995 1539 1545 10.1097/00007890-199560120-00028 8545887 PMC3000171 · DOI
  72. Lundequist A. Calounova G. Wensman H. Rönnberg E. Pejler G. Differential regulation of Nr4a subfamily nuclear receptors following mast cell activation Mol. Immunol. 48 2011 1753 1761 10.1016/j.molimm.2011.04.017 21621845 · DOI
  73. Luo H. Li Q. O'Neal J. Kreisel F. Beau M.M.L. Tomasson M.H. c-Myc rapidly induces acute myeloid leukemia in mice without evidence of lymphoma-associated antiapoptotic mutations Blood 106 2005 2452 2461 10.1182/blood-2005-02-0734 15972450 · DOI
  74. Mahajan S. Saini A. Chandra V. Nanduri R. Kalra R. Bhagyaraj E. Khatri N. Gupta P. Nuclear receptor Nr4a2 promotes alternative polarization of macrophages and confers protection in sepsis J. Biol. Chem. 290 2015 18304 18314 10.1074/jbc.m115.638064 25953901 PMC4513091 · DOI
  75. Majeti R. Becker M.W. Tian Q. Lee T.-L.M. Yan X. Liu R. Chiang J.-H. Hood L. Clarke M.F. Weissman I.L. Dysregulated gene expression networks in human acute myelogenous leukemia stem cells Proc. Natl. Acad. Sci. Unit. States Am. 106 2009 3396 3401 10.1073/pnas.0900089106 PMC2642659 19218430 · DOI · Paper page
  76. McCracken J.M. Allen L.-A.H. Regulation of human neutrophil apoptosis and lifespan in Health and disease J. Cell Death 7 2014 15 23 10.4137/jcd.s11038 25278783 PMC4167320 · DOI
  77. Menezes S. Melandri D. Anselmi G. Perchet T. Loschko J. Dubrot J. Patel R. Gautier E.L. Hugues S. Longhi M.P. Henry J.Y. Quezada S.A. Lauvau G. Lennon-Duménil A.-M. Gutiérrez-Martínez E. Bessis A. Gomez-Perdiguero E. Jacome-Galarza C.E. Garner H. Geissmann F. Golub R. Nussenzweig M.C. Guermonprez P. The heterogeneity of Ly6Chi monocytes controls their differentiation into iNOS+ macrophages or monocyte-derived dendritic cells Immunity 45 2016 1205 1218 10.1016/j.immuni.2016.12.001 28002729 PMC5196026 · DOI
  78. Menges M. Baumeister T. Rössner S. Stoitzner P. Romani N. Gessner A. Lutz M.B. IL‐4 supports the generation of a dendritic cell subset from murine bone marrow with altered endocytosis capacity J. Leukoc. Biol. 77 2005 535 543 10.1189/jlb.0804473 15618296 · DOI
  79. Mildner A. Schönheit J. Giladi A. David E. Lara-Astiaso D. Lorenzo-Vivas E. Paul F. Chappell-Maor L. Priller J. Leutz A. Amit I. Jung S. Genomic characterization of murine monocytes reveals C/EBPβ transcription factor dependence of Ly6C− cells Immunity 46 2017 849 862 10.1016/j.immuni.2017.04.018 e7 28514690 · DOI
  80. Miller J.C. Brown B.D. Shay T. Gautier E.L. Jojic V. Cohain A. Pandey G. Leboeuf M. Elpek K.G. Helft J. Hashimoto D. Chow A. Price J. Greter M. Bogunovic M. Bellemare-Pelletier A. Frenette P.S. Randolph G.J. Turley S.J. Merad M. Gautier E.L. Jakubzick C. Randolph G.J. Best A.J. Knell J. Goldrath A. Miller J. Brown B. Merad M. Jojic V. Koller D. Cohen N. Brennan P. Brenner M. Shay T. Regev A. Fletcher A. Elpek K. Bellemare-Pelletier A. Malhotra D. Turley S. Jianu R. Laidlaw D. Collins J. Narayan K. Sylvia K. Kang J. Gazit R. Rossi D.J. Kim F. Rao T.N. Wagers A. Shinton S.A. Hardy R.R. Monach P. Bezman N.A. Sun J.C. Kim C.C. Lanier L.L. Heng T. Kreslavsky T. Painter M. Ericson J. Davis S. Mathis D. Benoist C. Deciphering the transcriptional network of the dendritic cell lineage Nat. Immunol. 13 2012 888 899 10.1038/ni.2370 22797772 PMC3985403 · DOI
