Cited by 480Immune responses and vaccinationsNeonatal and Maternal InfectionsImmune Response and Inflammation

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Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny

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Kollmann, Tobias R., Kampmann, Beate, Mazmanian, Sarkis K., Marchant, Arnaud, Levy, Ofer·2017·Immunity

DOI 10.1016/j.immuni.2017.03.009

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Abstract

Infections in the first year of life are common and often severe. The newborn host demonstrates both quantitative and qualitative differences to the adult in nearly all aspects of immunity, which at least partially explain the increased susceptibility to infection. Here we discuss how differences in susceptibility to infection result not out of a state of immaturity, but rather reflect adaptation to the particular demands placed on the immune system in early life. We review the mechanisms underlying host defense in the very young, and discuss how specific developmental demands increase the risk of particular infectious diseases. In this context, we discuss how this plasticity, i.e. the capacity to adapt to demands encountered in early life, also provides the potential to leverage protection of the young against infection and disease through a number of interventions.

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From animal models to NAMs: a paradigm shift in developmental immunotoxicity testing
Iulini, M., de Bruijn, V., Hurem, S., Nygaard, U. C., Kerdine‐Römer, S., Spruck, C., Tigges, J., Vandebriel, R. J., & Corsini, E. (2026) · Archives of Toxicology · doi:10.1007/s00204-026-04424-w · Cited by 1
“TLRs expression and distribution are similar in monocytes of newborns and adults, but the functional outcomes of TLRs activation differ in newborns, with pre - term infants showing increased IL-10 production and term infants producing more IL-6 and IL-23 (Kollmann et al. 2017).”
Immune System Development—Pro Tips for Paediatricians
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“The structural forms of protection evolve and mature but are underdeveloped in children born very preterm [7].”
From barrier dysfunction to systems immunology: Emerging paradigms in personalized immune-mediated disease
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Long-Term Incidence of Infectious-Related Hospitalizations of Offspring Born to Mothers With Intrauterine Device
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“The human immune system develops early during fetal life and is functionally programmed to promote tolerance to the intrauterine environment and to commensal microbes, while tightly regulating perinatal inflammatory reactions.(14) Whereas exposure to commensal bacteria is important for the development of a healthy fet…”
Background
Sex differences in morphofunctional changes in the immune system in Wistar rats of different age groups with experimental endotoxinemia
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Assessment of Bacterial Profile and Antimicrobial Susceptibility Pattern of Bacterial Isolates from Blood Culture in Tertiary Level Paediatric Hospital of Nepal
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Age and ligand specificity influence the outcome of pathogen engagement on preleukemic and leukemic B-cell precursor populations
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Newly emerged bumblebees are highly susceptible to gut parasite infection
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“For example, newborn babies are more susceptible to some infections because adaptive components of the immune sys-tem, such as the complement, have not yet fully established (McGreal et al. 2012 ; Kollmann et al., 2017).”
Implications of neonatal absence of innate immune mediated NFκB/AP1 signaling in the murine liver
Grayck, M. R., McCarthy, W. C., Solar, M., Balasubramaniyan, N., Zheng, L., Orlicky, D. J., & Wright, C. J. (2024) · Pediatric Research · doi:10.1038/s41390-024-03071-0 · Cited by 1
Eosinophilic Modulation of Neonatal Vaccine Immune Responses in HIV-Exposed Infants
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Gambaran Karakteristik Pasien Diare Balita di Wilayah Kerja Puskesmas Bojongsoang Tahun 2023
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Plasma adenosine deaminase-1 and -2 activities are lower at birth in Papua New Guinea than in The Gambia but converge over the first weeks of life
Kouyate, T. S., Nguyen, A. N., Plotkin, A. L., Ford, R., Idoko, O. T., Odumade, O. A., Masiria, G., Jude, J., Diray‐Arce, J., McEnaney, K., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1425349 · Cited by 1
Self-citation
A Pediatric Research Imperative: Addressing Neonates in Drug Development Through Understanding Neonatal Clinical Pharmacology
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Translational lessons from the balanced immune system in bats
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“Immune tolerance restricts host-mediated pathology in young infants (Kollmann et al., 2017); thus, studying age-related differences in bat immunity could improve our understanding of viral fitness, maintenance and spill over.”
Infectivity studies of Leishmania (Leishmania) infantum chagasi isolated from non-ulcerated cutaneous leishmaniasis
Flores, G. V. A., Pacheco, C. M. S., Tomokane, T. Y., Ochoa, W. H. S., Sílveira, F. T., Zúñiga, C., Corbett, C. E. P., Soares, R. P., Passero, L. F. D., & Laurenti, M. D. (2025) · Revista do Instituto de Medicina Tropical de São Paulo · doi:10.1590/s1678-9946202567021 · Cited by 1
