Cited by 480Immune responses and vaccinationsNeonatal and Maternal InfectionsImmune Response and Inflammation

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Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny

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Kollmann, Tobias R., Kampmann, Beate, Mazmanian, Sarkis K., Marchant, Arnaud, Levy, Ofer·2017·Immunity

DOI 10.1016/j.immuni.2017.03.009

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Abstract

Infections in the first year of life are common and often severe. The newborn host demonstrates both quantitative and qualitative differences to the adult in nearly all aspects of immunity, which at least partially explain the increased susceptibility to infection. Here we discuss how differences in susceptibility to infection result not out of a state of immaturity, but rather reflect adaptation to the particular demands placed on the immune system in early life. We review the mechanisms underlying host defense in the very young, and discuss how specific developmental demands increase the risk of particular infectious diseases. In this context, we discuss how this plasticity, i.e. the capacity to adapt to demands encountered in early life, also provides the potential to leverage protection of the young against infection and disease through a number of interventions.

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“…factors (TF) for TH1 ( TBX21 ) or TH17 ( RORC ) cells, but the TH2 TFs GATA-3 and signal transducer and activator of transcription ( STAT) 6 were present in all SCs, and were especially upregulated in CD4_T MAIT SC. CD4_T REG SC included regulatory T cell-related transcripts, such as…”
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A place for neutrophils in the beneficial pathogen-agnostic effects of the BCG vaccine
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Neonatal and infant immunity for tuberculosis vaccine development: importance of age-matched animal models
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Risk factors associated with SARS-CoV-2 pneumonia in the pediatric population
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Background
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Sutterella and its metabolic pathways positively correlate with vaccine-elicited antibody responses in infant rhesus macaques
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Plasma Adenosine Deaminase (ADA)-1 and -2 Demonstrate Robust Ontogeny Across the First Four Months of Human Life
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“To devise age-appropriate strategies to reduce mortality during this period of heightenedvulnerability,understandingnewbornimmunityinthe ﬁ rst week is essential 6 .”
InfluentialSelf-citation

Authors: Kollmann, T. R., Kampmann, B., Mazmanian, S. K., Marchant, A., & Levy, O.
Affiliations: University of British Columbia (CA)
MRC Unit the Gambia (GM)
California Institute of Technology (US)
Université Libre de Bruxelles (BE)
Boston Children's Hospital (US)
Corresponding author: Kollmann, Tobias R.
Levy, Ofer
ORCID: Kollmann, Tobias R.
Kampmann, Beate
Mazmanian, Sarkis K.
Marchant, Arnaud
Levy, Ofer
Venue: Immunity
Publisher: Elsevier BV
Published: 2017-03
Volume: 46
Issue: 3
Pages: 350-363
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2017.03.009
OpenAlex: W2599501186
Semantic Scholar: e51f9b517003c880df24898208e6d4d93bb7cc87
Cited by: 478
References: 200
Citations by year: 2026: 62 · 2025: 45 · 2024: 54 · 2023: 51 · 2022: 40 · 2021: 67 · 2020: 69 · 2019: 39 · 2018: 36 · 2017: 15
FWCI: 4.45
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 385 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
Spiral (Imperial College London) (submittedVersion, cc-by-nc-nd)
Funders: Medical Research Council (MR/R005990/1)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and Maternal Infections
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: immune ontogeny, neonatal immunity, host defense, immune plasticity, neonatal infection
MeSH terms: Animals, Communicable Diseases, Disease Susceptibility, Humans, Immune System, Infant, Infant, Newborn

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Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny

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