  81. Mills E.L. Kelly B. Logan A. Costa A.S.H. Varma M. Bryant C.E. Tourlomousis P. Däbritz J.H.M. Gottlieb E. Latorre I. Corr S.C. McManus G. Ryan D. Jacobs H.T. Szibor M. Xavier R.J. Braun T. Frezza C. Murphy M.P. O'Neill L.A. Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages Cell 167 2016 457 470 10.1016/j.cell.2016.08.064 e13 27667687 PMC5863951 · DOI · Paper page
  82. Moore K.J. Tabas I. Macrophages in the pathogenesis of atherosclerosis Cell 145 2011 341 355 10.1016/j.cell.2011.04.005 21529710 PMC3111065 · DOI · Paper page
  83. Moran A.E. Holzapfel K.L. Xing Y. Cunningham N.R. Maltzman J.S. Punt J. Hogquist K.A. T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse J. Exp. Med. 208 2011 1279 1289 10.1084/jem.20110308 21606508 PMC3173240 · DOI
  84. Mullican S.E. Zhang S. Konopleva M. Ruvolo V. Andreeff M. Milbrandt J. Conneely O.M. Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia Nat. Med. 13 2007 730 735 10.1038/nm1579 17515897 · DOI
  85. Nagaoka M. Yashiro T. Uchida Y. Ando T. Hara M. Arai H. Ogawa H. Okumura K. Kasakura K. Nishiyama C. The orphan nuclear receptor NR4A3 is involved in the function of dendritic cells J. Immunol. 199 2017 2958 2967 10.4049/jimmunol.1601911 28893954 · DOI
  86. Nagatsu T. Sawada M. Inflammatory process in Parkinsons disease: role for cytokines Curr. Pharmaceut. Des. 11 2005 999 1016 10.2174/1381612053381620 15777250 · DOI
  87. Naik S.H. Proietto A.I. Wilson N.S. Dakic A. Schnorrer P. Fuchsberger M. Lahoud M.H. O'Keeffe M. Shao Q. Chen W. Villadangos J.A. Shortman K. Wu L. Cutting edge: generation of splenic CD8+ and CD8− dendritic cell equivalents in fms-like tyrosine kinase 3 ligand bone marrow cultures J. Immunol. 174 2005 6592 6597 10.4049/jimmunol.174.11.6592 15905497 · DOI
  88. Ng S.S.M. Chang T.-H. Tailor P. Ozato K. Kino T. Virus‐induced differential expression of nuclear receptors and coregulators in dendritic cells: implication to interferon production FEBS Lett. 585 2011 1331 1337 10.1016/j.febslet.2011.04.001 21492741 PMC3101080 · DOI
  89. Nonnenmacher Y. Hiller K. Biochemistry of proinflammatory macrophage activation Cell. Mol. Life Sci. 75 2018 2093 2109 10.1007/s00018-018-2784-1 29502308 PMC5948278 · DOI
  90. Odagiu L. Boulet S. Sousa D.M.D. Daudelin J.-F. Nicolas S. Labrecque N. Early programming of CD8+ T cell response by the orphan nuclear receptor NR4A3 Proc. Natl. Acad. Sci. Unit. States Am. 117 2020 24392 24402 10.1073/pnas.2007224117 PMC7533658 32913051 · DOI
  91. Odagiu L. May J. Boulet S. Baldwin T.A. Labrecque N. Role of the orphan nuclear receptor NR4A family in T-cell biology Front. Endocrinol. 11 2021 624122 10.3389/fendo.2020.624122 PMC7883379 33597928 · DOI · Paper page
  92. Ohl L. Mohaupt M. Czeloth N. Hintzen G. Kiafard Z. Zwirner J. Blankenstein T. Henning G. Förster R. CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions Immunity 21 2004 279 288 10.1016/j.immuni.2004.06.014 15308107 · DOI · Paper page
  93. Overington J.P. Al-Lazikani B. Hopkins A.L. How many drug targets are there? Nat. Rev. Drug Discov. 5 2006 993 996 10.1038/nrd2199 17139284 · DOI · Paper page
