Cited by 480Immune responses and vaccinationsNeonatal and Maternal InfectionsImmune Response and Inflammation

The DOI matches its Crossref record; 200 of the 200 references it cites were found in a registry or an index.

Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny

Open access

Kollmann, Tobias R., Kampmann, Beate, Mazmanian, Sarkis K., Marchant, Arnaud, Levy, Ofer·2017·Immunity

DOI 10.1016/j.immuni.2017.03.009

Open this paper in CoChat — free account Open PDF

Abstract

Infections in the first year of life are common and often severe. The newborn host demonstrates both quantitative and qualitative differences to the adult in nearly all aspects of immunity, which at least partially explain the increased susceptibility to infection. Here we discuss how differences in susceptibility to infection result not out of a state of immaturity, but rather reflect adaptation to the particular demands placed on the immune system in early life. We review the mechanisms underlying host defense in the very young, and discuss how specific developmental demands increase the risk of particular infectious diseases. In this context, we discuss how this plasticity, i.e. the capacity to adapt to demands encountered in early life, also provides the potential to leverage protection of the young against infection and disease through a number of interventions.

Integrity signals

Registry

Crossref · 10.1016/j.immuni.2017.03.009

Cites

200 of 200 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010
Murray, C. J. L., Vos, T., Lozano, R., Naghavi, M., Flaxman, A. D., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J. A., Abdalla, S., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61689-4 · Cited by 8,888
Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000
Liu, L., Johnson, H. L., Cousens, S., Perin, J., Scott, S., Lawn, J. E., Rudan, I., Campbell, H., Cibulskis, R., Li, M., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60560-1 · Cited by 3,934
A guide to immunometabolism for immunologists
O'Neill, L. A. J., Kishton, R. J., & Rathmell, J. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.70 · Cited by 3,315
Animals in a bacterial world, a new imperative for the life sciences
McFall‐Ngai, M., Hadfield, M. G., Bosch, T. C. G., Carey, H. V., Domazet‐Lošo, T., Douglas, A. E., Dubilier, N., Eberl, G., Fukami, T., Gilbert, S. F., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1218525110 · Cited by 2,879
Self-citation
IgG Subclasses and Allotypes: From Structure to Effector Functions
Vidarsson, G., Dekkers, G., & Rispens, T. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00520 · Cited by 2,667
The Placenta Harbors a Unique Microbiome
Aagaard, K., Ma, J., Antony, K. M., Ganu, R., Petrosino, J., & Versalovic, J. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008599 · Cited by 2,494
Control of adaptive immunity by the innate immune system
Iwasaki, A., & Medzhitov, R. (2015) · Nature Immunology · doi:10.1038/ni.3123 · Cited by 2,160
Every Newborn: progress, priorities, and potential beyond survival
Lawn, J. E., Blencowe, H., Oza, S., You, D., Lee, A. C., Waiswa, P., Lalli, M., Bhutta, Z., Barros, A. J., Christian, P., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60496-7 · Cited by 1,929
Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences
Cox, L. M., Yamanishi, S., Sohn, J., Alekseyenko, A. V., Leung, J. M., Cho, I., Kim, S. G., Li, H., Gao, Z., Mahana, D., et al. (2014) · Cell · doi:10.1016/j.cell.2014.05.052 · Cited by 1,859
Early infancy microbial and metabolic alterations affect risk of childhood asthma
Arrieta, M., Stiemsma, L. T., Dimitriu, P. A., Thorson, L., Russell, S., Yurist‐Doutsch, S., Kuzeljevic, B., Gold, M. J., Britton, H. M., Lefebvre, D. L., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aab2271 · Cited by 1,832
Self-citation
Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function
Olszak, T., An, D., Zeissig, S., Vera, M. P., Richter, J., Franke, A., Glickman, J. N., Siebert, R., Baron, R. M., Kasper, D. L., et al. (2012) · Science · doi:10.1126/science.1219328 · Cited by 1,661
Reciprocal interactions of the intestinal microbiota and immune system
Maynard, C. L., Elson, C. O., Hatton, R. D., & Weaver, C. T. (2012) · Nature · doi:10.1038/nature11551 · Cited by 1,598
Microbiota-mediated colonization resistance against intestinal pathogens
Buffie, C. G., & Pamer, E. G. (2013) · Nature reviews. Immunology · doi:10.1038/nri3535 · Cited by 1,564
Nutritional immunity: transition metals at the pathogen–host interface
Hood, M. I., & Skaar, E. P. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2836 · Cited by 1,535
T cell metabolism drives immunity
Buck, M. D., O’Sullivan, D., & Pearce, E. L. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20151159 · Cited by 1,238
The maternal microbiota drives early postnatal innate immune development
Gomez de Agüero, M., Ganal-Vonarburg, S. C., Fuhrer, T., Rupp, S., Uchimura, Y., Li, H., Steinert, A., Heikenwalder, M., Hapfelmeier, S., Sauer, U., et al. (2016) · Science · doi:10.1126/science.aad2571 · Cited by 1,231
Innate immunity of the newborn: basic mechanisms and clinical correlates
Levy, O. (2007) · Nature reviews. Immunology · doi:10.1038/nri2075 · Cited by 1,227
Self-citation
Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids
Wu, J., & Chen, Z. J. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120156 · Cited by 1,212
The Intestinal Microbiome in Early Life: Health and Disease
Arrieta, M.-C., Stiemsma, L. T., Amenyogbe, N., Brown, E. M., & Finlay, B. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00427 · Cited by 1,024
Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial
Sazawal, S., Black, R. E., Ramsan, M., Chwaya, H. M., Stoltzfus, R. J., Dutta, A., Dhingra, U., Kabole, I., Deb, S., Othman, M. K., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(06)67962-2 · Cited by 981
Probiotics for prevention of necrotizing enterocolitis in preterm infants
AlFaleh, K. M., & Anabrees, J. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005496.pub4 · Cited by 965
Maternal Alloantigens Promote the Development of Tolerogenic Fetal Regulatory T Cells in Utero
Mold, J. E., Michaëlsson, J., Burt, T. D., Muench, M. O., Beckerman, K., Busch, M. P., Lee, T., Nixon, D. F., & McCune, J. M. (2008) · Science · doi:10.1126/science.1164511 · Cited by 840
Directing Transition from Innate to Acquired Immunity: Defining a Role for IL-6
Jones, S. A. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.6.3463 · Cited by 773
Effectiveness of maternal pertussis vaccination in England: an observational study
Amirthalingam, G., Andrews, N., Campbell, H., Ribeiro, S., Kara, E., Donegan, K., Fry, N. K., Miller, E., & Ramsay, M. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60686-3 · Cited by 739
Antimicrobial peptides: The ancient arm of the human immune system