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“Consequently, newborns are highly susceptible to sepsis [2–4].”
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Prevalence and Clinical Laboratory Features of Cryptosporidiosis in Children under 5 Years of Age: A Cross-Sectional Study of Hospital Cases of Acute Intestinal Infection
Григорьевна, С. Е., Shubina, N. I., Voronkova, O. V., Kovshirina, Y. V., & Yarovoy, N. D. (2018) · Вопросы современной педиатрии · doi:10.15690/vsp.v17i4.1925 · Cited by 1
Distinct immunity of the newborn
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Self-citation
Innate Immunity Modulation during Zika Virus Infection on Pregnancy: What We Still Need to Know for Medical Sciences Breakthrough
Azamor, T., Torrentes‐Carvalho, A., de Vasconcelos, Z. F. M., Bom, A. P. D. A., & Melgaço, J. G. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.94861 · Cited by 1
Macrophage-infectivity potentiator of Trypanosoma cruzi (TcMIP) is a new pro-type 1 immuno-stimulating protein for neonatal human cells and vaccines in mice
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Specific immune-regulatory transcriptional signatures reveal sex and age differences in SARS-CoV-2 infected patientsPreprint
Freire, P. P., Marques, A. H. C., Baiocchi, G. C., Schimke, L. F., Fonseca, D. L. M., Salgado, R. C., Filgueiras, I. S., Napoleão, S. M. D. S., Plaça, D. R., Hirata, T. D. C., et al. (2020) · medRxiv · doi:10.1101/2020.11.12.20230417 · Cited by 1
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“…environments is the necessity to balance mounting an appropriate defense response, the energetic costs required to mount a response, and minimizing the level of damage that may stem from that immune response (Harbeson et al., 2018; Kollmann et al., 2017; Macpherson et al., 2017; Renz et al., 2018).”
BackgroundInfluential
Immunology of the Fetus and Newborn
Weitkamp, J.-H., Lewis, D. B., & Levy, O. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-82823-9.00032-5 · Cited by 1
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It takes a village : Exploring the effect of antibiotics and other modulators on raising the infant gut microbiota
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Atividade imunomoduladora do óxido nítrico na resposta in vitro de células mononucleares de recém-natos e adultos.
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Exploration of the Mechanisms of Adjuvanticity for Toll-like Receptor Agonists
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What are the Implications of Silent Replication in Fetal and Newborn Monocytes for Zika Therapeutic development?
Yoshikawa, F. S. Y., & Sato, M. N. (2019) · Future Virology · doi:10.2217/fvl-2019-0029
Avaliação da resposta à vacina de DNA LAMP-1/p55Gag do HIV-1 e da geração de células T foliculares na imunização de camundongos neonatos
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Single Cell RNAseq Reveals A Critical Role of Chloride Channels in Airway DevelopmentPreprint
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“, 2019), indicating that such hybrid state may appear under physiological conditions that favors inflammation, including the Th2 dominant immunity found in newborns (Iwasaki and Medzhitov, 2015; Kollmann et al., 2017; Levy, 2007; Simon et al., 2015).”
Background
Global considerations on maternal vaccine introduction and implementation
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Commentary: Is the developmentally immature immune response in paediatric sepsis a recapitulation of immune tolerance?
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The significance of the cathelicidin LL-37 level in blood serum and tracheobronchial aspirate in respiratory distress syndrome and congenital pneumonia in premature newborns
Журавлева, Л. Н. (2020) · Vestnik of Vitebsk State Medical University · doi:10.22263/2312-4156.2020.1.45
Hyperbilirubinemia May Protect Neonates from SARS-CoV-2 Infection: A Yellow Eye View of COVID-19Preprint
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Microflora Formation in Newborns Depending on the Mother Microbiological Profile and Locality Altitude
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Lost in transition? Immune regulatory mechanisms in early life
Hoeks, S. B. E. A. (2021) · doi:10.33540/392
Lactancia materna durante la Pandemia de COVID-19
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Detailed Analysis of Immune Tolerance Mechanisms to SARS-CoV-2 in Children Is Needed
Ehara, H. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.652838
SÍNDROME INFLAMATORIO PERINATAL PERSISTENTE. IMPORTANTE FACTOR DE MORBIMORTALIDAD EN EL PREMATURO EXTREMO
Villalón, H., Caussade, M., Vial, M. D. L. Á., Pantoja, S., Vergara, N., & Escobar, J. J. (2021) · Revista Médica Clínica Las Condes · doi:10.1016/j.rmclc.2021.10.003
Evaluation and Management of Main Bacterial Infections in Premature Infants
Cho, K. H. (2022) · JOURNAL OF THE KOREAN SOCIETY OF MATERNAL AND CHILD HEALTH · doi:10.21896/jksmch.2022.26.1.1
“또한 미숙아에서는 사이토카인, 케모카인, 급성기 반응물질, APPs, 보체계의 기능이 모두 저하되어 있고, 중성구 및 항원 전달 세포들의 기능도 저하되어 있다 (Kollmann et al., 2017; Maródi et al., 2001; Raymond et al., 2017).”
COVID-19 Vaccination During Gestation and Lactation: Leaps in Comprehension
Fatma, E. S., Mahmoud, A. S., Aboulwafa, M., & Riham, M. S. (2022) · Journal of Advanced Pharmacy Research · doi:10.21608/aprh.2021.104588.1145
Atopy Redefined
Chan, L. S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-84744-5.00002-4