  94. Pabst T. Mueller B.U. Zhang P. Radomska H.S. Narravula S. Schnittger S. Behre G. Hiddemann W. Tenen D.G. Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia Nat. Genet. 27 2001 263 270 10.1038/85820 11242107 · DOI · Paper page
  95. Paoli F.D. Eeckhoute J. Copin C. Vanhoutte J. Duhem C. Derudas B. Dubois-Chevalier J. Colin S. Zawadzki C. Jude B. Haulon S. Lefebvre P. Staels B. Chinetti-Gbaguidi G. The neuron-derived orphan receptor 1 (NOR1) is induced upon human alternative macrophage polarization and stimulates the expression of markers of the M2 phenotype Atherosclerosis 241 2015 18 26 10.1016/j.atherosclerosis.2015.04.798 25941992 · DOI
  96. Park K. Mikulski Z. Seo G.-Y. Andreyev A.Y. Marcovecchio P. Blatchley A. Kronenberg M. Hedrick C.C. The transcription factor NR4A3 controls CD103+ dendritic cell migration J. Clin. Invest. 126 2016 4603 4615 10.1172/jci87081 27820700 PMC5127666 · DOI
  97. Passlick B. Flieger D. Ziegler-Heitbrock H.W. Identification and characterization of a novel monocyte subpopulation in human peripheral blood Blood 74 1989 2527 2534 2478233
  98. Pearen M.A. Muscat G.E.O. Minireview: nuclear hormone receptor 4A signaling: implications for metabolic disease Mol. Endocrinol. 24 2010 1891 1903 10.1210/me.2010-0015 20392876 PMC5417389 · DOI
  99. Pei L. Castrillo A. Chen M. Hoffmann A. Tontonoz P. Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli J. Biol. Chem. 280 2005 29256 29262 10.1074/jbc.m502606200 15964844 · DOI
  100. Philips A. Lesage S. Gingras R. Maira M.H. Gauthier Y. Hugo P. Drouin J. Novel dimeric Nur77 signaling mechanism in endocrine and lymphoid cells Mol. Cell Biol. 17 1997 5946 5951 10.1128/mcb.17.10.5946 9315652 PMC232442 · DOI
  101. Porse B.T. Bryder D. Theilgaard-Mönch K. Hasemann M.S. Anderson K. Damgaard I. Jacobsen S.E.W. Nerlov C. Loss of C/EBPα cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage J. Exp. Med. 202 2005 85 96 10.1084/jem.20050067 15983063 PMC2212897 · DOI · Paper page
  102. Prince L.R. Prosseda S.D. Higgins K. Carlring J. Prestwich E.C. Ogryzko N.V. Rahman A. Basran A. Falciani F. Taylor P. Renshaw S.A. Whyte M.K.B. Sabroe I. NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival Blood 130 2017 1014 1025 10.1182/blood-2017-03-770164 28637666 PMC5570679 · DOI
  103. Qing H. Liu Y. Zhao Y. Aono J. Jones K.L. Heywood E.B. Howatt D. Binkley C.M. Daugherty A. Liang Y. Bruemmer D. Deficiency of the NR4A orphan nuclear receptor NOR1 in hematopoietic stem cells accelerates atherosclerosis Stem Cell. 32 2014 2419 2429 10.1002/stem.1747 PMC4138236 24806827 · DOI
  104. Rajan S. Jang Y. Kim C.-H. Kim W. Toh H.T. Jeon J. Song B. Serra A. Lescar J. Yoo J.Y. Beldar S. Ye H. Kang C. Liu X.-W. Feitosa M. Kim Y. Hwang D. Goh G. Lim K.-L. Park H.M. Lee C.H. Oh S.F. Petsko G.A. Yoon H.S. Kim K.-S. PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function Nat. Chem. Biol. 16 2020 876 886 10.1038/s41589-020-0553-6 32451509 PMC7405943 · DOI
  105. Ramirez-Herrick A.M. Mullican S.E. Sheehan A.M. Conneely O.M. Reduced NR4A gene dosage leads to mixed myelodysplastic/myeloproliferative neoplasms in mice Blood 117 2011 2681 2690 10.1182/blood-2010-02-267906 21205929 PMC3062356 · DOI