Wiesner, J., & Vilcinskas, A. (2010) · Virulence · doi:10.4161/viru.1.5.12983 · Cited by 702
Iron and Its Relation to Immunity and Infectious Disease
Oppenheimer, S. J. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.2.616s · Cited by 695
Amniotic Fluid: Not Just Fetal Urine Anymore
Underwood, M. A., Gilbert, W. M., & Sherman, M. P. (2005) · Journal of Perinatology · doi:10.1038/sj.jp.7211290 · Cited by 687
Innate immunity
Turvey, S. E., & Broide, D. H. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.07.016 · Cited by 686
Gut Microbiota Promote Hematopoiesis to Control Bacterial Infection
Khosravi, A., Yáñez, A., Price, J. G., Chow, A. T., Mérad, M., Goodridge, H. S., & Mazmanian, S. K. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.02.006 · Cited by 668
Self-citation
B-cell responses to vaccination at the extremes of age
Siegrist, C.-A., & Aspinall, R. (2009) · Nature Reviews Immunology · doi:10.1038/nri2508 · Cited by 659
Innate immune recognition of the microbiota promotes host-microbial symbiosis
Chu, H., & Mazmanian, S. K. (2013) · Nature Immunology · doi:10.1038/ni.2635 · Cited by 630
Self-citation
Long-Lasting Effects of BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity
Kleinnijenhuis, J., Quintin, J., Preijers, F. W. M. B., Benn, C. S., Joosten, L. A. B., Jacobs, C. W. M., van Loenhout, J., Xavier, R. J., Aaby, P., van der Meer, J. W. M., et al. (2013) · Journal of Innate Immunity · doi:10.1159/000355628 · Cited by 625
Evolution of Innate Immunity: Clues from Invertebrates via Fish to Mammals
Buchmann, K. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00459 · Cited by 606
Innate Immune Function by Toll-like Receptors: Distinct Responses in Newborns and the Elderly
Kollmann, T. R., Levy, O., Montgomery, R. R., & Goriely, S. (2012) · Immunity · doi:10.1016/j.immuni.2012.10.014 · Cited by 591
Self-citation
The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice
Deshmukh, H. S., Liu, Y., Menkiti, O. R., Mei, J., Dai, N., O'Leary, C. E., Oliver, P. M., Kolls, J. K., Weiser, J. N., & Worthen, G. S. (2014) · Nature Medicine · doi:10.1038/nm.3542 · Cited by 579
Maternal Antibodies: Clinical Significance, Mechanism of Interference with Immune Responses, and Possible Vaccination Strategies
Niewiesk, S. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00446 · Cited by 550
Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy
Liang, Q., Luo, Z., Zeng, J., Chen, W., Foo, S., Lee, S.-A., Ge, J., Wang, S., Goldman, S. A., Zloković, B. V., et al. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.07.019 · Cited by 545
TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination
Oh, J. Z., Ravindran, R., Chassaing, B., Carvalho, F. A., Maddur, M. S., Bower, M., Hakimpour, P., Gill, K. P., Nakaya, H. I., Yarovinsky, F., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.08.009 · Cited by 541
The impact of perinatal immune development on mucosal homeostasis and chronic inflammation
Renz, H., Brandtzæg, P., & Hornef, M. W. (2011) · Nature reviews. Immunology · doi:10.1038/nri3112 · Cited by 520
Bovine Lactoferrin Supplementation for Prevention of Late-Onset Sepsis in Very Low-Birth-Weight Neonates A Randomized Trial
Manzoni, P. (2009) · JAMA · doi:10.1001/jama.2009.1403 · Cited by 520
Immune cells in term and preterm labor
Gomez‐Lopez, N., StLouis, D., Lehr, M., Sánchez-Rodríguez, E. N., & Arenas‐Hernandez, M. (2014) · Cellular and Molecular Immunology · doi:10.1038/cmi.2014.46 · Cited by 494
Postnatal acquisition of endotoxin tolerance in intestinal epithelial cells
Lotz, M., Gütle, D., Walther, S., Ménard, S., Bogdan, C., & Hornef, M. W. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20050625 · Cited by 464
Fetal and Adult Hematopoietic Stem Cells Give Rise to Distinct T Cell Lineages in Humans
Mold, J. E., Venkatasubrahmanyam, S., Burt, T. D., Michaëlsson, J., Rivera, J. M., Galkina, S. A., Weinberg, K., Stoddart, C. A., & McCune, J. M. (2010) · Science · doi:10.1126/science.1196509 · Cited by 444
Characterisation and antimicrobial resistance of sepsis pathogens in neonates born in tertiary care centres in Delhi, India: a cohort study
† (2016) · The Lancet Global Health · doi:10.1016/s2214-109x(16)30148-6 · Cited by 437
The innate immune response of the respiratory epithelium: Innate immunity in the airway
Diamond, G., Legarda, D., & Ryan, L. K. (2000) · Immunological Reviews · doi:10.1034/j.1600-065x.2000.917304.x · Cited by 422
Immunosuppressive CD71+ erythroid cells compromise neonatal host defence against infection
Elahi, S., Ertelt, J. M., Kinder, J. M., Jiang, T. T., Zhang, X., Xin, L., Chaturvedi, V., Strong, B., Qualls, J. E., Steinbrecher, K. A., et al. (2013) · Nature · doi:10.1038/nature12675 · Cited by 421
Paneth cells, defensins, and the commensal microbiota: A hypothesis on intimate interplay at the intestinal mucosa
Salzman, N. H., Underwood, M. A., & Bevins, C. L. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.04.002 · Cited by 414
Newborns Develop a Th1-Type Immune Response to Mycobacterium bovis Bacillus Calmette-Guerin Vaccination
Marchant, A., Goetghebuer, T., Ota, M. O. C., Wolfe, I., Ceesay, S. J., Groote, D. D., Corrah, T., Bennett, S., Wheeler, J., Huygen, K., et al. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.4.2249 · Cited by 404
Self-citation
Stool microbiota and vaccine responses of infants
Huda, M. N., Lewis, Z., Kalanetra, K. M., Rashid, M., Ahmad, S. M., Raqib, R., Qadri, F., Underwood, M. A., Mills, D. A., & Stephensen, C. B. (2014) · PEDIATRICS · doi:10.1542/peds.2013-3937 · Cited by 392
Human TLRs and IL-1Rs in Host Defense: Natural Insights from Evolutionary, Epidemiological, and Clinical Genetics
Casanova, J., Abel, L., & Quintana‐Murci, L. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101335 · Cited by 377
Ontogeny of early life immunity
Dowling, D. J., & Levy, O. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.04.007 · Cited by 376
Self-citation
Regulation of Inflammation by Adenosine
Haskó, G., & Cronstein, B. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00085 · Cited by 367
No Vacancy: How Beneficial Microbes Cooperate with Immunity To Provide Colonization Resistance to Pathogens
Sassone‐Corsi, M., & Raffatellu, M. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1403169 · Cited by 346
Global Maternal, Newborn, and Child Health — So Near and Yet So Far
Bhutta, Z. A., & Black, R. E. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1111853 · Cited by 335
Differential Patterns of Methylation of the IFN-γ Promoter at CpG and Non-CpG Sites Underlie Differences in IFN-γ Gene Expression Between Human Neonatal and Adult CD45RO− T Cells
White, G., Watt, P. M., Holt, B. J., & Holt, P. G. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.6.2820 · Cited by 332