Authors: Kollmann, T. R., Kampmann, B., Mazmanian, S. K., Marchant, A., & Levy, O.
Affiliations: University of British Columbia (CA)
MRC Unit the Gambia (GM)
California Institute of Technology (US)
Université Libre de Bruxelles (BE)
Boston Children's Hospital (US)
Corresponding author: Kollmann, Tobias R.
Levy, Ofer
ORCID: Kollmann, Tobias R.
Kampmann, Beate
Mazmanian, Sarkis K.
Marchant, Arnaud
Levy, Ofer
Venue: Immunity
Publisher: Elsevier BV
Published: 2017-03
Volume: 46
Issue: 3
Pages: 350-363
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2017.03.009
OpenAlex: W2599501186
Semantic Scholar: e51f9b517003c880df24898208e6d4d93bb7cc87
Cited by: 478
References: 200
Citations by year: 2026: 62 · 2025: 45 · 2024: 54 · 2023: 51 · 2022: 40 · 2021: 67 · 2020: 69 · 2019: 39 · 2018: 36 · 2017: 15
FWCI: 4.45
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 385 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
Spiral (Imperial College London) (submittedVersion, cc-by-nc-nd)
Funders: Medical Research Council (MR/R005990/1)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and Maternal Infections
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: immune ontogeny, neonatal immunity, host defense, immune plasticity, neonatal infection
MeSH terms: Animals, Communicable Diseases, Disease Susceptibility, Humans, Immune System, Infant, Infant, Newborn

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Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny

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