  106. Roe J.-S. Mercan F. Rivera K. Pappin D.J. Vakoc C.R. BET bromodomain inhibition suppresses the function of hematopoietic transcription factors in acute myeloid leukemia Mol. Cell 58 2015 1028 1039 10.1016/j.molcel.2015.04.011 25982114 PMC4475489 · DOI
  107. Sabbah A. Chang T.H. Harnack R. Frohlich V. Tominaga K. Dube P.H. Xiang Y. Bose S. Activation of innate immune antiviral responses by Nod2 Nat. Immunol. 10 2009 1073 1080 10.1038/ni.1782 19701189 PMC2752345 · DOI
  108. Safe S. Jin U.-H. Morpurgo B. Abudayyeh A. Singh M. Tjalkens R.B. Nuclear receptor 4A (NR4A) family – orphans no more J. Steroid Biochem. Mol. Biol. 157 2016 48 60 10.1016/j.jsbmb.2015.04.016 25917081 PMC4618773 · DOI
  109. Saijo K. Winner B. Carson C.T. Collier J.G. Boyer L. Rosenfeld M.G. Gage F.H. Glass C.K. A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death Cell 137 2009 47 59 10.1016/j.cell.2009.01.038 19345186 PMC2754279 · DOI · Paper page
  110. Saini A. Mahajan S. Gupta P. Nuclear receptor expression atlas in BMDCs: Nr4a2 restricts immunogenicity of BMDCs and impedes EAE Eur. J. Immunol. 46 2016 1842 1853 10.1002/eji.201546229 27184189 · DOI
  111. Sallusto F. Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha J. Exp. Med. 179 1994 1109 1118 10.1084/jem.179.4.1109 8145033 PMC2191432 · DOI · Paper page
  112. Sever R. Glass C.K. Signaling by nuclear receptors Csh Perspect Biol 5 2013 a016709 10.1101/cshperspect.a016709 PMC3578364 23457262 · DOI · Paper page
  113. Shaked I. Hanna R.N. Shaked H. Chodaczek G. Nowyhed H.N. Tweet G. Tacke R. Basat A.B. Mikulski Z. Togher S. Miller J. Blatchley A. Salek-Ardakani S. Darvas M. Kaikkonen M.U. Thomas G.D. Lai-Wing-Sun S. Rezk A. Bar-Or A. Glass C.K. Bandukwala H. Hedrick C.C. Transcription factor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation Nat. Immunol. 16 2015 1228 1234 10.1038/ni.3321 26523867 PMC4833087 · DOI
  114. Shao Q. Shen L.-H. Hu L.-H. Pu J. Qi M.-Y. Li W.-Q. Tian F.-J. Jing Q. He B. Nuclear receptor Nur77 suppresses inflammatory response dependent on COX-2 in macrophages induced by oxLDL J. Mol. Cell. Cardiol. 49 2010 304 311 10.1016/j.yjmcc.2010.03.023 20381497 · DOI
  115. Shimizu R. Muto T. Aoyama K. Choi K. Takeuchi M. Koide S. Hasegawa N. Isshiki Y. Togasaki E. Kawajiri-Manako C. Nagao Y. Tsukamoto S. Sakai S. Takeda Y. Mimura N. Ohwada C. Sakaida E. Iseki T. Starczynowski D.T. Iwama A. Yokote K. Nakaseko C. Possible role of intragenic DNA hypermethylation in gene silencing of the tumor suppressor gene NR4A3 in acute myeloid leukemia Leuk. Res. 50 2016 85 94 10.1016/j.leukres.2016.09.018 27697661 PMC5729587 · DOI
  116. Sirin O. Lukov G.L. Mao R. Conneely O.M. Goodell M.A. The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cells Nat. Cell Biol. 12 2010 1213 1219 10.1038/ncb2125 21076412 PMC3059561 · DOI
  117. Slovak M.L. Ho J.P. Pettenati M.J. Khan A. Douer D. Lal S. Traweek S.T. Localization of amplified MYC gene sequences to double minute chromosomes in acute myelogenous leukemia Genes Chromosomes Cancer 9 1994 62 67 10.1002/gcc.2870090111 7507702 · DOI
  118. Sousa C.R. e Activation of dendritic cells: translating innate into adaptive immunity Curr. Opin. Immunol. 16 2004 21 25 10.1016/j.coi.2003.11.007 14734106 · DOI