Estimates of possible severe bacterial infection in neonates in sub-Saharan Africa, south Asia, and Latin America for 2012: a systematic review and meta-analysis
Seale, A. C., Blencowe, H. K., Manu, A. A., Nair, H., Bahl, R., Qazi, S., Zaidi, A. K. M., Berkley, J. A., Cousens, S. N., & Lawn, J. E. (2014) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(14)70804-7 · Cited by 330
Iron at the interface of immunity and infection
Nairz, M., Haschka, D., Demetz, E., & Weiss, G. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00152 · Cited by 325 · cited 1×
“human neonatal plasma Fe levels directly correlate with susceptibility to sepsis (Bullen et al., 2000; Johnson and Wessling-Resnick, 2012; Nairz et al., 2014; Oppenheimer, 2012; Wander et al., 2009).”
Finding the Missing Links among Metabolites, Microbes, and the Host
Dorrestein, P. C., Mazmanian, S. K., & Knight, R. (2014) · Immunity · doi:10.1016/j.immuni.2014.05.015 · Cited by 317
Self-citation
Early-life compartmentalization of human T cell differentiation and regulatory function in mucosal and lymphoid tissues
Thome, J. J. C., Bickham, K. L., Ohmura, Y., Kubota, M., Matsuoka, N., Gordon, C., Granot, T., Griesemer, A., Lerner, H., Kato, T., et al. (2016) · Nature Medicine · doi:10.1038/nm.4008 · Cited by 305
Cellular Self-Defense: How Cell-Autonomous Immunity Protects Against Pathogens
Randow, F., MacMicking, J. D., & James, L. C. (2013) · Science · doi:10.1126/science.1233028 · Cited by 297
Influence of Mycobacterium bovis Bacillus Calmette-Guerin on Antibody and Cytokine Responses to Human Neonatal Vaccination
Ota, M. O. C., Vekemans, J., Schlegel‐Haueter, S. E., Fielding, K., Sanneh, M., Kidd, M., Newport, M. J., Aaby, P., Whittle, H. C., Lambert, P., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.2.919 · Cited by 291
Self-citation
Overview of Lactoferrin as a Natural Immune Modulator.
Legrand, D. (2016) · Jornal de Pediatria · doi:10.1016/j.jpeds.2016.02.071 · Cited by 274
Innate immune memory: a paradigm shift in understanding host defense
Netea, M. G., Latz, E., Mills, K. H. G., & O'Neill, L. A. J. (2015) · Nature Immunology · doi:10.1038/ni.3178 · Cited by 269
The role of breastfeeding in prevention of neonatal infection
Hanson, L. Å., & Korotkova, M. (2002) · Seminars in Neonatology · doi:10.1016/s1084-2756(02)90124-7 · Cited by 261
Harnessing the beneficial heterologous effects of vaccination
Goodridge, H. S., Ahmed, S., Curtis, N. C., Kollmann, T. R., Levy, O., Netea, M. G., Pollard, A. J., van Crevel, R., & Wilson, C. B. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.43 · Cited by 260
Self-citation
Iron metabolism and the innate immune response to infection
Johnson, E. E., & Wessling-Resnick, M. (2012) · Microbes and Infection · doi:10.1016/j.micinf.2011.10.001 · Cited by 253
Effector Vγ9Vδ2 T cells dominate the human fetal γδ T-cell repertoire
Dimova, T., Brouwer, M., Gosselin, F., Tassignon, J., Léo, O., Donner, C., Marchant, A., & Vermijlen, D. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412058112 · Cited by 241
Self-citation
The Adenosine System Selectively Inhibits TLR-Mediated TNF-α Production in the Human Newborn
Levy, O., Coughlin, M. L., Cronstein, B. N., Roy, R. M., Desai, A., & Wessels, M. R. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.3.1956 · Cited by 236
Self-citation
Human cytomegalovirus elicits fetal γδ T cell responses in utero
Vermijlen, D., Brouwer, M., Donner, C., Liesnard, C., Tackoen, M., Rysselberge, M. V., Twité, N., Goldman, M., Marchant, A., & Willems, F. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20090348 · Cited by 236
Self-citation
Autophagy Controls BCG-Induced Trained Immunity and the Response to Intravesical BCG Therapy for Bladder Cancer
Buffen, K., Oosting, M., Quintin, J., Ng, A., Kleinnijenhuis, J., Kumar, V., van de Vosse, E., Wijmenga, C., van Crevel, R., Oosterwijk, E., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004485 · Cited by 235
Antimicrobial Polypeptides of Human Vernix Caseosa and Amniotic Fluid: Implications for Newborn Innate Defense
YOSHIO, H., Tollin, M., Gudmundsson, G. H., Lagercrantz, H., Jörnvall, H., Marchini, G., & Agerberth, B. (2003) · Pediatric Research · doi:10.1203/01.pdr.0000047471.47777.b0 · Cited by 232
Prophylactic Probiotics for Prevention of Necrotizing Enterocolitis in Very Low Birth Weight Newborns
Samanta, M., Sarkar, M., Ghosh, P., Ghosh, J., Sinha, M. K., & Chatterjee, S. (2008) · Journal of Tropical Pediatrics · doi:10.1093/tropej/fmn091 · Cited by 219
The role of environmental factors in modulating immune responses in early life
MacGillivray, D. M., & Kollmann, T. R. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00434 · Cited by 219
Self-citation
Activity of Abundant Antimicrobials of the Human Airway
Travis, S. M., Conway, B. D., Zabner, J., Smith, J. J., Anderson, N. N., Singh, P. K., Greenberg, E. P., & Welsh, M. J. (1999) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.20.5.3572 · Cited by 218
Neonatal Sepsis due to Coagulase-Negative Staphylococci
Marchant, E. A., Boyce, G. K., Sadarangani, M., & Lavoie, P. M. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/586076 · Cited by 217
Neutrophil Production and Function in Newborn Infants
Carr, R. A. (2000) · British Journal of Haematology · doi:10.1046/j.1365-2141.2000.01992.x · Cited by 212
Nonspecific (Heterologous) Protection of Neonatal BCG Vaccination Against Hospitalization Due to Respiratory Infection and Sepsis
de Castro, M. J., Pardo‐Seco, J., & Martinón‐Torres, F. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ144 · Cited by 209
Bovine lactoferrin supplementation for prevention of necrotizing enterocolitis in very-low-birth-weight neonates: a randomized clinical trial
Manzoni, P., Meyer, M. P., Stolfi, I., Rinaldi, M., Cattani, S., Pugni, L., Romeo, M. G., Messner, H., Decembrino, L., Laforgia, N., et al. (2014) · Early Human Development · doi:10.1016/s0378-3782(14)70020-9 · Cited by 203
Human CD4+ T cell recent thymic emigrants are identified by protein tyrosine kinase 7 and have reduced immune function
Haines, C. J., Giffon, T. D., Lu, L.-S., Lu, X., Tessier-Lavigne, M., Ross, D. T., & Lewis, D. B. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20080996 · Cited by 189
Ontogeny of Myeloid Cells
Kleer, I. D., Willems, F., Lambrecht, B. N., & Goriely, S. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00423 · Cited by 188
Valuing vaccination
Bärnighausen, T., Bloom, D. E., Cafiero-Fonseca, E. T., & O’Brien, J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400475111 · Cited by 188
The developing human preterm neonatal immune system: A case for more research in this area
Sharma, A., Jen, R., Butler, A., & Lavoie, P. M. (2012) · Clinical Immunology · doi:10.1016/j.clim.2012.08.006 · Cited by 186
The Biology of Recent Thymic Emigrants
