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Cited by 18Cardiac Fibrosis and RemodelingCongenital heart defects researchAtherosclerosis and Cardiovascular Diseases

Macrophage, a potential targeted therapeutic immune cell for cardiomyopathy

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Chen, Ganyi, Jiang, Hongwei, Yao, Yiwei, Tao, Zhonghao, Chen, Wen, Huang, Fuhua, Chen, Xin·2022·Frontiers in Cell and Developmental Biology
DOI 10.3389/fcell.2022.908790PMC PMC9561843
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Abstract

Cardiomyopathy is a major cause of heart failure, leading to systolic and diastolic dysfunction and promoting adverse cardiac remodeling. Macrophages, as key immune cells of the heart, play a crucial role in inflammation and fibrosis. Moreover, exogenous and cardiac resident macrophages are functionally and phenotypically different during cardiac injury. Although experimental evidence has shown that macrophage-targeted therapy is promising in cardiomyopathy, clinical translation remains challenging. In this article, the molecular mechanism of macrophages in cardiomyopathy has been discussed in detail based on existing literature. The issues and considerations of clinical treatment strategies for myocardial fibrosis has also been analyzed.

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  • Standard non-specific immunosuppressive therapies risk silencing reparative macrophage populations.

    “Currently, standard non-specific immunosuppressive therapies risk silencing reparative macrophage populations, highlighting the critical need to map specific functional subsets and their spatial niches for precision immunomodulation [3,10,16].”

    From Cardiac Macrophages Exhibit Dynamic Heterogeneity and Functional Specialization During Experimental Autoimmune Myocarditis. (2026) · cites this paper as [16]

    The Introduction and the section on cardiac remodeling describe reparative macrophages, and the therapeutic-strategy section proposes targeting macrophage phenotypes. But the paper does not say that standard non-specific immunosuppressive therapies risk silencing reparative macrophages; searches for immunosuppressive therapy and steroids did not establish that link. No page numbers were available in our copy. (LLM, conf=0.82)

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Authors
Chen, G., Jiang, H., Yao, Y., Tao, Z., Chen, W., Huang, F., & Chen, X.
Affiliations
  • Nanjing First Hospital (CN)
  • Tongji University (CN)
Corresponding author
  • Huang, Fuhua
  • Chen, Xin
ORCID
Venue
Frontiers in Cell and Developmental Biology
Publisher
Frontiers Media SA
Published
2022-09-30
Volume
10
Pages
908790-908790
ISSN
2296-634X (ISSN-L)
DOI
10.3389/fcell.2022.908790
PMC
PMC9561843
OpenAlex
W4298144487
Cited by
18
References
7
Citations by year
2026: 2 · 2025: 7 · 2024: 6 · 2023: 2 · 2022: 1
FWCI
0.81
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Cell and Developmental Biology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (81870193)
  • Shanghai Pulmonary Hospital
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Keywords
macrophages, cardiomyopathy, macrophage-targeted therapy, myocardial fibrosis, cardiac inflammation, cardiac remodeling, heart failure, cardiac resident macrophages, myocardial injury, clinical translation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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