  119. Stanley P. Smith A. McDowall A. Nicol A. Zicha D. Hogg N. Intermediate‐affinity LFA‐1 binds α‐actinin‐1 to control migration at the leading edge of the T cell EMBO J. 27 2008 62 75 10.1038/sj.emboj.7601959 18079697 PMC2147999 · DOI
  120. Stein J.V. Rot A. Luo Y. Narasimhaswamy M. Nakano H. Gunn M.D. Matsuzawa A. Quackenbush E.J. Dorf M.E. Andrian U.H. von The cc chemokine thymus-derived chemotactic agent 4 (Tca-4, secondary lymphoid tissue chemokine, 6ckine, exodus-2) triggers lymphocyte function–associated antigen 1–mediated arrest of rolling T lymphocytes in peripheral lymph node high endothelial venules J. Exp. Med. 191 2000 61 76 10.1084/jem.191.1.61 10620605 PMC2195804 · DOI
  121. Sternberg A. Killick S. Littlewood T. Hatton C. Peniket A. Seidl T. Soneji S. Leach J. Bowen D. Chapman C. Standen G. Massey E. Robinson L. Vadher B. Kaczmarski R. Janmohammed R. Clipsham K. Carr A. Vyas P. Evidence for reduced B-cell progenitors in early (low-risk) myelodysplastic syndrome Blood 106 2005 2982 2991 10.1182/blood-2005-04-1543 16076868 · DOI
  122. Sunderkötter C. Nikolic T. Dillon M.J. Rooijen N. van Stehling M. Drevets D.A. Leenen P.J.M. Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response J. Immunol. 172 2004 4410 4417 10.4049/jimmunol.172.7.4410 15034056 · DOI · Paper page
  123. Tacke F. Ginhoux F. Jakubzick C. Rooijen N. van Merad M. Randolph G.J. Immature monocytes acquire antigens from other cells in the bone marrow and present them to T cells after maturing in the periphery J. Exp. Med. 203 2006 583 597 10.1084/jem.20052119 16492803 PMC2118235 · DOI
  124. Tacke R. Hilgendorf I. Garner H. Waterborg C. Park K. Nowyhed H. Hanna R.N. Wu R. Swirski F.K. Geissmann F. Hedrick C.C. The transcription factor NR4A1 is essential for the development of a novel macrophage subset in the thymus Sci. Rep. 5 2015 10055 10.1038/srep10055 PMC4473761 26091486 · DOI
  125. Tannahill G.M. Curtis A.M. Adamik J. Palsson-McDermott E.M. McGettrick A.F. Goel G. Frezza C. Bernard N.J. Kelly B. Foley N.H. Zheng L. Gardet A. Tong Z. Jany S.S. Corr S.C. Haneklaus M. Caffrey B.E. Pierce K. Walmsley S. Beasley F.C. Cummins E. Nizet V. Whyte M. Taylor C.T. Lin H. Masters S.L. Gottlieb E. Kelly V.P. Clish C. Auron P.E. Xavier R.J. O'Neill L.A.J. Succinate is an inflammatory signal that induces IL-1β through HIF-1α Nature 496 2013 238 242 10.1038/nature11986 23535595 PMC4031686 · DOI · Paper page
  126. Tel-Karthaus N. Kers-Rebel E.D. Looman M.W. Ichinose H. Vries C.J. de Ansems M. Nuclear receptor Nur77 deficiency alters dendritic cell function Front. Immunol. 9 2018 1797 10.3389/fimmu.2018.01797 30123220 PMC6085422 · DOI
  127. Thomas G.D. Hanna R.N. Vasudevan N.T. Hamers A.A. Romanoski C.E. McArdle S. Ross K.D. Blatchley A. Yoakum D. Hamilton B.A. Mikulski Z. Jain M.K. Glass C.K. Hedrick C.C. Deleting an Nr4a1 super-enhancer subdomain ablates Ly6Clow monocytes while preserving macrophage gene function Immunity 45 2016 975 987 10.1016/j.immuni.2016.10.011 27814941 PMC5694686 · DOI
  128. Thompson J. Winoto A. During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain J. Exp. Med. 205 2008 1029 1036 10.1084/jem.20080101 18443228 PMC2373836 · DOI