Fink, P. J. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-100010 · Cited by 186
The Effect of Oral Polio Vaccine at Birth on Infant Mortality: A Randomized Trial
Lund, N., Andersen, A., Hansen, A. S., Jepsen, F. S., Barbosa, A., Biering-Sørensen, S. R., Rodrigues, A., Ravn, H., Aaby, P., & Benn, C. S. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ617 · Cited by 185
The role of breastfeeding in prevention of neonatal infection
Hanson, L. Å., & Korotkova, M. (2002) · Seminars in Neonatology · doi:10.1053/siny.2002.0124 · Cited by 181
Live Vaccine Against Measles, Mumps, and Rubella and the Risk of Hospital Admissions for Nontargeted Infections
Sørup, S., Benn, C. S., Poulsen, A., Krause, T. G., Aaby, P., & Ravn, H. (2014) · JAMA · doi:10.1001/jama.2014.470 · Cited by 180
Uninfected but not unaffected: chronic maternal infections during pregnancy, fetal immunity, and susceptibility to postnatal infections
Dauby, N., Goetghebuer, T., Kollmann, T. R., Lévy, J., & Marchant, A. (2012) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(11)70341-3 · Cited by 177
Self-citation
Maternal-Derived Hepatitis B Virus e Antigen Alters Macrophage Function in Offspring to Drive Viral Persistence after Vertical Transmission
Tian, Y., Kuo, C.-F., Akbari, O., & Ou, J. J. (2016) · Immunity · doi:10.1016/j.immuni.2016.04.008 · Cited by 176
The newborn infant is protected by an innate antimicrobial barrier: peptide antibiotics are present in the skin and vernix caseosa
Marchini, G., Lindow, S., Brismar, H., Ståbi, B., Berggren, V., Ulfgren, A.-K., Lonne‐Rahm, S., Agerberth, B., & Gudmundsson, G. H. (2002) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2002.05014.x · Cited by 173
Regulatory T-Cells at the Interface between Human Host and Pathogens in Infectious Diseases and Vaccination
Boer, M. C., Joosten, S. A., & Ottenhoff, T. H. M. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00217 · Cited by 170
Bovine Lactoferrin Prevents Invasive Fungal Infections in Very Low Birth Weight Infants: A Randomized Controlled Trial
Manzoni, P., Stolfi, I., Messner, H., Cattani, S., Laforgia, N., Romeo, M. G., Bollani, L., Rinaldi, M., Gallo, E., Quercia, M., et al. (2011) · PEDIATRICS · doi:10.1542/peds.2011-0279 · Cited by 169
Who has been caring for the baby?
Darmstadt, G. L., Kinney, M. V., Chopra, M., Cousens, S. N., Kak, L., Paul, V. K., Martines, J., Bhutta, Z. A., & Lawn, J. E. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60458-x · Cited by 169
Timely and spatially regulated maturation of B and T cell repertoire during human fetal development
Rechavi, E., Lev, A., Lee, Y. N., Simon, A. J., Yinon, Y., Lipitz, S., Amariglio, N., Weisz, B., Notarangelo, L. D., & Somech, R. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa0072 · Cited by 169
Developmental Immunology and Role of Host Defenses in Fetal and Neonatal Susceptibility to Infection
Lewis, D. B., & Wilson, C. B. (2006) · Elsevier eBooks · doi:10.1016/b0-72-160537-0/50006-2 · Cited by 151
Neonatal Skin in Mice and Humans Expresses Increased Levels of Antimicrobial Peptides: Innate Immunity During Development of the Adaptive Response
Dorschner, R. A., Lin, K. H., Murakami, M., & Gallo, R. L. (2003) · Pediatric Research · doi:10.1203/01.pdr.0000057205.64451.b7 · Cited by 151
Lactobacillus Reuteri for the prevention of necrotising enterocolitis in very low birthweight infants: a randomised controlled trial
Öncel, M. Y., Sarı, F. N., Arayıcı, S., Güzoğlu, N., Erdeve, Ö., Uraş, N., Oğuz, Ş. S., & Dilmen, U. (2013) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2013-304745 · Cited by 148
Oral lactoferrin for the prevention of sepsis and necrotizing enterocolitis in preterm infants
Pammi, M., & Abrams, S. A. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007137.pub2 · Cited by 146
Estimates of neonatal morbidities and disabilities at regional and global levels for 2010: introduction, methods overview, and relevant findings from the Global Burden of Disease study
Blencowe, H. K., Vos, T., Lee, A. C., Philips, R., Lozano, R., Alvarado, M., Cousens, S. N., & Lawn, J. E. (2013) · Pediatric Research · doi:10.1038/pr.2013.203 · Cited by 145
BCG-induced protection: Effects on innate immune memory
Netea, M. G., & van Crevel, R. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.09.006 · Cited by 144
Bordetella pertussis Infection in 2-Month-Old Infants Promotes Type 1 T Cell Responses
Mascart, F., Verscheure, V., Malfroot, A., Hainaut, M., Piérard, D., Temmerman, S. T., Peltier, A., Debrie, A., Lévy, J., Giudice, G. D., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.3.1504 · Cited by 142
Nonspecific effects of neonatal and infant vaccination: public-health, immunological and conceptual challenges
Aaby, P., Kollmann, T. R., & Benn, C. S. (2014) · Nature Immunology · doi:10.1038/ni.2961 · Cited by 141
Self-citation
The pathophysiology and pharmacology of hepcidin
Ruchala, P. P., & Nemeth, E. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.01.004 · Cited by 141
Autophagy in antiviral innate immunity
Richetta, C., & Faure, M. (2012) · Cellular Microbiology · doi:10.1111/cmi.12043 · Cited by 138
Unbalanced Neonatal CD4+ T-Cell Immunity
Debock, I., & Flamand, V. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00393 · Cited by 138
Breast-fed and bottle-fed infant rhesus macaques develop distinct gut microbiotas and immune systems
Ardeshir, A., Narayan, N. R., Méndez-Lagares, G., Lu, D., Rauch, M., Huang, Y., Van Rompay, K. K. A., Lynch, S. V., & Hartigan-O’Connor, D. J. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008791 · Cited by 134
Trained immunity: consequences for the heterologous effects of BCG vaccination
Kleinnijenhuis, J., van Crevel, R., & Netea, M. G. (2015) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1093/trstmh/tru168 · Cited by 133
Innate Immune Defences in the Human Uterus during Pregnancy
King, A. E., KELLY, R. W., Sallenave, J., Bocking, A. D., & Challis, J. R. G. (2007) · Placenta · doi:10.1016/j.placenta.2007.06.002 · Cited by 133
Cross-Generational Reproductive Fitness Enforced by Microchimeric Maternal Cells
Kinder, J. M., Jiang, T. T., Ertelt, J. M., Xin, L., Strong, B., Shaaban, A. F., & Way, S. S. (2015) · Cell · doi:10.1016/j.cell.2015.07.006 · Cited by 131
Interaction of Streptococcus agalactiae and Cellular Innate Immunity in Colonization and Disease
Landwehr-Kenzel, S., & Henneke, P. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00519 · Cited by 129
The efficacy of DPT and oral poliomyelitis immunization schedules initiated from birth to 12 weeks of age.
Halsey, N. A., & Gałazka, A. (1985) · PubMed · Cited by 126
Human fetuses are able to mount an adultlike CD8 T-cell response
Hermann, E., Truyens, C., Alonso‐Vega, C., Even, J., Rodríguez, P., Berthe, A., Gonzalez-Merino, E., Torrico, F., & Carlier, Y. (2002) · Blood · doi:10.1182/blood.v100.6.2153 · Cited by 125
CD4 T Cells with Effector Memory Phenotype and Function Develop in the Sterile Environment of the Fetus
Zhang, X., Mozeleski, B., Lemoine, S., Dériaud, E., Lim, A., Zhivaki, D., Azria, É., Ray, C. L., Roguet, G., Launay, O., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008748 · Cited by 125
Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection
Muenchhoff, M., Adland, E., Karimanzira, O., Crowther, C. E., Pace, M. J., Csala, A., Leitman, E. M., Moonsamy, A., McGregor, C., Hurst, J. M., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aag1048 · Cited by 119
Neonatal Immune Adaptation of the Gut and Its Role during Infections
Tourneur, E., & Chassin, C. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/270301 · Cited by 118
Expression and Activity of β-Defensins and LL-37 in the Developing Human Lung
Starner, T. D., Agerberth, B., Gudmundsson, G. H., & McCray, P. B. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.3.1608 · Cited by 116
Age-Dependent Mendelian Predisposition to Herpes Simplex Virus Type 1 Encephalitis in Childhood
Abel, L., Plancoulaine, S., Jouanguy, E., Zhang, S., Mahfoufi, N., Nicolas, N., Sancho‐Shimizu, V., Alcaïs, A., Guo, Y., Cardon, A., et al. (2010) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2010.04.020 · Cited by 115
The Role of Autophagy During Development in Higher Eukaryotes
Bartolomeo, S. D., Nazio, F., & Cecconi, F. (2010) · Traffic · doi:10.1111/j.1600-0854.2010.01103.x · Cited by 113
Vernix caseosa as a multi-component defence system based on polypeptides, lipids and their interactions
Tollin, M., Bergsson, G., Kai-Larsen, Y., Lengqvist, J., Sjövall, J., Griffiths, W. J., Skúladóttir, G. V., Haraldsson, Á., Jörnvall, H., Gudmundsson, G. H., et al. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5260-7 · Cited by 112
Maternal immunization as a strategy to decrease susceptibility to infection in newborn infants
Lindsey, B. B., Kampmann, B., & Jones, C. E. (2013) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e3283607a58 · Cited by 110
Self-citation
Predictors of serum ferritin and serum soluble transferrin receptor in newborns and their associations with iron status during the first 2 y of life
Hay, G., Refsum, H., Whitelaw, A., Melbye, E. L., Haug, E., & Borch‐Iohnsen, B. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.1.64 · Cited by 109
CpG methylation patterns in the IFNγ promoter in naive T cells: Variations during Th1 and Th2 differentiation and between atopics and non‐atopics
White, G., Hollams, E. M., Yerkovich, S. T., Bosco, A., Holt, B. J., Bassami, M. R., Kusel, M. M. H., Sly, P. D., & Holt, P. G. (2006) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2006.00465.x · Cited by 109
Influenza: Epidemiology, Clinical Features, Therapy, and Prevention
Clark, N. M., & Lynch, J. P. (2011) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0031-1283278 · Cited by 108
Hepatitis B immunisation induces higher antibody and memory Th2 responses in new-borns than in adults
Ota, M. O. C., Vekemans, J., Schlegel‐Haueter, S. E., Fielding, K., Whittle, H. C., Lambert, P., McAdam, K. P. W. J., Siegrist, C., & Marchant, A. (2003) · Vaccine · doi:10.1016/j.vaccine.2003.07.020 · Cited by 104
Self-citation
The iron-regulatory hormone hepcidin: A possible therapeutic target?
Rochette, L., Gudjoncik, A., Guénancia, C., Zeller, M., Cottin, Y., & Vergely, C. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.09.004 · Cited by 104
Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization
van Haren, S. D., Dowling, D. J., Foppen, W., Christensen, D., Andersen, P. L., Reed, S. G., Hershberg, R. M., Baden, L. R., & Levy, O. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600282 · Cited by 100
Self-citation
Oral lactoferrin for the prevention of sepsis and necrotizing enterocolitis in preterm infants
Pammi, M., & Abrams, S. A. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007137.pub4 · Cited by 100
Pathogenesis of invasive fungal infections
García‐Vidal, C., Viasus, D., & Carratalà, J. (2013) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e32835fb920 · Cited by 98
Autophagy, nutrition and immunology
Cuervo, A. M., & Macián, F. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.09.001 · Cited by 98
Evaluation of iron deficiency as a nutritional adaptation to infectious disease: An evolutionary medicine perspective
Wander, K., Shell‐Duncan, B., & McDade, T. W. (2008) · American Journal of Human Biology · doi:10.1002/ajhb.20839 · Cited by 97
Interferon regulatory factor 7‐mediated responses are defective in cord blood plasmacytoid dendritic cells
Danis, B., George, T. C., Goriely, S., Dutta, B., Renneson, J., Gatto, L., Fitzgerald-Bocarsly, P. A., Marchant, A., Goldman, M., Willems, F., et al. (2008) · European Journal of Immunology · doi:10.1002/eji.200737760 · Cited by 97
Self-citation
Role of enteric supplementation of probiotics on late-onset sepsis by candida species in preterm low birth weight neonates: A randomized, double blind, placebo-controlled trial
Chaudhuri, J., Sarkar, D., Ghosh, P., Chakraborty, S., & Roy, A. (2014) · North American Journal of Medical Sciences · doi:10.4103/1947-2714.125870 · Cited by 97
The interplay between central metabolism and innate immune responses
Cheng, S., Joosten, L. A. B., & Netea, M. G. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.06.008 · Cited by 97
Myeloid Derived Suppressor Cells Are Present at High Frequency in Neonates and Suppress In Vitro T Cell Responses
Gervassi, A. L., Lejarcegui, N., Dross, S., Jacobson, A. C., Itaya, G., Kidzeru, E. B., Gantt, S. M., Jaspan, H. B., & Horton, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107816 · Cited by 96
Immunity to HIV in Early Life
Muenchhoff, M., Prendergast, A. J., & Goulder, P. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00391 · Cited by 95
Recent advances towards tuberculosis control: vaccines and biomarkers
Weiner, J. M., & Kaufmann, S. H. E. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12212 · Cited by 92
Early life response to infection
Ghazal, P., Dickinson, P., & Smith, C. (2013) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e32835fb8bf · Cited by 92
Innate Immune Signaling in the Pathogenesis of Necrotizing Enterocolitis
Hackam, D. J., Afrazi, A., Good, M. L., & Sodhi, C. P. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/475415 · Cited by 91
The Host Defense Peptide Beta-Defensin 1 Confers Protection againstBordetella pertussisin Newborn Piglets
Elahi, S., Buchanan, R. M., ATTAH‐POKU, S. K., Townsend, H. G. G., Babiuk, L. A., & Gerdts, V. (2006) · Infection and Immunity · doi:10.1128/iai.74.4.2338-2352.2006 · Cited by 91
Soluble Ecto-5′-nucleotidase (5′-NT), Alkaline Phosphatase, and Adenosine Deaminase (ADA1) Activities in Neonatal Blood Favor Elevated Extracellular Adenosine