  129. Ufer F. Vargas P. Engler J.B. Tintelnot J. Schattling B. Winkler H. Bauer S. Kursawe N. Willing A. Keminer O. Ohana O. Salinas-Riester G. Pless O. Kuhl D. Friese M.A. Arc/Arg3.1 governs inflammatory dendritic cell migration from the skin and thereby controls T cell activation Sci. Immunol. 1 2016 10.1126/sciimmunol.aaf8665 eaaf8665–eaaf8665 28783680 · DOI
  130. Varga T. Mounier R. Gogolak P. Poliska S. Chazaud B. Nagy L. Tissue LyC6− macrophages are generated in the absence of circulating LyC6− monocytes and Nur77 in a model of muscle regeneration J. Immunol. 191 2013 5695 5701 10.4049/jimmunol.1301445 24133167 · DOI
  131. Varol C. Landsman L. Fogg D.K. Greenshtein L. Gildor B. Margalit R. Kalchenko V. Geissmann F. Jung S. Monocytes give rise to mucosal, but not splenic, conventional dendritic cells J. Exp. Med. 204 2007 171 180 10.1084/jem.20061011 17190836 PMC2118434 · DOI · Paper page
  132. Vera I.M.S. de Munoz-Tello P. Zheng J. Dharmarajan V. Marciano D.P. Matta-Camacho E. Giri P.K. Shang J. Hughes T.S. Rance M. Griffin P.R. Kojetin D.J. Defining a canonical ligand-binding pocket in the orphan nuclear receptor Nurr1 Structure 27 2019 66 77 10.1016/j.str.2018.10.002 e5 30416039 PMC6318021 · DOI
  133. Villani A.-C. Satija R. Reynolds G. Sarkizova S. Shekhar K. Fletcher J. Griesbeck M. Butler A. Zheng S. Lazo S. Jardine L. Dixon D. Stephenson E. Nilsson E. Grundberg I. McDonald D. Filby A. Li W. Jager P.L.D. Rozenblatt-Rosen O. Lane A.A. Haniffa M. Regev A. Hacohen N. Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors Science 356 2017 eaah4573 10.1126/science.aah4573 28428369 PMC5775029 · DOI · Paper page
  134. Wang T. Jiang Q. Chan C. Gorski K.S. McCadden E. Kardian D. Pardoll D. Whartenby K.A. Inhibition of activation-induced death of dendritic cells and enhancement of vaccine efficacy via blockade of MINOR Blood 113 2009 2906 2913 10.1182/blood-2008-08-176354 19164597 PMC2662637 · DOI
  135. Wang Z. Benoit G. Liu J. Prasad S. Aarnisalo P. Liu X. Xu H. Walker N.P.C. Perlmann T. Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors Nature 423 2003 555 560 10.1038/nature01645 12774125 · DOI
  136. Wansa K.D.S.A. Muscat G.E.O. TRAP220 is modulated by the antineoplastic agent 6-Mercaptopurine, and mediates the activation of the NR4A subgroup of nuclear receptors J. Mol. Endocrinol. 34 2005 835 848 10.1677/jme.1.01739 15956351 · DOI
  137. Westbrook L. Johnson A.C. Regner K.R. Williams J.M. Mattson D.L. Kyle P.B. Henegar J.R. Garrett M.R. Genetic susceptibility and loss of Nr4a1 enhances macrophage-mediated renal injury in CKD J. Am. Soc. Nephrol. 25 2014 2499 2510 10.1681/asn.2013070786 24722447 PMC4214519 · DOI
  138. Wilson T. Fahrner T. Johnston M. Milbrandt J. Identification of the DNA binding site for NGFI-B by genetic selection in yeast Science 252 1991 1296 1300 10.1126/science.1925541 1925541 · DOI
  139. Winoto A. Littman D.R. Nuclear hormone receptors in T lymphocytes Cell 109 2002 S57 S66 10.1016/s0092-8674(02)00710-9 11983153 · DOI
  140. Yamakita Y. Matsumura F. Lipscomb M.W. Chou P. Werlen G. Burkhardt J.K. Yamashiro S. Fascin1 promotes cell migration of mature dendritic cells J. Immunol. 186 2011 2850 2859 10.4049/jimmunol.1001667 21263068 PMC3526951 · DOI