Pettengill, M. A., Robson, S. C., Tresenriter, M., Millán, J. L., Usheva, A., Bingham, T. C., Belderbos, M. E., Bergelson, I., Burl, S., Kampmann, B., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.484212 · Cited by 89
Self-citation
Pattern Recognition Receptors and Autophagy
Oh, J. E., & Lee, H. K. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00300 · Cited by 88
Ontogeny of Innate T Lymphocytes – Some Innate Lymphocytes are More Innate than Others
Vermijlen, D., & Prinz, I. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00486 · Cited by 86
Soluble Mediators Regulating Immunity in Early Life
Pettengill, M. A., van Haren, S. D., & Levy, O. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00457 · Cited by 84
Self-citation
Immune Vulnerability of Infants to Tuberculosis
Driessche, K. V., Persson, A., Marais, B. J., Fink, P. J., & Urdahl, K. B. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/781320 · Cited by 83
Studies of iron requirements in infante and children. I. Normal values for serum iron, copper and free erythrocyte protoporphyrin.
Sturgeon, P. (1954) · PubMed · Cited by 80
Sepsis: the critical role of iron
Bullen, J., Griffiths, E., Rogers, H. J., & Ward, G. E. S. (2000) · Microbes and Infection · doi:10.1016/s1286-4579(00)00326-9 · Cited by 79
The state of global health in 2014
Sepúlveda, J., & Murray, C. J. L. (2014) · Science · doi:10.1126/science.1257099 · Cited by 78
History of Nutritional Immunology: Introduction and Overview
Beisel, W. R. (1992) · Journal of Nutrition · doi:10.1093/jn/122.suppl_3.591 · Cited by 77
The Role of Myeloid-Derived Suppressor Cells in Immune Ontogeny
Gantt, S. M., Gervassi, A. L., Jaspan, H. B., & Horton, H. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00387 · Cited by 75
Attenuated innate immune defenses in very premature neonates during the neonatal period
Marchant, E. A., Kan, B., Sharma, A., van Zanten, A., Kollmann, T. R., Brant, R., & Lavoie, P. M. (2015) · Pediatric Research · doi:10.1038/pr.2015.132 · Cited by 75
Self-citation
The Ontogeny of Skin
Visscher, M. O., & Narendran, V. (2013) · Advances in Wound Care · doi:10.1089/wound.2013.0467 · Cited by 72
STUDIES OF IRON REQUIREMENTS IN INFANTS AND CHILDREN
Sturgeon, P. (1954) · PEDIATRICS · doi:10.1542/peds.13.2.107 · Cited by 68
Functional Exhaustion Limits CD4+and CD8+T-Cell Responses to Congenital Cytomegalovirus Infection
Huygens, A., Lecomte, S., Tackoen, M., Olislagers, V., Delmarcelle, Y., Burny, W., Rysselberge, M. V., Liesnard, C., Larsen, M., Appay, V., et al. (2015) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiv071 · Cited by 65
Self-citation
“IDEAL” vaccines for resource poor settings
Levine, M. M. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.11.090 · Cited by 64
Systemic fungal infections in neonates
Ng, P. C. (1994) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/fn.71.2.f130 · Cited by 64
Vaccination against respiratory syncytial virus in pregnancy: a suitable tool to combat global infant morbidity and mortality?
Saso, A., & Kampmann, B. (2016) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(16)00119-5 · Cited by 63
Self-citation
Antimicrobial Proteins and Peptides in Early Life: Ontogeny and Translational Opportunities
Battersby, A., Khara, J. S., Wright, V., Levy, O., & Kampmann, B. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00309 · Cited by 63
Self-citation
Ex-vivo analysis of human Natural Killer T cells demonstrates heterogeneity between tissues and within established CD4+ and CD4− subsets
Chan, A. C., Leeansyah, E., Cochrane, A. D., Acoz, Y. D. U. D., Mittag, D., Harrison, L. C., Godfrey, D. I., & Berzins, S. P. (2012) · Clinical & Experimental Immunology · doi:10.1111/cei.12045 · Cited by 62
Neonatal fungal infections: when to treat?
Hsieh, E., Smith, P. B., Jacqz-Aigrain, É., Kaguelidou, F., Cohen‐Wolkowiez, M., Manzoni, P., & Benjamin, D. K. (2012) · Early Human Development · doi:10.1016/s0378-3782(12)70004-x · Cited by 62
Innate immune memory: implications for development of pediatric immunomodulatory agents and adjuvanted vaccines
Levy, O., & Netea, M. G. (2013) · Pediatric Research · doi:10.1038/pr.2013.214 · Cited by 61
Self-citation
New Insight into an Old Concept: Role of Immature Erythroid Cells in Immune Pathogenesis of Neonatal Infection
Elahi, S. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00376 · Cited by 59
In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant
van Haren, S. D., Ganapathi, L., Bergelson, I., Dowling, D. J., Banks, M., Samuels, R. C., Reed, S. G., Marshall, J. D., & Levy, O. (2016) · Cytokine · doi:10.1016/j.cyto.2016.04.001 · Cited by 59
Self-citation
Neonatal BCG vaccination is associated with enhanced T-helper 1 immune responses to heterologous infant vaccines
Libraty, D. H., Zhang, L., Woda, M., Acosta, L. P., Obcena, A., Brion, J. D., & Capeding, R. Z. (2013) · Trials in Vaccinology · doi:10.1016/j.trivac.2013.11.004 · Cited by 56
Phagocytosis-Associated Functions in Neonatal Monocyte-Derived Macrophages
Speer, C. P., Gahr, M. L., Wieland, M., & Eber, S. (1988) · Pediatric Research · doi:10.1203/00006450-198808000-00015 · Cited by 55
Ten years of the Global Alliance for Vaccines and Immunization: challenges and progress
Clemens, J. D., Holmgren, J. R., Kaufmann, S. H. E., & Mantovani, A. (2010) · Nature Immunology · doi:10.1038/ni1210-1069 · Cited by 52
Age-Related Gene Expression Differences in Monocytes from Human Neonates, Young Adults, and Older Adults
Lissner, M. M., Thomas, B. J., Wee, K., Tong, A.-J., Kollmann, T. R., & Smale, S. T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132061 · Cited by 51
Self-citation
Potential health effects from non‐specific stimulation of the immune function in early age: The example of BCG vaccination
Rousseau, M., Parent, M., & St‐Pierre, Y. (2008) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2007.00669.x · Cited by 51
The Molecular Mechanisms of Regulatory T Cell Immunosuppression
Pandiyan, P., Zheng, L., & Lenardo, M. J. (2011) · Frontiers in Immunology · doi:10.3389/fimmu.2011.00060 · Cited by 50
The Immunologic Basis for Severe Neonatal Herpes Disease and Potential Strategies for Therapeutic Intervention
Gantt, S. M., & Muller, W. J. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/369172 · Cited by 50
Serum cathelicidin level is associated with viral etiology and severity of bronchiolitis
Mansbach, J. M., Piedra, P. A., Borregaard, N., Martineau, A. R., Neuman, M. I., Espinola, J. A., & Camargo, C. A. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.07.044 · Cited by 45
Systemic and cellular consequences of macrophage control of iron metabolism
Recalcati, S., Locati, M., & Cairo, G. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2013.01.001 · Cited by 44
Dectin-1 activation unlocks IL12A expression and reveals the TH1 potency of neonatal dendritic cells
Lemoine, S., Jaron, B., Tabka, S., Ettreiki, C., Dériaud, E., Zhivaki, D., Ray, C. L., Launay, O., Majlessi, L., Tissières, P., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.02.030 · Cited by 44
Reduced levels of antimicrobial proteins and peptides in human cord blood plasma: Table 1
Strunk, T., Doherty, D. A., Richmond, P., Simmer, K. N., CHARLES, A. K., Levy, O., Liyanage, K., Smith, T., Currie, A. J., & Burgner, D. P. (2009) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/adc.2008.143438 · Cited by 43
Self-citation
Age-Dependent Immune Events during HBV Infection from Birth to Adulthood: An Alternative Interpretation
Bertoletti, A., & Hong, M. L. W. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00441 · Cited by 42
Systemic fungal infections in neonates.
Rao, S., & Ali, U. (2005) · PubMed · Cited by 40
Neonatal Host Defense against Staphylococcal Infections
Coombs, M. R. P., Kronforst, K. D., & Levy, O. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/826303 · Cited by 40
Self-citation
Maternal Immunization: Opportunities for Scientific Advancement
Beigi, R. H., Fortner, K. B., Muñoz, F. M., Roberts, J., Gordon, J. L., Han, H. H., Glenn, G. M., Dormitzer, P. R., Gu, X. X., Read, J. S., et al. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu708 · Cited by 39
Mechanism of Tuberculostasis in Mammalian Serum II. Induction of Serum Tuberculostasis in Guinea Pigs
Kochan, I., Golden, C. A., & Bukovic, J. A. (1969) · Journal of Bacteriology · doi:10.1128/jb.100.1.64-70.1969 · Cited by 36
Developmental Immunology and Role of Host Defenses in Fetal and Neonatal Susceptibility to Infection
Lewis, D. B., & Wilson, C. B. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-6400-8.00004-3 · Cited by 35
Adjuvant-induced Human Monocyte Secretome Profiles Reveal Adjuvant- and Age-specific Protein Signatures
Oh, D., Dowling, D. J., Ahmed, S., Choi, H., Brightman, S. E., Bergelson, I., Berger, S. T., Sauld, J. F. K., Pettengill, M. A., Kho, A. T., et al. (2016) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m115.055541 · Cited by 34
Self-citation
Differential Reliance on Autophagy for Protection from HSV Encephalitis between Newborns and Adults
Wilcox, D. R., Wadhwani, N. R., Longnecker, R., & Muller, W. J. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004580 · Cited by 33
Later development of Fas ligand‐mediated cytotoxicity as compared with granule‐mediated cytotoxicity during the maturation of natural killer cells
NAKAZAWA, T., Agematsu, K., & Yabuhara, A. (1997) · Immunology · doi:10.1046/j.1365-2567.1997.00343.x · Cited by 31
Neonatal bacillus Calmette–Guérin vaccination inhibits de novo allergic inflammatory response in mice via alteration of CD4+CD25+ T-regulatory cells
Li, Q., & Shen, H. (2008) · Acta Pharmacologica Sinica · doi:10.1038/aps.2008.3 · Cited by 31
Deficiency of Neutrophil Bactericidal Activity in Term and Preterm Infants
Chirico, G., Marconi, M., AMICI, M. D., Gasparoni, A., Mingrat, G., Chiara, A., Rondini, G., & Ugazio, A. G. (2009) · Biology of the Neonate · doi:10.1159/000242102 · Cited by 30
Neonatal CD71+ Erythroid Cells Do Not Modify Murine Sepsis Mortality
Wynn, J. L., Scumpia, P. O., Stocks, B. T., Romano-Keeler, J., Alrifai, M. W., Liu, J., Kim, A. S., Alford, C. E., Matta, P., Weitkamp, J.-H., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500771 · Cited by 29
What We Don't See
Hostetter, M. K. (2012) · New England Journal of Medicine · doi:10.1056/nejmra1111421 · Cited by 28
Ontogeny of Intestinal Epithelial Innate Immune Responses
Hornef, M. W., & Fulde, M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00474 · Cited by 26
Towards ending preventable child deaths
Chan, M., & Lake, A. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60908-8 · Cited by 23
Decreased Pattern Recognition Receptor Signaling, Interferon-Signature, and Bactericidal/Permeability-Increasing Protein Gene Expression in Cord Blood of Term Low Birth Weight Human Newborns
Singh, V. V., Chauhan, S. K., Rai, R., Kumar, A., Singh, S. M., & Rai, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062845 · Cited by 22
Asthma: Undoing millions of years of coevolution in early life?
Domínguez-Bello, M. G., & Blaser, M. J. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aad2741 · Cited by 20
Circulating Human Neonatal Naïve B Cells are Deficient in CD73 Impairing Purine Salvage
Pettengill, M. A., & Levy, O. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00121 · Cited by 20
Self-citation
Acute postnatal increase of extracellular antioxidant defence of neonates: the role of iron metabolism
Szabó, M., Vásárhelyi, B., Balla, G., Tulassay, T., Szabó, T. G., & Machay, T. (2001) · Acta Paediatrica · doi:10.1080/080352501317061585 · Cited by 19
Acute postnatal increase of extracellular antioxidant defence of neonates: the role of iron metabolism
Szabó, M., Vásárhelyi, B., Balla, G., et al. (2001) · Acta Paediatrica · doi:10.1111/j.1651-2227.2001.tb03248.x · Cited by 18
Distinct Functional Programs in Fetal T and Myeloid Lineages
Krow‐Lucal, E., & McCune, J. M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00314 · Cited by 15
Age-Dependent Differences in Systemic and Cell-Autonomous Immunity toL. monocytogenes
Sherrid, A. M., & Kollmann, T. R. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/917198 · Cited by 15
Self-citation
Probiotics to prevent early-life infection
Strunk, T., Kollmann, T. R., & Patole, S. (2015) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(15)70088-5 · Cited by 14
Self-citation
Bridging the gap: maternal immunisation as a means to reduce neonatal deaths from infectious diseases
Lindsey, B. B., Jones, C. E., & Kampmann, B. (2012) · Pathogens and Global Health · doi:10.1179/204777312x13462106637684 · Cited by 10
Self-citation
Iron and infection: narrative review of a major iron supplementation study in Papua New Guinea undertaken by the Department of Tropical Paediatrics, Liverpool School of Tropical Medicine, 1979–1983, its aftermath and the continuing relevance of its results
Oppenheimer, S. (2012) · Paediatrics and International Child Health · doi:10.1179/2046904712z.00000000075 · Cited by 6
Probiotics prevent necrotizing enterocolitis, sepsis and mortality in preterm infants: a multicenter analysis of more than 10,000 VLBW infants in German NICUs
Denkel, L., Schwab, F., Geffers, C., Gastmeier, P., Garten, L., & Piening, B. (2015) · Antimicrobial Resistance and Infection Control · doi:10.1186/2047-2994-4-s1-o39 · Cited by 5
Decoding the human immune system to transform the future of global disease prevention and control
Koff, W. C., & Schenkelberg, T. (2016) · Expert Review of Vaccines · doi:10.1586/14760584.2016.1170600 · Cited by 3
Potential role for BCG in treatment of autoimmune diseases
Curtis, N. C. (2016) · BMJ · doi:10.1136/bmj.i6091 · Cited by 3