  141. Yona S. Kim K.-W. Wolf Y. Mildner A. Varol D. Breker M. Strauss-Ayali D. Viukov S. Guilliams M. Misharin A. Hume D.A. Perlman H. Malissen B. Zelzer E. Jung S. Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis Immunity 38 2013 79 91 10.1016/j.immuni.2012.12.001 23273845 PMC3908543 · DOI · Paper page
  142. Zetterström R.H. Solomin L. Jansson L. Hoffer B.J. Olson L. Perlmann T. Dopamine neuron agenesis in Nurr1-deficient mice Science 276 1997 248 250 10.1126/science.276.5310.248 9092472 · DOI
  143. Zhan Y. Du X. Chen H. Liu J. Zhao B. Huang D. Li G. Xu Q. Zhang M. Weimer B.C. Chen D. Cheng Z. Zhang L. Li Q. Li S. Zheng Z. Song S. Huang Y. Ye Z. Su W. Lin S.-C. Shen Y. Wu Q. Cytosporone B is an agonist for nuclear orphan receptor Nur77 Nat. Chem. Biol. 4 2008 548 556 10.1038/nchembio.106 18690216 · DOI
  144. Zhao J.L. Ma C. O'Connell R.M. Mehta A. DiLoreto R. Heath J.R. Baltimore D. Conversion of danger signals into cytokine signals by hematopoietic stem and progenitor cells for regulation of stress-induced hematopoiesis Cell Stem Cell 14 2014 445 459 10.1016/j.stem.2014.01.007 24561084 PMC4119790 · DOI
  145. Zhao Y. Howatt D.A. Gizard F. Nomiyama T. Findeisen H.M. Heywood E.B. Jones K.L. Conneely O.M. Daugherty A. Bruemmer D. Deficiency of the NR4A orphan nuclear receptor NOR1 decreases monocyte adhesion and atherosclerosis Circ. Res. 107 2010 501 511 10.1161/circresaha.110.222083 20558821 PMC2924939 · DOI
  146. Zheng Z. Chiu S. Akbarpour M. Sun H. Reyfman P.A. Anekalla K.R. Abdala-Valencia H. Edgren D. Li W. Kreisel D. Korobova F.V. Fernandez R. McQuattie-Pimentel A. Zhang Z.J. Perlman H. Misharin A.V. Budinger G.R.S. Bharat A. Donor pulmonary intravascular nonclassical monocytes recruit recipient neutrophils and mediate primary lung allograft dysfunction Sci. Transl. Med. 9 2017 eaal4508 10.1126/scitranslmed.aal4508 PMC5568853 28615357 · DOI

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Authors
Boulet, S., Le Corre, L., Odagiu, L., & Labrecque, N.
Affiliations
Hôpital Maisonneuve-Rosemont (CA)
Corresponding author
Labrecque, Nathalie
ORCID
Venue
Current Research in Immunology
Publisher
Elsevier BV
Published
2022
Volume
3
Pages
23-36
ISSN
2590-2555 (ISSN-L)
DOI
10.1016/j.crimmu.2022.02.001
PMC
PMC9040138
OpenAlex
W4213190714
Cited by
17
References
7
Citations by year
2026: 2 · 2025: 6 · 2024: 4 · 2023: 4 · 2022: 1
FWCI
1.66
Type
journal article
Language
en
Open access
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Locations
  • Current Research in Immunology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Canadian Institutes of Health Research (MOP 142333, PJT 168910)
  • Fonds de Recherche du Québec - Santé
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
Keywords
orphan nuclear receptor, Nur77, Nurr1, NR4A3, myeloid cells, monocytes, dendritic cells, macrophages, granulocytes, myeloid leukemia, cell differentiation, cell migration, cell activation, cellular metabolism, innate immunity, transcription factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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