Flagged first, then by citations

Research works printed but not linked: 1

Vergnano, 2005, J. Exp. Med., 207, 807

Sorted by citations

COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study
Götzinger, F., Santiago, B., Noguera‐Julián, A., Lanaspa, M., Lancella, L., Carducci, F. I. C., Gabrovska, N., Velizarova, S. A., Prunk, P., Osterman, V., et al. (2020) · The Lancet Child & Adolescent Health · doi:10.1016/s2352-4642(20)30177-2 · Cited by 1,276
Stereotypic Immune System Development in Newborn Children
Olin, A., Henckel, E., Chen, Y., Lakshmikanth, T., Pou, C., Mikeš, J., Gustafsson, A., Bernhardsson, A. K., Zhang, C., Bohlin, K., et al. (2018) · Cell · doi:10.1016/j.cell.2018.06.045 · Cited by 708
“Newborn children are also susceptible to infections, especially when born preterm, but the basis for this is not fully understood (Kollmann et al., 2017).”
Background
Regulation of inflammation by microbiota interactions with the host
Blander, J. M., Longman, R., Iliev, I. D., Sonnenberg, G. F., & Artis, D. (2017) · Nature Immunology · doi:10.1038/ni.3780 · Cited by 654
Interferons and Proinflammatory Cytokines in Pregnancy and Fetal Development
Yockey, L. J., & Iwasaki, A. (2018) · Immunity · doi:10.1016/j.immuni.2018.07.017 · Cited by 588
“The first trimester is the critical period of placental development, and the origins of many common pregnancy complications can be traced back to abnormal placental development in the first trimester (Kroener et al., 2016).”
Background
Early-life interactions between the microbiota and immune system: impact on immune system development and atopic disease
Donald, K., & Finlay, B. B. (2023) · Nature reviews. Immunology · doi:10.1038/s41577-023-00874-w · Cited by 394
“Infants are certainly immunologically vulnerable and more susceptible to infections and severe inflammatory responses than healthy adults 3 .”
Background

See all 480

Authors: Kollmann, T. R., Kampmann, B., Mazmanian, S. K., Marchant, A., & Levy, O.
Affiliations: University of British Columbia (CA)
MRC Unit the Gambia (GM)
California Institute of Technology (US)
Université Libre de Bruxelles (BE)
Boston Children's Hospital (US)
Corresponding author: Kollmann, Tobias R.
Levy, Ofer
ORCID: Kollmann, Tobias R.
Kampmann, Beate
Mazmanian, Sarkis K.
Marchant, Arnaud
Levy, Ofer
Venue: Immunity
Publisher: Elsevier BV
Published: 2017-03
Volume: 46
Issue: 3
Pages: 350-363
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2017.03.009
OpenAlex: W2599501186
Semantic Scholar: e51f9b517003c880df24898208e6d4d93bb7cc87
Cited by: 478
References: 200
Citations by year: 2026: 62 · 2025: 45 · 2024: 54 · 2023: 51 · 2022: 40 · 2021: 67 · 2020: 69 · 2019: 39 · 2018: 36 · 2017: 15
FWCI: 4.45
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 385 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
Spiral (Imperial College London) (submittedVersion, cc-by-nc-nd)
Funders: Medical Research Council (MR/R005990/1)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and Maternal Infections
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: immune ontogeny, neonatal immunity, host defense, immune plasticity, neonatal infection
MeSH terms: Animals, Communicable Diseases, Disease Susceptibility, Humans, Immune System, Infant, Infant, Newborn

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks